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Literature summary for 1.1.1.21 extracted from

  • Ramana, K.V.; Bhatnagar, A.; Srivastava, S.K.
    Aldose reductase regulates TNF-alpha-induced cell signaling and apoptosis in vascular endothelial cells (2004), FEBS Lett., 570, 189-194.
    View publication on PubMed

Application

Application Comment Organism
medicine inhibition of enzyme prevents TNF-alpha-induced increase in Bax and Bak and the downregulation of Bcl-2, inhibition abrogates Ap-1 DNA binding activity and prevents the activation of caspase-3, JNK, and p38 MAPK in cells stimulated by TNFalpha Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
sorbinil
-
Homo sapiens
Tolrestat
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens enzyme is a critical regulator of TNF-alpha-induced apoptotic signaling in endothelial cells ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell umbilical vein endothelial cell Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme is a critical regulator of TNF-alpha-induced apoptotic signaling in endothelial cells Homo sapiens ?
-
?