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Literature summary for 1.1.1.21 extracted from

  • Hwang, Y.C.; Sato, S.; Tsai, J.Y.; Yan, S.; Bakr, S.; Zhang, H.; Oates, P.J.; Ramasamy, R.
    Aldose reductase activation is a key component of myocardial response to ischemia (2002), FASEB J., 16, 243-245.
    View publication on PubMed

Application

Application Comment Organism
medicine myocardial enzyme activity is increased during ischemia, partially due to activation by nitric oxide, enzyme inhibition increases glycolysis and glucose oxidation Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
zopolrestat inhibition of enzyme, increase in rates of glycolysis and glucose oxidation Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.19
-
DL-glyceraldehyde pH 6.2, 25°C, enzyme from ischemic heart Rattus norvegicus
0.2
-
DL-glyceraldehyde pH 6.2, 25°C, enzyme from normal heart Rattus norvegicus
28.9
-
D-xylose pH 6.2, 25°C, enzyme from normal heart Rattus norvegicus
29
-
D-xylose pH 6.2, 25°C, enzyme from ischemic heart Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-xylose + NADPH
-
Rattus norvegicus ?
-
?
DL-glyceraldehyde + NADPH
-
Rattus norvegicus glycerol + NADP+
-
?