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Literature summary for 1.1.1.21 extracted from

  • Attwood, M.A.; Doughty, C.C.
    Purification and properties of calf liver aldose reductase (1974), Biochim. Biophys. Acta, 370, 358-368.
    View publication on PubMed

General Stability

General Stability Organism
dithiothreitol, 2 mM stabilizes, other sulfhydryl compounds such as beta-mercaptoethanol, glutathione and cysteine are less effective Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
2'-AMP
-
Bos taurus
2-mercaptoethanol
-
Bos taurus
3'-AMP
-
Bos taurus
5'-AMP
-
Bos taurus
c-3',5'-AMP
-
Bos taurus
dithiothreitol
-
Bos taurus
HgCl2
-
Bos taurus
iodoacetate
-
Bos taurus
p-hydroxymercuribenzoate
-
Bos taurus
sulfhydryl inhibitors
-
Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.01 0.015 NADPH
-
Bos taurus
0.22
-
NADH
-
Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30500
-
2 * 30500, SDS-PAGE Bos taurus
61000
-
gel filtration Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
aldose + NAD(P)H Bos taurus
-
alditol + NAD(P)+
-
r

Organism

Organism UniProt Comment Textmining
Bos taurus
-
calf
-

Purification (Commentary)

Purification (Comment) Organism
calf Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
11.2
-
-
Bos taurus

Storage Stability

Storage Stability Organism
-45°C, stable at any stage of purification Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrobenzaldehyde + NAD(P)H
-
Bos taurus 4-nitrobenzyl alcohol + NAD(P)+
-
?
acetaldehyde + NAD(P)H + H+
-
Bos taurus ethanol + NAD(P)+
-
?
alditol + NAD(P)+
-
Bos taurus aldose + NAD(P)H
-
r
aldose + NAD(P)H
-
Bos taurus alditol + NAD(P)+
-
r
benzaldehyde + NAD(P)H
-
Bos taurus benzyl alcohol + NAD(P)+
-
?
butyraldehyde + NAD(P)H
-
Bos taurus butanol + NAD(P)+
-
?
D-glucose + NAD(P)H low activity Bos taurus sorbitol + NAD(P)+
-
r
D-xylose + NAD(P)H low activity Bos taurus xylitol + NAD(P)+
-
r
dihydroxyacetone + NAD(P)H
-
Bos taurus glycerol + NAD(P)+
-
?
n-pentanal + NAD(P)H + H+
-
Bos taurus n-pentanol + NAD(P)+
-
?
propionaldehyde + NAD(P)H
-
Bos taurus propanol + NAD(P)+
-
?
succinic semialdehyde + NADH + H+
-
Bos taurus 4-hydroxybutyrate + NAD+
-
?
xylitol + NAD(P)+
-
Bos taurus D-xylose + NAD(P)H + H+
-
r

Subunits

Subunits Comment Organism
dimer 2 * 30500, SDS-PAGE Bos taurus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
50
-
10 min, inactivation Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.7
-
glyceraldehyde + NAD(P)H Bos taurus
9.7 10.4 glycerol + NAD(P)H Bos taurus

Cofactor

Cofactor Comment Organism Structure
NADH 50% Bos taurus