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Literature summary for 1.1.1.209 extracted from
- A 3(17) alpha-hydroxysteroid dehydrogenase of female rabbit kidney cytosol. Purification and characterization of multiple forms of the enzyme (1982), J. Biol. Chem., 257, 9444-9449.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Oryctolagus cuniculus | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 40000 | - |
female rabbit, form IB, gel filtration | Oryctolagus cuniculus |
| 41000 | - |
female rabbit, forms II and III, gel filtration | Oryctolagus cuniculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
emale | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| female, 4 forms of enzyme | Oryctolagus cuniculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Oryctolagus cuniculus | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C | Oryctolagus cuniculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 17alpha-estradiol + NAD(P)+ | - |
Oryctolagus cuniculus | estrone + NAD(P)H | - |
? |  |
| 17alpha-estradiol 3-glucuronide + NAD(P)+ | - |
Oryctolagus cuniculus | estrone 3-glucuronide + NAD(P)H | - |
? | |
| 3alpha-hydroxy-5alpha-androstan-17-one + NAD(P)+ | i.e. androsterone | Oryctolagus cuniculus | 5alpha-androstan-3,17-dione + NAD(P)H | - |
? | |
| 5alpha-androstan-3alpha,17beta-diol + NAD(P)+ | - |
Oryctolagus cuniculus | 17beta-hydroxy-5alpha-androstan-3-one + NAD(P)H | - |
? | |
| epitestosterone + NAD(P)+ | - |
Oryctolagus cuniculus | androst-4-en-3,17-dione + NAD(P)H + H+ | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 40000, female rabbit, form IB, 1 * 41000, female rabbit, forms II and III, SDS-PAGE | Oryctolagus cuniculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | low activity | Oryctolagus cuniculus | |
| NADH | low activity | Oryctolagus cuniculus | |
| NADP+ | preferred | Oryctolagus cuniculus | |
| NADPH | preferred | Oryctolagus cuniculus | |
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Release 2026.1 (March 2026)
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