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Literature summary for 1.1.1.202 extracted from

  • Jiang, W.; Wang, S.; Wang, Y.; Fang, B.
    Key enzymes catalyzing glycerol to 1,3-propanediol (2016), Biotechnol. Biofuels, 9, 57.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.202

Application

Application Comment Organism
synthesis the enzyme can be used for 1,3-propandiol synthesis for use in resaerch and industrial applications, especially in biodiesel industry, but also as a monomer for polycondensation to manufacture plastics with special properties, i.e., polyesters, polyethers, polyurethanes, and polytrimethylene terephthalate as a monomer for cyclic compounds, and as a polyglycol-type lubricant Klebsiella pneumoniae
synthesis the enzyme can be used for 1,3-propandiol synthesis for use in resaerch and industrial applications, especially in biodiesel industry, but also as a monomer for polycondensation to manufacture plastics with special properties, i.e., polyesters, polyethers, polyurethanes, and polytrimethylene terephthalate as a monomer for cyclic compounds, and as a polyglycol-type lubricant Pantoea agglomerans
synthesis the enzyme can be used for 1,3-propandiol synthesis for use in resaerch and industrial applications, especially in biodiesel industry, but also as a monomer for polycondensation to manufacture plastics with special properties, i.e., polyesters, polyethers, polyurethanes, and polytrimethylene terephthalate as a monomer for cyclic compounds, and as a polyglycol-type lubricant Clostridium pasteurianum
synthesis the enzyme can be used for 1,3-propandiol synthesis for use in resaerch and industrial applications, especially in biodiesel industry, but also as a monomer for polycondensation to manufacture plastics with special properties, i.e., polyesters, polyethers, polyurethanes, and polytrimethylene terephthalate as a monomer for cyclic compounds, and as a polyglycol-type lubricant Levilactobacillus brevis
synthesis the enzyme can be used for 1,3-propandiol synthesis for use in resaerch and industrial applications, especially in biodiesel industry, but also as a monomer for polycondensation to manufacture plastics with special properties, i.e., polyesters, polyethers, polyurethanes, and polytrimethylene terephthalate as a monomer for cyclic compounds, and as a polyglycol-type lubricant Clostridium butyricum
synthesis the enzyme can be used for 1,3-propandiol synthesis for use in resaerch and industrial applications, especially in biodiesel industry, but also as a monomer for polycondensation to manufacture plastics with special properties, i.e., polyesters, polyethers, polyurethanes, and polytrimethylene terephthalate as a monomer for cyclic compounds, and as a polyglycol-type lubricant Citrobacter freundii
synthesis the enzyme can be used for 1,3-propandiol synthesis for use in resaerch and industrial applications, especially in biodiesel industry, but also as a monomer for polycondensation to manufacture plastics with special properties, i.e., polyesters, polyethers, polyurethanes, and polytrimethylene terephthalate as a monomer for cyclic compounds, and as a polyglycol-type lubricant Lentilactobacillus buchneri
synthesis the enzyme can be used for 1,3-propandiol synthesis for use in resaerch and industrial applications, especially in biodiesel industry, but also as a monomer for polycondensation to manufacture plastics with special properties, i.e., polyesters, polyethers, polyurethanes, and polytrimethylene terephthalate as a monomer for cyclic compounds, and as a polyglycol-type lubricant Clostridium perfringens
synthesis the enzyme can be used for 1,3-propandiol synthesis for use in resaerch and industrial applications, especially in biodiesel industry, but also as a monomer for polycondensation to manufacture plastics with special properties, i.e., polyesters, polyethers, polyurethanes, and polytrimethylene terephthalate as a monomer for cyclic compounds, and as a polyglycol-type lubricant Thermotoga maritima
synthesis the enzyme can be used for 1,3-propandiol synthesis for use in resaerch and industrial applications, especially in biodiesel industry, but also as a monomer for polycondensation to manufacture plastics with special properties, i.e., polyesters, polyethers, polyurethanes, and polytrimethylene terephthalate as a monomer for cyclic compounds, and as a polyglycol-type lubricant Limosilactobacillus reuteri

Cloned(Commentary)

Cloned (Comment) Organism
gene dhaT, part of the dha regulon, genetic structure, overview. Coexpressions of the PDOR and GDHt from gene dhaB in Klebsiella pneumoniae result in an increase of molar yield from 50.6-64.0% of 1,3-propanediol Clostridium butyricum
gene dhaT, part of the dha regulon, genetic structure, recombinant expression in Escherichia coli Citrobacter freundii
gene dhaT, part of the dha regulon, genetic structure, recombinant expression in Escherichia coli Clostridium perfringens
gene dhaT, part of the dha regulon, genetic structure, recombinant expression in Escherichia coli Thermotoga maritima
gene dhaT, part of the dha regulon, recombinant expression in Escherichia coli Klebsiella pneumoniae
gene dhaT, part of the dha regulon, recombinant expression in Escherichia coli Pantoea agglomerans
gene dhaT, part of the dha regulon, recombinant expression in Escherichia coli Clostridium pasteurianum
gene dhaT, part of the dha regulon, recombinant expression in Escherichia coli Levilactobacillus brevis
gene dhaT, part of the dha regulon, recombinant expression in Escherichia coli Lentilactobacillus buchneri
gene dhaT, part of the dha regulon, recombinant expression in Escherichia coli Limosilactobacillus reuteri

Protein Variants

Protein Variants Comment Organism
additional information the PDOR isozyme activity increases 4.6times, when the yqhD gene is expressed in the Klebsiella pneumoniae mutant strains AK, which is a knockout mutant of the GDH and PDOR Klebsiella pneumoniae

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ activates Levilactobacillus brevis
Ca2+ activates Lentilactobacillus buchneri
Fe2+ required, activates Klebsiella pneumoniae
Fe2+ required, activates Clostridium pasteurianum
Fe2+ required, activates Levilactobacillus brevis
Fe2+ required, activates Clostridium butyricum
Fe2+ required, activates Citrobacter freundii
Fe2+ required, activates Lentilactobacillus buchneri
Fe2+ required, activates Clostridium perfringens
Fe2+ required, activates Thermotoga maritima
Fe2+ required, activates Limosilactobacillus reuteri
K+ activates Limosilactobacillus reuteri
Li+ activates Clostridium butyricum
Mg2+ activates Levilactobacillus brevis
Mg2+ activates Lentilactobacillus buchneri
Mn2+ activates Klebsiella pneumoniae
Mn2+ activates Pantoea agglomerans
Mn2+ activates Clostridium pasteurianum
Mn2+ activates Levilactobacillus brevis
Mn2+ activates Clostridium butyricum
Mn2+ activates Citrobacter freundii
Mn2+ activates Lentilactobacillus buchneri
Mn2+ activates Clostridium perfringens
Mn2+ activates Thermotoga maritima
Mn2+ activates Limosilactobacillus reuteri
additional information the highest enzyme activity occurs with Mn2+, while the enzyme activity declines by 60-90% with other cations Clostridium pasteurianum
additional information the highest enzyme activity occurs with Mn2+, while the enzyme activity declines by 60-90% with other cations Clostridium butyricum
Na+ activates Klebsiella pneumoniae
Na+ activates Clostridium butyricum
NH4+ activates Klebsiella pneumoniae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
38500
-
-
 Pantoea agglomerans
41500
-
-
 Klebsiella pneumoniae
42000
-
 x * 42000 Klebsiella pneumoniae
42000
-
 x * 42000 Clostridium butyricum
43400
-
-
 Citrobacter freundii
336000
-
-
 Klebsiella pneumoniae
347000
-
-
 Citrobacter freundii
350000
-
-
 Levilactobacillus brevis
355000
-
-
 Pantoea agglomerans
384200
-
-
 Clostridium butyricum
387000
-
-
 Klebsiella pneumoniae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1,2-propylene glycol + NAD+ Klebsiella pneumoniae
-
 ? + NADH + H+
-
 r
1,2-propylene glycol + NAD+ Pantoea agglomerans
-
 ? + NADH + H+
-
 r
1,2-propylene glycol + NAD+ Clostridium pasteurianum
-
 ? + NADH + H+
-
 r
1,2-propylene glycol + NAD+ Levilactobacillus brevis
-
 ? + NADH + H+
-
 r
1,2-propylene glycol + NAD+ Clostridium butyricum
-
 ? + NADH + H+
-
 r
1,2-propylene glycol + NAD+ Citrobacter freundii
-
 ? + NADH + H+
-
 r
1,2-propylene glycol + NAD+ Lentilactobacillus buchneri
-
 ? + NADH + H+
-
 r
1,2-propylene glycol + NAD+ Clostridium perfringens
-
 ? + NADH + H+
-
 r
1,2-propylene glycol + NAD+ Thermotoga maritima
-
 ? + NADH + H+
-
 r
1,2-propylene glycol + NAD+ Limosilactobacillus reuteri
-
 ? + NADH + H+
-
 r
1,2-propylene glycol + NAD+ Citrobacter freundii DSM 30040
-
 ? + NADH + H+
-
 r
1,2-propylene glycol + NAD+ Klebsiella pneumoniae DSM2026
-
 ? + NADH + H+
-
 r
1,4-butanediol + NAD+ Klebsiella pneumoniae
-
 4-hydroxybutanal + NADH + H+
-
 r
1,4-butanediol + NAD+ Pantoea agglomerans
-
 4-hydroxybutanal + NADH + H+
-
 r
1,4-butanediol + NAD+ Clostridium pasteurianum
-
 4-hydroxybutanal + NADH + H+
-
 r
1,4-butanediol + NAD+ Levilactobacillus brevis
-
 4-hydroxybutanal + NADH + H+
-
 r
1,4-butanediol + NAD+ Clostridium butyricum
-
 4-hydroxybutanal + NADH + H+
-
 r
1,4-butanediol + NAD+ Citrobacter freundii
-
 4-hydroxybutanal + NADH + H+
-
 r
1,4-butanediol + NAD+ Lentilactobacillus buchneri
-
 4-hydroxybutanal + NADH + H+
-
 r
1,4-butanediol + NAD+ Clostridium perfringens
-
 4-hydroxybutanal + NADH + H+
-
 r
1,4-butanediol + NAD+ Thermotoga maritima
-
 4-hydroxybutanal + NADH + H+
-
 r
1,4-butanediol + NAD+ Limosilactobacillus reuteri
-
 4-hydroxybutanal + NADH + H+
-
 r
1-butyl alcohol + NAD+ Klebsiella pneumoniae
-
 1-butanal + NADH + H+
-
 r
1-butyl alcohol + NAD+ Pantoea agglomerans
-
 1-butanal + NADH + H+
-
 r
1-butyl alcohol + NAD+ Clostridium pasteurianum
-
 1-butanal + NADH + H+
-
 r
1-butyl alcohol + NAD+ Levilactobacillus brevis
-
 1-butanal + NADH + H+
-
 r
1-butyl alcohol + NAD+ Clostridium butyricum
-
 1-butanal + NADH + H+
-
 r
1-butyl alcohol + NAD+ Citrobacter freundii
-
 1-butanal + NADH + H+
-
 r
1-butyl alcohol + NAD+ Lentilactobacillus buchneri
-
 1-butanal + NADH + H+
-
 r
1-butyl alcohol + NAD+ Clostridium perfringens
-
 1-butanal + NADH + H+
-
 r
1-butyl alcohol + NAD+ Thermotoga maritima
-
 1-butanal + NADH + H+
-
 r
1-butyl alcohol + NAD+ Limosilactobacillus reuteri
-
 1-butanal + NADH + H+
-
 r
1-propanol + NAD+ Klebsiella pneumoniae
-
 propanal + NADH + H+
-
 r
1-propanol + NAD+ Pantoea agglomerans
-
 propanal + NADH + H+
-
 r
1-propanol + NAD+ Clostridium pasteurianum
-
 propanal + NADH + H+
-
 r
1-propanol + NAD+ Levilactobacillus brevis
-
 propanal + NADH + H+
-
 r
1-propanol + NAD+ Clostridium butyricum
-
 propanal + NADH + H+
-
 r
1-propanol + NAD+ Citrobacter freundii
-
 propanal + NADH + H+
-
 r
1-propanol + NAD+ Lentilactobacillus buchneri
-
 propanal + NADH + H+
-
 r
1-propanol + NAD+ Clostridium perfringens
-
 propanal + NADH + H+
-
 r
1-propanol + NAD+ Thermotoga maritima
-
 propanal + NADH + H+
-
 r
1-propanol + NAD+ Limosilactobacillus reuteri
-
 propanal + NADH + H+
-
 r
1-propanol + NAD+ Clostridium butyricum E5
-
 propanal + NADH + H+
-
 r
1-propanol + NAD+ Citrobacter freundii DSM 30040
-
 propanal + NADH + H+
-
 r
1-propanol + NAD+ Klebsiella pneumoniae DSM2026
-
 propanal + NADH + H+
-
 r
glycerol + NAD+ Klebsiella pneumoniae
-
 glyceraldehyde + NADH + H+
-
 r
glycerol + NAD+ Pantoea agglomerans
-
 glyceraldehyde + NADH + H+
-
 r
glycerol + NAD+ Clostridium pasteurianum
-
 glyceraldehyde + NADH + H+
-
 r
glycerol + NAD+ Levilactobacillus brevis
-
 glyceraldehyde + NADH + H+
-
 r
glycerol + NAD+ Clostridium butyricum
-
 glyceraldehyde + NADH + H+
-
 r
glycerol + NAD+ Citrobacter freundii
-
 glyceraldehyde + NADH + H+
-
 r
glycerol + NAD+ Lentilactobacillus buchneri
-
 glyceraldehyde + NADH + H+
-
 r
glycerol + NAD+ Clostridium perfringens
-
 glyceraldehyde + NADH + H+
-
 r
glycerol + NAD+ Thermotoga maritima
-
 glyceraldehyde + NADH + H+
-
 r
glycerol + NAD+ Limosilactobacillus reuteri
-
 glyceraldehyde + NADH + H+
-
 r
glycerol + NAD+ Clostridium butyricum E5
-
 glyceraldehyde + NADH + H+
-
 r
glycerol + NAD+ Citrobacter freundii DSM 30040
-
 glyceraldehyde + NADH + H+
-
 r
glycerol + NAD+ Klebsiella pneumoniae DSM2026
-
 glyceraldehyde + NADH + H+
-
 r
additional information Clostridium pasteurianum the enzyme can also use 1,4-butanediol, 1-butyl alcohol, 1-propanol, glycerol, or 1,2-propylene glycol as substrate. The optimal substrate is 3-hydroxypropanal in the catalytic reduction reaction, and the optimal substrate is propane-1,3-diol in the catalytic oxidation reaction ?
-
 ?
additional information Clostridium butyricum the enzyme can also use 1,4-butanediol, 1-butyl alcohol, 1-propanol, glycerol, or 1,2-propylene glycol as substrate. The optimal substrate is 3-hydroxypropanal in the catalytic reduction reaction, and the optimal substrate is propane-1,3-diol in the catalytic oxidation reaction ?
-
 ?
additional information Clostridium butyricum E5 the enzyme can also use 1,4-butanediol, 1-butyl alcohol, 1-propanol, glycerol, or 1,2-propylene glycol as substrate. The optimal substrate is 3-hydroxypropanal in the catalytic reduction reaction, and the optimal substrate is propane-1,3-diol in the catalytic oxidation reaction ?
-
 ?
propane-1,3-diol + NAD+ Klebsiella pneumoniae
-
 3-hydroxypropanal + NADH + H+
-
 r
propane-1,3-diol + NAD+ Pantoea agglomerans
-
 3-hydroxypropanal + NADH + H+
-
 r
propane-1,3-diol + NAD+ Clostridium pasteurianum
-
 3-hydroxypropanal + NADH + H+
-
 r
propane-1,3-diol + NAD+ Levilactobacillus brevis
-
 3-hydroxypropanal + NADH + H+
-
 r
propane-1,3-diol + NAD+ Clostridium butyricum
-
 3-hydroxypropanal + NADH + H+
-
 r
propane-1,3-diol + NAD+ Citrobacter freundii
-
 3-hydroxypropanal + NADH + H+
-
 r
propane-1,3-diol + NAD+ Lentilactobacillus buchneri
-
 3-hydroxypropanal + NADH + H+
-
 r
propane-1,3-diol + NAD+ Clostridium perfringens
-
 3-hydroxypropanal + NADH + H+
-
 r
propane-1,3-diol + NAD+ Thermotoga maritima
-
 3-hydroxypropanal + NADH + H+
-
 r
propane-1,3-diol + NAD+ Limosilactobacillus reuteri
-
 3-hydroxypropanal + NADH + H+
-
 r
propane-1,3-diol + NAD+ Clostridium butyricum E5
-
 3-hydroxypropanal + NADH + H+
-
 r
propane-1,3-diol + NAD+ Citrobacter freundii DSM 30040
-
 3-hydroxypropanal + NADH + H+
-
 r
propane-1,3-diol + NAD+ Klebsiella pneumoniae DSM2026
-
 3-hydroxypropanal + NADH + H+
-
 r

Organism

Organism UniProt Comment Textmining
Citrobacter freundii
-
-
-
Citrobacter freundii DSM 30040
-
-
-
Clostridium butyricum
-
-
-
Clostridium butyricum E5
-
-
-
Clostridium pasteurianum
-
-
-
Clostridium perfringens
-
-
-
Klebsiella pneumoniae
-
-
-
Klebsiella pneumoniae DSM2026
-
-
-
Lentilactobacillus buchneri
-
-
-
Levilactobacillus brevis
-
-
-
Limosilactobacillus reuteri
-
-
-
Pantoea agglomerans
-
-
-
Thermotoga maritima
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.42
-
 pH and temperature not specified in the publication Pantoea agglomerans
4.51
-
 pH and temperature not specified in the publication Clostridium butyricum
7.28
-
 pH and temperature not specified in the publication Levilactobacillus brevis
9.85
-
 pH and temperature not specified in the publication Klebsiella pneumoniae
11
-
 pH and temperature not specified in the publication Citrobacter freundii
37
-
 pH and temperature not specified in the publication Klebsiella pneumoniae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,2-propylene glycol + NAD+
-
 Klebsiella pneumoniae ? + NADH + H+
-
 r
1,2-propylene glycol + NAD+
-
 Pantoea agglomerans ? + NADH + H+
-
 r
1,2-propylene glycol + NAD+
-
 Clostridium pasteurianum ? + NADH + H+
-
 r
1,2-propylene glycol + NAD+
-
 Levilactobacillus brevis ? + NADH + H+
-
 r
1,2-propylene glycol + NAD+
-
 Clostridium butyricum ? + NADH + H+
-
 r
1,2-propylene glycol + NAD+
-
 Citrobacter freundii ? + NADH + H+
-
 r
1,2-propylene glycol + NAD+
-
 Lentilactobacillus buchneri ? + NADH + H+
-
 r
1,2-propylene glycol + NAD+
-
 Clostridium perfringens ? + NADH + H+
-
 r
1,2-propylene glycol + NAD+
-
 Thermotoga maritima ? + NADH + H+
-
 r
1,2-propylene glycol + NAD+
-
 Limosilactobacillus reuteri ? + NADH + H+
-
 r
1,2-propylene glycol + NAD+
-
 Citrobacter freundii DSM 30040 ? + NADH + H+
-
 r
1,2-propylene glycol + NAD+
-
 Klebsiella pneumoniae DSM2026 ? + NADH + H+
-
 r
1,4-butanediol + NAD+
-
 Klebsiella pneumoniae 4-hydroxybutanal + NADH + H+
-
 r
1,4-butanediol + NAD+
-
 Pantoea agglomerans 4-hydroxybutanal + NADH + H+
-
 r
1,4-butanediol + NAD+
-
 Clostridium pasteurianum 4-hydroxybutanal + NADH + H+
-
 r
1,4-butanediol + NAD+
-
 Levilactobacillus brevis 4-hydroxybutanal + NADH + H+
-
 r
1,4-butanediol + NAD+
-
 Clostridium butyricum 4-hydroxybutanal + NADH + H+
-
 r
1,4-butanediol + NAD+
-
 Citrobacter freundii 4-hydroxybutanal + NADH + H+
-
 r
1,4-butanediol + NAD+
-
 Lentilactobacillus buchneri 4-hydroxybutanal + NADH + H+
-
 r
1,4-butanediol + NAD+
-
 Clostridium perfringens 4-hydroxybutanal + NADH + H+
-
 r
1,4-butanediol + NAD+
-
 Thermotoga maritima 4-hydroxybutanal + NADH + H+
-
 r
1,4-butanediol + NAD+
-
 Limosilactobacillus reuteri 4-hydroxybutanal + NADH + H+
-
 r
1-butyl alcohol + NAD+
-
 Klebsiella pneumoniae 1-butanal + NADH + H+
-
 r
1-butyl alcohol + NAD+
-
 Pantoea agglomerans 1-butanal + NADH + H+
-
 r
1-butyl alcohol + NAD+
-
 Clostridium pasteurianum 1-butanal + NADH + H+
-
 r
1-butyl alcohol + NAD+
-
 Levilactobacillus brevis 1-butanal + NADH + H+
-
 r
1-butyl alcohol + NAD+
-
 Clostridium butyricum 1-butanal + NADH + H+
-
 r
1-butyl alcohol + NAD+
-
 Citrobacter freundii 1-butanal + NADH + H+
-
 r
1-butyl alcohol + NAD+
-
 Lentilactobacillus buchneri 1-butanal + NADH + H+
-
 r
1-butyl alcohol + NAD+
-
 Clostridium perfringens 1-butanal + NADH + H+
-
 r
1-butyl alcohol + NAD+
-
 Thermotoga maritima 1-butanal + NADH + H+
-
 r
1-butyl alcohol + NAD+
-
 Limosilactobacillus reuteri 1-butanal + NADH + H+
-
 r
1-propanol + NAD+
-
 Klebsiella pneumoniae propanal + NADH + H+
-
 r
1-propanol + NAD+
-
 Pantoea agglomerans propanal + NADH + H+
-
 r
1-propanol + NAD+
-
 Clostridium pasteurianum propanal + NADH + H+
-
 r
1-propanol + NAD+
-
 Levilactobacillus brevis propanal + NADH + H+
-
 r
1-propanol + NAD+
-
 Clostridium butyricum propanal + NADH + H+
-
 r
1-propanol + NAD+
-
 Citrobacter freundii propanal + NADH + H+
-
 r
1-propanol + NAD+
-
 Lentilactobacillus buchneri propanal + NADH + H+
-
 r
1-propanol + NAD+
-
 Clostridium perfringens propanal + NADH + H+
-
 r
1-propanol + NAD+
-
 Thermotoga maritima propanal + NADH + H+
-
 r
1-propanol + NAD+
-
 Limosilactobacillus reuteri propanal + NADH + H+
-
 r
1-propanol + NAD+
-
 Clostridium butyricum E5 propanal + NADH + H+
-
 r
1-propanol + NAD+
-
 Citrobacter freundii DSM 30040 propanal + NADH + H+
-
 r
1-propanol + NAD+
-
 Klebsiella pneumoniae DSM2026 propanal + NADH + H+
-
 r
3-hydroxypropanal + NADH + H+
-
 Klebsiella pneumoniae propane-1,3-diol + NAD+
-
 r
3-hydroxypropanal + NADH + H+
-
 Pantoea agglomerans propane-1,3-diol + NAD+
-
 r
3-hydroxypropanal + NADH + H+
-
 Clostridium pasteurianum propane-1,3-diol + NAD+
-
 r
3-hydroxypropanal + NADH + H+
-
 Levilactobacillus brevis propane-1,3-diol + NAD+
-
 r
3-hydroxypropanal + NADH + H+
-
 Clostridium butyricum propane-1,3-diol + NAD+
-
 r
3-hydroxypropanal + NADH + H+
-
 Citrobacter freundii propane-1,3-diol + NAD+
-
 r
3-hydroxypropanal + NADH + H+
-
 Lentilactobacillus buchneri propane-1,3-diol + NAD+
-
 r
3-hydroxypropanal + NADH + H+
-
 Clostridium perfringens propane-1,3-diol + NAD+
-
 r
3-hydroxypropanal + NADH + H+
-
 Thermotoga maritima propane-1,3-diol + NAD+
-
 r
3-hydroxypropanal + NADH + H+
-
 Limosilactobacillus reuteri propane-1,3-diol + NAD+
-
 r
3-hydroxypropanal + NADH + H+
-
 Clostridium butyricum E5 propane-1,3-diol + NAD+
-
 r
3-hydroxypropanal + NADH + H+
-
 Citrobacter freundii DSM 30040 propane-1,3-diol + NAD+
-
 r
3-hydroxypropanal + NADH + H+
-
 Klebsiella pneumoniae DSM2026 propane-1,3-diol + NAD+
-
 r
glycerol + NAD+
-
 Klebsiella pneumoniae glyceraldehyde + NADH + H+
-
 r
glycerol + NAD+
-
 Pantoea agglomerans glyceraldehyde + NADH + H+
-
 r
glycerol + NAD+
-
 Clostridium pasteurianum glyceraldehyde + NADH + H+
-
 r
glycerol + NAD+
-
 Levilactobacillus brevis glyceraldehyde + NADH + H+
-
 r
glycerol + NAD+
-
 Clostridium butyricum glyceraldehyde + NADH + H+
-
 r
glycerol + NAD+
-
 Citrobacter freundii glyceraldehyde + NADH + H+
-
 r
glycerol + NAD+
-
 Lentilactobacillus buchneri glyceraldehyde + NADH + H+
-
 r
glycerol + NAD+
-
 Clostridium perfringens glyceraldehyde + NADH + H+
-
 r
glycerol + NAD+
-
 Thermotoga maritima glyceraldehyde + NADH + H+
-
 r
glycerol + NAD+
-
 Limosilactobacillus reuteri glyceraldehyde + NADH + H+
-
 r
glycerol + NAD+
-
 Clostridium butyricum E5 glyceraldehyde + NADH + H+
-
 r
glycerol + NAD+
-
 Citrobacter freundii DSM 30040 glyceraldehyde + NADH + H+
-
 r
glycerol + NAD+
-
 Klebsiella pneumoniae DSM2026 glyceraldehyde + NADH + H+
-
 r
additional information the enzyme can also use 1,4-butanediol, 1-butyl alcohol, 1-propanol, glycerol, or 1,2-propylene glycol as substrate. The optimal substrate is 3-hydroxypropanal in the catalytic reduction reaction, and the optimal substrate is propane-1,3-diol in the catalytic oxidation reaction Clostridium pasteurianum ?
-
 ?
additional information the enzyme can also use 1,4-butanediol, 1-butyl alcohol, 1-propanol, glycerol, or 1,2-propylene glycol as substrate. The optimal substrate is 3-hydroxypropanal in the catalytic reduction reaction, and the optimal substrate is propane-1,3-diol in the catalytic oxidation reaction Clostridium butyricum ?
-
 ?
additional information the enzyme can also use 1,4-butanediol, 1-butyl alcohol, 1-propanol, glycerol, or 1,2-propylene glycol as substrate. The optimal substrate is 3-hydroxypropanal in the catalytic reduction reaction, and the optimal substrate is propane-1,3-diol in the catalytic oxidation reaction Clostridium butyricum E5 ?
-
 ?
propane-1,3-diol + NAD+
-
 Klebsiella pneumoniae 3-hydroxypropanal + NADH + H+
-
 r
propane-1,3-diol + NAD+
-
 Pantoea agglomerans 3-hydroxypropanal + NADH + H+
-
 r
propane-1,3-diol + NAD+
-
 Clostridium pasteurianum 3-hydroxypropanal + NADH + H+
-
 r
propane-1,3-diol + NAD+
-
 Levilactobacillus brevis 3-hydroxypropanal + NADH + H+
-
 r
propane-1,3-diol + NAD+
-
 Clostridium butyricum 3-hydroxypropanal + NADH + H+
-
 r
propane-1,3-diol + NAD+
-
 Citrobacter freundii 3-hydroxypropanal + NADH + H+
-
 r
propane-1,3-diol + NAD+
-
 Lentilactobacillus buchneri 3-hydroxypropanal + NADH + H+
-
 r
propane-1,3-diol + NAD+
-
 Clostridium perfringens 3-hydroxypropanal + NADH + H+
-
 r
propane-1,3-diol + NAD+
-
 Thermotoga maritima 3-hydroxypropanal + NADH + H+
-
 r
propane-1,3-diol + NAD+
-
 Limosilactobacillus reuteri 3-hydroxypropanal + NADH + H+
-
 r
propane-1,3-diol + NAD+
-
 Clostridium butyricum E5 3-hydroxypropanal + NADH + H+
-
 r
propane-1,3-diol + NAD+
-
 Citrobacter freundii DSM 30040 3-hydroxypropanal + NADH + H+
-
 r
propane-1,3-diol + NAD+
-
 Klebsiella pneumoniae DSM2026 3-hydroxypropanal + NADH + H+
-
 r

Subunits

Subunits Comment Organism
oligomer x * 42000 Klebsiella pneumoniae
oligomer x * 42000 Clostridium butyricum
oligomer x * 38500 Pantoea agglomerans
oligomer x * 41000-46000 Levilactobacillus brevis
oligomer x * 41500 Klebsiella pneumoniae
oligomer x * 43400 Citrobacter freundii

Synonyms

Synonyms Comment Organism
1,3-propanediol-oxydoreductase
-
 Klebsiella pneumoniae
1,3-propanediol-oxydoreductase
-
 Pantoea agglomerans
1,3-propanediol-oxydoreductase
-
 Clostridium pasteurianum
1,3-propanediol-oxydoreductase
-
 Levilactobacillus brevis
1,3-propanediol-oxydoreductase
-
 Clostridium butyricum
1,3-propanediol-oxydoreductase
-
 Citrobacter freundii
1,3-propanediol-oxydoreductase
-
 Lentilactobacillus buchneri
1,3-propanediol-oxydoreductase
-
 Clostridium perfringens
1,3-propanediol-oxydoreductase
-
 Thermotoga maritima
1,3-propanediol-oxydoreductase
-
 Limosilactobacillus reuteri
DhaT
-
 Klebsiella pneumoniae
DhaT
-
 Pantoea agglomerans
DhaT
-
 Clostridium pasteurianum
DhaT
-
 Levilactobacillus brevis
DhaT
-
 Clostridium butyricum
DhaT
-
 Citrobacter freundii
DhaT
-
 Lentilactobacillus buchneri
DhaT
-
 Clostridium perfringens
DhaT
-
 Thermotoga maritima
DhaT
-
 Limosilactobacillus reuteri
PDOR
-
 Klebsiella pneumoniae
PDOR
-
 Pantoea agglomerans
PDOR
-
 Clostridium pasteurianum
PDOR
-
 Levilactobacillus brevis
PDOR
-
 Clostridium butyricum
PDOR
-
 Citrobacter freundii
PDOR
-
 Lentilactobacillus buchneri
PDOR
-
 Clostridium perfringens
PDOR
-
 Thermotoga maritima
PDOR
-
 Limosilactobacillus reuteri

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
-
 Klebsiella pneumoniae
37
-
-
 Pantoea agglomerans
37
-
-
 Levilactobacillus brevis
37
-
-
 Clostridium butyricum
37
-
-
 Citrobacter freundii
55
-
-
 Klebsiella pneumoniae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.6
-
 aldehyde reduction Clostridium pasteurianum
6.6
-
 aldehyde reduction Levilactobacillus brevis
6.6
-
 aldehyde reduction Clostridium butyricum
6.6
-
 aldehyde reduction Lentilactobacillus buchneri
6.6
-
 aldehyde reduction Limosilactobacillus reuteri
7.7
-
-
 Citrobacter freundii
7.8
-
-
 Pantoea agglomerans
9
-
 alcohol oxidation Clostridium pasteurianum
9
-
 alcohol oxidation Lentilactobacillus buchneri
9
-
 alcohol oxidation Limosilactobacillus reuteri
9.1
-
 alcohol oxidation Clostridium butyricum
9.5
-
 alcohol oxidation Klebsiella pneumoniae
10
-
 alcohol oxidation Klebsiella pneumoniae

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Klebsiella pneumoniae
NAD+
-
 Pantoea agglomerans
NAD+
-
 Clostridium pasteurianum
NAD+
-
 Levilactobacillus brevis
NAD+
-
 Clostridium butyricum
NAD+
-
 Citrobacter freundii
NAD+
-
 Lentilactobacillus buchneri
NAD+
-
 Clostridium perfringens
NAD+
-
 Thermotoga maritima
NAD+
-
 Limosilactobacillus reuteri
NADH
-
 Klebsiella pneumoniae
NADH
-
 Pantoea agglomerans
NADH
-
 Clostridium pasteurianum
NADH
-
 Levilactobacillus brevis
NADH
-
 Clostridium butyricum
NADH
-
 Citrobacter freundii
NADH
-
 Lentilactobacillus buchneri
NADH
-
 Clostridium perfringens
NADH
-
 Thermotoga maritima
NADH
-
 Limosilactobacillus reuteri

General Information

General Information Comment Organism
evolution PDOR belongs to the Fe-NAD-dependent alcohol dehydrogenase third family, and it is also a typical iron-ion activation-type dehydrogenase Klebsiella pneumoniae
evolution PDOR belongs to the Fe-NAD-dependent alcohol dehydrogenase third family, and it is also a typical iron-ion activation-type dehydrogenase Pantoea agglomerans
evolution PDOR belongs to the Fe-NAD-dependent alcohol dehydrogenase third family, and it is also a typical iron-ion activation-type dehydrogenase Clostridium pasteurianum
evolution PDOR belongs to the Fe-NAD-dependent alcohol dehydrogenase third family, and it is also a typical iron-ion activation-type dehydrogenase Levilactobacillus brevis
evolution PDOR belongs to the Fe-NAD-dependent alcohol dehydrogenase third family, and it is also a typical iron-ion activation-type dehydrogenase Clostridium butyricum
evolution PDOR belongs to the Fe-NAD-dependent alcohol dehydrogenase third family, and it is also a typical iron-ion activation-type dehydrogenase Citrobacter freundii
evolution PDOR belongs to the Fe-NAD-dependent alcohol dehydrogenase third family, and it is also a typical iron-ion activation-type dehydrogenase Lentilactobacillus buchneri
evolution PDOR belongs to the Fe-NAD-dependent alcohol dehydrogenase third family, and it is also a typical iron-ion activation-type dehydrogenase Clostridium perfringens
evolution PDOR belongs to the Fe-NAD-dependent alcohol dehydrogenase third family, and it is also a typical iron-ion activation-type dehydrogenase Thermotoga maritima
evolution PDOR belongs to the Fe-NAD-dependent alcohol dehydrogenase third family, and it is also a typical iron-ion activation-type dehydrogenase Limosilactobacillus reuteri
malfunction accumulation of 3-HPA can inhibit the activity of glycerol dehydratase to prevent the growth of bacteria and result in reducing the production of propane-1,3-diol, leading to a major influence in the production of propane-1,3-diol Clostridium pasteurianum
malfunction accumulation of 3-hydroxypropanal can inhibit the activity of glycerol dehydratase to prevent the growth of bacteria and result in reducing the production of propane-1,3-diol, leading to a major influence in the production of propane-1,3-diol Klebsiella pneumoniae
malfunction accumulation of 3-hydroxypropanal can inhibit the activity of glycerol dehydratase to prevent the growth of bacteria and result in reducing the production of propane-1,3-diol, leading to a major influence in the production of propane-1,3-diol Pantoea agglomerans
malfunction accumulation of 3-hydroxypropanal can inhibit the activity of glycerol dehydratase to prevent the growth of bacteria and result in reducing the production of propane-1,3-diol, leading to a major influence in the production of propane-1,3-diol Levilactobacillus brevis
malfunction accumulation of 3-hydroxypropanal can inhibit the activity of glycerol dehydratase to prevent the growth of bacteria and result in reducing the production of propane-1,3-diol, leading to a major influence in the production of propane-1,3-diol Clostridium butyricum
malfunction accumulation of 3-hydroxypropanal can inhibit the activity of glycerol dehydratase to prevent the growth of bacteria and result in reducing the production of propane-1,3-diol, leading to a major influence in the production of propane-1,3-diol Citrobacter freundii
malfunction accumulation of 3-hydroxypropanal can inhibit the activity of glycerol dehydratase to prevent the growth of bacteria and result in reducing the production of propane-1,3-diol, leading to a major influence in the production of propane-1,3-diol Lentilactobacillus buchneri
malfunction accumulation of 3-hydroxypropanal can inhibit the activity of glycerol dehydratase to prevent the growth of bacteria and result in reducing the production of propane-1,3-diol, leading to a major influence in the production of propane-1,3-diol Clostridium perfringens
malfunction accumulation of 3-hydroxypropanal can inhibit the activity of glycerol dehydratase to prevent the growth of bacteria and result in reducing the production of propane-1,3-diol, leading to a major influence in the production of propane-1,3-diol Thermotoga maritima
malfunction accumulation of 3-hydroxypropanal can inhibit the activity of glycerol dehydratase to prevent the growth of bacteria and result in reducing the production of propane-1,3-diol, leading to a major influence in the production of propane-1,3-diol Limosilactobacillus reuteri
metabolism glycerol dehydratase, 1,3-propanediol dehydrogenase, and glycerol dehydrogenase are key enzymes in glycerol bioconversion into 1,3-propanediol and dihydroxyacetone Klebsiella pneumoniae
metabolism glycerol dehydratase, 1,3-propanediol dehydrogenase, and glycerol dehydrogenase are key enzymes in glycerol bioconversion into 1,3-propanediol and dihydroxyacetone Pantoea agglomerans
metabolism glycerol dehydratase, 1,3-propanediol dehydrogenase, and glycerol dehydrogenase are key enzymes in glycerol bioconversion into 1,3-propanediol and dihydroxyacetone Clostridium pasteurianum
metabolism glycerol dehydratase, 1,3-propanediol dehydrogenase, and glycerol dehydrogenase are key enzymes in glycerol bioconversion into 1,3-propanediol and dihydroxyacetone Levilactobacillus brevis
metabolism glycerol dehydratase, 1,3-propanediol dehydrogenase, and glycerol dehydrogenase are key enzymes in glycerol bioconversion into 1,3-propanediol and dihydroxyacetone Clostridium butyricum
metabolism glycerol dehydratase, 1,3-propanediol dehydrogenase, and glycerol dehydrogenase are key enzymes in glycerol bioconversion into 1,3-propanediol and dihydroxyacetone Citrobacter freundii
metabolism glycerol dehydratase, 1,3-propanediol dehydrogenase, and glycerol dehydrogenase are key enzymes in glycerol bioconversion into 1,3-propanediol and dihydroxyacetone Lentilactobacillus buchneri
metabolism glycerol dehydratase, 1,3-propanediol dehydrogenase, and glycerol dehydrogenase are key enzymes in glycerol bioconversion into 1,3-propanediol and dihydroxyacetone Clostridium perfringens
metabolism glycerol dehydratase, 1,3-propanediol dehydrogenase, and glycerol dehydrogenase are key enzymes in glycerol bioconversion into 1,3-propanediol and dihydroxyacetone Thermotoga maritima
metabolism glycerol dehydratase, 1,3-propanediol dehydrogenase, and glycerol dehydrogenase are key enzymes in glycerol bioconversion into 1,3-propanediol and dihydroxyacetone Limosilactobacillus reuteri