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Literature summary for 1.1.1.189 extracted from

  • Schieber, A.; Frank, R.W.; Ghisla, S.
    Purification and properties of prostaglandin 9-ketoreductase from pig and human kidney. Identity with human carbonyl reductase (1992), Eur. J. Biochem., 206, 491-502.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0023
-
9,10-phenanthrenequinone
-
Sus scrofa
0.0052
-
NADPH
-
Sus scrofa
0.16
-
prostaglandin E2
-
Sus scrofa
0.31
-
menadione
-
Sus scrofa
0.45
-
4-nitrobenzaldehyde
-
Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
28000
-
gel filtration, 4 isoforms Sus scrofa
32000
-
alpha, 1 * 32000, SDS-PAGE Sus scrofa
34000
-
alpha, 1 * 34000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens
-
Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Homo sapiens
-
kidney
-
Sus scrofa
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.02
-
-
Sus scrofa
0.034
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NAD(P)+
-
Homo sapiens (5Z,13E)-11alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H
-
?
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NAD(P)+
-
Sus scrofa (5Z,13E)-11alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H
-
ir
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
Homo sapiens (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
-
?
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
Homo sapiens (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
-
r
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ enzyme is pro(S) stereo selective with regard to hydrogen transfer from NADPH Sus scrofa (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+
-
r
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
Homo sapiens (5Z,13E)-9alpha,11alpha-dihydroxy-15-oxoprosta-5,13-dienoate + NADPH + H+
-
?
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+
-
Sus scrofa (5Z,13E)-9alpha,11alpha-dihydroxy-15-oxoprosta-5,13-dienoate + NADPH + H+
-
ir
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADP+
-
Homo sapiens (5Z,13E)-9alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate + NADPH
-
?
(5Z,13E)-(15S)-9alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate + NADP+
-
Sus scrofa (5Z,13E)-9alpha-hydroxy-11,15-dioxoprosta-5,13-dienoate + NADPH
-
ir
17alpha-hydroxyprogesterone + NADPH
-
Sus scrofa ?
-
?
2,6-dichloroindophenol + NADPH
-
Sus scrofa ?
-
?
4-nitrobenzaldehyde + NADPH
-
Sus scrofa ?
-
?
5alpha-dihydrotestosterone + NADPH
-
Sus scrofa ?
-
?
9,10-phenanthrenequinone + NADPH
-
Sus scrofa ?
-
?
alpha-tocopherolquinone + NADPH
-
Sus scrofa ?
-
?
corticosterone + NADPH + H+
-
Sus scrofa ?
-
?
cortisole + NADPH
-
Sus scrofa ?
-
?
menadione + NADPH
-
Sus scrofa ?
-
?
phenylglyoxal + NADPH
-
Sus scrofa ?
-
?

Subunits

Subunits Comment Organism
monomer alpha, 1 * 34000, SDS-PAGE Homo sapiens
monomer alpha, 1 * 32000, SDS-PAGE Sus scrofa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
Homo sapiens
37
-
-
Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8 9
-
Sus scrofa
8
-
-
Sus scrofa

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens
NADPH
-
Sus scrofa