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Literature summary for 1.1.1.150 extracted from

  • Keller, B.; Adamski, J.
    RDH12, a retinol dehydrogenase causing Lebers congenital amaurosis, is also involved in steroid metabolism (2007), J. Steroid Biochem. Mol. Biol., 104, 190-194.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expression in HeLa cell and 293T cell Homo sapiens
expression in HeLa cell and 293T cell Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum isoform RDH12 Homo sapiens 5783
-
endoplasmic reticulum
-
 Mus musculus 5783
-
mitochondrion isoform RDH13 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 retinol dehydrogenase isoforms RDH12 and RDH13
-
Mus musculus
-
 retinol dehydrogenase isoform RDH12
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dihydrotestosterone + NADH substrate for retinol dehydrogenase isoform RDH12, no substrate for isoform RDH13 Homo sapiens androstanediol + NAD+
-
 ?
additional information contrary to the human enzyme, dihydrotestosterone is not a substrate for mouse retinol dehydrogenase isoform RDH12 Mus musculus ?
-
 ?