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Literature summary for 1.1.1.146 extracted from

  • Hardy, R.S.; Fenton, C.; Croft, A.P.; Naylor, A.J.; Begum, R.; Desanti, G.; Buckley, C.D.; Lavery, G.; Cooper, M.S.; Raza, K.
    11 Beta-hydroxysteroid dehydrogenase type 1 regulates synovitis, joint destruction, and systemic bone loss in chronic polyarthritis (2018), J. Autoimmun., 92, 104-113 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
11-dehydrocorticosterone + NADPH + H+ Mus musculus
-
 corticosterone + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus P50172
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11-dehydrocorticosterone + NADPH + H+
-
 Mus musculus corticosterone + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
11 beta-hydroxysteroid dehydrogenase type 1
-
 Mus musculus
11beta-HSD1
-
 Mus musculus

General Information

General Information Comment Organism
malfunction global deletion of isoform 11beta-HSD1 drives an enhanced inflammatory phenotype, characterized by florid synovitis, joint destruction and systemic bone loss. This is associated with increased pannus invasion into subchondral bone, a marked polarisation towards pro-inflammatory M1 macrophages at sites of inflammation and increased osteoclast numbers Mus musculus
physiological function isoform 11beta-HSD1 plays a fundamental role in the suppression of synovitis, joint destruction, and systemic bone loss Mus musculus