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Literature summary for 1.1.1.146 extracted from

  • Zhang, L.; Shen, Y.; Zhu, H.J.; Wang, F.; Leng, Y.; Liu, J.K.
    Pentanol derivatives from basidiomycete Catathelasma imperiale and their 11beta-hydroxysteroid dehydrogenases inhibitory activity (2009), J. Antibiot., 62, 239-242.
    View publication on PubMed
Search for more literature for 1.1.1.146

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cell Homo sapiens
expressed in HEK-293 cell Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
(2S)-5-(acetyloxy)-2-hydroxypentyl acetate
-
 Homo sapiens
2-oxopentane-1,5-diyl diacetate
-
 Homo sapiens
2-oxopentane-1,5-diyl diacetate
-
 Mus musculus
5-hydroxy-4-oxopentyl acetate
-
 Homo sapiens
5-hydroxy-4-oxopentyl acetate
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cortisone + NADPH + H+
-
 Homo sapiens cortisol + NADP+
-
 ?
cortisone + NADPH + H+
-
 Mus musculus cortisol + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
11beta-hydroxysteroid dehydrogenase 1
-
 Homo sapiens
11beta-hydroxysteroid dehydrogenase 1
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Homo sapiens
NADP+
-
 Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
 IC50 = 0.0287 mg/ml, pH not specified in the publication, temperature not specified in the publication Homo sapiens 2-oxopentane-1,5-diyl diacetate
additional information
-
 IC50 = 0.0474 mg/ml, pH not specified in the publication, temperature not specified in the publication Homo sapiens 5-hydroxy-4-oxopentyl acetate
additional information
-
 IC50 = 0.0623 mg/ml, pH not specified in the publication, temperature not specified in the publication Homo sapiens (2S)-5-(acetyloxy)-2-hydroxypentyl acetate
additional information
-
 IC50 = 0.0304 mg/ml, pH not specified in the publication, temperature not specified in the publication Mus musculus 2-oxopentane-1,5-diyl diacetate
additional information
-
 IC50 = 0.1492 mg/ml, pH not specified in the publication, temperature not specified in the publication Mus musculus 5-hydroxy-4-oxopentyl acetate