Literature summary for 1.1.1.145 extracted from

Kim, H.H.; Kwak, D.H.; Yon, J.M.; Baek, I.J.; Lee, S.R.; Lee, J.E.; Nahm, S.S.; Jeong, J.H.; Lee, B.J.; Yun, Y.W.; Nam, S.Y.
Differential expression of 3beta-hydroxysteroid dehydrogenase mRNA in rat testes exposed to endocrine disruptors (2007), J. Reprod. Dev., 53, 465-471.

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Activating Compound

Activating Compound	Comment	Organism	Structure
flutamide	increase in mRNA expression in testis	Rattus norvegicus
testosterone	at low dose, increase in mRNA expression. At doses above 0.2 mg/kg/day, downregulation of 3beta-hydroxysteroid dehydrogenase mRNA	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
4-nonylphenol	downregulation of 3beta-hydroxysteroid dehydrogenase mRNA at all doses tested	Rattus norvegicus
diethylhexyl phthalate	downregulation of 3beta-hydroxysteroid dehydrogenase mRNA at all doses tested	Rattus norvegicus
diethylstilbestrol	downregulation of 3beta-hydroxysteroid dehydrogenase mRNA at all doses tested	Rattus norvegicus
ketoconazole	downregulation of 3beta-hydroxysteroid dehydrogenase mRNA at all doses tested	Rattus norvegicus
octylphenol	downregulation of 3beta-hydroxysteroid dehydrogenase mRNA at all doses tested	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
testis	-	Rattus norvegicus	-

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Release 2023.1 (January 2023)