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Literature summary for 1.1.1.145 extracted from

  • Rogerson, F.M.; LeHoux, J.G.; Mason, J.I.
    Expression and characterization of isoforms of 3beta-hydroxysteroid dehydrogenase/delta 5->4-isomerase in the hamster (1995), J. Steroid Biochem. Mol. Biol., 55, 481-487.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in 293 human fetal kidney cells Cricetinae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0024
-
dehydroepiandrosterone type I Cricetinae
0.0029
-
dehydroepiandrosterone type II Cricetinae
0.0055
-
pregnenolone type I Cricetinae
0.0088
-
pregnenolone type II Cricetinae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dehydroepiandrosterone + NAD+ Cricetinae
-
androst-5-en-3,17-dione + NADH + H+
-
?
pregnenolone + NAD(P)+ Cricetinae
-
pregn-5-en-3,20-dione + NAD(P)H + H+
-
?

Organism

Organism UniProt Comment Textmining
Cricetinae
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
Cricetinae
-
kidney
-
Cricetinae
-
liver male Cricetinae
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dehydroepiandrosterone + NAD+
-
Cricetinae androst-5-en-3,17-dione + NADH + H+
-
?
pregnenolone + NAD(P)+
-
Cricetinae pregn-5-en-3,20-dione + NAD(P)H + H+
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Cricetinae