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Literature summary for 1.1.1.145 extracted from

  • Clarke, T.R.; Bain, P.A.; Sha, L.; Payne, A.H.
    Enzyme characteristics of two distinct forms of mouse 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4-isomerase complementary deoxyribonucleic acids expressed in COS-1 cells (1993), Endocrinology, 132, 1971-1976.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression of 3beta HSD I and III in COS-1 cells Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.00008
-
pregnenolone 3betaHSD I Mus musculus
0.00014
-
dehydroepiandrosterone 3betaHSD I Mus musculus
0.00016
-
androstanediol 3betaHSD I Mus musculus
0.00046
-
androstanediol 3betaHSD III Mus musculus
0.00049
-
dehydroepiandrosterone 3betaHSD III Mus musculus
0.00103
-
pregnenolone 3betaHSD III Mus musculus
0.0055
-
stanolone 3betaHSD I Mus musculus
0.0068
-
stanolone 3betaHSD III Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dehydroepiandrosterone + NAD+ Mus musculus
-
androst-5-en-3,17-dione + NADH + H+
-
?
pregnenolone + NAD(P)+ Mus musculus
-
pregn-5-en-3,20-dione + NAD(P)H + H+
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland 3betaHSD I Mus musculus
-
kidney 3betaHSD II and III Mus musculus
-
liver 3betaHSD II and III Mus musculus
-
ovary 3betaHSD I Mus musculus
-
testis 3betaHSD I and VI Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3beta,17alpha-dihydroxy-5-pregnen-20-one + NAD(P)+
-
Mus musculus 17alpha-hydroxypregn-5-ene-3,20-dione + NAD(P)H
-
?
5alpha-androstanediol + NAD+
-
Mus musculus 5alpha-dihydrotestosterone + NADH
-
r
androstanediol + NAD+
-
Mus musculus dihydrotestosterone + NADH + H+
-
r
dehydroepiandrosterone + NAD+
-
Mus musculus androst-5-en-3,17-dione + NADH + H+
-
?
pregnenolone + NAD(P)+
-
Mus musculus pregn-5-en-3,20-dione + NAD(P)H + H+
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Mus musculus