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Literature summary for 1.1.1.105 extracted from

  • Strate, I.; Min, T.H.; Iliev, D.; Pera, E.M.
    Retinol dehydrogenase 10 is a feedback regulator of retinoic acid signalling during axis formation and patterning of the central nervous system (2009), Development, 136, 461-472.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293T cells Xenopus laevis

Inhibitors

Inhibitors Comment Organism Structure
additional information treatment with 0.005 mM retinoic acid induces a severe reduction of RDH10 expression, a combination of retinal dehydrogenase 2 mRNA and treatment with 0.005 mM retinal causes a robust downregulation of RDH10 transcription Xenopus laevis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Xenopus laevis RDH10 is required for proper retinoic acid signalling in the early embryo, RDH10 cooperates with retinal dehydrogenase 2 during axis development and central nervous system patterning ?
-
?

Organism

Organism UniProt Comment Textmining
Xenopus laevis C3TWL9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo dorsal blastopore lip Xenopus laevis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information RDH10 is required for proper retinoic acid signalling in the early embryo, RDH10 cooperates with retinal dehydrogenase 2 during axis development and central nervous system patterning Xenopus laevis ?
-
?
retinal + NADH + H+
-
Xenopus laevis retinol + NAD+
-
r

Synonyms

Synonyms Comment Organism
RDH10
-
Xenopus laevis
retinol dehydrogenase 10
-
Xenopus laevis

Cofactor

Cofactor Comment Organism Structure
NADH
-
Xenopus laevis