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BRENDA support

Ligand NADP+

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Basic Ligand Information

Molecular Structure
Picture of NADP+ (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
Molfile
C21H28N7O17P3
NADP+
XJLXINKUBYWONI-NNYOXOHSSA-O
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Synonyms:
2'-NADP+, beta-NADP+, coenzyme II, NAD(P)(+), NAD(P)+, NADP, nicotinamide adenine dinucleotide 3'-phosphate, TPN

Related pathways

Pathway Source
Pathways
BRENDA
3-chlorocatechol degradation, 3-phenylpropionate degradation, 4-hydroxymandelate degradation, acetate fermentation, acetyl CoA biosynthesis more
KEGG
Alcoholic liver disease, Aldosterone synthesis and secretion, Biosynthesis of cofactors, Chemical carcinogenesis - reactive oxygen species, Diabetic cardiomyopathy more
MetaCyc
(+)-pisatin biosynthesis, (-)-glycinol biosynthesis, (-)-maackiain biosynthesis, (-)-medicarpin biosynthesis, (1'S,5'S)-averufin biosynthesis more


Show all pahtways known for Show all BRENDA pathways known for NADP+

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3811 results)

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EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(S)-3-(imidazol-5-yl)lactate + NAD(P)+ = 3-(imidazol-5-yl)pyruvate + NAD(P)H
show the reaction diagram
-
D-glucose + NADP+ = D-glucono-1,5-lactone + NADPH + H+
show the reaction diagram
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L-fucose + NADP+ = L-fuconolactone + NADPH + H+
show the reaction diagram
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L-sorbose + NADP+ = 5-dehydro-D-fructose + NADPH + H+
show the reaction diagram
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D-fructose + NADP+ = 5-dehydro-D-fructose + NADPH
show the reaction diagram
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D-ribitol 5-phosphate + NAD(P)+ = D-ribulose 5-phosphate + NAD(P)H + H+
show the reaction diagram
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D-sorbitol 6-phosphate + NADP+ = D-fructose 6-phosphate + NADPH + H+
show the reaction diagram
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5D-5-O-methyl-chiro-inositol + NADP+ = 5D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + NADPH + H+
show the reaction diagram
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(S)-ureidoglycolate + NAD(P)+ = oxalureate + NAD(P)H
show the reaction diagram
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glycerol + NADP+ = dihydroxyacetone + NADPH + H+
show the reaction diagram
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D-erythrulose + NAD(P)+ = ?
show the reaction diagram
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D-mannitol 1-phosphate + NADP+ = D-fructose 6-phosphate + NADPH + H+
show the reaction diagram
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a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(P)+ = a 3-oxosteroid + CO2 + NAD(P)H
show the reaction diagram
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cholate + NADP+ = 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate + NADPH + H+
show the reaction diagram
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sn-glycerol 3-phosphate + NADP+ = D-glyceraldehyde 3-phosphate + NADPH + H+
show the reaction diagram
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TDP-D-glucose + 2 NADP+ + H2O = TDP-D-galacturonate + 2 NADPH + 2 H+
show the reaction diagram
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prostaglandin D2 + NADP+ = 15-ketoprostaglandin D2 + NADPH + H+
show the reaction diagram
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prostaglandin E2 + NADP+ = 15-oxoprostaglandin E2 + NADPH + H+
show the reaction diagram
L-gulono-1,4-lactone + NADP+ = D-glucurono-3,6-lactone + NADPH
show the reaction diagram
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D-sorbitol 6-phosphate + NADP+ = D-glucose 6-phosphate + NADPH + H+
show the reaction diagram
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farnesol + NADP+ = farnesal + NADPH
show the reaction diagram
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D-mannitol 1-phosphate + NADP+ = D-mannose 6-phosphate + NADPH + H+
show the reaction diagram
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3alpha-hydroxyglycyrrhetic acid + NADP+ = 3-ketoglycyrrhetic acid + NADPH
show the reaction diagram
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(5Z,13E)-(15S)-6,9alpha-epoxy-11alpha,15-dihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-6,9alpha-epoxy-11alpha-hydroxy-15-oxoprosta-5,13-dienoate + NADPH
show the reaction diagram
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quinic acid + NAD(P)+ = dehydroquinic acid + NAD(P)H + H+
show the reaction diagram
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6-endo-hydroxycineole + NAD(P)+ = 6-oxocineole + NAD(P)H
show the reaction diagram
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dTDP-D-fucose + NADP+ = dTDP-4-dehydro-6-deoxy-D-glucose + NADPH
show the reaction diagram
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(3)H-dehydroepiandrosterone + NAD(P)+ = ?
show the reaction diagram
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an (R)-2-hydroxycarboxylate + NADP+ = a 2-oxocarboxylate + NADPH + H+
show the reaction diagram
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2-dehydro-D-gulonate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+
show the reaction diagram
3beta-hydroxy-5beta-pregnane-20-one + NADP+ = 5beta-pregnane-3,20-dione + NADPH
show the reaction diagram
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GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H
show the reaction diagram
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(S)-lactaldehyde + NADP+ = methylglyoxal + NADPH + H+
show the reaction diagram
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S-(hydroxymethyl)glutathione + NAD(P)+ = S-formylglutathione + NAD(P)H + H+
show the reaction diagram
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D-arabitinol + NADP+ = D-xylulose + NADPH + H+
show the reaction diagram
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1,5-anhydro-D-mannitol + NADP+ = 1,5-anhydro-D-fructose + NADPH
show the reaction diagram
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71-hydroxychlorophyllide a + NADP+ = chlorophyllide b + NADPH + H+
show the reaction diagram
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3-hydroxy-2-methylpropanoate + NADP+ = 2-methyl-3-oxopropanoate + NADPH + H+
show the reaction diagram
(S)-benzoin + NADP+ = benzil + NADPH + H+
show the reaction diagram
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(R)-benzoin + NADP+ = benzil + NADPH + H+
show the reaction diagram
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(-)-endo-fenchol + NAD(P)+ = (+)-fenchone + NAD(P)H + H+
show the reaction diagram
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(+)-thujan-3-ol + NAD(P)+ = (+)-thujan-3-one + NAD(P)H + H+
show the reaction diagram
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2-dehydro-L-gulonate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+
show the reaction diagram
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vestitone + NADP+ = 7,2'-dihydroxy-4'-methoxyisoflavanol + NADPH + H+
show the reaction diagram
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6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+
show the reaction diagram
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5'-hydroxyaverantin + NADP+ = 5'-oxoaverantin + NADPH + H+
show the reaction diagram
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L-galactonate + NADP+ = D-galacturonate + NADPH + H+
show the reaction diagram
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UDP-2-acetamido-2,6-dideoxy-beta-L-talose + NAD(P)+ = UDP-2-acetamido-2,6-beta-L-arabino-hexul-4-ose + NAD(P)H + H+
show the reaction diagram
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scyllo-inositol + NADP+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADPH + H+
show the reaction diagram
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L-rhamnose + NADP+ = L-rhamno-1,4-lactone + NADPH + H+
show the reaction diagram
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D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH + H+
show the reaction diagram
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3beta,12alpha-dihydroxy-5beta-cholan-24-oic acid + NADP+ = 12alpha-hydroxy-3-oxo-5beta-cholan-24-oic acid + NADPH + H+
show the reaction diagram
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D-erythritol 1-phosphate + NADP+ = D-erythrulose 1-phosphate + NADPH + H+
show the reaction diagram
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(2R,3S)-2-alkyl-3-hydroxyalkanoate + NADP+ = (R)-2-alkyl-3-oxoalkanoate + NADPH + H+
show the reaction diagram
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xylitol + NADP+ = D-xylose + NADPH + H+
show the reaction diagram
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D-glucose + NADP+ = 6-dehydro-D-glucose + NADPH + H+
show the reaction diagram
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beta-L-fucopyranose + NADP+ = L-fucono-1,5-lactone + NADPH + H+
show the reaction diagram
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15alpha-stemmadenine + NADP+ = 17-dehydrostemmadenine + NADPH + 2 H+
show the reaction diagram
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ditrans,polycis-polyprenol + NADP+ = ditrans,polycis-polyprenal + NADPH + H+
show the reaction diagram
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L-arabinose + NADP+ = L-arabinono-1,4-lactone + NADPH + H+
show the reaction diagram
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glycerol + NADP+ = dihydroxyacetone + NADPH + H+
show the reaction diagram
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4-hydroxybutanoate + NADP+ = succinate semialdehyde + NADPH + H+
show the reaction diagram
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pyridoxine + NADP+ = pyridoxal + NADPH
show the reaction diagram
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L-1-amino-2-propanol + NADP+ = aminoacetone + NADPH + H+
show the reaction diagram
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(S)-malate + NADP+ = oxaloacetate + NADPH + H+
show the reaction diagram
3-hydroxybenzyl alcohol + NADP+ = 3-hydroxybenzaldehyde + NADPH
show the reaction diagram
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dTDP-alpha-D-fucopyranose + NADP+ = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + NADPH + H+
show the reaction diagram
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xylitol + NADP+ = D-xylulose + NADPH + H+
show the reaction diagram
-
D-sorbitol + NADP+ = L-sorbose + NADPH
show the reaction diagram
-
(-)-trans-acenaphthene-1,2-diol + NADP+ = acenaphthenequinone + NADPH
show the reaction diagram
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H2 + NADP+ = H+ + NADPH
show the reaction diagram
Hg + NADP+ + H+ = Hg2+ + NADPH
show the reaction diagram
2 Fe(II)-siderophore + NAD(P)+ + H+ = 2 Fe(III)-siderophore + NAD(P)H
show the reaction diagram
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2 Fe(II)-siderophore + NADP+ + H+ = 2 Fe(III)-siderophore + NADPH
show the reaction diagram
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formate + NADP+ = CO2 + NADPH
show the reaction diagram
(2R,3S)-catechin + NADP+ + H2O = 2,3-trans-3,4-cis-leucocyanidin + NADPH + H+
show the reaction diagram
isopentenyl diphosphate + NAD(P)+ + H2O = (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H
show the reaction diagram
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ferroheme o + H2O + 2 NAD(P)+ = ferroheme a + 2 NAD(P)H + 2 H+
show the reaction diagram
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reduced rubredoxin + NAD(P)+ = oxidized rubredoxin + NAD(P)H
show the reaction diagram
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2 reduced rubredoxin + NAD(P)+ + H+ = 2 oxidized rubredoxin + NAD(P)H
show the reaction diagram
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reduced [2Fe-2S] ferredoxin + NADP+ + H+ = oxidized [2Fe-2S] ferredoxin + NADPH
show the reaction diagram
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[amino group carrier protein LysW]-gamma-aminoadipic semialdehyde + phosphate + NADP+ = [amino group carrier protein LysW]-gamma-alpha-aminoadipate phosphate + NADPH + H+
show the reaction diagram
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[amino-group carrier protein LysW]-C-terminal-gamma-aminoadipic semialdehyde + phosphate + NADP+ = [amino-group carrier protein LysW]-C-terminal-gamma-(alpha-aminoadipate) phosphate + NADPH + H+
show the reaction diagram
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(S)-lactaldehyde + NAD(P)+ + H2O = (S)-lactate + NAD(P)H + 2 H+
show the reaction diagram
L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH + H+
show the reaction diagram
cis-11-hexadecenal + CoA + NADP+ = (E)-hexadec-11-enoyl-CoA + NADPH + H+
show the reaction diagram
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pyruvate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH
show the reaction diagram
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6-oxohexanoate + NADP+ + H2O = adipate + NADPH
show the reaction diagram
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coniferaldehyde + CoA + NADP+ = feruloyl-CoA + NADPH + H+
show the reaction diagram
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L-glutamate 1-semialdehyde + NADP+ + tRNAGlu = L-glutamyl-tRNAGlu + NADPH + H+
show the reaction diagram
a long-chain aldehyde + an [acyl-carrier protein] + NAD(P)+ = a long-chain acyl-[acyl-carrier protein] + NAD(P)H + H+
show the reaction diagram
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D-glyceraldehyde + NADP+ + H2O = D-glycerate + NADPH + H+
show the reaction diagram
3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + NADP+ + H2O = 3-oxo-5,6-dehydrosuberyl-CoA + NADPH + H+
show the reaction diagram
(2S)-3-sulfolactaldehyde + NADP+ + H2O = (2S)-3-sulfolactate + NADPH + H+
show the reaction diagram
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5'-hydroxyaverantin + NADP+ = (1'S)-5'-oxoaverantin + NADPH + H+
show the reaction diagram
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(+)-lariciresinol + NADP+ = (+)-pinoresinol + NADPH + H+
show the reaction diagram
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trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+
show the reaction diagram
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5alpha-pregnan-3,20-dione + NADP+ = progesterone + NADPH + H+
show the reaction diagram
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geissoschizine + NADP+ = 4,21-dehydrogeissoschizine + NADPH
show the reaction diagram
3-oxo-2((2Z)-pentenyl)-cyclopentane-1-octanoic acid + NADP+ = ?
show the reaction diagram
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cis-2,3-dihydro-2,3-dihydroxybiphenyl + NAD(P)+ = 2,3-dihydroxybiphenyl + NAD(P)H
show the reaction diagram
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4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADP+ = 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol + NADPH + H+
show the reaction diagram
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5alpha-cholest-7-en-3beta-ol + NADP+ = 5alpha-cholesta-7,24-dien-3beta-ol + NADPH + H+
show the reaction diagram
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17-O-acetylnorajmaline + NADP+ = 1,2-dihydrovomilenine + NADPH + H+
show the reaction diagram
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L-arogenate + NADP+ = L-tyrosine + NADPH + CO2
show the reaction diagram
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L-arogenate + NAD(P)+ = L-tyrosine + NAD(P)H + CO2
show the reaction diagram
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primary fluorescent chlorophyll catabolite + NADP+ = red chlorophyll catabolite + NADPH + H+
show the reaction diagram
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coproporphyrinogen-III + 2 NADP+ = protoporphyrinogen-IX + 2 CO2 + 2 NADPH + 2 H+
show the reaction diagram
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primary fluorescent chlorophyll catabolite + NADP+ = red chlorophyll catabolite + NADPH + H+
show the reaction diagram
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all-trans-13,14-dihydroretinol + NADP+ = all-trans-retinol + NADPH + H+
show the reaction diagram
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L-glutamate + NADP+ + H2O = NH3 + 2-oxoglutarate + NADPH + H+
show the reaction diagram
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L-lysine + NAD(P)+ + H2O = (S)-2-aminoadipate 6-semialdehyde + NAD(P)H + H+ + NH3
show the reaction diagram
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L-tryptophan + NAD(P)+ = indol-3-yl-pyruvate + NH3 + NAD(P)H
show the reaction diagram
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(2R,4S)-2,4-diaminopentanoate + H2O + NADP+ = (2R)-2-amino-4-oxopentanoate + NH3 + NADPH + H+
show the reaction diagram
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L-valine + NAD(P)+ + H2O = 2-oxoisovalerate + NH3 + NAD(P)H
show the reaction diagram
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2 L-glutamate + NADP+ = L-glutamine + 2-oxoglutarate + NADPH + H+
show the reaction diagram
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5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH + H+
show the reaction diagram
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N2-(D-1,3-dicarboxypropyl)-L-arginine + NADP+ + H2O = L-arginine + 2-oxoglutarate + NADPH + H+
show the reaction diagram
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5-methyltetrahydrofolate + NADP+ = 5,10-methylenetetrahydrofolate + NADPH
show the reaction diagram
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thiomorpholine 3-carboxylate + NAD(P)+ = 3,4-dehydro-thiomorpholine-3-carboxylate + NAD(P)H + H+
show the reaction diagram
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(R)-canadine + 2 NADP+ = berberine + 2 NADPH + H+
show the reaction diagram
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1,2-dihydrovomilenine + NADP+ = vomilenine + NADPH + H+
show the reaction diagram
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5,6,7,8-tetrahydropteridine + NAD(P)+ = 6,7-dihydropteridine + NAD(P)H
show the reaction diagram
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FMNH2 + NADP+ = FMN + NADPH + H+
show the reaction diagram
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17-dehydrostemmadenine + NADP+ = 3,17-didehydrostemmadenine + NADPH + H+
show the reaction diagram
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N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-lysine + 2-oxoglutarate + NADPH + H+
show the reaction diagram
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IMP + NH3 + NADP+ = GMP + NADPH + H+
show the reaction diagram
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2 mycothiol + NADP+ = mycothione + NADPH + H+
show the reaction diagram
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NADP+ + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide
show the reaction diagram
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[protein]-N6-[(2S,3R)-2-amino-8-carboxyoctan-3-yl]-L-lysine + CO2 + H2O + NAD(P)+ = (7R,8S)-8-amino-7-(carboxyamino)nonanoate + [protein]-(S)-2-amino-6-oxohexanoate + NAD(P)H + H+
show the reaction diagram
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NADP+ + H2O = NAD+ + phosphate
show the reaction diagram
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NADP+ + H2O = nicotinic acid mononucleotide + phosphate
show the reaction diagram
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NADP+ + H2O = NMN + adenosine 3',5'-diphosphate
show the reaction diagram
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NADP+ + H2O = nicotinic acid mononucleotide + phosphate
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (10152 results)

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EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3-(4-hydroxyphenyl)pyruvate + NAD(P)H = (R)-3-(4-hydroxyphenyl)lactate + NAD(P)+
show the reaction diagram
286312, -
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fructose + NADPH = sorbitol + NADP+
show the reaction diagram
-
(4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + NADPH = 2-dehydro-3-deoxy-D-gluconate + NADP+
show the reaction diagram
2,5-didehydro-3-deoxy-D-gluconate + NADPH + H+ = 2-dehydro-3-deoxy-D-gluconate + NADP+
show the reaction diagram
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(4R,5S)-4,5,6-trihydroxy-2,3-dioxohexanoate + NAD(P)H = 3-dehydro-L-gulonate + NAD(P)+
show the reaction diagram
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D-mannuronate + NADPH = D-mannonate + NADP+
show the reaction diagram
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TDP-6-deoxy-D-xylo-4-hexosulose + NADPH = TDP-6-deoxy-L-talose + NADP+
show the reaction diagram
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GDP-4-dehydro-6-deoxy-D-talose + NAD(P)H = GDP-6-deoxy-D-talose + NAD(P)+
show the reaction diagram
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