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Ligand GDP-6-deoxy-alpha-D-mannose Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Basic Ligand Information
C1 6 H2 5 N5 O1 5 P2
GDP-6-deoxy-alpha-D-mannose
LQEBEXMHBLQMDB-GDJBGNAASA-N
GDP-6-deoxy-D-mannose, GDP-6-deoxymannose, GDP-alpha-D-rhamnose, GDP-D-rhamnose
Related pathways
MetaCyc
astaxanthin dirhamnoside biosynthesis, GDP-D-rhamnose biosynthesis
Roles as Enzyme Ligand
In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H
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In Vivo Product in Enzyme-catalyzed Reactions (3 results)Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H = GDP-6-deoxy-D-mannose + NAD(P)+
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GDP-4-dehydro-6-deoxy-D-mannose + NADPH = GDP-6-deoxy-D-mannose + NADP+
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GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+ = GDP-D-rhamnose + NAD(P)+
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Substrate in Enzyme-catalyzed Reactions (1 result)
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GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H
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Product in Enzyme-catalyzed Reactions (9 results)
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GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H = GDP-6-deoxy-D-mannose + NAD(P)+
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GDP-4-dehydro-alpha-D-rhamnose + NAD(P)H + H+ = GDP-alpha-D-rhamnose + NAD(P)+
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GDP-4-dehydro-alpha-D-rhamnose + NADH + H+ = GDP-alpha-D-rhamnose + NAD+
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GDP-4-dehydro-6-deoxy-D-mannose + NADPH = GDP-6-deoxy-D-mannose + NADP+
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GDP-6-deoxy-D-lyxo-4-hexulose + NADH + H+ = GDP-alpha-D-rhamnose + NAD+
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GDP-6-deoxy-D-lyxo-4-hexulose + NADPH + H+ = GDP-alpha-D-rhamnose + NADP+
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GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+ = GDP-D-rhamnose + NAD(P)+
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GDP-4-dehydro-6-deoxy-D-mannose = GDP-D-rhamnose
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GDP-4-dehydro-6-deoxy-D-mannose = GDP-D-rhamnose
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Inhibitor in Enzyme-catalyzed Reactions (1 result)
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3D Structure of Enzyme-Ligand-Complex (PDB) (10 results)
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Enzyme Kinetic Parameters
Ki Value (1 result)
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IC50 Value (1 result)
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References & Links Literature References (6)
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Guanosine diphosphate-4-keto-D-rhamnose reductase. A non-stereoselective enzyme
1971
Winkler, N.W.; Markovitz, A.
J. Biol. Chem.
246
5868-5876
The synthesis of guanosine 5-diphosphate D-rhamnose by enzymes of a higher plant
1968
Barber, G.A.
Biochim. Biophys. Acta
165
68-75
Specificity of GDP-Man:dolichyl-phosphate mannosyltransferase for the guanosine diphosphate esters of mannose analogues containing deoxy and deoxyfluoro substituents
1989
McDowell, W.; Schwarz, R.T.
FEBS Lett.
243
413-416
Identification of two GDP-6-deoxy-D-lyxo-4-hexulose reductases synthesizing GDP-D-rhamnose in Aneurinibacillus thermoaerophilus L420-91T
2001
Kneidinger, B.; Graninger, M.; Adam, G.; Puchberger, M.; Kosma, P.; Zayni, S.; Messner, P.
J. Biol. Chem.
276
5577-5583
Functional expression of Pseudomonas aeruginosa GDP-4-keto-6-deoxy-D-mannose reductase which synthesizes GDP-rhamnose
2002
Mäki, M.; Järvinen, N.; Räbinä, J.; Roos, C.; Maaheimo, H.; Mattila, P.; Renkonen, R.
Eur. J. Biochem.
269
593-601
GDP-Mannose pyrophosphorylase is essential in the bloodstream form of Trypanosoma brucei
2010
Denton, H.; Fyffe, S.; Smith, T.K.
Biochem. J.
425
603-614
Links to other databases for GDP-6-deoxy-alpha-D-mannose
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