Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Two chinese hamster ovary glycosylation mutants affected in the conversion of GDP-mannose to GDP-fucose
1986
Ripka, J.; Adamany, A.; Stanley, P.
Arch. Biochem. Biophys.
249
533-545
Purification and characterization of GDP-D-mannose 4,6 dehydratase from porcine thyroid
1985
Broschat, K.O.; Chang, S.; Serif, G.
Eur. J. Biochem.
153
397-401
Purification of guanosine 5'-diphosphate d-mannose oxidoreductase from Phaseolus vulgaris
1972
Liao, T.H.; Barber, G.A.
Biochim. Biophys. Acta
276
85-93
The biosynthesis of cell wall lipopolysaccharide in Escherichia coli
1965
Elbein, A.D.; Heath, E.C.
J. Biol. Chem.
240
1926-1931
Stereochemistry and mechanism of the GDP-mannose dehydratase reaction
1990
Oths, P.J.; Mayer, R.M.; Floss, H.G.
Carbohydr. Res.
198
91-100
Molecular cloning of human GDP-mannose 4,6-Dehydratase and reconstitution of GDP-fucose biosynthesis in vitro
1998
Sullivan, F.X.; Kumar, R.; Kriz, R.; Stahl, M.; Xu, G.Y.; Rouse, G.; Chang, X.J.; Boodhoo, A.; Potvin, B.; Cumming, D.A.
J. Biol. Chem.
273
8193-8202
Expression, purification and characterization of GDP-D-mannose 4,6,-dehydratase from Escherichia coli
1997
Sturla, L.; Bisso, A.; Zanardi, D.; Benatti, U.; De Flora, A.; Tonetti, M.
FEBS Lett.
412
126-130
Defective intracellular activity of GDP-D-mannose 4,6-dehydratase in leukocyte adhesion deficiency type II syndrome
1998
Sturla, L.; Etzioni, A.; Biso, A.; Zanardi, D.; De Flora, G.; Silengo, L.; De Flora, A.; Tonetti, M.
FEBS Lett.
429
274-278
Evidence that the enzyme catalyzing the conversion of guanosine diphosphate D-mannose to a 4-keto sugar nucleotide intermediate requires nicotinamide adenine dinucleotide phosphate
1993
Yamamoto, K.; Katayama, I.; Onoda, Y.; Inami, M.; Kumagai, H.; Tochikura, T.
Arch. Biochem. Biophys.
300
694-698
The MUR1 gene of Arabidopsis thaliana encodes an isoform of GDP-D-mannose-4,6-dehydratase, catalyzing the first step in the de novo synthesis of GDP-L-fucose
1997
Bonin, C.P.; Potter, I.; Vanzin, G.F.; Reiter, W.D.
Proc. Natl. Acad. Sci. USA
94
2085-2090
The metabolism of 6-deoxyhexoses in bacterial and animal cells
1998
Tonetti, M.; Sturla, L.; Bisso, A.; Zanardi, D.; Benatti, U.; De Flora, A.
Biochimie
80
923-931
Biosynthesis of guanosine diphosphate D-rhamnose and guanosine diphosphate D-talomethylose from guanosine diphosphate alpha-D-mannose
1964
Markovitz, A.
J. Biol. Chem.
239
2091-2098
Guanosine diphosphate-4-keto-D-rhamnose reductase. A non-stereoselective enzyme
1971
Winkler, N.W.; Markovitz, A.
J. Biol. Chem.
246
5868-5876
The synthesis of guanosine 5-diphosphate D-rhamnose by enzymes of a higher plant
1968
Barber, G.A.
Biochim. Biophys. Acta
165
68-75
A bifunctional epimerase-reductase acts downstream of the MUR1 gene product and completes the de novo synthesis of GDP-L-fucose in Arabidopsis
2000
Bonin, C.P.; Reiter, W.D.
Plant J.
21
445-454
An epimerase-reductase in L-fucose synthesis
1988
Chang, S.; Duerr, B.; Serif, G.
J. Biol. Chem.
263
1693-1697
Cloning and expression of Helicobacter pylori GDP-L-fucose synthesizing enzymes (GMD and GMER) in Saccharomyces cerevisiae
2001
Jarvinen, N.; Maki, M.; Rabina, J.; Roos, C.; Mattila, P.; Renkonen, R.
Eur. J. Biochem.
268
6458-6464
Functional expression of Escherichia coli enzymes synthesizing GDP-L-fucose from inherent GDP-D-mannose in Saccharomyces cerevisiae
2000
Mattila, P.; Rabina, J.; Hortling, S.; Helin, J.; Renkonen, R.
Glycobiology
10
1041-1047
Stereochemical course and steady state mechanism of the reaction catalyzed by the GDP-fucose synthetase from Escherichia coli
1999
Menon, S.; Stahl, M.; Kumar, R.; Xu, G.Y.; Sullivan, F.
J. Biol. Chem.
274
26743-26750
Molecular cloning and expression of GDP-D-mannose-4,6-dehydratase, a key enzyme for fucose metabolism defective in Lec13 cells
1998
Ohyama, C.; Smith, P.L.; Angata, K.; Fukuda, M.N.; Lowe, J.B.; Fukuda, M.
J. Biol. Chem.
273
14582-14587
Identification and characterization of GDP-D-mannose 4,6-dehydratase and GDP-L-fucose synthetase in a GDP-L-fucose biosynthetic gene cluster from Helicobacter pylori
2001
Wu, B.; Zhang, Y.; Wang, P.G.
Biochem. Biophys. Res. Commun.
285
364-371
Functional expression of Pseudomonas aeruginosa GDP-4-keto-6-deoxy-D-mannose reductase which synthesizes GDP-rhamnose
2002
Mäki, M.; Järvinen, N.; Räbinä, J.; Roos, C.; Maaheimo, H.; Mattila, P.; Renkonen, R.
Eur. J. Biochem.
269
593-601
Structure of the MUR1 GDP-mannose 4,6-dehydratase from Arabidopsis thaliana: implications for ligand binding and specificity
2002
Mulichak, A.M.; Bonin, C.P.; Reiter, W.D.; Garavito, R.M.
Biochemistry
41
15578-15589
Guanosine diphosphate-4-keto-6-deoxy-D-mannose reductase in the pathway for the synthesis of GDP-6-deoxy-D-talose in Actinobacillus actinomycetemcomitans
2002
Suzuki, N.; Nakano, Y.; Yoshida, Y.; Nezu, T.; Terada, Y.; Yamashita, Y.; Koga, T.
Eur. J. Biochem.
269
5963-5971
Structural and enzymatic characterization of human recombinant GDP-D-mannose-4,6-dehydratase
1999
Bisso, A.; Sturla, L.; Zanardi, D.; De Flora, A.; Tonetti, M.
FEBS Lett.
456
370-374
-
Interaction of GDP-4-keto-6-deoxymannose-3,5-epimerase-4-reductase with GDP-mannose-4,6-dehydratase stabilizes the enzyme activity for formation of GDP-fucose from GDP-mannose
2003
Nakayama, K.; Maeda, Y.; Jigami, Y.
Glycobiology
13
673R-680R
Crystal structure of a tetrameric GDP-D-mannose 4,6-dehydratase from a bacterial GDP-D-rhamnose biosynthetic pathway
2004
Webb, N.A.; Mulichak, A.M.; Lam, J.S.; Rocchetta, H.L.; Garavito, R.M.
Protein Sci.
13
529-539
Structural and kinetic analysis of Escherichia coli GDP-mannose 4,6 dehydratase provides insights into the enzyme's catalytic mechanism and regulation by GDP-fucose
2000
Somoza, J.R.; Menon, S.; Schmidt, H.; Joseph-McCarthy, D.; Dessen, A.; Stahl, M.L.; Somers, W.S.; Sullivan, F.X.
Structure Fold. Des.
8
123-135
Cloning and functional expression of a novel GDP-6-deoxy-D-talose synthetase from Actinobacillus actinomycetemcomitans
2003
Maki, M.; Jarvinen, N.; Rabina, J.; Maaheimo, H.; Mattila, P.; Renkonen, R.
Glycobiology
13
295-303
Differential gene expression of GDP-L-fucose-synthesizing enzymes, GDP-fucose transporter and fucosyltransferase VII
2006
Niittymaki, J.; Mattila, P.; Renkonen, R.
APMIS
114
539-548
Reconstitution in vitro of the GDP-fucose biosynthetic pathways of Caenorhabditis elegans and Drosophila melanogaster
2006
Rhomberg, S.; Fuchsluger, C.; Rendi?, D.; Paschinger, K.; Jantsch, V.; Kosma, P.; Wilson, I.B.
FEBS J.
273
2244-2256
Production of GDP-L-fucose, L-fucose donor for fucosyloligosaccharide synthesis, in recombinant Escherichia coli
2007
Byun, S.G.; Kim, M.D.; Lee, W.H.; Lee, K.J.; Han, N.S.; Seo, J.H.
Appl. Microbiol. Biotechnol.
74
768-775
Deciphering the genetic bases of the structural diversity of phenolic glycolipids in strains of the Mycobacterium tuberculosis complex
2008
Malaga, W.; Constant, P.; Euphrasie, D.; Cataldi, A.; Daffe, M.; Reyrat, J.M.; Guilhot, C.
J. Biol. Chem.
283
15177-15184
Mechanism and active site residues of GDP-fucose synthase
2008
Lau, S.T.; Tanner, M.E.
J. Am. Chem. Soc.
130
17593-17602
Biochemical characterization of GDP-L-fucose de novo synthesis pathway in fungus Mortierella alpina
2010
Ren, Y.; Perepelov, A.V.; Wang, H.; Zhang, H.; Knirel, Y.A.; Wang, L.; Chen, W.
Biochem. Biophys. Res. Commun.
391
1663-1669
The structural basis for catalytic function of GMD and RMD, two closely related enzymes from the GDP-D-rhamnose biosynthesis pathway
2009
King, J.D.; Poon, K.K.; Webb, N.A.; Anderson, E.M.; McNally, D.J.; Brisson, J.R.; Messner, P.; Garavito, R.M.; Lam, J.S.
FEBS J.
276
2686-2700
Cloning and characterization of GDP-perosamine synthetase (Per) from Escherichia coli O157:H7 and synthesis of GDP-perosamine in vitro
2007
Zhao, G.; Liu, J.; Liu, X.; Chen, M.; Zhang, H.; Wang, P.G.
Biochem. Biophys. Res. Commun.
363
525-530
Biosynthesis of colitose: expression, purification, and mechanistic characterization of GDP-4-keto-6-deoxy-D-mannose-3-dehydrase (ColD) and GDP-L-colitose synthase (ColC)
2004
Alam, J.; Beyer, N.; Liu, H.W.
Biochemistry
43
16450-16460
Accommodation of GDP-linked sugars in the active site of GDP-perosamine synthase
2008
Cook, P.D.; Carney, A.E.; Holden, H.M.
Biochemistry
47
10685-10693
GDP-perosamine synthase: structural analysis and production of a novel trideoxysugar
2008
Cook, P.D.; Holden, H.M.
Biochemistry
47
2833-2840
Two site-directed mutations are required for the conversion of a sugar dehydratase into an aminotransferase
2009
Cook, P.D.; Kubiak, R.L.; Toomey, D.P.; Holden, H.M.
Biochemistry
48
5246-5253
Identification of the GDP-N-acetyl-d-perosamine producing enzymes from Escherichia coli O157:H7
2008
Albermann, C.; Beuttler, H.
FEBS Lett.
582
479-484
Expression and identification of the RfbE protein from Vibrio cholerae O1 and its use for the enzymatic synthesis of GDP-D-perosamine
2001
Albermann, C.; Piepersberg, W.
Glycobiology
11
655-661
The crystal structure of human GDP-L-fucose synthase
2013
Zhou, H.; Sun, L.; Li, J.; Xu, C.; Yu, F.; Liu, Y.; Ji, C.; He, J.
Acta Biochim. Biophys. Sin. (Shanghai)
45
720-725
Metabolic engineering of Corynebacterium glutamicum to produce GDP-L-fucose from glucose and mannose
2013
Chin, Y.W.; Park, J.B.; Park, Y.C.; Kim, K.H.; Seo, J.H.
Bioprocess Biosyst. Eng.
36
749-756
-
A structural study of GDP-4-keto-6-deoxy-D-mannose-3-dehydratase: Caught in the act of geminal diamine formation
2007
Cook, P.; Holden, H.
Biochemistry
46
14215-14224
GDP-4-keto-6-deoxy-D-mannose 3-dehydratase, accommodating a sugar substrate in the active site
2008
Cook, P.; Holden, H.
J. Biol. Chem.
283
4295-4303
Defects in D-rhamnosyl residue biosynthetic genes affect lipopolysaccharide structure, motility, and cell-surface hydrophobicity in Pseudomonas syringae pathovar glycinea race 4
2013
Chiku, K.; Tsunemi, K.; Yamamoto, M.; Ohnishi-Kameyama, M.; Yoshida, M.; Ishii, T.; Taguchi, F.; Iwaki, M.; Ichinose, Y.; Ono, H.
Biosci. Biotechnol. Biochem.
77
505-510
Biosynthesis of GDP-fucose and other sugar nucleotides in the blood stages of Plasmodium falciparum
2013
Sanz, S.; Bandini, G.; Ospina, D.; Bernabeu, M.; Marino, K.; Fernandez-Becerra, C.; Izquierdo, L.
J. Biol. Chem.
288
16506-16517
An alkynyl-fucose halts hepatoma cell migration and invasion by inhibiting GDP-fucose-synthesizing enzyme FX, TSTA3
2017
Kizuka, Y.; Nakano, M.; Yamaguchi, Y.; Nakajima, K.; Oka, R.; Sato, K.; Ren, C.T.; Hsu, T.L.; Wong, C.H.; Taniguchi, N.
Cell Chem. Biol.
24
1467-1478
One-pot synthesis of GDP-L-fucose by a four-enzyme cascade expressed in Lactococcus lactis
2017
Li, L.; Kim, S.; Heo, J.; Kim, T.; Seo, J.; Han, N.
J. Biotechnol.
264
1-7