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The bacterial catabolism of pteridines
1978
Tsusue, M.; Takikawa, S.; Yokokawa, C.K.
Dev. Biochem.
4
153-158
Pterin deaminase from Bacillus megaterium
1979
Takikawa, S.; Kitayama-Yokokawa, C.; Tsusue, M.
J. Biochem.
85
785-790
The application of 8-aminoguanosine triphosphate, a new inhibitor of GTP cyclohydrolase I, to the purification of the enzyme from human liver
1986
Blau, N.; Niederwieser, A.
Biochim. Biophys. Acta
880
26-31
Occurrence of sepiapterin deaminase in the normal type silkworm, Bombyx mori
1977
Tsusue, M.; Mazda, T.
Experientia
33
854-855
Studies on sepiapterin deaminase from the silkworm, Bombyx mori. Purification and some properties of the enzyme
1971
Tsusue, M.
J. Biochem.
69
781-788
Occurrence of sepiapterin deaminase in the silkworm, Bombyx mori
1967
Tsusue, M.
Experientia
23
116-117
-
Localization of sepiapterin deaminase and pteridines in the granules in epidermal cells of the silkworm, Bombyx mori
1990
Tsusue, M.; Kuroda, S.; Sawada, H.
Pteridines
2
175-182
-
Purification and characterization of sepiapterin deaminase from the silkworm, Bombyx mori
1998
Sawada, H.; Kanekatsu, M.; Nakagoshi, M.; Dohke, K.; Iino, T.; Takikawa, S.I.
Pteridines
9
18-21
Isolation and expression of rat liver sepiapterin reductase cDNA
1990
Citron, B.A.; Milstien, S.; Gutierrez, J.C.; Levine, R.A.; Yanak, B.L.; Kaufman, S.
Proc. Natl. Acad. Sci. USA
87
6436-6440
Studies on sepiapterin reductase: further characterization of the reaction product
1968
Nagai, M.
Arch. Biochem. Biophys.
126
426-435
Sepiapterin reductase
1966
Matsubara, M.; Katoh, S.; Akino, M.; Kaufman, S.
Biochim. Biophys. Acta
122
202-212
Sepiapterin reductase from horse liver: purification and properties of the enzyme
1971
Katoh, S.
Arch. Biochem. Biophys.
146
202-214
Sepiapterin reductase in blood of various animals and of leukemic rats
1974
Katoh, S.; Arai, Y.; Taketani, T.; Yamada, S.
Biochim. Biophys. Acta
370
378-388
Purification and characterization of sepiapterin reductase from rat erythrocytes
1982
Sueoka, T.; Katoh, S.
Biochim. Biophys. Acta
717
265-271
Sepiapterin reductase in cultured human cells
1987
Fere, J.; Naylor, E.W.
Biochem. Biophys. Res. Commun.
148
1475-1481
Tetrahydrobiopterin biosynthetic activities in human macrophages, fibroblasts, THP-1, and T 24 cells. GTP-cyclohydrolase I is stimulated by interferon-gamma, and 6-pyruvoyl tetrahydropterin synthase and sepiapterin reductase are constitutively present
1990
Werner, E.R.; Werner-Felmayer, G.; Fuchs, D.; Hausen, A.; Reibnegger, G.; Yim, J.J.; Pfleiderer, W.; Wachter, H.
J. Biol. Chem.
265
3189-3192
Analysis of the tetrahydrobiopterin synthesizing system during maturation of murine reticulocytes
1990
Kerler, F.; Hultner, L.; Ziegler, I.; Katzenmaier, G.; Bacher, A.
J. Cell. Physiol.
142
268-271
Isomerization of 6-lactoyl tetrahydropterin by sepiapterin reductase
1987
Katoh, S.; Sueoka, T.
J. Biochem.
101
275-278
Sepiapterin reductase exhibits a NADPH-dependent dicarbonyl reductase activity
1984
Katoh, S.; Sueoka, T.
Biochem. Biophys. Res. Commun.
118
859-866
Carbonyl reductase activity of sepiapterin reductase from rat erythrocytes
1985
Sueoka, T.; Katoh, S.
Biochim. Biophys. Acta
843
193-198
Tetrahydrobiopterin biosynthesis. Studies with specifically labeled (2H)NAD(P)H and 2H2O and of the enzymes involved
1985
Curtius, H.C.; Heintel, D.; Ghisla, S.; Kuster, T.; Leimbacher, W.; Niederwieser, A.
Eur. J. Biochem.
148
413-419
Direct inhibition of brain sepiapterin reductase by a catecholamine and an indoleamine
1982
Katoh, S.; Sueoka, T.; Yamada, S.
Biochem. Biophys. Res. Commun.
105
75-81
On the role of sepiapterin reductase in the biosynthesis of tetrahydrobiopterin
1987
Smith, G.K.
Arch. Biochem. Biophys.
255
254-266
Purification and properties of human sepiapterin reductase from placenta
1993
Maier, J.; Ziegler, I.
Adv. Exp. Med. Biol.
338
199-202
-
Sepiapterin reductase producing L-threo-dihydrobiopterin from Chlorobium tepidum
1999
Cho, S.H.; Na, J.U.; Youn, H.; Hwang, C.S.; Lee, C.H.; Kang, S.O.
Biochem. J.
340
497-503
New inhibitors of sepiapterin reductase
1992
Smith, G.K.; Duch, D.S.; Edelstein, M.P.; Bigham, E.C.
J. Biol. Chem.
267
5599-5607
Role of the conserved Ser-Tyr-Lys triad of the SDR family in sepiapterin reductase
2001
Fujimoto, K.; Hara, M.; Yamada, H.; Sakurai, M.; Inaba, A.; Tomomura, A.; Katoh, S.
Chem. Biol. Interact.
130-132
825-832
Characterization of sepiapterin reductase activity from Drosophila melanogaster
1996
Ruiz-Vazquez, P.; Silva, F.J.; Ferre, J.
Comp. Biochem. Physiol. B
113
131-136
Characterization of recombinant Dictyostelium discoideum sepiapterin reductase expressed in E. coli
2000
Kim, Y.A.; Chung, H.J.; Kim, Y.J.; Choi, Y.K.; Hwang, Y.K.; Lee, S.W.; Park, Y.S.
Mol. Cells
10
405-410
-
Isolation and characterization of sepiapterin reductase from Drosophila melanogaster
1993
Yoon, K.H.; Cha, K.W.; Park, S.I.; Yim, J.J.
Pteridines
4
43-50
The 1.25 A crystal structure of sepiapterin reductase reveals its binding mode to pterins and brain neurotransmitters
1997
Auerbach, G.; Herrmann, A.; Gutlich, M.; Fischer, M.; Jacob, U.; Bacher, A.; Huber, R.
EMBO J.
16
7219-7230
Sepiapterin reductase and ALR2 ("aldose reductase") from bovine brain
1993
Dowling, T.G.; O'Rourke, J.F.; Tipton, K.F.
Adv. Exp. Med. Biol.
328
313-324
Escherichia coli 6-pyruvoyltetrahydropterin synthase ortholog encoded by ygcM has a new catalytic activity for conversion of sepiapterin to 7,8-dihydropterin
2002
Woo, H.J.; Hwang, Y.K.; Kim, Y.J.; Kang, J.Y.; Choi, Y.K.; Kim, C.G.; Park, Y.S.
FEBS Lett.
523
234-238
Production of sepiapterin in Escherichia coli by coexpression of cyanobacterial GTP cyclohydrolase I and human 6-pyruvoyltetrahydropterin synthase
2002
Woo, H.J.; Kang, J.Y.; Choi, Y.K.; Park, Y.S.
Appl. Environ. Microbiol.
68
3138-3140
Localization of sepiapterin reductase in the human brain
2002
Ikemoto, K.; Suzuki, T.; Ichinose, H.; Ohye, T.; Nishimura, A.; Nishi, K.; Nagatsu, I.; Nagatsu, T.
Brain Res.
954
237-246
Sepiapterin reductases from Chlorobium tepidum and Chlorobium limicola catalyze the synthesis of L-threo-tetrahydrobiopterin from 6-pyruvoyltetrahydropterin
2005
Choi, Y.K.; Jun, S.R.; Cha, E.Y.; Park, J.S.; Park, Y.S.
FEMS Microbiol. Lett.
242
95-99
-
Studies on sepiapterin reductase: further characterization of the reaction product
1968
Nagai, M.
Arch. Biochem. Biophys.
126
420-435
A brain-specific decrease of the tyrosine hydroxylase protein in sepiapterin reductase-null mice - as a mouse model for Parkinsons disease
2008
Takazawa, C.; Fujimoto, K.; Homma, D.; Sumi-Ichinose, C.; Nomura, T.; Ichinose, H.; Katoh, S.
Biochem. Biophys. Res. Commun.
367
787-792
Sepiapterin reductase expression is increased in Parkinsons disease brain tissue
2007
Tobin, J.E.; Cui, J.; Wilk, J.B.; Latourelle, J.C.; Laramie, J.M.; McKee, A.C.; Guttman, M.; Karamohamed, S.; DeStefano, A.L.; Myers, R.H.
Brain Res.
1139
42-47
Regulation of tetrahydrobiopterin biosynthesis by shear stress
2007
Widder, J.D.; Chen, W.; Li, L.; Dikalov, S.; Thoeny, B.; Hatakeyama, K.; Harrison, D.G.
Circ. Res.
101
830-838
Tetrahydropteridine deficiency impairs mitochondrial function in Dictyostelium discoideum Ax2
2007
Kim, H.L.; Choi, Y.K.; Kim, d.o..H.; Park, S.O.; Han, J.; Park, Y.S.
FEBS Lett.
581
5430-5434
Oxidative stress and increased eNOS and NADPH oxidase expression in mouse microvessel endothelial cells
2007
Ding, H.; Aljofan, M.; Triggle, C.R.
J. Cell. Physiol.
212
682-689
Cellular uptake of sepiapterin and push-pull accumulation of tetrahydrobiopterin
2008
Sawabe, K.; Yamamoto, K.; Harada, Y.; Ohashi, A.; Sugawara, Y.; Matsuoka, H.; Hasegawa, H.
Mol. Genet. Metab.
94
410-416
Role of Phe-99 and Trp-196 of sepiapterin reductase from Chlorobium tepidum in the production of L-threo-tetrahydrobiopterin
2008
Supangat, S.; Park, S.O.; Seo, K.H.; Lee, S.Y.; Park, Y.S.; Lee, K.H.
Acta Biochim. Biophys. Sin. (Shanghai)
40
513-518
Sepiapterin reductase regulation of endothelial tetrahydrobiopterin and nitric oxide bioavailability
2009
Gao, L.; Pung, Y.F.; Zhang, J.; Chen, P.; Wang, T.; Li, M.; Meza, M.; Toro, L.; Cai, H.
Am. J. Physiol. Heart Circ. Physiol.
297
H331-H339
Expression analysis of the aldo-keto reductases involved in the novel biosynthetic pathway of tetrahydrobiopterin in human and mouse tissues
2009
Hirakawa, H.; Sawada, H.; Yamahama, Y.; Takikawa, S.; Shintaku, H.; Hara, A.; Mase, K.; Kondo, T.; Iino, T.
J. Biochem.
146
51-60
The silkworm mutant lemon (lemon lethal) is a potential insect model for human sepiapterin reductase deficiency
2009
Meng, Y.; Katsuma, S.; Daimon, T.; Banno, Y.; Uchino, K.; Sezutsu, H.; Tamura, T.; Mita, K.; Shimada, T.
J. Biol. Chem.
284
11698-11705
Escherichia coli QueD is a 6-carboxy-5,6,7,8-tetrahydropterin synthase
2009
McCarty, R.M.; Somogyi, A.; Bandarian, V.
Biochemistry
48
2301-2303
Sepiapterin Reductase Mediates Chemical Redox Cycling in Lung Epithelial Cells
2013
Yang, S.; Jan, Y.H.; Gray, J.P.; Mishin, V.; Heck, D.E.; Laskin, D.L.; Laskin, J.D.
J. Biol. Chem.
288
19221-19237
Novel interaction of ornithine decarboxylase with sepiapterin reductase regulates neuroblastoma cell proliferation
2014
Lange, I.; Geerts, D.; Feith, D.J.; Mocz, G.; Koster, J.; Bachmann, A.S.
J. Mol. Biol.
426
332-346
Expression and enzyme activity detection of a sepiapterin reductase gene from Musca domestica larva
2016
Tang, Y.; Pei, Z.; Liu, L.; Wang, D.; Kong, L.; Liu, S.; Jiang, X.; Gao, Y.; Ma, H.
Appl. Biochem. Biotechnol.
181
604-612
Effect of sulfasalazine on human neuroblastoma: Analysis of sepiapterin reductase (SPR) as a new therapeutic target
2015
Yco, L.; Geerts, D.; Mocz, G.; Koster, J.; Bachmann, A.
BMC Cancer
15
477
Sulfa drugs inhibit sepiapterin reduction and chemical redox cycling by sepiapterin reductase
2015
Yang, S.; Jan, Y.H.; Mishin, V.; Richardson, J.R.; Hossain, M.M.; Heindel, N.D.; Heck, D.E.; Laskin, D.L.; Laskin, J.D.
J. Pharmacol. Exp. Ther.
352
529-540
Biochemical and structural studies of 6-carboxy-5,6,7,8-tetrahydropterin synthase reveal the molecular basis of catalytic promiscuity within the tunnel-fold superfamily
2014
Miles, Z.D.; Roberts, S.A.; McCarty, R.M.; Bandarian, V.
J. Biol. Chem.
289
23641-23652
Biochemical and structural studies of 6-carboxy-5,6,7,8-tetrahydropterin synthase reveal the molecular basis of catalytic promiscuity within the tunnel-fold superfamily
2014
Miles, Z.D.; Roberts, S.A.; McCarty, R.M.; Bandarian, V.
J. Biol. Chem.
289
23641-23652
Substrate and inhibitor specificity of tRNA-guanine ribosyltransferase
1984
Farkas, W.; Jacobson, K.; Katze, J.
Biochim. Biophys. Acta
781
64-75
Substrate and inhibitor specificity of tRNA-guanine ribosyltransferase
1984
Farkas, W.; Jacobson, K.; Katze, J.
Biochim. Biophys. Acta
781
64-75
Virtual screening to identify potent sepiapterin reductase inhibitors
2020
Gao, H.; Schneider, S.; Andrews, P.; Wang, K.; Huang, X.; Sparling, B.A.
Bioorg. Med. Chem. Lett.
30
126793
Sepiapterin reductase Characteristics and role in diseases
2020
Wu, Y.; Chen, P.; Sun, L.; Yuan, S.; Cheng, Z.; Lu, L.; Du, H.; Zhan, M.
J. Cell. Mol. Med.
24
9495-9506
Fragment-based discovery of novel potent sepiapterin reductase inhibitors
2019
Alen, J.; Schade, M.; Wagener, M.; Christian, F.; Nordhoff, S.; Merla, B.; Dunkern, T.R.; Bahrenberg, G.; Ratcliffe, P.
J. Med. Chem.
62
6391-6397
Fragment-based discovery of novel potent sepiapterin reductase inhibitors
2019
Alen, J.; Schade, M.; Wagener, M.; Christian, F.; Nordhoff, S.; Merla, B.; Dunkern, T.R.; Bahrenberg, G.; Ratcliffe, P.
J. Med. Chem.
62
6391-6397
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