Disease on EC 3.4.22.B50 - papain-like proteinase 2

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DISEASE
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Bone Resorption
Different cysteine proteinases involved in bone resorption and osteoclast formation.
Bronchitis
Characterization of the two overlapping papain-like proteinase domains encoded in gene 1 of the coronavirus infectious bronchitis virus and determination of the C-terminal cleavage site of an 87-kDa protein.
Identification of a novel cleavage activity of the first papain-like proteinase domain encoded by open reading frame 1a of the coronavirus Avian infectious bronchitis virus and characterization of the cleavage products.
Carcinoma
Crystal structure of SCCA1 and insight about the interaction with JNK1.
Carcinoma, Squamous Cell
Crystal structure of SCCA1 and insight about the interaction with JNK1.
Coronavirus Infections
Inhibitor recognition specificity of MERS-CoV papain-like protease may differ from that of SARS-CoV.
COVID-19
Structure-based drug designing of naphthalene based SARS-CoV PLpro inhibitors for the treatment of COVID-19.
Drug-Related Side Effects and Adverse Reactions
Nanoparticles of ZnO/Berberine complex contract COVID-19 and respiratory co-bacterial infection in addition to elimination of hydroxychloroquine toxicity.
Foot-and-Mouth Disease
Foot-and-mouth disease virus leader proteinase: a papain-like enzyme requiring an acidic environment in the active site.
Multifunctional roles of leader protein of foot-and-mouth disease viruses in suppressing host antiviral responses.
Recognition of eukaryotic initiation factor 4G isoforms by picornaviral proteinases.
The Leader Proteinase of Foot-and-Mouth Disease Virus Negatively Regulates the Type I Interferon Pathway by Acting as a Viral Deubiquitinase.
Hepatitis
Characterization of a second cleavage site and demonstration of activity in trans by the papain-like proteinase of the murine coronavirus mouse hepatitis virus strain A59.
Identification of mouse hepatitis virus papain-like proteinase 2 activity.
Identification of the murine coronavirus p28 cleavage site.
Replication of murine hepatitis virus is regulated by papain-like proteinase 1 processing of nonstructural proteins 1, 2, and 3.
The autocatalytic release of a putative RNA virus transcription factor from its polyprotein precursor involves two paralogous papain-like proteases that cleave the same peptide bond.
Mouth Diseases
Recognition of eukaryotic initiation factor 4G isoforms by picornaviral proteinases.
Retinoblastoma
Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation.
Severe Acute Respiratory Syndrome
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity.
Structure-Based Screening to Discover New Inhibitors for Papain-like Proteinase of SARS-CoV-2: An In Silico Study.