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(2S)-2-(3,5-dichlorophenyl)-N-[(3S)-1-[2-[(2-[[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]amino]-2-oxoethyl)amino]-2-oxoethyl]-2-oxopyrrolidin-3-yl]butanamide
-
-
2,2'-(hydroxynitrosohydrazono)bis-ethaneamine
-
NO generated from 2,2'-(hydroxynitrosohydrazono)bis-ethaneamine inhibits
3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxy-N-(2-[[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]amino]-2-oxoethyl)benzamide
-
-
glutamic acid
-
inhibition by displacement of viral DNA from complexes with enzyme
L-trans-epoxy-succinyl-leucylamido-(4-guanidino)-butane
-
-
L-trans-epoxy-succinyl-leucylamido-(4-guanidino)-butane-tyrosine
-
-
N-(2-[[(2-cyanopyrimidin-4-yl)methyl]amino]-2-oxoethyl)-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxybenzamide
-
-
N-(2-[[(2-cyanopyrimidin-4-yl)methyl]amino]-2-oxoethyl)-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-[(dimethylamino)oxy]benzamide
-
-
N-[(2S)-2-(3,5-dichlorophenyl)-2-(ethylamino)acetyl]-3-methyl-L-valylglycyl-N-[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]glycinamide
-
-
N-[(2S)-2-(3-chlorophenyl)-2-[(methylsulfonyl)amino]acetyl]-L-phenylalanyl-N-(cyanomethyl)glycinamide
-
-
N-[(3,5-dichlorophenyl)acetyl]-3-methyl-L-valylglycyl-N-[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]glycinamide
-
-
N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[(3,5-dichlorophenyl)acetyl]-4-methoxybenzamide
-
-
N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxybenzamide
-
-
N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-[(dimethylamino)oxy]benzamide
-
-
N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)propanoyl]-4-methoxybenzamide
-
-
N-[4-[1-(3-aminopropyl)-2-hydroxy-2-nitrosohydrazino]butyl]-1,3-propanediamine
-
NO generated from N-[4-[1-(3-aminopropyl)-2-hydroxy-2-nitrosohydrazino]butyl]-1,3-propanediamine inhibits the enzyme
NaCl
-
inhibition by displacement of viral DNA from complexes with enzyme
NO
-
inhibits adenovirus replication by targeting the adenovirus proteinase, inhibition is reversible with dithiothreitol
p-chloromercuribenzoate
-
-
Phenylmethylsulfonylfluoride
-
-
Soybean trypsin inhibitor
-
-
-
tosyl-lysinechloromethyl ketone
-
-
tosylamide phenylethylchloromethyl ketone
-
-
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0.000002 - 0.000004
(2S)-2-(3,5-dichlorophenyl)-N-[(3S)-1-[2-[(2-[[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]amino]-2-oxoethyl)amino]-2-oxoethyl]-2-oxopyrrolidin-3-yl]butanamide
0.000001
3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxy-N-(2-[[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]amino]-2-oxoethyl)benzamide
0.0000002 - 0.0000006
N-(2-[[(2-cyanopyrimidin-4-yl)methyl]amino]-2-oxoethyl)-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxybenzamide
0.0000001
N-(2-[[(2-cyanopyrimidin-4-yl)methyl]amino]-2-oxoethyl)-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-[(dimethylamino)oxy]benzamide
0.000001
N-[(2S)-2-(3,5-dichlorophenyl)-2-(ethylamino)acetyl]-3-methyl-L-valylglycyl-N-[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]glycinamide
Human adenovirus sp.
-
IC50 below 0.000001 mM, isoform AVP8, pH and temperature not specified in the publication
0.00001
N-[(3,5-dichlorophenyl)acetyl]-3-methyl-L-valylglycyl-N-[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]glycinamide
0.0011 - 0.00274
N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[(3,5-dichlorophenyl)acetyl]-4-methoxybenzamide
0.00003 - 0.00004
N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxybenzamide
0.000007 - 0.00001
N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-[(dimethylamino)oxy]benzamide
0.00031 - 0.00095
N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)propanoyl]-4-methoxybenzamide
0.000002
(2S)-2-(3,5-dichlorophenyl)-N-[(3S)-1-[2-[(2-[[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]amino]-2-oxoethyl)amino]-2-oxoethyl]-2-oxopyrrolidin-3-yl]butanamide
Human adenovirus sp.
-
isoform AVP5, pH and temperature not specified in the publication
0.000004
(2S)-2-(3,5-dichlorophenyl)-N-[(3S)-1-[2-[(2-[[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]amino]-2-oxoethyl)amino]-2-oxoethyl]-2-oxopyrrolidin-3-yl]butanamide
Human adenovirus sp.
-
isoform AVP8, pH and temperature not specified in the publication
0.000001
3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxy-N-(2-[[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]amino]-2-oxoethyl)benzamide
Human adenovirus sp.
-
isoform AVP5, pH and temperature not specified in the publication
0.000001
3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxy-N-(2-[[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]amino]-2-oxoethyl)benzamide
Human adenovirus sp.
-
isoform AVP8, pH and temperature not specified in the publication
0.0000002
N-(2-[[(2-cyanopyrimidin-4-yl)methyl]amino]-2-oxoethyl)-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxybenzamide
Human adenovirus sp.
-
isoform AVP5, pH and temperature not specified in the publication
0.0000006
N-(2-[[(2-cyanopyrimidin-4-yl)methyl]amino]-2-oxoethyl)-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxybenzamide
Human adenovirus sp.
-
isoform AVP8, pH and temperature not specified in the publication
0.0000001
N-(2-[[(2-cyanopyrimidin-4-yl)methyl]amino]-2-oxoethyl)-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-[(dimethylamino)oxy]benzamide
Human adenovirus sp.
-
isoform AVP5, pH and temperature not specified in the publication
0.0000001
N-(2-[[(2-cyanopyrimidin-4-yl)methyl]amino]-2-oxoethyl)-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-[(dimethylamino)oxy]benzamide
Human adenovirus sp.
-
isoform AVP8, pH and temperature not specified in the publication
0.00001
N-[(3,5-dichlorophenyl)acetyl]-3-methyl-L-valylglycyl-N-[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]glycinamide
Human adenovirus sp.
-
isoform AVP5, pH and temperature not specified in the publication
0.00001
N-[(3,5-dichlorophenyl)acetyl]-3-methyl-L-valylglycyl-N-[(2E)-3-(methylsulfonyl)prop-2-en-1-yl]glycinamide
Human adenovirus sp.
-
isoform AVP8, pH and temperature not specified in the publication
0.0011
N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[(3,5-dichlorophenyl)acetyl]-4-methoxybenzamide
Human adenovirus sp.
-
isoform AVP5, pH and temperature not specified in the publication
0.00274
N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[(3,5-dichlorophenyl)acetyl]-4-methoxybenzamide
Human adenovirus sp.
-
isoform AVP8, pH and temperature not specified in the publication
0.00003
N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxybenzamide
Human adenovirus sp.
-
isoform AVP5, pH and temperature not specified in the publication
0.00004
N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-methoxybenzamide
Human adenovirus sp.
-
isoform AVP8, pH and temperature not specified in the publication
0.000007
N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-[(dimethylamino)oxy]benzamide
Human adenovirus sp.
-
isoform AVP5, pH and temperature not specified in the publication
0.00001
N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)-2-methylpropanoyl]-4-[(dimethylamino)oxy]benzamide
Human adenovirus sp.
-
isoform AVP8, pH and temperature not specified in the publication
0.00031
N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)propanoyl]-4-methoxybenzamide
Human adenovirus sp.
-
isoform AVP5, pH and temperature not specified in the publication
0.00095
N-[2-[(cyanomethyl)amino]-2-oxoethyl]-3-[2-(3,5-dichlorophenyl)propanoyl]-4-methoxybenzamide
Human adenovirus sp.
-
isoform AVP8, pH and temperature not specified in the publication
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Weber, J.M.
The active adenovirus protease is the intact L3 23K protein
Handbook of proteolytic enzymes (Barrett, A. J. , Rawlings, N. D. , Woessner, J. F. , eds. ) Academic Press
741-743
1998
unidentified adenovirus
-
brenda
Webster, A.; Kemp, G.
Characterization of the adenovirus proteinase: substrate specificity
J. Gen. Virol.
74
1415-1420
1993
unidentified adenovirus
brenda
Webster, A.; Russel, S.; Talbot, P.; Russel, W.C.; Kemp, G.D.
The role of the adenovirus protease on virus entry into cells
J. Gen. Virol.
70
3225-3234
1989
unidentified adenovirus
brenda
Greber, U.F.; Webster, P.; Weber, J.; Helenius, A.
Expression and purification of the adenovirus proteinase polypeptide and of a synthetic proteinase substrate
EMBO J.
15
1766-1777
1996
unidentified adenovirus
brenda
Anderson, C.W.
Crystal structure of the human adenovirus proteinase with its 11 amino acid cofactor
Protein Expr. Purif.
4
8-15
1993
unidentified adenovirus
brenda
Ding, J.; McGrath, W.J.; Sweet, R.M.; Mangel, W.F.
Crystal structure of the human adenovirus proteinase with its 11 amino acid cofactor
EMBO J.
15
1778-1783
1996
unidentified adenovirus
brenda
Diouri, M.; Geoghegan, K.F.; Weber, J.M.
The adenovirus protease is activated by a virus-coded disulphide-linked peptide
Protein Pept. Lett.
2
363-370
1995
unidentified adenovirus
-
brenda
Webster, A.; Hay, R.T.; Kemp, G.
Characterization of three components of human adenovirus proteinase activity in vitro
Cell
72
97-104
1993
unidentified adenovirus
brenda
Mangel, W.F.; Toledo, D.L.; Brown, M.T.; Martin, J.H.; McGrath, W.J.
Cleavage efficiency by adenovirus protease is site-dependent
J. Biol. Chem.
271
536-543
1996
unidentified adenovirus
brenda
Diouri, M.; Keyvani-Amineh, H.; Geoghegan, K.F.; Weber, J.M.
Activation of the adenovirus protease requires sequence elements from both ends of the activating peptide
J. Biol. Chem.
271
32511-32514
1996
unidentified adenovirus
brenda
Cabrita, G.; Iqbal, M.; Reddy, H.; Kemps, G.
Protease of adenovirus type 2: partial characterization
J. Biol. Chem.
272
5635-5639
1997
unidentified adenovirus
brenda
Bhatti, A.R.; Weber, J.
Protease of adenovirus type 2. Subcellular localization
Virology
96
478-485
1979
unidentified adenovirus
brenda
Bhatti, A.R.; Weber, J.
Activation of adenovirus-coded protease and processing of preterminal protein
J. Biol. Chem.
254
12265-12268
1979
unidentified adenovirus
brenda
Webster, A.; Leith, I.R.; Hay, R.T.
The protease of adenovirus serotype 2 requires cysteine residues for both activation and catalysis
J. Virol.
68
7292-7300
1994
unidentified adenovirus
brenda
Grierson, A.W.; Nicholson, R.; Talbot, P.; Webster, A.; Kemp, G.
Viral DNA and a viral peptide can act as cofactors of adenovirus virion proteinase activity
J. Gen. Virol.
75
2761-2764
1994
unidentified adenovirus
brenda
Mangel, W.F.; McGrath, W.J.; Toledo, D.L.; Anderson, C.W.
Isolation and properties of adenovirus type 2 proteinase
Nature
361
274-275
1993
unidentified adenovirus
brenda
Tihanyi, K.; Bourbonniere, M.; Houde, A.; Rancourt, C.; Weber, J.M.
Isolation and properties of adenovirus type 2 proteinase
J. Biol. Chem.
268
1780-1785
1993
unidentified adenovirus
brenda
McGrath, W.J.; Abola, A.P.; Toledo, D.L.; Brown, M.T.; Mangel, W.F.
Characterization of human adenovirus proteinase activity in disrupted virus particles
Virology
217
131-138
1996
unidentified adenovirus
brenda
Baniecki, M.L.; McGrath, W.J.; Dauter, Z.; Mangel, W.F.
Adenovirus proteinase: crystallization and preliminary X-ray diffraction studies to atomic resolution
Acta Crystallogr. Sect. D
58
1462-1464
2002
unidentified adenovirus
brenda
Baniecki, M.L.; McGrath, W.J.; McWhirter, S.M.; Li, C.; Toledo, D.L.; Pellicena, P.; Barnard, D.L.; Thorn, K.S.; Mangel, W.F.
Interaction of the human adenovirus proteinase with its 11-amino acid cofactor pVIc
Biochemistry
40
12349-12356
2001
Human adenovirus sp.
brenda
McGrath, W.J.; Baniecki, M.L.; Li, C.; McWhirter, S.M.; Brown, M.T.; Toledo, D.L.; Mangel, W.F.
Human adenovirus proteinase: DNA binding and stimulation of proteinase activity by DNA
Biochemistry
40
13237-13245
2001
Human adenovirus sp.
brenda
McGrath, W.J.; Ding, J.; Didwania, A.; Sweet, R.M.; Mangel, W.F.
Crystallographic structure at 1.6-A resolution of the human adenovirus proteinase in a covalent complex with its 11-amino-acid peptide cofactor: insights on a new fold
Biochim. Biophys. Acta
1648
1-11
2003
Human adenovirus sp.
brenda
Cao, W.; Baniecki, M.L.; McGrath, W.J.; Bao, C.; Deming, C.B.; Rade, J.J.; Lowenstein, C.J.; Mangel, W.F.
Nitric oxide inhibits the adenovirus proteinase in vitro and viral infectivity in vivo
FASEB J.
17
2345-2346
2003
unidentified adenovirus
brenda
Balakirev, M.Y.; Jaquinod, M.; Haas, A.L.; Chroboczek, J.
Deubiquitinating function of adenovirus proteinase
J. Virol.
76
6323-6331
2002
unidentified adenovirus
brenda
McGrath, W.J.; Aherne, K.S.; Mangel, W.F.
In the virion, the 11-amino-acid peptide cofactor pVIc is covalently linked to the adenovirus proteinase
Virology
296
234-240
2002
unidentified adenovirus
brenda
Bajpayee, N.S.; McGrath, W.J.; Mangel, W.F.
Interaction of the adenovirus proteinase with protein cofactors with high negative charge densities
Biochemistry
44
8721-8729
2005
unidentified adenovirus
brenda
Honkavuori, K.S.; Pollard, B.D.; Rodriguez, M.S.; Hay, R.T.; Kemp, G.D.
Dual role of the adenovirus pVI C terminus as a nuclear localization signal and activator of the viral protease
J. Gen. Virol.
85
3367-3376
2004
unidentified adenovirus
brenda
Grosche, P.; Sirockin, F.; Mac Sweeney, A.; Ramage, P.; Erbel, P.; Melkko, S.; Bernardi, A.; Hughes, N.; Ellis, D.; Combrink, K.D.; Jarousse, N.; Altmann, E.
Structure-based design and optimization of potent inhibitors of the adenoviral protease
Bioorg. Med. Chem. Lett.
25
438-443
2015
Human adenovirus sp.
brenda
Graziano, V.; McGrath, W.J.; Suomalainen, M.; Greber, U.F.; Freimuth, P.; Blainey, P.C.; Luo, G.; Xie, X.S.; Mangel, W.F.
Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: I. binding to DNA and to hexon of the precursor to protein VI, pVI, of human adenovirus
J. Biol. Chem.
288
2059-2067
2013
Human adenovirus sp.
brenda
Graziano, V.; Luo, G.; Blainey, P.C.; Perez-Berna, A.J.; McGrath, W.J.; Flint, S.J.; San Martin, C.; Xie, X.S.; Mangel, W.F.
Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: II. adenovirus proteinase is activated in an unusual one-dimensional biochemical reaction
J. Biol. Chem.
288
2068-2080
2013
Human adenovirus sp.
brenda
Baniecki, M.L.; McGrath, W.J.; Mangel, W.F.
Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: III. Atomic resolution structure of the nascent form of the adenovirus proteinase
J. Biol. Chem.
288
2081-2091
2013
Human adenovirus sp. (P03252)
brenda
Blainey, P.C.; Graziano, V.; Perez-Berna, A.J.; McGrath, W.J.; Flint, S.J.; San Martin, C.; Xie, X.S.; Mangel, W.F.
Regulation of a viral proteinase by a peptide and DNA in one-dimensional space: IV. Viral proteinase slides along DNA to locate and process its substrates
J. Biol. Chem.
288
2092-2102
2013
Human adenovirus sp.
brenda