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Disease on EC 3.4.17.23 - angiotensin-converting enzyme 2

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DISEASE
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Acne Vulgaris
[Androgens and Antiandrogens influence on COVID-19 disease in men].
Acquired Immunodeficiency Syndrome
Computational studies reveal Fluorine based quinolines to be potent inhibitors for proteins involved in SARS-CoV-2 assembly.
Potential protease inhibitors and their combinations to block SARS-CoV-2.
Acute Coronary Syndrome
Angiotensin-converting enzyme 2 A1075G polymorphism is associated with survival in an acute coronary syndromes cohort.
Acute Kidney Injury
Acute Kidney Injury in a Case Series of Patients with Confirmed COVID-19 (Coronavirus Disease 2019): Role of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Blockade.
Acute Kidney Injury in COVID-19: a Brief Review.
Acute kidney injury in the rat causes cardiac remodelling and increases angiotensin-converting enzyme 2 expression.
Novel Evidence of Acute Kidney Injury in COVID-19.
Relationship Between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Etiology of Acute Kidney Injury (AKI).
Acute Lung Injury
A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome.
ACE2 Antagonizes VEGFa to Reduce Vascular Permeability During Acute Lung Injury.
ACE2 exhibits protective effects against LPS-induced acute lung injury in mice by inhibiting the LPS-TLR4 pathway.
Acidic preconditioning reduces lipopolysaccharide-induced acute lung injury by upregulating the expression of angiotensin-converting enzyme 2.
Age-Dependent Changes in the Pulmonary Renin-Angiotensin System Are Associated With Severity of Lung Injury in a Model of Acute Lung Injury in Rats.
Angiotensin-(1-7) Protects From Experimental Acute Lung Injury.
Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury.
Angiotensin-Converting Enzyme 2 Inhibits Apoptosis of Pulmonary Endothelial Cells During Acute Lung Injury Through Suppressing MiR-4262.
Angiotensin-Converting Enzyme 2 Inhibits Apoptosis of Pulmonary Endothelial Cells During Acute Lung Injury Through Suppressing SMAD2 Phosphorylation.
Angiotensin-converting enzyme 2 prevents lipopolysaccharide-induced rat acute lung injury via suppressing the ERK1/2 and NF-?B signaling pathways.
Angiotensin-converting enzyme 2 regulates autophagy in acute lung injury through AMPK/mTOR signaling.
Angiotensin-converting enzyme inhibition attenuates lipopolysaccharide-induced lung injury by regulating the balance between Angiotensin-converting enzyme and Angiotensin-converting enzyme 2 and inhibiting mitogen-activated protein kinase activation.
Author Correction: Angiotensin-converting enzyme 2 prevents lipopolysaccharide-induced rat acute lung injury via suppressing the ERK1/2 and NF-?B signaling pathways.
Cationic nanoparticles directly bind angiotensin-converting enzyme 2 and induce acute lung injury in mice.
Crosstalk between ACE2 and PLGF regulates vascular permeability during acute lung injury.
Downregulation of angiotensin-converting enzyme 2 by the neuraminidase protein of influenza A (H1N1) virus.
Dyspneic and non-dyspneic (silent) hypoxemia in COVID-19: Possible neurological mechanism.
Mesenchymal stem cell-based angiotensin-converting enzyme 2 in treatment of acute lung injury rat induced by bleomycin.
microRNA-1246 mediates lipopolysaccharide-induced pulmonary endothelial cell apoptosis and acute lung injury by targeting angiotensin-converting enzyme 2.
Molecular and cellular mechanisms of the inhibitory effects of ACE-2/ANG1-7/Mas axis on lung injury.
MSCs with ACE II gene affect apoptosis pathway of acute lung injury induced by bleomycin.
Multifunctional angiotensin converting enzyme 2, the SARS-CoV-2 entry receptor, and critical appraisal of its role in acute lung injury.
Osthole Alleviates Bleomycin-Induced Pulmonary Fibrosis via Modulating Angiotensin-Converting Enzyme 2/Angiotensin-(1-7) Axis and Decreasing Inflammation Responses in Rats.
Osthole protects lipopolysaccharide-induced acute lung injury in mice by preventing down-regulation of angiotensin-converting enzyme 2.
Prevention of pulmonary hypertension by Angiotensin-converting enzyme 2 gene transfer.
Recombinant angiotensin-converting enzyme 2 improves pulmonary blood flow and oxygenation in lipopolysaccharide-induced lung injury in piglets.
Residues affecting the chloride regulation and substrate selectivity of the angiotensin-converting enzymes (ACE and ACE2) identified by site-directed mutagenesis.
Role and mechanism of angiotensin-converting enzyme 2 in acute lung injury in coronavirus disease 2019.
The angiotensin-converting enzyme 2/angiotensin (1-7)/mas axis protects against pyroptosis in LPS-induced lung injury by inhibiting NLRP3 activation.
The discovery of angiotensin-converting enzyme 2 and its role in acute lung injury in mice.
The roles of vitamin D in increasing the body's immunity and reducing injuries due to viral infections: With an emphasis on its possible role in SARS-CoV-2 (COVID-19).
Use of pioglitazone in people with type 2 diabetes mellitus with coronavirus disease 2019 (COVID-19): Boon or bane?
[ACE2 agonist DIZE alleviates lung injury induced by limb ischemia-reperfusion in mice].
[Effect of endotoxin on expression of angiotensin converting enzyme-2 in cultured rat pulmonary microvascular endothelial cells.]
Adenocarcinoma
Characterization of ETS gene aberrations in select histologic variants of prostate carcinoma.
Co?expression of peripheral olfactory receptors with SARS?CoV?2 infection mediators: Potential implications beyond loss of smell as a COVID?19 symptom.
Colorectal Cancer that Highly Express Both ACE2 and TMPRSS2, Suggesting Severe Symptoms to SARS-CoV-2 Infection.
Commentary on "ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients." Baena E, Shao Z, Linn DE, Glass K, Hamblen MJ, Fujiwara Y, Kim J, Nguyen M, Zhang X, Godinho FJ, Bronson RT, Mucci LA, Loda M, Yuan GC, Orkin SH, Li Z, Division of Hematology and Oncology, Boston Children's Hospital, Boston, MA, USA.: Genes Dev 2013;27(6):683-98.
Decreased expression of Angiotensin-converting enzyme 2 in pancreatic ductal adenocarcinoma is associated with tumor progression.
Detection of TMPRSS2 gene deletions and translocations in carcinoma, intraepithelial neoplasia, and normal epithelium of the prostate by direct fluorescence in situ hybridization.
ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients.
Genetic Susceptibility of ACE2 and TMPRSS2 in Six Common Cancers and Possible Impacts on COVID-19.
Heterogeneity of TMPRSS2 gene rearrangements in multifocal prostate adenocarcinoma: molecular evidence for an independent group of diseases.
Nicotine upregulates ACE2 expression and increases competence for SARS-CoV-2 in human pneumocytes.
Pan?cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS?CoV?2 infection leading to COVID-19.
Prostate adenocarcinoma and COVID-19: The possible impacts of TMPRSS2 expressions in susceptibility to SARS-CoV-2.
The androgen-regulated type II serine protease TMPRSS2 is differentially expressed and mislocalized in prostate adenocarcinoma.
The TMPRSS2 gene encoding transmembrane serine protease is overexpressed in a majority of prostate cancer patients: detection of mutated TMPRSS2 form in a case of aggressive disease.
TMPRSS2 Correlated With Immune Infiltration Serves as a Prognostic Biomarker in Prostatic Adenocarcinoma: Implication for the COVID-2019.
Adenocarcinoma of Lung
Angiotensin-converting enzyme 2 is a potential therapeutic target for EGFR-mutant lung adenocarcinoma.
Comparative Investigation of Composition, Antifungal, and Anti-Inflammatory Effects of the Essential Oil from Three Industrial Hemp Varieties from Italian Cultivation.
Expression and Clinical Significance of SARS-CoV-2 Human Targets in Neoplastic and Non-Neoplastic Lung Tissues.
Genetic Susceptibility of ACE2 and TMPRSS2 in Six Common Cancers and Possible Impacts on COVID-19.
In silico analysis identifies neuropilin-1 as a potential therapeutic target for SARS-Cov-2 infected lung cancer patients.
Lung adenocarcinoma patients have higher risk of SARS-CoV-2 infection.
Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell.
The Landscape of Coronavirus Disease 2019 (COVID-19) and Integrated Analysis SARS-CoV-2 Receptors and Potential Inhibitors in Lung Adenocarcinoma Patients.
Unravelling the Phytochemical Composition and the Pharmacological Properties of an Optimized Extract from the Fruit from Prunus mahaleb L.: From Traditional Liqueur Market to the Pharmacy Shelf.
Adenocarcinoma, Mucinous
Characterization of ETS gene aberrations in select histologic variants of prostate carcinoma.
Adenoma
Aldosterone and cortisol synthesis regulation by angiotensin-(1-7) and angiotensin-converting enzyme 2 in the human adrenal cortex.
Ageusia
Osmotic Adaptation by Na+-Dependent Transporters and ACE2: Correlation with Hemostatic Crisis in COVID-19.
Albuminuria
Daily exercise training protects against albuminuria and angiotensin converting enzyme 2 shedding in db/db diabetic mice.
Glomerular localization and expression of Angiotensin-converting enzyme 2 and Angiotensin-converting enzyme: implications for albuminuria in diabetes.
Low urinary levels of angiotensin-converting enzyme 2 may contribute to albuminuria in children with sickle cell anaemia.
New aspects of the renin-angiotensin system: angiotensin-converting enzyme 2 - a potential target for treatment of hypertension and diabetic nephropathy.
Alopecia
Androgen Receptor Genetic Variant Predicts COVID-19 Disease Severity: A Prospective Longitudinal Study of Hospitalized COVID-19 Male Patients.
[Androgens and Antiandrogens influence on COVID-19 disease in men].
Alzheimer Disease
Angiotensin-converting enzyme 2 (ACE2) is upregulated in Alzheimer's disease brain.
Angiotensin-converting enzyme 2 is reduced in Alzheimer's disease in association with increasing amyloid-? and tau pathology.
Protein Expression of Angiotensin-Converting Enzyme 2 (ACE2) is Upregulated in Brains with Alzheimer's Disease.
SARS-CoV-2, the Angiotensin Converting Enzyme 2 (ACE2) Receptor and Alzheimer's disease.
Anaphylaxis
Screening strategy of TMPRSS2 inhibitors by FRET-based enzymatic activity for TMPRSS2-based cancer and COVID-19 treatment.
Anemia
Low urinary levels of angiotensin-converting enzyme 2 may contribute to albuminuria in children with sickle cell anaemia.
Anemia, Sickle Cell
Low urinary levels of angiotensin-converting enzyme 2 may contribute to albuminuria in children with sickle cell anaemia.
Aneurysm
Novel findings: Expression of angiotensin-converting enzyme and angiotensin-converting enzyme 2 in thoracic aortic dissection and aneurysm.
Update on SARS-CoV-2 infection in children.
Aneurysm, Dissecting
Novel findings: Expression of angiotensin-converting enzyme and angiotensin-converting enzyme 2 in thoracic aortic dissection and aneurysm.
Angioedema
Computational drug repurposing strategy predicted peptide-based drugs that can potentially inhibit the interaction of SARS-CoV-2 spike protein with its target (humanACE2).
Effect of COVID-19 on hereditary angioedema activity and quality of life.
Angioedemas, Hereditary
Effect of COVID-19 on hereditary angioedema activity and quality of life.
angiotensin-converting enzyme 2 deficiency
A Dual-Route Perspective of SARS-CoV-2 Infection: Lung- vs. Gut-specific Effects of ACE-2 Deficiency.
Angiotensin-converting enzyme 2 deficiency accelerates and angiotensin 1-7 restores age-related muscle weakness in mice.
Angiotensin-Converting Enzyme 2 Deficiency Aggravates Glucose Intolerance via Impairment of Islet Microvascular Density in Mice with High-Fat Diet.
Angiotensin-converting enzyme 2 deficiency in whole body or bone marrow-derived cells increases atherosclerosis in low-density lipoprotein receptor-/- mice.
Angiotensin-converting enzyme 2 deficiency is associated with impaired gestational weight gain and fetal growth restriction.
COVID-19 and relative angiotensin-converting enzyme 2 deficiency: role in disease severity and therapeutic response.
Retinal Microcirculation as a Correlate of a Systemic Capillary Impairment After Severe Acute Respiratory Syndrome Coronavirus 2 Infection.
Anosmia
Anosmia and COVID-19: perspectives on its association and the pathophysiological mechanisms involved.
Elevated ACE-2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory SARS-CoV-2 entry and replication.
Nasal lavage containing Angiotensin-Converting Enzyme-2 agonist can prevent and reduce viral load in COVID-19.
SARS-CoV-2 Infection: A Role for S1P/S1P Receptor Signaling in the Nervous System?
Aortic Aneurysm, Abdominal
Angiotensin-converting enzyme 2 decreases formation and severity of angiotensin II-induced abdominal aortic aneurysms.
Angiotensin-converting enzyme 2, coronavirus disease 2019, and abdominal aortic aneurysms.
Mas receptor deficiency augments angiotensin II-induced atherosclerosis and aortic aneurysm ruptures in hypercholesterolemic male mice.
Resveratrol Inhibits Growth of Experimental Abdominal Aortic Aneurysm Associated With Upregulation of Angiotensin-Converting Enzyme 2.
Serum angiotensin-converting enzyme 2 is an independent risk factor for in-hospital mortality following open surgical repair of ruptured abdominal aortic aneurysm.
Aortic Valve Stenosis
Plasma ACE2 Activity Predicts Mortality in Aortic Stenosis and Is Associated With Severe Myocardial Fibrosis.
Arrhythmias, Cardiac
Cardiovascular Considerations in Coronavirus Disease 2019 with a Special Focus on Arrhythmia.
Arthritis
Diminazene aceturate--An antiparasitic drug of antiquity: Advances in pharmacology & therapeutics.
Arthritis, Experimental
Inflammation Alters Angiotensin Converting Enzymes (ACE and ACE-2) Balance in Rat Heart.
Asthma
Activation of angiotensin-converting enzyme 2 (ACE2) attenuates allergic airway inflammation in rat asthma model.
Angiotensin Converting Enzyme-2 (ACE2) receptors, asthma and severe COVID-19 infection risk.
Asthma and COVID-19 pandemic: focused on the eosinophil count and ACE2 expression.
Asthma and severe acute respiratory syndrome coronavirus 2019: current evidence and knowledge gaps.
Comparative Study of SARS-CoV-2, SARS-CoV-1, MERS-CoV, HCoV-229E and Influenza Host Gene Expression in Asthma: Importance of Sex, Disease Severity, and Epithelial Heterogeneity.
Correction to: Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma.
COVID-19 and bronchial asthma: current perspectives.
COVID-19-related Genes in Sputum Cells in Asthma. Relationship to Demographic Features and Corticosteroids.
Integrated Bioinformatics Analysis Reveals Key Candidate Genes and Cytokine Pathways Involved in COVID-19 After Rhinovirus Infection in Asthma Patients.
Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma.
Type 2 inflammation modulates ACE2 and TMPRSS2 in airway epithelial cells.
Asymptomatic Infections
Regulation of the Expression of SARS-CoV-2 Receptor Angiotensin-Converting Enzyme 2 in Nasal Mucosa.
Atherosclerosis
Activation of the Renin-Angiotensin system mediates the effects of dietary salt intake on atherogenesis in the apolipoprotein E knockout mouse.
Angiotensin converting enzyme 2 and atherosclerosis.
Angiotensin converting enzyme-2 confers endothelial protection and attenuates atherosclerosis.
Angiotensin-converting enzyme 2 deficiency in whole body or bone marrow-derived cells increases atherosclerosis in low-density lipoprotein receptor-/- mice.
Circulating angiotensin converting enzyme 2 activity as a biomarker of silent atherosclerosis in patients with chronic kidney disease.
Circulating miR-421 Targeting Leucocytic Angiotensin Converting Enzyme 2 Is Elevated in Patients with Chronic Kidney Disease.
Deletion of angiotensin-converting enzyme 2 promotes the development of atherosclerosis and arterial neointima formation.
Diminazene enhances stability of atherosclerotic plaques in ApoE-deficient mice.
Hydrogen Sulfide Attenuates Atherosclerosis in a Partially Ligated Carotid Artery Mouse model via Regulating Angiotensin Converting Enzyme 2 Expression.
Immunolocalization of ACE2 and AT2 Receptors in Rabbit Atherosclerotic Plaques.
Mas receptor deficiency augments angiotensin II-induced atherosclerosis and aortic aneurysm ruptures in hypercholesterolemic male mice.
Monocytic angiotensin-converting enzyme 2 relates to atherosclerosis in patients with chronic kidney disease.
Potential mechanisms of cerebrovascular diseases in COVID-19 patients.
Residues affecting the chloride regulation and substrate selectivity of the angiotensin-converting enzymes (ACE and ACE2) identified by site-directed mutagenesis.
Soluble Angiotensin-Converting Enzyme 2, Cardiac Biomarkers, Structure, and Function, and Cardiovascular Events (From the Atherosclerosis Risk in Communities Study).
The Case Fatality Rate in COVID-19 Patients With Cardiovascular Disease: Global Health Challenge and Paradigm in the Current Pandemic.
Atrial Fibrillation
Angiotensin converting enzyme 2 activity and human atrial fibrillation: increased plasma angiotensin converting enzyme 2 activity is associated with atrial fibrillation and more advanced left atrial structural remodelling.
Angiotensin-converting enzyme 2 (ACE2) levels in relation to risk factors for COVID-19 in two large cohorts of patients with atrial fibrillation.
Downregulation of angiotensin converting enzyme II is associated with pacing-induced sustained atrial fibrillation.
N-Terminal Pro-Brain Natriuretic Peptide and Angiotensin-Converting Enzyme-2 Levels and Their Association With Postoperative Cardiac Complications After Emergency Orthopedic Surgery.
Polymorphisms of angiotensin-converting enzyme 2 gene confer a risk to lone atrial fibrillation in Chinese male patients.
[Effects of angiotensin converting enzyme inhibitor on the expression of angiotensin converting enzyme 2 in atrium of patients with atrial fibrillation]
Bacterial Infections
A Dynamic Variation of Pulmonary ACE2 Is Required to Modulate Neutrophilic Inflammation in Response to Pseudomonas aeruginosa Lung Infection in Mice.
Bradycardia
Overexpression of AT2R in the solitary-vagal complex improves baroreflex in the spontaneously hypertensive rat.
Brain Diseases, Metabolic
COVID-19 Encephalopathy in Adults.
Brain Injuries
Human placenta mesenchymal stem cell protection in ischemic stroke is angiotensin converting enzyme-2 and masR receptor-dependent.
Breast Neoplasms
Cross talk between COVID-19 and breast cancer.
Dexmedetomidine promotes breast cancer cell migration through Rab11-mediated secretion of exosomal TMPRSS2.
Erratum to dexmedetomidine promotes breast cancer cell migration through Rab11-mediated secretion of exosomal TMPRSS2.
Methylation Changes of Primary Tumors, Monolayer, and Spheroid Tissue Culture Environments in Malignant Melanoma and Breast Carcinoma.
SARS-CoV-2 cell receptor gene ACE2 -mediated immunomodulation in breast cancer subtypes.
The potential role of abnormal angiotensin-converting enzyme 2 expression correlated with immune infiltration after SARS-CoV-2 infection in the prognosis of breast cancer.
Carcinogenesis
Association between SARS-CoV-2 infection and disease severity among prostate cancer patients on androgen deprivation therapy: a systematic review and meta-analysis.
Elevated expression and potential roles of human Sp5, a member of Sp transcription factor family, in human cancers.
Gene of the month: TMPRSS2 (transmembrane serine protease 2).
Hypermethylation-mediated transcriptional repression of TMPRSS2 in androgen receptor-negative prostate cancer cells.
In vitro characterization of TMPRSS2 inhibition in IPEC-J2 cells.
Phenotypic analysis of mice lacking the Tmprss2-encoded protease.
Prostate adenocarcinoma and COVID-19: The possible impacts of TMPRSS2 expressions in susceptibility to SARS-CoV-2.
Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2.
The androgen-regulated type II serine protease TMPRSS2 is differentially expressed and mislocalized in prostate adenocarcinoma.
The role of chromosome 21 in hematology and oncology.
TMPRSS2-ERG fusions linked to prostate cancer racial health disparities: A focus on Africa.
What is the molecular pathology of low-risk prostate cancer?
Carcinoma
Analysis of laser-microdissected prostate cancer tissues reveals potential tumor markers.
Characterization of ETS gene aberrations in select histologic variants of prostate carcinoma.
Detection of TMPRSS2 gene deletions and translocations in carcinoma, intraepithelial neoplasia, and normal epithelium of the prostate by direct fluorescence in situ hybridization.
Downregulation of ACE2 expression by SARS-CoV-2 worsens the prognosis of KIRC and KIRP patients via metabolism and immunoregulation.
ERG rearrangement and protein expression in the progression to castration-resistant prostate cancer.
Expression of the COVID-19 receptor ACE2 in the human conjunctiva.
Genetic Susceptibility of ACE2 and TMPRSS2 in Six Common Cancers and Possible Impacts on COVID-19.
Molecular biology underlying the clinical heterogeneity of prostate cancer: an update.
Mutation analyses of 268 candidate genes in human tumor cell lines.
Pan?cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS?CoV?2 infection leading to COVID-19.
Phenotypic analysis of mice lacking the Tmprss2-encoded protease.
Prostate adenocarcinoma and COVID-19: The possible impacts of TMPRSS2 expressions in susceptibility to SARS-CoV-2.
Prostatic adenocarcinoma CNS parenchymal and dural metastases: alterations in ERG, CHD1 and MAP3K7 expression.
Structural Basis of Covalent Inhibitory Mechanism of TMPRSS2-Related Serine Proteases by Camostat.
TMPRSS2-ERG gene fusion causing ERG overexpression precedes chromosome copy number changes in prostate carcinomas and paired HGPIN lesions.
Carcinoma, Hepatocellular
ACE2 inhibits breast cancer angiogenesis via suppressing the VEGFa/VEGFR2/ERK pathway.
Clinical significance and molecular mechanism of angiotensin-converting enzyme 2 in hepatocellular carcinoma tissues.
Genetic Susceptibility of ACE2 and TMPRSS2 in Six Common Cancers and Possible Impacts on COVID-19.
Carcinoma, Non-Small-Cell Lung
ACE2 inhibits breast cancer angiogenesis via suppressing the VEGFa/VEGFR2/ERK pathway.
Angiotensin-converting enzyme 2 attenuates the metastasis of non-small cell lung cancer through inhibition of epithelial-mesenchymal transition.
Association between Serum Angiotensin-converting Enzyme 2 Level with Postoperative Morbidity and Mortality after Major Pulmonary Resection in Non-small Cell Lung Cancer Patients.
The angiotensin-converting enzyme 2 in tumor growth and tumor-associated angiogenesis in non-small cell lung cancer.
Carcinoma, Renal Cell
Renal Carcinoma Is Associated With Increased Risk of Coronavirus Infections.
Carcinoma, Small Cell
Characterization of ETS gene aberrations in select histologic variants of prostate carcinoma.
Carcinoma, Squamous Cell
Expression of the COVID-19 receptor ACE2 in the human conjunctiva.
Pan?cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS?CoV?2 infection leading to COVID-19.
Carcinosarcoma
Pan?cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS?CoV?2 infection leading to COVID-19.
Cardiomegaly
Activation of the Cardiac Renin-Angiotensin System in High Oxygen-Exposed Newborn Rats: Angiotensin Receptor Blockade Prevents the Developmental Programming of Cardiac Dysfunction.
Angiotensin-converting enzyme 2 over-expression in the central nervous system reduces angiotensin-II-mediated cardiac hypertrophy.
Cardiac protective effects of irbesartan via the PPAR-gamma signaling pathway in angiotensin-converting enzyme 2-deficient mice.
Inhibition of Angiotensin-Converting Enzyme 2 Exacerbates Cardiac Hypertrophy and Fibrosis in Ren-2 Hypertensive Rats.
Role of angiotensin-converting enzyme 2 in cardiac hypertrophy induced by nitric oxide synthase inhibition.
Cardiomyopathies
Angiotensin-converting enzyme 2 overexpression protects against doxorubicin-induced cardiomyopathy by multiple mechanisms in rats.
Detection of soluble angiotensin-converting enzyme 2 in heart failure: insights into the endogenous counter-regulatory pathway of the renin-angiotensin-aldosterone system.
Soluble angiotensin-converting enzyme 2 in human heart failure: relation with myocardial function and clinical outcomes.
Cardiomyopathy, Dilated
Olmesartan medoxomil treatment potently improves cardiac myosin-induced dilated cardiomyopathy via the modulation of ACE-2 and ANG 1-7 mas receptor.
Cardiomyopathy, Hypertrophic
Genetic variation in angiotensin-converting enzyme 2 gene is associated with extent of left ventricular hypertrophy in hypertrophic cardiomyopathy.
Polymorphisms of angiotensin-converting enzyme 2 gene associated with magnitude of left ventricular hypertrophy in male patients with hypertrophic cardiomyopathy.
Cardiotoxicity
Cardiovascular disease during the COVID-19 pandemic: Think ahead, protect hearts, reduce mortality.
SARS-CoV-2 and cardiovascular complications: From molecular mechanisms to pharmaceutical management.
Cardiovascular Diseases
ACE2 activity was increased in atherosclerotic plaque by losartan: Possible relation to anti-atherosclerosis.
ACE2 overexpression inhibits angiotensin II-induced monocyte chemoattractant protein-1 expression in macrophages.
ACE2/Ang 1-7 axis: A critical regulator of epicardial adipose tissue inflammation and cardiac dysfunction in obesity.
Age-associated difference in circulating ACE2, the gateway for SARS-COV-2, in humans: results from the InCHIANTI study.
Angiotensin-converting enzyme 2 (ACE2) levels in relation to risk factors for COVID-19 in two large cohorts of patients with atrial fibrillation.
Angiotensin-converting enzyme 2 activation improves endothelial function.
Angiotensin-Converting Enzyme 2 Activator Ameliorates Severe Pulmonary Hypertension in a Rat Model of Left Pneumonectomy Combined With VEGF Inhibition.
Angiotensin-converting enzyme 2 and kidney diseases in the era of coronavirus disease 2019.
Angiotensin-converting enzyme 2 inhibits high-mobility group box 1 and attenuates cardiac dysfunction post-myocardial ischemia.
Angiotensin-converting enzyme 2 overexpression protects against doxorubicin-induced cardiomyopathy by multiple mechanisms in rats.
Angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker treatment and haemodynamic factors are associated with increased cardiac mRNA expression of angiotensin-converting enzyme 2 in patients with cardiovascular disease.
Cardiovascular Manifestations of COVID-19.
Centrally administered angiotensin-(1-7) increases the survival of stroke-prone spontaneously hypertensive rats.
Cerebroprotection by angiotensin (1-7) in endothelin-1 induced ischemic stroke.
Circulating angiotensin converting enzyme 2 activity as a biomarker of silent atherosclerosis in patients with chronic kidney disease.
Circulating angiotensin-converting enzyme 2 activity in patients with chronic kidney disease without previous history of cardiovascular disease.
Coronavirus uses as binding site in humans angiotensin-converting enzyme 2 functional receptor that is involved in arterial blood pressure control and fibrotic response to damage and is a drug target in cardiovascular disease. Is this just a phylogenetic coincidence?
Insufficient hypothalamic angiotensin-converting enzyme 2 is associated with hypertension in SHR rats.
Is There an Association Between COVID-19 Mortality and the Renin-Angiotensin System? A Call for Epidemiologic Investigations.
Level of the SARS-CoV-2 receptor ACE2 activity is highly elevated in old-aged patients with aortic stenosis: implications for ACE2 as a biomarker for the severity of COVID-19.
Multiple functions of angiotensin-converting enzyme 2 and its relevance in cardiovascular diseases.
Overexpression of angiotensin-converting enzyme 2 by renin-angiotensin system inhibitors. Truth or myth? A systematic review of animal studies.
Prediction of death status on the course of treatment in SARS-COV-2 patients with deep learning and machine learning methods.
Prediction of Off-Target Effects on Angiotensin-Converting Enzyme 2.
Protection from angiotensin II-induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats.
Sex differences in COVID-19: candidate pathways, genetics of ACE2, and sex hormones.
SHOX Duplication and Tall Stature in a Patient with Xq Deletion and Vascular Disease.
Soluble Angiotensin-Converting Enzyme 2, Cardiac Biomarkers, Structure, and Function, and Cardiovascular Events (From the Atherosclerosis Risk in Communities Study).
Species-specific inhibitor sensitivity of angiotensin-converting enzyme 2 (ACE2) and its implication for ACE2 activity assays.
Structure-based discovery of a novel angiotensin-converting enzyme 2 inhibitor.
Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents.
Targeting angiotensin-converting enzyme 2 as a new therapeutic target for cardiovascular diseases.
The Association Between ACE2 Gene Polymorphism and the Stroke Recurrence in Chinese Population.
The beneficial effects of angiotensin-converting enzyme II (ACE2) activator in pulmonary hypertension secondary to left ventricular dysfunction.
The COVID-19 pandemic, heart and cardiovascular diseases: What we have learned.
The role of angiotensin-converting enzyme 2 in coronaviruses/influenza viruses and cardiovascular disease.
Cerebral Amyloid Angiopathy
Angiotensin-converting enzyme 2 is reduced in Alzheimer's disease in association with increasing amyloid-? and tau pathology.
Cerebral Hemorrhage
Screening strategy of TMPRSS2 inhibitors by FRET-based enzymatic activity for TMPRSS2-based cancer and COVID-19 treatment.
Cerebrovascular Disorders
Altered COVID-19 receptor ACE2 expression in a higher risk group for cerebrovascular disease and ischemic stroke.
The Association Between ACE2 Gene Polymorphism and the Stroke Recurrence in Chinese Population.
Chagas Cardiomyopathy
Impact of diminazene aceturate on renin-angiotensin system, infectious myocarditis and skeletal myositis in mice: An in vitro and in vivo study.
Chronic Periodontitis
COVID-19 and periodontitis: reflecting on a possible association.
Coinfection
Antiviral Activity of Type I, II, and III Interferons Counterbalances ACE2 Inducibility and Restricts SARS-CoV-2.
Men and COVID-19: A Pathophysiologic Review.
Colitis
Mica Can Alleviate TNBS-Induced Colitis in Mice by Reducing Angiotensin II and IL-17A and Increasing Angiotensin-Converting Enzyme 2, Angiotensin 1-7, and IL-10.
Colonic Neoplasms
Colorectal Cancer that Highly Express Both ACE2 and TMPRSS2, Suggesting Severe Symptoms to SARS-CoV-2 Infection.
Pan?cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS?CoV?2 infection leading to COVID-19.
Colorectal Neoplasms
Absence of fusion of TMPRSS2 and ETS transcription factor genes in gastric and colorectal carcinomas.
ACE2 and TMPRSS2 expression by clinical, HLA, immune, and microbial correlates across 34 human cancers and matched normal tissues: implications for SARS-CoV-2 COVID-19.
Colorectal Cancer that Highly Express Both ACE2 and TMPRSS2, Suggesting Severe Symptoms to SARS-CoV-2 Infection.
Gastrointestinal insights during the COVID-19 epidemic.
High expression of ACE2 and TMPRSS2 and clinical characteristics of COVID-19 in colorectal cancer patients.
Unexpected tumor reduction in metastatic colorectal cancer patients during SARS-Cov-2 infection: effect of ACE-2 expression on tumor cells or molecular mimicry phenomena? Two not mutually exclusive hypotheses.
Communicable Diseases
Dysregulation of Angiotensin Converting Enzyme 2 Expression and Function in Comorbid Disease Conditions Possibly Contributes to Coronavirus Infectious Disease 2019 Complication Severity.
Lung Cancer Models Reveal Severe Acute Respiratory Syndrome Coronavirus 2-Induced Epithelial-to-Mesenchymal Transition Contributes to Coronavirus Disease 2019 Pathophysiology.
Pulmonary vascular endothelial injury and acute pulmonary hypertension caused by COVID-19: the fundamental cause of refractory hypoxemia?
Risk for COVID-19 infection in patients with tobacco smoke-associated cancers of the upper and lower airway.
SARS-CoV-2 infection induces EMT-like molecular changes, including ZEB1-mediated repression of the viral receptor ACE2, in lung cancer models.
Similarities in Risk for COVID-19 and Cancer Disparities.
Tannic acid suppresses SARS-CoV-2 as a dual inhibitor of the viral main protease and the cellular TMPRSS2 protease.
Conjunctivitis
Ocular tropism of coronavirus (CoVs): a comparison of the interaction between the animal-to-human transmitted coronaviruses (SARS-CoV-1, SARS-CoV-2, MERS-CoV, CoV-229E, NL63, OC43, HKU1) and the eye.
Connective Tissue Diseases
Autoantibodies to angiotensin-converting enzyme 2 in patients with connective tissue diseases.
Decreased serum ACE2 levels in patients with connective tissue diseases.
Coronary Artery Disease
Elevated plasma angiotensin converting enzyme 2 activity is an independent predictor of major adverse cardiac events in patients with obstructive coronary artery disease.
[Relationship of angiotensin-converting enzyme 2 gene polymorphisms and vulnerability to coronary heart disease in patients with type 2 diabetes mellitus]
Coronary Disease
The influence of angiotensin-converting enzyme 2 gene polymorphisms on type 2 diabetes mellitus and coronary heart disease.
[Relationship of angiotensin-converting enzyme 2 gene polymorphisms and vulnerability to coronary heart disease in patients with type 2 diabetes mellitus]
Coronavirus Infections
A model for COVID-19-induced dysregulation of ACE2 shedding by ADAM17.
ACE2 and TMPRSS2 polymorphisms in various diseases with special reference to its impact on COVID-19 disease.
Air pollution by NO2 and PM2.5 explains COVID-19 infection severity by overexpression of angiotensin-converting enzyme 2 in respiratory cells: a review.
Binding of SARS-COV-2 (COVID-19) and SARS-COV to human ACE2: Identifying binding sites and consequences on ACE2 stiffness.
Clinical Isolates of Human Coronavirus 229E Bypass the Endosome for Cell Entry.
COVID-19 and human reproduction: A pandemic that packs a serious punch.
COVID-19 and Inflammatory Bowel Diseases: Risk Assessment, Shared Molecular Pathways, and Therapeutic Challenges.
COVID-19 in age-related neurodegenerative diseases: is there a role for vitamin D3 as a possible therapeutic strategy?
Differential virological and immunological outcome of severe acute respiratory syndrome coronavirus infection in susceptible and resistant transgenic mice expressing human angiotensin-converting enzyme 2.
Discovery of TMPRSS2 Inhibitors from Virtual Screening as a Potential Treatment of COVID-19.
Highlights in the fight against COVID-19: does autophagy play a role in SARS-CoV-2 infection?
Human and novel coronavirus infections in children: a review.
Identification of pulmonary Oct-4+ stem/progenitor cells and demonstration of their susceptibility to SARS coronavirus (SARS-CoV) infection in vitro.
Immunogenetic Predictors of Severe COVID-19.
Mice transgenic for human angiotensin-converting enzyme 2 provide a model for SARS coronavirus infection.
MicroRNA Mimics or Inhibitors as Antiviral Therapeutic Approaches Against COVID-19.
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection Mediated by the Transmembrane Serine Protease TMPRSS2.
Myasthenia gravis at the crossroad of COVID-19: focus on immunological and respiratory interplay.
Neurological manifestations of coronavirus infections: role of angiotensin-converting enzyme 2 in COVID-19.
Renal Carcinoma Is Associated With Increased Risk of Coronavirus Infections.
SAMHD1 as the Potential Link Between SARS-CoV-2 Infection and Neurological Complications.
Screening strategy of TMPRSS2 inhibitors by FRET-based enzymatic activity for TMPRSS2-based cancer and COVID-19 treatment.
Severe acute respiratory syndrome coronavirus infection of mice transgenic for the human Angiotensin-converting enzyme 2 virus receptor.
Severe COVID-19 in Alzheimer's disease: APOE4's fault again?
Soluble angiotensin-converting enzyme 2: a potential approach for coronavirus infection therapy?
The potential effects of DPP-4 inhibitors on cardiovascular system in COVID-19 patients.
The Role of Angiotensin Converting Enzyme 2 in Modulating Gut Microbiota, Intestinal Inflammation, and Coronavirus Infection.
TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection.
TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections.
[Androgens and Antiandrogens influence on COVID-19 disease in men].
Cough
An overview of viruses discovered over the last decades and drug development for the current pandemic.
Non-steroidal anti-inflammatory drugs, pharmacology, and COVID-19 infection.
Repurposing the mucolytic cough suppressant and TMPRSS2 protease inhibitor bromhexine for the prevention and management of SARS-CoV-2 infection.
Sars-CoV-2: A clinical update - II.
COVID-19
"Molecular Masks" for ACE2 to Effectively and Safely Block SARS-CoV-2 Virus Entry.
1,2,3,4,6-Pentagalloyl Glucose, a RBD-ACE2 Binding Inhibitor to Prevent SARS-CoV-2 Infection.
17?-estradiol reduces SARS-CoV-2 infection in vitro.
3-Hydroxyphthalic Anhydride-Modified Chicken Ovalbumin as a Potential Candidate Inhibits SARS-CoV-2 Infection by Disrupting the Interaction of Spike Protein With Host ACE2 Receptor.
A bifluorescent-based assay for the identification of neutralizing antibodies against SARS-CoV-2 variants of concern in vitro and in vivo.
A brief review of interplay between vitamin D and angiotensin-converting enzyme 2: Implications for a potential treatment for COVID-19.
A comprehensive guide to the pharmacologic regulation of angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 entry receptor.
A comprehensive investigation of the mRNA and protein level of ACE2, the putative receptor of SARS-CoV-2, in human tissues and blood cells.
A Comprehensive Review of COVID-19 Associated Neurological Manifestations.
A Correlation among the COVID-19 Spread, Particulate Matters, and Angiotensin-Converting Enzyme 2: A Review.
A data-driven approach to identify risk profiles and protective drugs in COVID-19.
A Dual-Route Perspective of SARS-CoV-2 Infection: Lung- vs. Gut-specific Effects of ACE-2 Deficiency.
A glycan gate controls opening of the SARS-CoV-2 spike protein.
A human cell-based SARS-CoV-2 vaccine elicits potent neutralizing antibody responses and protects mice from SARS-CoV-2 challenge.
A mouse model for SARS-CoV-2 infection by exogenous delivery of hACE2 using alphavirus replicon particles.
A Narrative Review of a Pulmonary Aerosolized Formulation or a Nasal Drop Using Sera Containing Neutralizing Antibodies Collected from COVID-19-Recovered Patients as a Probable Therapy for COVID-19.
A Network Medicine Approach to Investigation and Population-based Validation of Disease Manifestations and Drug Repurposing for COVID-19.
A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19.
A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells.
A novel hypothesis for COVID-19 pathogenesis: Retinol depletion and retinoid signaling disorder.
A novel mouse AAV6 hACE2 transduction model of wild-type SARS-CoV-2 infection studied using synDNA immunogens.
A phase I study of high dose camostat mesylate in healthy adults provides a rationale to repurpose the TMPRSS2 inhibitor for the treatment of COVID-19.
A pilot study to assess the circulating renin-angiotensin system in COVID-19 acute respiratory failure.
A pressor dose of angiotensin II has no influence on the angiotensin-converting enzyme 2 and other molecules associated with SARS-CoV-2 infection in mice.
A protein interaction map identifies existing drugs targeting SARS-CoV-2.
A Recombinant Fragment of Human Surfactant Protein D Binds Spike Protein and Inhibits Infectivity and Replication of SARS-CoV-2 in Clinical Samples.
A Review on Expression, Pathological Roles, and Inhibition of TMPRSS2, the Serine Protease Responsible for SARS-CoV-2 Spike Protein Activation.
A safety consideration of mesenchymal stem cell therapy on COVID-19.
A single-dose mRNA vaccine provides a long-term protection for hACE2 transgenic mice from SARS-CoV-2.
A tale of two diseases: Sarcoidosis, COVID-19 and new therapeutic options with dual RAS inhibition and tetanus-diphtheria vaccine.
A variant in TMPRSS2 is associated with decreased disease severity in COVID-19.
A Viewpoint on Angiotensin-Converting Enzyme 2, Anti-Hypertensives and Coronavirus Disease 2019 (COVID-19).
Abnormal apelin-ACE2 and SGLT2 signaling contribute to adverse cardiorenal injury in patients with COVID-19.
ACE deletion allele is associated with susceptibility to SARS-CoV-2 infection and mortality rate: An epidemiological study in the Asian population.
ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study.
ACE inhibitors, angiotensin receptor blockers and endothelial injury in COVID-19.
ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19.
ACE-2-interacting Domain of SARS-CoV-2 (AIDS) Peptide Suppresses Inflammation to Reduce Fever and Protect Lungs and Heart in Mice: Implications for COVID-19 Therapy.
ACE2 (Angiotensin-Converting Enzyme 2) and TMPRSS2 (Transmembrane Serine Protease 2) Expression and Localization of SARS-CoV-2 Infection in the Human Heart.
ACE2 and TMPRSS2 are expressed on the human ocular surface, suggesting susceptibility to SARS-CoV-2 infection.
ACE2 and TMPRSS2 expression by clinical, HLA, immune, and microbial correlates across 34 human cancers and matched normal tissues: implications for SARS-CoV-2 COVID-19.
ACE2 and TMPRSS2 polymorphisms in various diseases with special reference to its impact on COVID-19 disease.
ACE2 and TMPRSS2 Potential Involvement in Genetic Susceptibility to SARS-COV-2 in Cancer Patients.
ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy.
ACE2 and TMPRSS2 variation in savanna monkeys (Chlorocebus spp.): Potential risk for zoonotic/anthroponotic transmission of SARS-CoV-2 and a potential model for functional studies.
ACE2 Down-Regulation May Act as a Transient Molecular Disease Causing RAAS Dysregulation and Tissue Damage in the Microcirculatory Environment Among COVID-19 Patients.
ACE2 Interaction Networks in COVID-19: A Physiological Framework for Prediction of Outcome in Patients with Cardiovascular Risk Factors.
ACE2 Is an Adjacent Element of Atherosclerosis and COVID-19 Pathogenesis.
ACE2 mouse models: a toolbox for cardiovascular and pulmonary research.
ACE2, a multifunctional protein - from cardiovascular regulation to COVID-19.
ACE2, angiotensin 1-7 and skeletal muscle: review in the era of COVID-19.
ACE2, Metformin, and COVID-19.
ACE2, TMPRSS2 distribution and extrapulmonary organ injury in patients with COVID-19.
ACE2, TMPRSS2, and furin gene expression in the airways of people with asthma-implications for COVID-19.
ACE2, TMPRSS2, and Furin variants and SARS-CoV-2 infection in Madrid, Spain.
ACE2/ADAM17/TMPRSS2 Interplay May Be the Main Risk Factor for COVID-19.
ACE2: the molecular doorway to SARS-CoV-2.
Acidic preconditioning reduces lipopolysaccharide-induced acute lung injury by upregulating the expression of angiotensin-converting enzyme 2.
Activation of Interferon-Stimulated Transcriptomes and ACE2 Isoforms in Human Airway Epithelium Is Curbed by Janus Kinase Inhibitors.
Acute Kidney Injury in a Case Series of Patients with Confirmed COVID-19 (Coronavirus Disease 2019): Role of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Blockade.
Acute Kidney Injury in COVID-19.
Acute Kidney Injury in COVID-19: a Brief Review.
Acute mesenteric ischemia and small bowel imaging findings in COVID-19: A comprehensive review of the literature.
Acute Pancreatitis in a Patient With COVID-19 After the Resolution of Respiratory Symptoms.
Advanced-glycation end-products axis: A contributor to the risk of severe illness from COVID-19 in diabetes patients.
Age and gender differences in ACE2 and TMPRSS2 expressions in oral epithelial cells.
Age-associated difference in circulating ACE2, the gateway for SARS-COV-2, in humans: results from the InCHIANTI study.
Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 disease severity.
Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity.
Aging- and gender-related modulation of RAAS: potential implications in COVID-19 disease.
Air pollution by NO2 and PM2.5 explains COVID-19 infection severity by overexpression of angiotensin-converting enzyme 2 in respiratory cells: a review.
Air-liquid interphase culture confers SARS-CoV-2 susceptibility to A549 alveolar epithelial cells.
Airways Expression of SARS-CoV-2 Receptor, ACE2, and TMPRSS2 Is Lower in Children Than Adults and Increases with Smoking and COPD.
Akt-independent effects of triciribine on ACE2 expression in human lung epithelial cells: Potential benefits in restricting SARS-CoV2 infection.
Alert to US physicians: DHEA, widely used as an OTC androgen supplement, may exacerbate COVID-19.
Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection.
Alpha-1-antitrypsin: A possible host protective factor against Covid-19.
Altered COVID-19 receptor ACE2 expression in a higher risk group for cerebrovascular disease and ischemic stroke.
Ambroxol Hydrochloride Inhibits the Interaction between Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein's Receptor Binding Domain and Recombinant Human ACE2.
An Enzymatic TMPRSS2 Assay for Assessment of Clinical Candidates and Discovery of Inhibitors as Potential Treatment of COVID-19.
An Insight into the Sex Differences in COVID-19 Patients: What are the Possible Causes?
An unusual presentation of COVID-19: Acute pancreatitis.
Analysis of 2019-nCoV receptor ACE2 expression in different tissues and its significance study.
Analysis of Gastrointestinal and Hepatic Manifestations of SARS-CoV-2 Infection in 892 Patients in Queens, NY.
Analysis of the Role of N-Linked Glycosylation in Cell Surface Expression, Function, and Binding Properties of SARS-CoV-2 Receptor ACE2.
Androgen Receptor Genetic Variant Predicts COVID-19 Disease Severity: A Prospective Longitudinal Study of Hospitalized COVID-19 Male Patients.
Androgen Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men.
Androgen regulation of pulmonary AR, TMPRSS2 and ACE2 with implications for sex-discordant COVID-19 outcomes.
Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (N = 4532).
Angiotensin converting enzyme 2 at the interface between renin-angiotensin system inhibition and coronavirus disease 2019.
Angiotensin Converting Enzyme 2 May Mediate Disease Severity In COVID-19.
Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers and Outcomes in patients with COVID-19: A Systematic Review and Meta-Analysis.
Angiotensin Converting Enzyme-2 (ACE2) receptors, asthma and severe COVID-19 infection risk.
Angiotensin converting enzyme-2 as therapeutic target in COVID-19.
Angiotensin receptor blockers as tentative SARS-CoV-2 therapeutics.
Angiotensin-converting enzyme 2 (ACE2) is upregulated in Alzheimer's disease brain.
Angiotensin-converting enzyme 2 (ACE2) levels in relation to risk factors for COVID-19 in two large cohorts of patients with atrial fibrillation.
Angiotensin-converting enzyme 2 (ACE2), SARS-CoV-2 and the pathophysiology of coronavirus disease 2019 (COVID-19).
Angiotensin-converting enzyme 2 (ACE2): COVID 19 gate way to multiple organ failure syndromes.
Angiotensin-Converting Enzyme 2 and Antihypertensives (Angiotensin Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors) in Coronavirus Disease 2019.
Angiotensin-converting enzyme 2 and COVID-19 in cardiorenal diseases.
Angiotensin-converting enzyme 2 and COVID-19: patients, comorbidities, and therapies.
Angiotensin-converting enzyme 2 and kidney diseases in the era of coronavirus disease 2019.
Angiotensin-Converting Enzyme 2 as the Molecular Bridge Between Epidemiologic and Clinical Features of COVID-19.
Angiotensin-converting enzyme 2 connects COVID-19 with cancer and cancer immunotherapy.
Angiotensin-converting enzyme 2 decreased expression during kidney inflammatory diseases: implications to predisposing to COVID-19 kidney complications.
Angiotensin-converting enzyme 2 expression in COPD and IPF fibroblasts: the forgotten cell in COVID-19.
Angiotensin-Converting Enzyme 2 in the Pathogenesis of Renal Abnormalities Observed in COVID-19 Patients.
Angiotensin-converting enzyme 2 receptors, chronic liver diseases, common medications, and clinical outcomes in coronavirus disease 2019 patients.
Angiotensin-converting Enzyme 2 roles in the Pathogenesis of COVID-19.
Angiotensin-converting Enzyme 2 Specific Cell Subset Identification in Oral Tissues: A Need of the Hour in COVID-19 Research.
Angiotensin-converting enzyme 2, coronavirus disease 2019, and abdominal aortic aneurysms.
Angiotensin-converting enzyme 2, sex differences, and COVID-19: The missing link.
Angiotensin-converting enzyme 2, the complement system, the kallikrein-kinin system, type-2 diabetes, interleukin-6, and their interactions regarding the complex COVID-19 pathophysiological crossroads.
Angiotensin-converting enzyme 2: a double-edged sword in COVID-19 patients with an increased risk of heart failure.
Animal Models of COVID-19 II. Comparative Immunology.
Another perspective for COVID-19 pandemic: Angiotensin-converting enzyme 2 and ethnicity.
Antibodies at work in the time of severe acute respiratory syndrome coronavirus 2.
Antibodies to neutralising epitopes synergistically block the interaction of the receptor-binding domain of SARS-CoV-2 to ACE 2.
Antiviral Activity of Type I, II, and III Interferons Counterbalances ACE2 Inducibility and Restricts SARS-CoV-2.
Are Migraine Patients at Increased Risk for Symptomatic Coronavirus Disease 2019 Due to Shared Comorbidities?
Arterial Hypertension as a Risk Comorbidity Associated with COVID-19 Pathology.
Aspiration of periodontopathic bacteria due to poor oral hygiene potentially contributes to the aggravation of COVID-19.
Assessing COVID-19 susceptibility through analysis of the genetic and epigenetic diversity of ACE2-mediated SARS-CoV-2 entry.
Assessment of Hypokalemia and Clinical Characteristics in Patients With Coronavirus Disease 2019 in Wenzhou, China.
Assessment of risk conferred by coding and regulatory variations of TMPRSS2 and CD26 in susceptibility to SARS-CoV-2 infection in human.
Association between ACE2 and TMPRSS2 nasopharyngeal expression and COVID-19 respiratory distress.
Association between SARS-CoV-2 infection and disease severity among prostate cancer patients on androgen deprivation therapy: a systematic review and meta-analysis.
Association of ACE2 receptor and ACEIs/ARBs with disease severity in COVID-19.
Association of ACEi/ARB Use and Clinical Outcomes of COVID-19 Patients With Hypertension.
Association of Angiotensin-Converting Enzyme Inhibitor or Angiotensin Receptor Blocker Use With COVID-19 Diagnosis and Mortality.
Associations between mortality from COVID-19 in two Italian regions and outdoor air pollution as assessed through tropospheric nitrogen dioxide.
Asthma and COVID-19 pandemic: focused on the eosinophil count and ACE2 expression.
Asthma and severe acute respiratory syndrome coronavirus 2019: current evidence and knowledge gaps.
At the heart of COVID-19.
Atrial fibrillation in COVID-19: A review of possible mechanisms.
Azithromycin and ambroxol as potential pharmacotherapy for SARS-CoV-2.
Benign Evolution of SARS-Cov2 Infections in Children With Inflammatory Bowel Disease: Results From Two International Databases.
Binding of SARS-CoV-2 spike protein to ACE2 is disabled by thiol-based drugs; evidence from in vitro SARS-CoV-2 infection studies.
Bioactive Alkaloids from Genus Aspergillus: Mechanistic Interpretation of Their Antimicrobial and Potential SARS-CoV-2 Inhibitory Activity Using Molecular Modelling.
Bioinformatic characterization of angiotensin-converting enzyme 2, the entry receptor for SARS-CoV-2.
Biological Context Linking Hypertension and Higher Risk for COVID-19 Severity.
Biological sex impacts COVID-19 outcomes.
Bivalent binding of a fully human IgG to the SARS-CoV-2 spike proteins reveals mechanisms of potent neutralization.
BNT162b2 Vaccine Encoding the SARS-CoV-2 P2 S Protects Transgenic hACE2 Mice against COVID-19.
Bromelain Inhibits SARS-CoV-2 Infection in VeroE6 Cells.
Bromelain inhibits SARS-CoV-2 infection via targeting ACE-2, TMPRSS2, and spike protein.
Camostat mesylate against SARS-CoV-2 and COVID-19-Rationale, dosing and safety.
Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity.
Can Host Cell Proteins Like ACE2, ADAM17, TMPRSS2, Androgen Receptor be the Efficient Targets in SARS-CoV-2 Infection?
Cardiac arrest and COVID-19: inflammation, angiotensin-converting enzyme 2, and the destabilization of non-significant coronary artery disease-a case report.
Cardiovascular Considerations in Coronavirus Disease 2019 with a Special Focus on Arrhythmia.
Cardiovascular medications and regulation of COVID-19 receptors expression.
Cardiovascular Outcomes in the Acute Phase of COVID-19.
Cardiovascular Pharmacology in the Time of COVID-19: A Focus on Angiotensin-Converting Enzyme 2.
Case Report: Ischemic Colitis in Severe COVID-19 Pneumonia: An Unforeseen Gastrointestinal Complication.
Case Report: Paralytic Ileus: A Potential Extrapulmonary Manifestation of Severe COVID-19.
CD-sACE2 inclusion compounds: An effective treatment for coronavirus disease 2019 (COVID-19).
Cellular and Humoral Immune Responses in Covid-19 and Immunotherapeutic Approaches.
Cellular Tropism of SARS-CoV-2 across Human Tissues and Age-related Expression of ACE2 and TMPRSS2 in Immune-inflammatory Stromal Cells.
Characterization of ACE Inhibitors and AT1R Antagonists with Regard to Their Effect on ACE2 Expression and Infection with SARS-CoV-2 Using a Caco-2 Cell Model.
Chemical composition and pharmacological mechanism of ephedra-glycyrrhiza drug pair against coronavirus disease 2019 (COVID-19).
Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2.
Chronic E-Cigarette Aerosol Inhalation Alters the Immune State of the Lungs and Increases ACE2 Expression, Raising Concern for Altered Response and Susceptibility to SARS-CoV-2.
Cigarette Smoke Stimulates SARS-CoV-2 Internalization by Activating AhR and Increasing ACE2 Expression in Human Gingival Epithelial Cells.
Classical and alternative receptors for SARS-CoV-2 therapeutic strategy.
Classical and Counter-Regulatory Renin-Angiotensin System: Potential Key Roles in COVID-19 Pathophysiology.
Classification of the present pharmaceutical agents based on the possible effective mechanism on the COVID-19 infection.
Clinical analysis and pluripotent stem cells-based model reveal possible impacts of ACE2 and lung progenitor cells on infants vulnerable to COVID-19.
Clinical Profile of COVID-19 in Children and Research Progress on Angiotensin-converting Enzyme 2: A Mini-review.
Clinical significance and molecular mechanism of angiotensin-converting enzyme 2 in hepatocellular carcinoma tissues.
Clinically Suspected Myocarditis in the Course of Severe Acute Respiratory Syndrome Novel Coronavirus-2 Infection: Fact or Fiction?
CNS implications of COVID-19: a comprehensive review.
Co-Expression of Mitochondrial Genes and ACE2 in Cornea Involved in COVID-19.
Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study.
Cognitive impact of COVID-19: looking beyond the short term.
Coincidence of COVID-19 Infection and Smell-Taste Perception Disorders.
Colonic Epithelial Angiotensin-Converting Enzyme 2 (ACE2) Expression in Blacks and Whites: Potential Implications for Pathogenesis Covid-19 Racial Disparities.
Colorectal Cancer that Highly Express Both ACE2 and TMPRSS2, Suggesting Severe Symptoms to SARS-CoV-2 Infection.
Combination and tricombination therapy to destabilize the structural integrity of COVID-19 by some bioactive compounds with antiviral drugs: insights from molecular docking study.
Combination of Angiotensin (1-7) Agonists and Convalescent Plasma as a New Strategy to Overcome Angiotensin Converting Enzyme 2 (ACE2) Inhibition for the Treatment of COVID-19.
Combination Therapy Using Inhalable GapmeR and Recombinant ACE2 for COVID-19.
Common determinants of severe Covid-19 infection are explicable by SARS-CoV-2 secreted glycoprotein interaction with the CD33-related Siglecs, Siglec-3 and Siglec-5/14.
Common variants at 21q22.3 locus influence MX1 and TMPRSS2 gene expression and susceptibility to severe COVID-19.
Comorbidities in COVID-19: Outcomes in hypertensive cohort and controversies with renin angiotensin system blockers.
Comparative transcriptomic analysis of SARS-CoV-2 infected cell model systems reveals differential innate immune responses.
Comparison of Transgenic and Adenovirus hACE2 Mouse Models for SARS-CoV-2 Infection.
Comparison of transgenic and adenovirus hACE2 mouse models for SARS-CoV-2 infection.
Computational analysis of TMPRSS2 expression in normal and SARS-CoV-2-infected human tissues.
Computational Biology Analysis of COVID-19 Receptor-Binding Domains: A Target Site for Indocyanine Green Through Antimicrobial Photodynamic Therapy.
Computational insights into binding mechanism of drugs as potential inhibitors against SARS-CoV-2 targets.
Computational optimization of the SARS-CoV-2 receptor-binding-motif affinity for human ACE2.
Consideration on TMPRSS2 and the risk of COVID-19 infection in Cushing's syndrome.
Considerations for Gut Microbiota and Probiotics in Patients with Diabetes Amidst the Covid-19 Pandemic: A Narrative Review.
Consistent localization of SARS-CoV-2 spike glycoprotein and ACE2 over TMPRSS2 predominance in placental villi of 15 COVID-19 positive maternal-fetal dyads.
Construction of a Human Cell Landscape of COVID-19 Infection at Single-cell Level.
Context contribution to the intermolecular recognition of human ACE2-derived peptides by SARS-CoV-2 spike protein: implications for improving the peptide affinity but not altering the peptide specificity by optimizing indirect readout.
Contributions of human ACE2 and TMPRSS2 in determining host-pathogen interaction of COVID-19.
Corilagin prevents SARS-CoV-2 infection by targeting RBD-ACE2 binding.
Coronavirus disease 2019 (COVID-19) and the renin-angiotensin system: A closer look at angiotensin-converting enzyme 2 (ACE2).
Coronavirus Disease 2019 (COVID-19) in Children: Prevalence, Diagnosis, Clinical Symptoms, and Treatment.
Coronavirus Disease 2019 (SARS-CoV-2) and polycystic ovarian disease: Is there a higher risk for these women?
Coronavirus disease 2019 and cardiovascular system: A narrative review.
Coronavirus Disease 2019 and Hypertension: The Role of Angiotensin-Converting Enzyme 2 and the Renin-Angiotensin System.
Coronavirus Disease 2019 and the Cerebrovascular-Cardiovascular Systems: What Do We Know So Far?
Coronavirus Disease 2019 Infection among Children: Pathogenesis, Treatment, and Outcome.
Coronavirus Disease 2019 Transmission: Blood Viremia and Aerosol Generation from Spinal Surgery. Is There an Increased Risk to the Surgical Team?
Coronavirus Disease 2019-Associated Thrombosis and Coagulopathy: Review of the Pathophysiological Characteristics and Implications for Antithrombotic Management.
Coronavirus Disease 2019: A Gastroenterologist's Perspective in May 2020.
Coronavirus in Hematologic Malignancies: Targeting Molecules Beyond the Angiotensin-Converting Enzyme 2 (ACE2) Wall in COVID-19.
Coronaviruses in cats and other companion animals: Where does SARS-CoV-2/COVID-19 fit?
Correspondence: Angiotensin-converting enzyme 2 coated nanoparticles containing respiratory masks, chewing gums and nasal filters may be used for protection against COVID-19 infection.
Could Anti-Hypertensive Drug Therapy Affect the Clinical Prognosis of Hypertensive Patients With COVID-19 Infection? Data From Centers of Southern Italy.
Counter-regulatory 'Renin-Angiotensin' System-based Candidate Drugs to Treat COVID-19 Diseases in SARS-CoV-2-infected patients.
COVID-19 (Novel Coronavirus 2019) - recent trends.
COVID-19 - Does This Disease Kill Due to Imbalance of the Renin Angiotensin System (RAS) Caused by Genetic and Gender Differences in the Response to Viral ACE 2 Attack?
COVID-19 and Alzheimer's disease: how one crisis worsens the other.
COVID-19 and androgen-targeted therapy for prostate cancer patients.
COVID-19 and cardiovascular consequences: Is the endothelial dysfunction the hardest challenge?
COVID-19 and Cardiovascular Disease.
COVID-19 and diabetes mellitus: how one pandemic worsens the other.
COVID-19 and Genetic Variants of Protein Involved in the SARS-CoV-2 Entry into the Host Cells.
COVID-19 and Hartnup disease: an affair of intestinal amino acid malabsorption.
COVID-19 and human reproduction: A pandemic that packs a serious punch.
COVID-19 and male reproductive system: pathogenic features and possible mechanisms.
COVID-19 and metabolic comorbidities: An update on emerging evidences for optimal therapies.
COVID-19 and nicotine as a mediator of ACE-2.
COVID-19 and periodontitis: reflecting on a possible association.
COVID-19 and pulmonary fibrosis: therapeutics in clinical trials, repurposing, and potential development.
COVID-19 and relative angiotensin-converting enzyme 2 deficiency: role in disease severity and therapeutic response.
COVID-19 and Renal Diseases: An Update.
COVID-19 and renin-angiotensin system inhibition: role of angiotensin converting enzyme 2 (ACE2) - Is there any scientific evidence for controversy?
COVID-19 and the digestive system: A comprehensive review.
COVID-19 and the kidney.
COVID-19 and the male susceptibility: the role of ACE2, TMPRSS2 and the androgen receptor.
COVID-19 and the nervous system.
COVID-19 and the pituitary.
COVID-19 in Smokeless Tobacco Habitués: Increased Susceptibility and Transmission.
COVID-19 pandemic and therapy with ibuprofen or renin-angiotensin system blockers: no need for interruptions or changes in ongoing chronic treatments.
COVID-19 pandemic: Insights into structure, function, and hACE2 receptor recognition by SARS-CoV-2.
COVID-19 preclinical models: human angiotensin-converting enzyme 2 transgenic mice.
COVID-19 retinal microangiopathy as an in vivo biomarker of systemic vascular disease?
COVID-19 Susceptibility in Bronchial Asthma.
COVID-19 susceptibility in pregnancy: Immune/inflammatory considerations, the role of placental ACE-2 and research considerations.
CoViD-19 Susceptibility.
COVID-19 Vaccine and Hyperosmolar Hyperglycemic State.
COVID-19 With an Initial Presentation of Intraperitoneal Hemorrhage Secondary to Spontaneous Splenic Rupture.
COVID-19, ACE2, and the cardiovascular consequences.
COVID-19, Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Inhibition: Implications for Practice.
COVID-19, Renin-Angiotensin System, Angiotensin-Converting Enzyme 2, and Nicotine: What is the Interrelation?
Covid-19, TMPRSS2, and whether android regulation affects pandemic virus gender incidence and age distribution of disease.
COVID-19-A Theory of Autoimmunity Against ACE-2 Explained.
COVID-19-Associated Nonocclusive Fibrin Microthrombi in the Heart.
COVID-19-related Genes in Sputum Cells in Asthma. Relationship to Demographic Features and Corticosteroids.
COVID-19-Related Intracerebral Hemorrhage.
COVID-19: angiotensin-converting enzyme 2 (ACE2) expression and tissue susceptibility to SARS-CoV-2 infection.
COVID-19: social distancing, ACE 2 receptors, protease inhibitors and beyond?
COVID-19: The Influence of ACE Genotype and ACE-I and ARBs on the Course of SARS-CoV-2 Infection in Elderly Patients.
Covid-19: the renin-angiotensin system imbalance hypothesis.
COVID-19: the role of excessive cytokine release and potential ACE2 down-regulation in promoting hypercoagulable state associated with severe illness.
COVID-19: Zinc and Angiotensin-Converting Enzyme 2 (ACE2) Deficiencies as Determinants of Risk and Severity of Disease: A Narrative Review.
Critical ACE2 Determinants of SARS-CoV-2 and Group 2B Coronavirus Infection and Replication.
Critical Interactions Between the SARS-CoV-2 Spike Glycoprotein and the Human ACE2 Receptor.
Cross talk between COVID-19 and breast cancer.
Crosstalk between COVID-19 and prostate cancer.
Current Status of Putative Animal Sources of SARS-CoV-2 Infection in Humans: Wildlife, Domestic Animals and Pets.
Cutaneous susceptibility to SARS-CoV-2 infection according to the expression of viral entry factors in the skin.
Cyclic gallium-68 labeled peptides for specific detection of human angiotensin-converting enzyme 2.
Cytomegalovirus haemorrhagic enterocolitis associated with severe infection with COVID-19.
Data, Reagents, Assays and Merits of Proteomics for SARS-CoV-2 Research and Testing.
De novo design of protein peptides to block association of the SARS-CoV-2 spike protein with human ACE2.
Dealing with lung cancer in the COVID-19 scenario (A review).
Decreased Mortality Rate Among COVID-19 Patients Prescribed Statins: Data From Electronic Health Records in the US.
Defusing SARS-CoV-2: Emergency Brakes in a Vaccine Failure Scenario.
Delayed hemodialysis in COVID-19: Case series with literature review.
Delayed onset of fatal encephalitis in a COVID-19 positive patient.
Delineating clinical characteristics and comorbidities among 206 COVID-19 deceased patients in India: Emerging significance of renin angiotensin system derangement.
Dermatological aspects of SARS-CoV-2 infection: mechanisms and manifestations.
Detection of viral RNA fragments in human iPSC cardiomyocytes following treatment with extracellular vesicles from SARS-CoV-2 coding sequence overexpressing lung epithelial cells.
Detection of Viral RNA Fragments in Human iPSC-Cardiomyocytes following Treatment with Extracellular Vesicles from SARS-CoV-2 Coding-Sequence-Overexpressing Lung Epithelial Cells.
Determinants of SARS-CoV-2 receptor gene expression in upper and lower airways.
Developing new drugs that activate the protective arm of the renin-angiotensin system as a potential treatment for respiratory failure in COVID-19 patients.
Development of a SARS-CoV-2-derived receptor-binding domain-based ACE2 biosensor.
Development of IgG, IgM, and IgA autoantibodies against angiotensin converting enzyme 2 in patients with COVID-19.
Development of spike receptor-binding domain nanoparticle as a vaccine candidate against SARS-CoV-2 infection in ferrets.
Diabetes and metabolic syndrome as risk factors for COVID-19.
Different kinds of stem cells in the development of SARS-CoV-2 treatments.
Differential expression and immune correlation analysis of COVID-19 receptor ACE2 and TMPRSS2 genes in all normal and tumor tissues.
Differential Expression of Rab5 and Rab7 Small GTPase Proteins in Placental Tissues From Pregnancies Affected by Maternal Coronavirus Disease 2019.
Discovery of potential multi-target-directed ligands by targeting host-specific SARS-CoV-2 structurally conserved main protease.
Discovery of Small Anti-ACE2 Peptides to Inhibit SARS-CoV-2 Infectivity.
Discovery of TMPRSS2 Inhibitors from Virtual Screening as a Potential Treatment of COVID-19.
Disequilibrium between the classic renin-angiotensin system and its opposing arm in SARS-CoV-2-related lung injury.
Distinct mechanisms for TMPRSS2 expression explain organ-specific inhibition of SARS-CoV-2 infection by enzalutamide.
Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages.
DNA methylation architecture of the ACE2 gene in nasal cells of children.
DNA Methylation Architecture of the ACE2 gene in Nasal Cells.
Do Anti-androgens Have Potential as Therapeutics for COVID-19?
Do Changes in ACE-2 Expression Affect SARS-CoV-2 Virulence and Related Complications: A Closer Look into Membrane-Bound and Soluble Forms.
Do genetic polymorphisms in angiotensin converting enzyme 2 (ACE2) gene play a role in coronavirus disease 2019 (COVID-19)?
Do inflammaging and coagul-aging play a role as conditions contributing to the co-occurrence of the severe hyper-inflammatory state and deadly coagulopathy during COVID-19 in older people?
Do sex-specific immunobiological factors and differences in angiotensin converting enzyme 2 (ACE2) expression explain increased severity and mortality of COVID-19 in males?
Dodging COVID-19 infection: low expression and localization of ACE2 and TMPRSS2 in multiple donor-derived lines of human umbilical cord-derived mesenchymal stem cells.
Does Angiotensin II Peak in Response to SARS-CoV-2?
Does hereditary angioedema make COVID-19 worse?
Does severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) cause orchitis in patients with coronavirus disease 2019 (COVID-19)?
Does taking an angiotensin inhibitor increase the risk for COVID-19? - a systematic review and meta-analysis.
Does the compromised sleep and circadian disruption of night and shiftworkers make them highly vulnerable to 2019 coronavirus disease (COVID-19)?
Downregulation of ACE2 expression by SARS-CoV-2 worsens the prognosis of KIRC and KIRP patients via metabolism and immunoregulation.
Downregulation of Membrane-bound Angiotensin Converting Enzyme 2 (ACE2) Receptor has a Pivotal Role in COVID-19 Immunopathology.
Drug treatments affecting ACE2 in COVID-19 infection: a systematic review protocol.
Drugs acting on the renin-angiotensin system and SARS-CoV-2.
Effect of Common Medications on the Expression of SARS-CoV-2 Entry Receptors in Kidney Tissue.
Effect of COVID-19 on hereditary angioedema activity and quality of life.
Effect of Spironolactone on COVID-19 in Patients With Underlying Liver Cirrhosis: A Nationwide Case-Control Study in South Korea.
Effects of COVID-19 on male sex function and its potential sexual transmission.
Effects of Renin-Angiotensin Inhibition on ACE2 (Angiotensin-Converting Enzyme 2) and TMPRSS2 (Transmembrane Protease Serine 2) Expression: Insights Into COVID-19.
Effects of Renin-Angiotensin Inhibition on ACE2 and TMPRSS2 Expression: Insights into COVID-19.
Effects of SARS-CoV-2 infection on male sex-related hormones in recovering patients.
Effects of SARS-CoV-2 on Cardiovascular System: The Dual Role of Angiotensin-Converting Enzyme 2 (ACE2) as the Virus Receptor and Homeostasis Regulator-Review.
Effects of Smoking on ACE2 Expression Pattern: Risk and Severity of SARS-CoV-2 Infection.
Effects of the severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV) on the nervous system. What can we expect from SARS -CoV-2?
Efficacy of the TMPRSS2 inhibitor camostat mesilate in patients hospitalized with Covid-19-a double-blind randomized controlled trial.
Elucidating Interactions Between SARS-CoV-2 Trimeric Spike Protein and ACE2 Using Homology Modeling and Molecular Dynamics Simulations.
Elucidating the drug repurposing spectra of COVID-19 with its analogues SARS and MERS.
EMMPRIN/BASIGIN as a biological modulator of oral cancer and COVID-19 interaction: Novel propositions.
Endocrine and metabolic aspects of COVID-19.
Endothelial cell dysfunction, coagulation, and angiogenesis in coronavirus disease 2019 (COVID-19).
Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science.
Endothelial Immunity Trained by Coronavirus Infections, DAMP Stimulations and Regulated by Anti-Oxidant NRF2 May Contribute to Inflammations, Myelopoiesis, COVID-19 Cytokine Storms and Thromboembolism.
Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells.
Environmental Determinants of Coronavirus Disease 2019 (COVID-19).
Enzyme inhibition as a potential therapeutic strategy to treat COVID-19 infection.
Enzyme Therapy: Current Challenges and Future Perspectives.
Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19.
Erratum: Lung Expression of Human Angiotensin-Converting Enzyme 2 Sensitizes the Mouse to SARS-CoV-2 Infection.
Estrogen and Androgen Receptor Inhibitors: Unexpected Allies in the Fight Against COVID-19.
Estrogen receptors are linked to angiotensin-converting enzyme 2 (ACE2), ADAM metallopeptidase domain 17 (ADAM-17), and transmembrane protease serine 2 (TMPRSS2) expression in the human atrium: insights into COVID-19.
Ethnic differences in alpha-1 antitrypsin deficiency allele frequencies may partially explain national differences in COVID-19 fatality rates.
Evaluating the potency of Sulawesi propolis compounds as ACE-2 inhibitors through molecular docking for COVID-19 drug discovery preliminary study.
Evaluation of Cell-Based and Surrogate SARS-CoV-2 Neutralization Assays.
Evaluation of K18-hACE2 Mice as a Model of SARS-CoV-2 Infection.
Evaluation of the efficacy and safety of icatibant and C1 esterase/kallikrein inhibitor in severe COVID-19: study protocol for a three-armed randomized controlled trial.
Evaluation of the susceptibility and fatality of lung cancer patients towards the COVID-19 infection: A systemic approach through analyzing the ACE2, CXCL10 and their co-expressed genes.
Evaluation of vertical transmission of SARS-CoV-2 in utero: Nine pregnant women and their newborns.
Evidence for Use or Disuse of Renin-Angiotensin System Modulators in Patients Having COVID-19 With an Underlying Cardiorenal Disorder.
Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host-Virus Interaction, and Proposed Neurotropic Mechanisms.
Evidence Regarding Vitamin D and Risk of COVID-19 and Its Severity.
Evidence-Based Considerations Exploring Relations between SARS-CoV-2 Pandemic and Air Pollution: Involvement of PM2.5-Mediated Up-Regulation of the Viral Receptor ACE-2.
Existence of SARS-CoV-2 Entry Molecules in the Oral Cavity.
Experimental Technologies in the Diagnosis and Treatment of COVID-19 in Patients with Comorbidities.
Expert Opinions on the Current Therapeutic Management of Inflammatory Bowel Disease during the COVID-19 Pandemic: Japan IBD COVID-19 Taskforce, Intractable Diseases, the Health and Labor Sciences Research.
Exploring G protein-coupled receptors and yeast surface display strategies for viral detection in baker's yeast: SARS-CoV-2 as a case study.
Expression and co-expression analyses of TMPRSS2, a key element in COVID-19.
Expression of ACE2 and TMPRSS2 proteins in the upper and lower aerodigestive tracts of rats: implications on COVID 19 infections.
Expression of ACE2, TMPRSS2, and Furin in Mouse Ear Tissue, and the Implications for SARS-CoV-2 Infection.
Expression of angiotensin-converting enzyme 2 and proteases in COVID-19 patients: A potential role of cellular FURIN in the pathogenesis of SARS-CoV-2.
Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19.
Expression of SARS-CoV-2 receptor ACE2 and TMPRSS2 in human primary conjunctival and pterygium cell lines and in mouse cornea.
Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues.
Expression profiles of the SARS-CoV-2 host invasion genes in nasopharyngeal and oropharyngeal swabs of COVID-19 patients.
Expressions and significances of the angiotensin-converting enzyme 2 gene, the receptor of SARS-CoV-2 for COVID-19.
Fatal neuroinvasion of SARS-CoV-2 in K18-hACE2 mice is partially dependent on hACE2 expression.
Feminising hormone therapy reduces testicular ACE-2 receptor expression: Implications for treatment or prevention of COVID-19 infection in men.
Femoral Arterial Thrombosis in a Young Adult after Nonsevere COVID-19.
Fibrinolysis influences SARS-CoV-2 infection in ciliated cells.
Food Enrichment with Glycyrrhiza glabra Extract Suppresses ACE2 mRNA and Protein Expression in Rats-Possible Implications for COVID-19.
From angiotensin-converting enzyme 2 disruption to thromboinflammatory microvascular disease: A paradigm drawn from COVID-19.
From bedside to bench: regulation of host factors in SARS-CoV-2 infection.
From cellular function to global impact: the vascular perspective on COVID-19.
Functional ACE2 deficiency leading to angiotensin imbalance in the pathophysiology of COVID-19.
Gastrointestinal and hepatic diseases during the COVID-19 pandemic: Manifestations, mechanism and management.
Gastrointestinal insights during the COVID-19 epidemic.
Gastrointestinal Manifestations in COVID-19 Infection and Its Practical Applications.
GB-2 inhibits ACE2 and TMPRSS2 expression: In vivo and in vitro studies.
Gender susceptibility to COVID-19: a review of the putative role of sex hormones and X chromosome.
Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue.
Gene expression network analysis provides potential targets against SARS-CoV-2.
Gene Expression of Angiotensin-Converting Enzyme 2 Receptor in Skin and the Implications for COVID-19.
Genetic alteration, RNA expression, and DNA methylation profiling of coronavirus disease 2019 (COVID-19) receptor ACE2 in malignancies: a pan-cancer analysis.
Genetic Associations With Plasma Angiotensin Converting Enzyme 2 Concentration: Potential Relevance to COVID-19 Risk.
Genetic gateways to COVID-19 infection: Implications for risk, severity, and outcomes.
Genetic Risk Factors for the Development of COVID-19 Coronavirus Infection.
Genetic Susceptibility of ACE2 and TMPRSS2 in Six Common Cancers and Possible Impacts on COVID-19.
Genetic susceptibility of COVID-19: a systematic review of current evidence.
Genetic variability in COVID-19-related genes in the Brazilian population.
Genetic variants that influence SARS-CoV-2 receptor TMPRSS2 expression among population cohorts from multiple continents.
Genetics Insight for COVID-19 Susceptibility and Severity: A Review.
Genome-wide screening of SARS-CoV-2 infection-related genes based on the blood leukocytes sequencing data set of patients with COVID-19.
Genomic, epigenomic, and immune subtype analysis of CTSL/B and SARS-CoV-2 receptor ACE2 in pan-cancer.
Geraniin Inhibits the Entry of SARS-CoV-2 by Blocking the Interaction between Spike Protein RBD and Human ACE2 Receptor.
Glycated ACE2 receptor in diabetes: open door for SARS-COV-2 entry in cardiomyocyte.
Goblet Cell Hyperplasia Increases SARS-CoV-2 Infection in COPD.
H1N1 exposure during the convalescent stage of SARS-CoV-2 infection results in enhanced lung pathologic damage in hACE2 transgenic mice.
HDL-scavenger receptor B type 1 facilitates SARS-CoV-2 entry.
Health concerns regarding the effect of the COVID-19 pandemic on male fertility.
Heparan Sulfate Facilitates Spike Protein-Mediated SARS-CoV-2 Host Cell Invasion and Contributes to Increased Infection of SARS-CoV-2 G614 Mutant and in Lung Cancer.
Hesperidin Is a Potential Inhibitor against SARS-CoV-2 Infection.
High expression of ACE2 and TMPRSS2 and clinical characteristics of COVID-19 in colorectal cancer patients.
High Expression of ACE2 and TMPRSS2 at the Resection Margin Makes Lung Cancer Survivors Susceptible to SARS-CoV-2 With Unfavorable Prognosis.
Highlights in the fight against COVID-19: does autophagy play a role in SARS-CoV-2 infection?
Highly expressed ACE-2 receptors during pregnancy: A protective factor for SARS-COV-2 infection?
Histone deacetylase inhibitors suppress ACE2 and ABO simultaneously, suggesting a preventive potential against COVID-19.
Histopathology and Ultrastructural Findings of Fatal COVID-19 Infections on Testis.
HIV infection drives interferon signaling within intestinal SARS-CoV-2 target cells.
Host genomics of COVID-19: Evidence point towards Alpha 1 antitrypsin deficiency as a putative risk factor for higher mortality rate.
Human and novel coronavirus infections in children: a review.
Human angiotensin-converting enzyme 2 transgenic mice infected with SARS-CoV-2 develop severe and fatal respiratory disease.
Human eggs, zygotes, and embryos express the receptor angiotensin 1-converting enzyme 2 and transmembrane serine protease 2 protein necessary for severe acute respiratory syndrome coronavirus 2 infection.
Human gene polymorphisms and their possible impact on the clinical outcome of SARS-CoV-2 infection.
Human Gene Sequences in SARS-CoV-2 and Other Viruses.
Human genetic basis of coronavirus disease 2019.
Human Immunodeficiency Viruses Pseudotyped with SARS-CoV-2 Spike Proteins Infect a Broad Spectrum of Human Cell Lines through Multiple Entry Mechanisms.
Human iPSC-derived alveolar and airway epithelial cells can be cultured at air-liquid interface and express SARS-CoV-2 host factors.
Human mesenchymal stromal cells do not express ACE2 and TMPRSS2 and are not permissive to SARS-CoV-2 infection.
Human SARS CoV-2 spike protein mutations.
Hydroxychloroquine as a Chemoprophylactic Agent for COVID-19: A Clinico-Pharmacological Review.
Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2.
Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney.
Hypotheses about sub-optimal hydration in the weeks before coronavirus disease (COVID-19) as a risk factor for dying from COVID-19.
Hypoxia alters the expression of ACE2 and TMPRSS2 SARS-CoV-2 cell entry mediators in hCMEC/D3 brain endothelial cells.
Identification of 13 Guanidinobenzoyl- or Aminidinobenzoyl-Containing Drugs to Potentially Inhibit TMPRSS2 for COVID-19 Treatment.
Identification of a special cell type as a determinant of the kidney tropism of SARS-CoV-2.
Identification of natural compounds as SARS-CoV-2 entry inhibitors by molecular docking-based virtual screening with bio-layer interferometry.
Identification of Novel Hypothalamic MicroRNAs as Promising Therapeutics for SARS-CoV-2 by Regulating ACE2 and TMPRSS2 Expression: An In Silico Analysis.
Identification of novel inhibitors of angiotensin-converting enzyme 2 (ACE-2) receptor from Urtica dioica to combat coronavirus disease 2019 (COVID-19).
Identification of novel transmembrane Protease Serine Type 2 drug candidates for COVID-19 using computational studies.
Identification of potential anti-TMPRSS2 natural products through homology modelling, virtual screening and molecular dynamics simulation studies.
Identification of Potential Peptide Inhibitors of ACE-2 Target of SARS-CoV-2 from Buckwheat & Quinoa.
Identification of the SARS-CoV-2 Entry Receptor ACE2 as a Direct Target for Transcriptional Repression by Miz1.
Identifying compounds that prevent the binding of the SARS-CoV-2 S-protein to ACE2.
IgM autoantibodies recognizing ACE2 are associated with severe COVID-19.
ILRUN Downregulates ACE2 Expression and Blocks Infection of Human Cells by SARS-CoV-2.
Immune Interaction Map of Human SARS-CoV-2 Target Genes: Implications for Therapeutic Avenues.
Immunity, Sex Hormones, and Environmental Factors as Determinants of COVID-19 Disparity in Women.
Immunogenetic Predictors of Severe COVID-19.
Immunohistochemical expression of angiotensin-converting enzyme 2 in minor salivary glands during SARS-CoV-2 infection.
Immunological response to COVID-19 and its role as a predisposing factor in invasive aspergillosis.
Immunometabolic Status of COVID-19 Cancer Patients.
Impact of COVID-19 on the Endocrine System - a mini-review.
Impact of cytokine storm and systemic inflammation on liver impairment patients infected by SARS-CoV-2: Prospective therapeutic challenges.
Impact of natural selection on global patterns of genetic variation, and association with clinical phenotypes, at genes involved in SARS-CoV-2 infection.
Impact of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in the Nervous System: Implications of COVID-19 in Neurodegeneration.
Impact of Thiol-Disulfide Balance on the Binding of Covid-19 Spike Protein with Angiotensin-Converting Enzyme 2 Receptor.
Implications of COVID-19 Pandemic on Evolution of Diabetes in Malaria-Endemic African Region.
Implications of SARS-CoV-2 infection for neurogastroenterology.
In silico analysis identifies neuropilin-1 as a potential therapeutic target for SARS-Cov-2 infected lung cancer patients.
In silico analysis of the potential mechanism of a preventive Chinese medicine formula on coronavirus disease 2019.
In silico screening of Allium cepa phytochemicals for their binding abilities to SARS and SARS-CoV-2 3C-like protease and COVID-19 human receptor ACE-2.
In silico screening of potential anti-COVID-19 bioactive natural constituents from food sources by molecular docking.
In Silico Screening of Potential Chinese Herbal Medicine Against COVID-19 by Targeting SARS-CoV-2 3CLpro and Angiotensin Converting Enzyme II Using Molecular Docking.
In silico screening of Pueraria tuberosa (PTY-2) for targeting COVID-19 by countering dual targets Mpro and TMPRSS2.
In silico study the inhibition of angiotensin converting enzyme 2 receptor of COVID-19 by Ammoides verticillata components harvested from Western Algeria.
In Silico, In Vitro and In Cellulo Models for Monitoring SARS-CoV-2 Spike/Human ACE2 Complex, Viral Entry and Cell Fusion.
Increased ACE2 Levels and Mortality Risk of Patients With COVID-19 on Proton Pump Inhibitor Therapy.
Increased Angiotensin-Converting Enzyme 2 and Loss of Alveolar Type II Cells in COVID-19 Related ARDS.
Increased blood angiotensin converting enzyme 2 activity in critically ill COVID-19 patients.
Induced dysregulation of ACE2 by SARS-CoV-2 plays a key role in COVID-19 severity.
Infectivity and Progression of COVID-19 Based on Selected Host Candidate Gene Variants.
Influenza virus infection increases ACE2 expression and shedding in human small airway epithelial cells.
Inhaled modified angiotensin converting enzyme 2 (ACE2) as a decoy to mitigate SARS-CoV-2 infection.
Inhibiting SARS-CoV-2 infection in vitro by suppressing its receptor, angiotensin-converting enzyme 2, via aryl-hydrocarbon receptor signal.
Inhibitors of endosomal acidification suppress SARS-CoV-2 replication and relieve viral pneumonia in hACE2 transgenic mice.
Inhibitory efficiency of potential drugs against SARS-CoV-2 by blocking human angiotensin converting enzyme-2: Virtual screening and molecular dynamics study.
Initial study on TMPRSS2 p.Val160Met genetic variant in COVID-19 patients.
Insights into disparities observed with COVID-19.
Insights on SARS-CoV-2 Molecular Interactions With the Renin-Angiotensin System.
Insights to SARS-CoV-2 life cycle, pathophysiology, and rationalized treatments that target COVID-19 clinical complications.
Instigators of COVID-19 in Immune Cells are Increased in Tobacco Cigarette Smokers and Electronic Cigarette Vapers Compared to Non-smokers.
Integrated Bioinformatic Analysis of SARS-CoV-2 Infection Related Genes ACE2, BSG and TMPRSS2 in Aerodigestive Cancers.
Integrative analysis of miRNA and mRNA sequencing data reveals potential regulatory mechanisms of ACE2 and TMPRSS2.
Interferons and viruses induce a novel primate-specific isoform dACE2 and not the SARS-CoV-2 receptor ACE2.
Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor.
Involvement of digestive system in COVID-19: manifestations, pathology, management and challenges.
Ipomoeassin-F inhibits the in vitro biogenesis of the SARS-CoV-2 spike protein and its host cell membrane receptor.
Irisin modulates genes associated with severe coronavirus disease (COVID-19) outcome in human subcutaneous adipocytes cell culture.
Is COVID-19 Gender-sensitive?
Is diabetes mellitus a wrongdoer to COVID-19 severity?
Is highly expressed ACE 2 in pregnant women "a curse" in times of COVID-19 pandemic?
Is multisystem inflammatory syndrome related with coronavirus disease 2019, Kawasaki disease, and angiotensin-converting enzyme 2 in children?
Is RAS the Link Between COVID-19 and Increased Stress in Head and Neck Cancer Patients?
Is SARS-CoV-2 infection a risk factor for early pregnancy loss? ACE2 and TMPRSS2 co-expression and persistent replicative infection in primitive trophoblast.
Is there a common pathophysiological mechanism between COVID-19 and depression?
Is There a Link between Bisphenol A (BPA), a Key Endocrine Disruptor, and the Risk for SARS-CoV-2 Infection and Severe COVID-19?
Isolation of a human monoclonal antibody specific for the receptor binding domain of SARS-CoV-2 using a competitive phage biopanning strategy.
JAK inhibitors dampen activation of interferon-stimulated transcription of ACE2 isoforms in human airway epithelial cells.
Kidney ACE2 expression: Implications for chronic kidney disease.
Kobophenol A Inhibits Binding of Host ACE2 Receptor with Spike RBD Domain of SARS-CoV-2, a Lead Compound for Blocking COVID-19.
Lack of Association Between Genetic Variants at ACE2 and TMPRSS2 Genes Involved in SARS-CoV-2 Infection and Human Quantitative Phenotypes.
Let's talk about sex in the context of COVID-19.
Lethality of SARS-CoV-2 infection in K18 human angiotensin-converting enzyme 2 transgenic mice.
Letter to the Editor: COVID-19 utilization of ACE-2 receptor to enter the host cell.
Lipid Nanoparticle RBD-hFc mRNA Vaccine Protects hACE2 Transgenic Mice against a Lethal SARS-CoV-2 Infection.
Localization of Cell Receptor-Related Genes of SARS-CoV-2 in the Kidney through Single-Cell Transcriptome Analysis.
Low plasma angiotensin-converting enzyme 2 level in diabetics increases the risk of severe COVID-19 infection.
Lower Gene Expression of Angiotensin Converting Enzyme 2 Receptor in Lung Tissues of Smokers with COVID-19 Pneumonia.
Lung and Kidney ACE2 and TMPRSS2 in Renin-Angiotensin System Blocker-Treated Comorbid Diabetic Mice Mimicking Host Factors That Have Been Linked to Severe COVID-19.
Lung Cancer Models Reveal Severe Acute Respiratory Syndrome Coronavirus 2-Induced Epithelial-to-Mesenchymal Transition Contributes to Coronavirus Disease 2019 Pathophysiology.
Lung Expression of Human ACE2 Sensitizes the Mouse to SARS-CoV-2 Infection.
Magnesium Treatment on Methylation Changes of Transmembrane Serine Protease 2 (TMPRSS2).
Magnesium treatment on methylation changes of transmembrane serine protease 2 (TMPRSS2).
Making a complex dental care tailored to the person: population health in focus of predictive, preventive and personalised (3P) medical approach.
Male bias in ACE2 basic science research: missed opportunity for discovery in the time of COVID-19.
Management recommendations for patients with chronic kidney disease during the novel coronavirus disease 2019 (COVID-19) epidemic.
Mapping COVID-19 with nuclear imaging: from infection to functional sequelae.
Maternal endothelial dysfunction in HIV-associated preeclampsia comorbid with COVID-19: a review.
MDM2-Mediated Ubiquitination of Angiotensin-Converting Enzyme 2 Contributes to the Development of Pulmonary Arterial Hypertension.
Mechanics Insights of Alpha-Lipoic Acid against Cardiovascular Diseases during COVID-19 Infection.
Mechanisms and treatments of myocardial injury in patients with corona virus disease 2019.
Mega doses of retinol: A possible immunomodulation in Covid-19 illness in resource-limited settings.
MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection.
Men and COVID-19: A Pathophysiologic Review.
Mendelian randomization analysis provides causality of smoking on the expression of ACE2, a putative SARS-CoV-2 receptor.
Mesenchymal stem cell immunomodulation and regeneration therapeutics as an ameliorative approach for COVID-19 pandemics.
Metabolic impact of weight loss induced reduction of adipose ACE-2 - Potential implication in COVID-19 infections?
Metabolic Perturbations and Severe COVID-19 Disease: Implication of Molecular Pathways.
MicroRNAs targeting the SARS-CoV-2 entry receptor ACE2 in cardiomyocytes.
Microstructure, pathophysiology, and potential therapeutics of COVID-19: A comprehensive review.
miR-98 Regulates TMPRSS2 Expression in Human Endothelial Cells: Key Implications for COVID-19.
miRNAs; a novel strategy for the treatment of COVID-19.
Modeling the Molecular Impact of SARS-CoV-2 Infection on the Renin-Angiotensin System.
Modulation of ACE-2 mRNA by inflammatory cytokines in human thyroid cells: a pilot study.
Molecular basis of the new COVID-19 target neuropilin-1 in complex with SARS-CoV-2 S1 C-end rule peptide and small-molecule antagonists.
Molecular docking between human TMPRSS2 and SARS-CoV-2 spike protein: conformation and intermolecular interactions.
Molecular dynamics analysis of a flexible loop at the binding interface of the SARS-CoV-2 spike protein receptor-binding domain.
Molecular dynamics analysis of phytochemicals from Ageratina adenophora against COVID-19 main protease (Mpro) and human angiotensin-converting enzyme 2 (ACE2).
Molecular mechanism of anti-SARS-CoV2 activity of Ashwagandha-derived withanolides.
Molecular pathways triggered by COVID-19 in different organs: ACE2 receptor-expressing cells under attack? A review.
More light on cancer and COVID-19 reciprocal interaction.
Multimodal single-cell omics analysis identifies epithelium-immune cell interactions and immune vulnerability associated with sex differences in COVID-19.
Multiple Expression Assessments of ACE2 and TMPRSS2 SARS-CoV-2 Entry Molecules in the Urinary Tract and Their Associations with Clinical Manifestations of COVID-19.
Multiple relationships between aerosol and COVID-19: A framework for global studies.
Mutations and polymorphisms in genes involved in the infections by covid 19: a review.
Mutations in spike protein and allele variations in ACE2 impact targeted therapy strategies against SARS-CoV-2.
Myocyte Specific Upregulation of ACE2 in Cardiovascular Disease: Implications for SARS-CoV-2 mediated myocarditis.
Nasal lavage containing Angiotensin-Converting Enzyme-2 agonist can prevent and reduce viral load in COVID-19.
Natural Agents Modulating ACE-2: A Review of Compounds with Potential against SARS-CoV-2 Infections.
Natural Killer cell activation, reduced ACE2, TMPRSS2, cytokines G-CSF, M-CSF and SARS-CoV-2-S pseudovirus infectivity by MEK inhibitor treatment of human cells.
Natural Products Modulating Angiotensin Converting Enzyme 2 (ACE2) as Potential COVID-19 Therapies.
Network Pharmacology Analysis to Identify Phytochemicals in Traditional Chinese Medicines That May Regulate ACE2 for the Treatment of COVID-19.
Neurobiochemical Cross-talk Between COVID-19 and Alzheimer's Disease.
Neurological manifestations of coronavirus infections: role of angiotensin-converting enzyme 2 in COVID-19.
Neuropathobiology of COVID-19: The Role for Glia.
New insights into genetic susceptibility of COVID-19: an ACE2 and TMPRSS2 polymorphism analysis.
New insights on possible vaccine development against SARS-CoV-2.
New normal: two aspects of adipose tissue in COVID-19-treat and threat?
New perspectives on angiotensin-converting enzyme 2 and its related diseases.
No evidence of severe acute respiratory syndrome-coronavirus 2 in semen of males recovering from coronavirus disease 2019.
Non-steroidal anti-inflammatory drugs dampen the cytokine and antibody response to SARS-CoV-2 infection.
Non-steroidal anti-inflammatory drugs, pharmacology, and COVID-19 infection.
Novel Coronavirus-2019 (2019-nCoV): Perspectives of emergence, prophylaxis and predicted treatment approaches.
Novel COVID-19: A Comprehensive Review of Transmission, Manifestation, and Pathogenesis.
Novel transgenic mice with Cre-dependent co-expression of GFP and human ACE2: a safe tool for study of COVID-19 pathogenesis.
Obesity alters Ace2 and Tmprss2 expression in lung, trachea, and esophagus in a sex-dependent manner: Implications for COVID-19.
Obesity and COVID-19: ACE 2, the Missing Tile.
Obesity and Outcomes in COVID-19: When an Epidemic and Pandemic Collide.
Obesity considerations during the COVID-19 outbreak.
Ocular pathology and occasionally detectable intraocular SARS-CoV-2 RNA in five fatal COVID-19 cases.
Ocular Surface Expression of SARS-CoV-2 Receptors.
Ocular tropism of coronavirus (CoVs): a comparison of the interaction between the animal-to-human transmitted coronaviruses (SARS-CoV-1, SARS-CoV-2, MERS-CoV, CoV-229E, NL63, OC43, HKU1) and the eye.
Ogilvie Syndrome and COVID-19 Infection.
Oncolytic effect of SARS-CoV2 in a patient with NK lymphoma.
Optimizing testing regimes for the detection of COVID-19 in children and older adults.
Oral lesions in patients with SARS-CoV-2 infection: could the oral cavity be a target organ?
Oral Mucosa Could Be an Infectious Target of SARS-CoV-2.
Organ-protective effect of angiotensin-converting enzyme 2 and its effect on the prognosis of COVID-19.
Osmotic Adaptation by Na+-Dependent Transporters and ACE2: Correlation with Hemostatic Crisis in COVID-19.
Overexpression of the Severe Acute Respiratory Syndrome Coronavirus-2 Receptor, Angiotensin-Converting Enzyme 2, in Diabetic Kidney Disease: Implications for Kidney Injury in Novel Coronavirus Disease 2019.
Paediatric COVID-19 and the GUT.
Pain as clinical manifestations of COVID-19 infection and its management in the pandemic era: a literature review.
Pan-Cancer Analysis of Genomic and Prognostic Characteristics Associated With Coronavirus Disease 2019 Regulators.
Pandemic COVID-19 caused by SARS-CoV-2: genetic structure, vaccination, and therapeutic approaches.
Pandemic Perspective: Commonalities Between COVID-19 and Cardio-Oncology.
Particulate matter exposure exacerbates susceptibility to SARS-CoV-2 infection in humanized ACE2 mice.
Pathogeny of cerebral venous thrombosis in SARS-Cov-2 infection: Case reports.
Pathophysiological Association of Endothelial Dysfunction with Fatal Outcome in COVID-19.
Pathophysiology of COVID-19: Everywhere You Look You Will See ACE2!
Pernio (Chilblains), SARS-CoV-2, and COVID Toes Unified Through Cutaneous and Systemic Mechanisms.
Pharmacogenomics of genetic polymorphism within the genes responsible for SARS-CoV-2 susceptibility and the drug-metabolising genes used in treatment.
Pharmacoinformatics-based identification of transmembrane protease serine-2 inhibitors from Morus Alba as SARS-CoV-2 cell entry inhibitors.
Physical Exercise and the Renin Angiotensin System: Prospects in the COVID-19.
Physiological implications of COVID-19 in reproduction: angiotensin-converting enzyme 2 a key player.
Physiological Relevance of Angiotensin Converting Enzyme 2 As a Metabolic Linker and Therapeutic Implication of Mesenchymal Stem Cells in COVID-19 and Hypertension.
Phytopharmaceuticals mediated Furin and TMPRSS2 receptor blocking: can it be a potential therapeutic option for Covid-19?
Placental expression of ACE2 and TMPRSS2 in maternal SARS-CoV-2 infection: are placental defenses mediated by fetal sex?
Placental response to maternal SARS-CoV-2 infection.
Plasma angiotensin-converting enzyme 2: novel biomarker in heart failure with implications for COVID-19.
Plasma-activated water: An alternative disinfectant for S protein inactivation to prevent SARS-CoV-2 infection.
PM2.5, NO2, wildfires, and other environmental exposures are linked to higher Covid 19 incidence, severity, and death rates.
Pneumatosis Intestinalis Due to COVID-19 Infection in Kidney Transplant Recipient: A Case Report.
Population-Specific ACE2 Single-Nucleotide Polymorphisms Have Limited Impact on SARS-CoV-2 Infectivity In Vitro.
Positive association of angiotensin II receptor blockers, not angiotensin-converting enzyme inhibitors, with an increased vulnerability to SARS-CoV-2 infection in patients hospitalized for suspected COVID-19 pneumonia.
Possible therapeutic interventions in COVID-19 induced ARDS by cotinine as an ACE-2 promoter and AT-1R blocker.
Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features.
Post-COVID 19 neurological syndrome: Implications for sequelae's treatment.
Potency of Mesenchymal Stem Cell and Its Secretome in Treating COVID-19.
Potential antiviral activity of isorhamnetin against SARS-CoV-2 spike pseudotyped virus in vitro.
Potential approaches to combat COVID-19: a mini-review.
Potential benefits of dietary seaweeds as protection against COVID-19.
Potential detrimental role of soluble ACE2 in severe COVID-19 comorbid patients.
Potential harmful effects of discontinuing ACE-inhibitors and ARBs in COVID-19 patients.
Potential inhibitors of angiotensin converting enzyme 2 receptor of COVID-19 by Corchorus olitorius Linn using docking, molecular dynamics, conceptual DFT investigation and pharmacophore mapping.
Potential mechanisms of cerebrovascular diseases in COVID-19 patients.
Potential neurological manifestations of COVID-19: a narrative review.
Potential pathogenesis of severe acute respiratory syndrome coronavirus 2.
Potential role of endothelial cell surface ectopic redox complexes in COVID-19 disease pathogenesis.
Potential Role of Peptide-Based Antiviral Therapy Against SARS-CoV-2 Infection.
Potential Simultaneous Inhibitors of Angiotensin-Converting Enzyme 2 and Transmembrane Protease, Serine 2.
Potential Using of Fat-derived Stromal Cells in the Treatment of Active Disease, and also, in Both Pre- and Post-Periods in COVID-19.
Predicted therapeutic targets for COVID-19 disease by inhibiting SARS-CoV-2 and its related receptors.
Prediction and mitigation of mutation threats to COVID-19 vaccines and antibody therapies.
Prediction of repurposed drugs for treating lung injury in COVID-19.
Preventing transmission among operating room staff during COVID-19 pandemic: the role of the Aerosol Box and other personal protective equipment.
Prior Routine Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Important Outcomes in Hospitalised Patients with COVID-19.
Pro-inflammatory microenvironment and systemic accumulation of CXCR3+ cell exacerbate lung pathology of old rhesus macaques infected with SARS-CoV-2.
Problems associated with antiviral drugs and vaccines development for COVID-19: approach to intervention using expression vectors via GPI anchor.
Production of high-quality SARS-CoV-2 antigens: Impact of bioprocess and storage on glycosylation, biophysical attributes, and ELISA serologic tests performance.
Profiling COVID-19 Genetic Research: A Data-Driven Study Utilizing Intelligent Bibliometrics.
Prostate adenocarcinoma and COVID-19: The possible impacts of TMPRSS2 expressions in susceptibility to SARS-CoV-2.
Protective Effects of CVD and DM Medications in SARS-CoV-2 Infection.
Protective Role of a TMPRSS2 Variant on Severe COVID-19 Outcome in Young Males and Elderly Women.
Protein Expression of Angiotensin-Converting Enzyme 2 (ACE2) is Upregulated in Brains with Alzheimer's Disease.
Protoporphyrin IX and verteporfin potently inhibit SARS-CoV-2 infection in vitro and in a mouse model expressing human ACE2.
Pulmonary adverse drug event data in hypertension with implications on COVID-19 morbidity.
Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2 and ADAM17 in rats with heart failure: Potential implication for COVID-19 disease.
Quantitative assessment of retinal changes in COVID-19 patients.
Questionnaire Survey on the Current Situation and Experience in Prevention and Control Measures at Urology Clinics During the COVID-19 Epidemic in China.
Racial and Gender-Based Differences in COVID-19.
Rapid generation of mouse model for emerging infectious disease with the case of severe COVID-19.
Regulation of the ACE2 locus in human airways cells.
Relationship Between COVID-19 and Angiotensin-Converting Enzyme 2: A Scoping Review.
Relationship Between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Etiology of Acute Kidney Injury (AKI).
Relevance Between COVID-19 and Host Genetics of Immune Response.
Relevance of SARS-CoV-2 related factors ACE2 and TMPRSS2 expressions in gastrointestinal tissue with pathogenesis of digestive symptoms, diabetes-associated mortality, and disease recurrence in COVID-19 patients.
Renal Manifestations of Covid-19: Physiology and Pathophysiology.
Renin Angiotensin Converting Enzyme 2 and COVID-19: Prevention and Treatment.
Renin Angiotensin System, COVID-19 and Male Fertility: Any Risk for Conceiving?
Renin-angiotensin system at the heart of COVID-19 pandemic.
Renin-angiotensin system at the interface of COVID-19 infection.
Renin-angiotensin system blockers and severe acute respiratory syndrome coronavirus 2.
Renin-Angiotensin System Implications to COVID-19 Comorbidities.
Renin-angiotensin system inhibition and risk of infection and mortality in COVID-19: a systematic review and meta-analysis.
Renin-Angiotensin System Inhibitors in COVID-19: Current Concepts.
Renin-Angiotensin-Aldosterone System Inhibitors and Risk of Covid-19.
Replication-competent vesicular stomatitis virus vaccine vector protects against SARS-CoV-2-mediated pathogenesis.
Repurposing Methotrexate in Dampening SARS-CoV2-S1-Mediated IL6 Expression: Lessons Learnt from Lung Cancer.
Repurposing the mucolytic cough suppressant and TMPRSS2 protease inhibitor bromhexine for the prevention and management of SARS-CoV-2 infection.
Research progress in nervous system damage caused by SARS-CoV-2.
Research Progress on the Cardiac Injury from ACE2 Targeting in SARS-CoV-2 Infection.
Response to recent commentaries regarding the involvement of angiotensin-converting enzyme 2 (ACE2) and renin-angiotensin system blockers in SARS-CoV-2 infections.
Retinal Microcirculation as a Correlate of a Systemic Capillary Impairment After Severe Acute Respiratory Syndrome Coronavirus 2 Infection.
Revealing Tissue-Specific SARS-CoV-2 Infection and Host Responses using Human Stem Cell-Derived Lung and Cerebral Organoids.
Review of COVID-19 and male genital tract.
Risk for COVID-19 infection in patients with tobacco smoke-associated cancers of the upper and lower airway.
Robust SARS-CoV-2 infection in nasal turbinates after treatment with systemic neutralizing antibodies.
Role and mechanism of angiotensin-converting enzyme 2 in acute lung injury in coronavirus disease 2019.
Role of ACE2 genetic polymorphisms in susceptibility to SARS-CoV-2 among highly exposed but non infected healthcare workers.
Role of ACE2 polymorphism in COVID-19: impact of age.
Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19.
Role of angiotensin-converting enzyme 2 and pericytes in cardiac complications of COVID-19 infection.
Role of angiotensin-converting enzyme 2 in neurodegenerative diseases during the COVID-19 pandemic.
Role of comorbidities like diabetes on severe acute respiratory syndrome coronavirus-2: A review.
Role of endothelial cell receptors in the context of SARS-CoV-2 infection (COVID-19).
Role of Genetic Variants and Gene Expression in the Susceptibility and Severity of COVID-19.
Role of indoor aerosols for COVID-19 viral transmission: a review.
Role of leukotriene pathway and montelukast in pulmonary and extrapulmonary manifestations of Covid-19: The enigmatic entity.
Role of neutrophil chemoattractant CXCL5 in SARS-CoV-2 infection-induced lung inflammatory innate immune response in an in vivo hACE2 transfection mouse model.
Roles of steroid receptors in the lung and COVID-19.
Roux-en-Y Gastric Bypass Downregulates Angiotensin-Converting Enzyme 2 (ACE2) Gene Expression in Subcutaneous White Adipose Tissue: A Putative Protective Mechanism Against Severe COVID-19.
SARS-CoV-2 activates lung epithelial cell proinflammatory signaling and leads to immune dysregulation in COVID-19 patients.
SARS-CoV-2 and Acute Cerebrovascular Events: An Overview.
SARS-CoV-2 and SARS-CoV spike-mediated cell-cell fusion differ in the requirements for receptor expression and proteolytic activation.
SARS-CoV-2 and the cardiovascular system.
SARS-CoV-2 and the Gastrointestinal Tract in Children.
SARS-CoV-2 and Viral Sepsis: Immune Dysfunction and Implications in Kidney Failure.
SARS-CoV-2 Antibody Responses Correlate with Resolution of RNAemia But Are Short-Lived in Patients with Mild Illness.
SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19.
SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology: a series of 19 placentas from COVID-19-positive mothers.
SARS-CoV-2 Causes a Specific Dysfunction of the Kidney Proximal Tubule.
SARS-CoV-2 cell entry receptor ACE2 mediated endothelial dysfunction leads to vascular thrombosis in COVID-19 patients.
SARS-CoV-2 Entry Factors: ACE2 and TMPRSS2 Are Expressed in Peri-Implantation Embryos and the Maternal-Fetal Interface.
SARS-CoV-2 entry inhibitors by dual targeting TMPRSS2 and ACE2: An in silico drug repurposing study.
SARS-CoV-2 Immuno-Pathogenesis and Potential for Diverse Vaccines and Therapies: Opportunities and Challenges.
SARS-CoV-2 Infection and Lung Cancer: Potential Therapeutic Modalities.
SARS-CoV-2 Infection and Racial Disparities in Children: Protective Mechanisms and Severe Complications Related to MIS-C.
SARS-CoV-2 infection induces EMT-like molecular changes, including ZEB1-mediated repression of the viral receptor ACE2, in lung cancer models.
SARS-CoV-2 Infection: A Role for S1P/S1P Receptor Signaling in the Nervous System?
SARS-CoV-2 infection: physiological and environmental gift factors at high altitude.
SARS-CoV-2 leads to a small vessel endotheliitis in the heart.
SARS-CoV-2 may hijack GPCR signaling pathways to dysregulate lung ion and fluid transport.
SARS-CoV-2 orf1b Gene Sequence in the NTNG1 Gene on Human Chromosome 1.
SARS-CoV-2 perturbs the renin-angiotensin system and energy metabolism.
SARS-CoV-2 Receptor ACE2 Gene Is Associated with Hypertension and Severity of COVID 19: Interaction with Sex, Obesity, and Smoking.
SARS-CoV-2 receptor is co-expressed with elements of the kinin-kallikrein, renin-angiotensin and coagulation systems in alveolar cells.
SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract.
SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2.
SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II receptor signaling in epithelial cells.
SARS-CoV-2 spike protein-mediated cell signaling in lung vascular cells.
SARS-CoV-2 Viral Entry Proteins in Hyperandrogenemic Female Mice: Implications for Women with PCOS and COVID-19.
SARS-CoV-2, an Underestimated Pathogen of the Nervous System.
SARS-CoV-2: Pathogenesis, Molecular Targets and Experimental Models.
SARS-CoV-2: what it is, how it acts, and how it manifests in imaging studies.
SARS-CoV-2 cell receptor gene ACE2 -mediated immunomodulation in breast cancer subtypes.
Scientific Hypothesis for Treatment of COVID-19's Lung Lesions by Adjusting ACE/ACE2 Imbalance.
Screening strategy of TMPRSS2 inhibitors by FRET-based enzymatic activity for TMPRSS2-based cancer and COVID-19 treatment.
Scutellaria barbata D. Don Inhibits the Main Proteases (Mpro and TMPRSS2) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection.
Searching therapeutic strategy of new coronavirus pneumonia from angiotensin-converting enzyme 2: the target of COVID-19 and SARS-CoV.
Serum ACE2, Angiotensin II, and Aldosterone Levels Are Unchanged in Patients With COVID-19.
Severe Acute Respiratory Syndrome Coronavirus 2 and Male Reproduction: Relationship, Explanations, and Clinical Remedies.
Severe acute respiratory syndrome coronavirus 2 is penetrating to dementia research.
Severe Acute Respiratory Syndrome Coronavirus 2 Nucleocapsid Protein in the Ocular Tissues of a Patient Previously Infected With Coronavirus Disease 2019.
Severe COVID-19 in Alzheimer's disease: APOE4's fault again?
Severe Epistaxis after Tissue Plasminogen Activator administration for Acute Ischemic Stroke in SARS-COV-2 Infection.
Sex differences in COVID-19: candidate pathways, genetics of ACE2, and sex hormones.
Sex differences in the induction of angiotensin converting enzyme 2 (ACE-2) in mouse lungs after e-cigarette vapor exposure and its relevance to COVID-19.
Sex, androgens and regulation of pulmonary AR, TMPRSS2 and ACE2.
Sex-mediated effects of ACE2 and TMPRSS2 on the incidence and severity of COVID-19; The need for genetic implementation.
Shedding Light on the Inhibitory Mechanisms of SARS-CoV-1/CoV-2 Spike Proteins by ACE2-Designed Peptides.
Short-term effects of COVID-19 on semen parameters: A multicenter study of 69 cases.
Should We Be Concerned about the Association of Diabetes Mellitus and Periodontal Disease in the Risk of Infection by SARS-CoV-2? A Systematic Review and Hypothesis.
Similarities in Risk for COVID-19 and Cancer Disparities.
Single Cell RNA-seq Data Analysis Reveals the Potential Risk of SARS-CoV-2 Infection Among Different Respiratory System Conditions.
Single-cell analysis of SARS-CoV-2 receptor ACE2 and spike protein priming expression of proteases in the human heart.
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics.
Single-cell RNA analysis on ACE2 expression provides insights into SARS-CoV-2 potential entry into the bloodstream and heart injury.
Single-cell RNA sequencing identify SDCBP in ACE2-positive bronchial epithelial cells negatively correlates with COVID-19 severity.
Single-Cell Transcriptome Analysis Decipher New Potential Regulation Mechanism of ACE2 and NPs Signaling Among Heart Failure Patients Infected With SARS-CoV-2.
Single-cell Transcriptome Analysis Indicates New Potential Regulation Mechanism of ACE2 and NPs signaling among heart failure patients infected with SARS-CoV-2.
Small Resistance Artery Disease and ACE2 in Hypertension: A New Paradigm in the Context of COVID-19.
Smoking and COVID-19: Similar bronchial ACE2 and TMPRSS2 expression and higher TMPRSS4 expression in current versus never smokers.
Smoking Enigma in Coronavirus Disease 2019: A Tug of War between Predisposition and Possible Way Out.
Smoking, ACE-2 and COVID-19: ongoing controversies.
Soluble ACE2 as a potential therapy for COVID-19.
Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system.
Soluble Angiotensin Converting Enzyme 2 (ACE2) Is Upregulated and Soluble Endothelial Nitric Oxide Synthase (eNOS) Is Downregulated in COVID-19-induced Acute Respiratory Distress Syndrome (ARDS).
Soluble angiotensin-converting enzyme 2 is transiently elevated in COVID-19 and correlates with specific inflammatory and endothelial markers.
Spiking dependence of SARS-CoV-2 pathogenicity on TMPRSS2.
Spironolactone may provide protection from SARS-CoV-2: Targeting androgens, angiotensin converting enzyme 2 (ACE2), and renin-angiotensin-aldosterone system (RAAS).
Spontaneous binding of potential COVID-19 drugs (Camostat and Nafamostat) to human serine protease TMPRSS2.
Stapled Peptides Based on Human Angiotensin-Converting Enzyme 2 (ACE2) Potently Inhibit SARS-CoV-2 Infection In Vitro.
Strategies for Targeting SARS CoV-2: Small Molecule Inhibitors-The Current Status.
Stress Decreases Host Viral Resistance and Increases Covid Susceptibility in Embryonic Stem Cells.
Stroke in patients infected by the novel coronavirus and its causal mechanisms: A narrative review.
Strong Binding of Leupeptin with TMPRSS2 Protease May Be an Alternative to Camostat and Nafamostat for SARS-CoV-2 Repurposed Drug: Evaluation from Molecular Docking and Molecular Dynamics Simulations.
Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants.
Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2.
Structural Basis of Covalent Inhibitory Mechanism of TMPRSS2-Related Serine Proteases by Camostat.
Structural Decoding of a Small Molecular Inhibitor on the Binding of SARS-CoV-2 to the ACE 2 Receptor.
Structural modeling and analysis of the SARS-CoV-2 cell entry inhibitor camostat bound to the trypsin-like protease TMPRSS2.
Structural Variability, Expression Profile, and Pharmacogenetic Properties of TMPRSS2 Gene as a Potential Target for COVID-19 Therapy.
Structure-Based Design of Novel Peptidomimetics Targeting the SARS-CoV-2 Spike Protein.
Structure-based phylogeny identifies avoralstat as a TMPRSS2 inhibitor that prevents SARS-CoV-2 infection in mice.
Suggestions on cleavage embryo and blastocyst vitrification/transfer based on expression profile of ACE2 and TMPRSS2 in current COVID-19 pandemic.
Surface adhesion of viruses and bacteria: Defend only and/or vibrationally extinguish also?! A perspective.
Survived COVID-19 patient presented with death on arrival: A case report.
Susceptibility of the Elderly to SARS-CoV-2 Infection: ACE-2 Overexpression, Shedding, and Antibody-dependent Enhancement (ADE).
Symptomatic Protective Action of Glycyrrhizin (Licorice) in COVID-19 Infection?
Synergistic block of SARS-CoV-2 infection by combined drug inhibition of the host entry factors PIKfyve kinase and TMPRSS2 protease.
Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell.
Tackling Covid-19 using disordered-to-order transition of residues in the spike protein upon angiotensin-converting enzyme 2 binding.
Target-Centered Drug Repurposing Predictions of Human Angiotensin-Converting Enzyme 2 (ACE2) and Transmembrane Protease Serine Subtype 2 (TMPRSS2) Interacting Approved Drugs for Coronavirus Disease 2019 (COVID-19) Treatment through a Drug-Target Interaction Deep Learning Model.
Targeting ACE2 for COVID-19 Therapy: Opportunities and Challenges.
Targeting androgen regulation of TMPRSS2 and ACE2 as a therapeutic strategy to combat COVID-19.
Targeting Neprilysin (NEP) pathways: A potential new hope to defeat COVID-19 ghost.
Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators.
Targeting the intestinal TMPRSS2 protease to prevent SARS-CoV-2 entry into enterocytes-prospects and challenges.
Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infection.
Targeting TMPRSS2 in SARS-CoV-2 Infection.
Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2.
Temporal changes in soluble angiotensin-converting enzyme 2 associated with metabolic health, body composition, and proteome dynamics during a weight loss diet intervention: a randomized trial with implications for the COVID-19 pandemic.
Testis and blood-testis barrier in Covid-19 infestation: role of angiotensin-converting enzyme 2 in male infertility.
Testosterone in COVID-19 - Foe, Friend or Fatal Victim?
The absence of coronavirus in expressed prostatic secretion in COVID-19 patients in Wuhan city.
The ACE-2 in COVID-19: Foe or Friend?
The Adrenal Cortex, an Underestimated Site of SARS-CoV-2 Infection.
The age-dependent decline of the extracellular thiol-disulfide balance and its role in SARS-CoV-2 infection.
The Altered Anatomical Distribution of ACE2 in the Brain With Alzheimer's Disease Pathology.
The angiotensin-converting enzyme 2 (ACE2) receptor in the prevention and treatment of COVID-19 are distinctly different paradigms.
The Antiviral Roles of Hydrogen Sulfide by Blocking the Interaction between SARS-CoV-2 and Its Potential Cell Surface Receptors.
The Benefits of Vitamin D Supplementation for Athletes: Better Performance and Reduced Risk of COVID-19.
The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection.
The contrasting role of nasopharyngeal angiotensin converting enzyme 2 (ACE2) transcription in SARS-CoV-2 infection: A cross-sectional study of people tested for COVID-19 in British Columbia, Canada.
The Contribution of Biophysics and Structural Biology to Current Advances in COVID-19.
The correlation between serum selenium, zinc, and COVID-19 severity: an observational study.
The COVID-19 Menace.
The COVID-19 outbreak and the angiotensin-converting enzyme 2: too little or too much?
The COVID-19 pandemic, heart and cardiovascular diseases: What we have learned.
The COVID-19 Pandemic: A Global Health Crisis.
The Deadly Duo of COVID-19 and Cancer!
The Effect of Coronavirus Disease 2019 on Cardiovascular Diseases.
The Effects of COVID-19 on Placenta and Pregnancy: What Do We Know So Far?
The effects of novel coronavirus (SARS-CoV-2) infection on cardiovascular diseases and cardiopulmonary injuries.
The Efficacy and Potential Mechanisms of Metformin in the Treatment of COVID-19 in the Diabetics: A Systematic Review.
The Emerging Threat of (Micro)Thrombosis in COVID-19 and Its Therapeutic Implications.
The Expression and Polymorphism of Entry Machinery for COVID-19 in Human: Juxtaposing Population Groups, Gender, and Different Tissues.
The expression level of angiotensin-converting enzyme 2 determines the severity of COVID-19: lung and heart tissue as targets.
The gut microbiome: an under-recognised contributor to the COVID-19 pandemic?
The Hyperlipidaemic Drug Fenofibrate Significantly Reduces Infection by SARS-CoV-2 in Cell Culture Models.
The identification of novel inhibitors of human angiotensin-converting enzyme 2 and main protease of Sars-Cov-2: A combination of in silico methods for treatment of COVID-19.
The Impact of Angiotensin-Converting Enzyme 2 (ACE2) Expression Levels in Patients with Comorbidities on COVID-19 Severity: A Comprehensive Review.
The Impact of Angiotensin-Converting Enzyme 2 (ACE2) Expression on the Incidence and Severity of COVID-19 Infection.
The Ineluctable Role of ACE-2 Receptors in SARS COV-2 Infection and Drug Repurposing as a Plausible SARS COV-2 Therapy : A Concise Treatise.
The Influence of Coronavirus Disease-2019 (COVID-19) On Parkinson's Disease: An Updated Systematic Review.
The interaction of SARS-CoV-2 and other coronavirus with Angiotensin Converting Enzyme 2 (ACE2) as their main receptor: therapeutic implications.
The interplay of hypertension, ACE-2 and SARS-CoV-2: Emerging data as the "Ariadne's thread" for the "labyrinth" of COVID-19.
The Lung, the Heart, the Novel Coronavirus, and the Renin-Angiotensin System; The Need for Clinical Trials.
The Mechanisms and Animal Models of SARS-CoV-2 Infection.
The molecular dynamics of possible inhibitors for SARS-CoV-2.
The other side of COVID-19 pandemic: Effects on male fertility.
THE PECULIARITY OF COVID- 19 GENOME AND THE CORONAVIRUS RNA TRANSLATION PROCESS AS APOTENTIAL TARGET FOR ETIOTROPIC MEDICATIONSWITH ADENINE AND OTHER NUCLEOTIDE ANALOGUES (REVIEW).
The Physiological TMPRSS2 Inhibitor HAI-2 Alleviates SARS-CoV-2 Infection.
The Pivotal Role of Adipocyte-Na K peptide in Reversing Systemic Inflammation in Obesity and COVID-19 in the Development of Heart Failure.
The pivotal role of TMPRSS2 in coronavirus disease 2019 and prostate cancer.
The potential involvement of JAK-STAT signaling pathway in the COVID-19 infection assisted by ACE2.
The potential role of abnormal angiotensin-converting enzyme 2 expression correlated with immune infiltration after SARS-CoV-2 infection in the prognosis of breast cancer.
The potential use of ABO blood group system for risk stratification of COVID-19.
The Promising Enzymes for Inhibitors Development against COVID-19.
The Pursuit of COVID-19 Biomarkers: Putting the Spotlight on ACE2 and TMPRSS2 Regulatory Sequences.
The renin-angiotensin system and specifically angiotensin-converting enzyme 2 as a potential therapeutic target in SARS-CoV-2 infections.
The Resilient Child: Sex-Steroid Hormones and COVID-19 Incidence in Pediatric Patients.
The role and significance of angiotensin-converting enzyme 2 peptides in the treatment of coronavirus disease 2019.
The Role of Angiotensin Converting Enzyme 2 in Modulating Gut Microbiota, Intestinal Inflammation, and Coronavirus Infection.
The role of angiotensin-converting enzyme 2 (ACE2) receptor in the intestine in COVID-19: more research needed.
The role of angiotensin-converting enzyme 2 in COVID-19 induced lung injury.
The role of angiotensin-converting enzyme 2 in the pathogenesis of COVID-19: the villain or the hero?
The role of hypertension on the severity of COVID-19: a review.
The role of Interleukin-4 in COVID-19 associated male infertility - A hypothesis.
The Role of Renin-Angiotensin-Aldosterone System in the Heart and Lung: Focus on COVID-19.
The Role of Sex in the Risk of Mortality From COVID-19 Amongst Adult Patients: A Systematic Review.
The Role of Smoking and Nicotine in the Transmission and Pathogenesis of COVID-19.
The roles of vitamin D in increasing the body's immunity and reducing injuries due to viral infections: With an emphasis on its possible role in SARS-CoV-2 (COVID-19).
The SARS-CoV-2 receptor, ACE-2, is expressed on many different cell types: implications for ACE-inhibitor- and angiotensin II receptor blocker-based cardiovascular therapies.
The scRNA-seq Expression Profiling of the Receptor ACE2 and the Cellular Protease TMPRSS2 Reveals Human Organs Susceptible to SARS-CoV-2 Infection.
The structure-activity relationship of the interactions of SARS-CoV-2 spike glycoproteins with glucuronomannan and sulfated galactofucan from Saccharina japonica.
The TMPRSS2 Inhibitor Nafamostat Reduces SARS-CoV-2 Pulmonary Infection in Mouse Models of COVID-19.
The Virological, Immunological, and Imaging Approaches for COVID-19 Diagnosis and Research.
Thermodynamics of the Interaction between the Spike Protein of Severe Acute Respiratory Syndrome Coronavirus-2 and the Receptor of Human Angiotensin-Converting Enzyme 2. Effects of Possible Ligands.
Tissue-specific expression of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2, in mouse models of chronic kidney disease.
TMPRSS2 activity may mediate sex differences in COVID-19 severity.
TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention?
TMPRSS2 and RNA-Dependent RNA Polymerase Are Effective Targets of Therapeutic Intervention for Treatment of COVID-19 Caused by SARS-CoV-2 Variants (B.1.1.7 and B.1.351).
TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes.
TMPRSS2 Correlated With Immune Infiltration Serves as a Prognostic Biomarker in Prostatic Adenocarcinoma: Implication for the COVID-2019.
TMPRSS2 expression dictates the entry route used by SARS-CoV-2 to infect host cells.
Tmprss2 specific miRNAs as promising regulators for SARS-CoV-2 entry checkpoint.
TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients.
TMPRSS2: Potential Biomarker for COVID-19 Outcomes.
Transcriptomic analysis reveals novel mechanisms of SARS-CoV-2 infection in human lung cells.
Transmembrane serine protease 2 Polymorphisms and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Type 2 Infection: A German Case-Control Study.
Treatment Options Available for COVID-19 and an Analysis on Possible Role of Combination of rhACE2, Angiotensin (1-7) and Angiotensin (1-9) as Effective Therapeutic Measure.
TRIM28 regulates SARS-CoV-2 cell entry by targeting ACE2.
TRP channels in COVID-19 disease: Potential targets for prevention and treatment.
Truncated human angiotensin converting enzyme 2; a potential inhibitor of SARS-CoV-2 spike glycoprotein and potent COVID-19 therapeutic agent.
Tumor markers as an entry for SARS-CoV-2 infection?
Two important controversial risk factors in SARS-CoV-2 infection: Obesity and smoking.
Two pronged approach for prevention and therapy of COVID-19 (Sars-CoV-2) by a multi-targeted herbal drug, a component of ayurvedic decoction.
Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium.
Type 2 inflammation modulates ACE2 and TMPRSS2 in airway epithelial cells.
Type-2 Diabetes as a Risk Factor for Severe COVID-19 Infection.
Understanding COVID-19: A hypothesis regarding digit ratio (2D:4D), ACE I/D polymorphism, oxygen metabolism and national case fatality rates.
Understanding the Co-Epidemic of Obesity and COVID-19: Current Evidence, Comparison with Previous Epidemics, Mechanisms, and Preventive and Therapeutic Perspectives.
Understanding the role of ACE-2 receptor in pathogenesis of COVID-19 disease: a potential approach for therapeutic intervention.
Unexpected tumor reduction in metastatic colorectal cancer patients during SARS-Cov-2 infection: effect of ACE-2 expression on tumor cells or molecular mimicry phenomena? Two not mutually exclusive hypotheses.
Unraveling the Role of ACE2, the Binding Receptor for SARS-CoV-2, in Inflammatory Bowel Disease.
Unravelling high-affinity binding compounds towards transmembrane protease serine 2 enzyme in treating SARS-CoV-2 infection using molecular modelling and docking studies.
Unveiling COVID-19-associated organ-specific cell types and cell-specific pathway cascade.
Up-regulation of ACE2, the SARS-CoV-2 receptor, in asthmatics on maintenance inhaled corticosteroids.
Update on SARS-CoV-2 infection in children.
Updates of Cardiovascular Manifestations in COVID-19: Korean Experience to Broaden Worldwide Perspectives.
Upregulation of ACE2 and TMPRSS2 by particulate matter and idiopathic pulmonary fibrosis: a potential role in severe COVID-19.
Urinary Levels of SARS-CoV-2 Nucleocapsid Protein Associate With Risk of AKI and COVID-19 Severity: A Single-Center Observational Study.
Use of pioglitazone in people with type 2 diabetes mellitus with coronavirus disease 2019 (COVID-19): Boon or bane?
Variants in ACE2 and TMPRSS2 Genes Are Not Major Determinants of COVID-19 Severity in UK Biobank Subjects.
Variants in ACE2; potential influences on virus infection and COVID-19 severity.
Vascular skin symptoms in COVID-19: a french observational study.
Vigilance on New-Onset Atherosclerosis Following SARS-CoV-2 Infection.
What dentists need to know about COVID-19.
What GI Physicians Need to Know During COVID-19 Pandemic.
What Is the Role of Angiotensin-Converting Enzyme 2 (ACE2) in COVID-19 Infection in Hypertensive Patients With Diabetes?
What is the significance of the conjunctiva as a potential transmission route for SARS-CoV-2 infections?
Why does SARS-CoV-2 hit in different ways? Host genetic factors can influence the acquisition or the course of COVID-19.
Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections.
Why Is COVID-19 More Severe in Patients With Diabetes? The Role of Angiotensin-Converting Enzyme 2, Endothelial Dysfunction and the Immunoinflammatory System.
Will a little change do you good? A putative role of polymorphisms in COVID-19.
Xeno-nucleic Acid (XNA) 2'-Fluoro-Arabino Nucleic Acid (FANA) Aptamers to the Receptor Binding Domain of SARS-CoV-2 S Protein Block ACE2 Binding.
[A review on the role of angiotensin-converting enzyme 2 in children with coronavirus disease 2019].
[Association of age distribution with the expression of angiotensin-converting enzyme 2 in lung tissues in severe acute respiratory syndrome coronavirus 2 infection: reflections from the study of RAS pathway expression in mice].
[Association of hypertension and antihypertensive agents and the severity of COVID-19 pneumonia. A monocentric French prospective study].
[Cardiac Involvement in COVID-19].
[COVID-19 and the impact of cardiovascular comorbidities].
[Hypertension, RAAS blockade and risk in COVID-19 patients].
[What is the importance of the conjunctiva as a potential transmission pathway for SARS-CoV-2 infections?]
Crohn Disease
A Network Medicine Approach to Investigation and Population-based Validation of Disease Manifestations and Drug Repurposing for COVID-19.
A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19.
Severe Acute Respiratory Syndrome Coronavirus 2 Attachment Receptor Angiotensin-Converting Enzyme 2 Is Decreased in Crohn's Disease and Regulated By Microbial and Inflammatory Signaling.
Cushing Syndrome
Consideration on TMPRSS2 and the risk of COVID-19 infection in Cushing's syndrome.
Cystic Fibrosis
SARS-CoV-2 Entry Genes Expression in Relation with Interferon Response in Cystic Fibrosis Patients.
Cysts
Functional characterisation of a cyst nematode acetylcholinesterase gene using Caenorhabditis elegans as a heterologous system.
Cytomegalovirus Infections
Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections.
Deafness
An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss.
Dementia
Severe COVID-19 in Alzheimer's disease: APOE4's fault again?
Demyelinating Diseases
CNS implications of COVID-19: a comprehensive review.
De Novo Movement Disorders and COVID-19: Exploring the Interface.
Diabetes Complications
Relevance of SARS-CoV-2 related factors ACE2 and TMPRSS2 expressions in gastrointestinal tissue with pathogenesis of digestive symptoms, diabetes-associated mortality, and disease recurrence in COVID-19 patients.
Diabetes Mellitus
Association of somatic and N-domain angiotensin-converting enzymes from Wistar rat tissue with renal dysfunction in diabetes mellitus.
COVID-19-related Genes in Sputum Cells in Asthma. Relationship to Demographic Features and Corticosteroids.
Downregulation of spinal angiotensin converting enzyme 2 is involved in neuropathic pain associated with type 2 diabetes mellitus in mice.
Heightened ACE Activity and Unfavorable Consequences in COVID-19 Diabetic Subjects.
Immune Interaction Map of Human SARS-CoV-2 Target Genes: Implications for Therapeutic Avenues.
Implications of COVID-19 Pandemic on Evolution of Diabetes in Malaria-Endemic African Region.
Is hypertension in African-descent populations contributed to by an imbalance in the activities of the ACE2/Ang-(1-7)/Mas and the ACE/Ang II/AT1 axes?
Outcomes in Patients with COVID-19 Infection Taking ACEI/ARB.
RELATIONSHIP OF OXIDATIVE STRESS TO URINARY ANGIOTENSIN CONVERTING ENZYME 2 IN TYPE 2 DIABETES MELLITUS PATIENTS.
Should We Be Concerned about the Association of Diabetes Mellitus and Periodontal Disease in the Risk of Infection by SARS-CoV-2? A Systematic Review and Hypothesis.
The influence of angiotensin converting enzyme-2 gene polymorphisms: what does it predict in patients with diabetes mellitus and coronary heart disease?
The influence of angiotensin-converting enzyme 2 gene polymorphisms on type 2 diabetes mellitus and coronary heart disease.
The role of Interleukin-4 in COVID-19 associated male infertility - A hypothesis.
[Relationship of angiotensin-converting enzyme 2 gene polymorphisms and vulnerability to coronary heart disease in patients with type 2 diabetes mellitus]
Diabetes Mellitus, Type 1
Overexpression of heterogeneous nuclear ribonucleoprotein F stimulates renal Ace-2 gene expression and prevents TGF-?1-induced kidney injury in a mouse model of diabetes.
Diabetes Mellitus, Type 2
Downregulation of spinal angiotensin converting enzyme 2 is involved in neuropathic pain associated with type 2 diabetes mellitus in mice.
Erratum to: Urinary angiotensin converting enzyme 2 is strongly related to urinary nephrin in type 2 diabetes patients.
Implications of COVID-19 Pandemic on Evolution of Diabetes in Malaria-Endemic African Region.
Increased ACE 2 and decreased ACE protein in renal tubules from diabetic mice: a renoprotective combination?
Is hypertension in African-descent populations contributed to by an imbalance in the activities of the ACE2/Ang-(1-7)/Mas and the ACE/Ang II/AT1 axes?
RELATIONSHIP OF OXIDATIVE STRESS TO URINARY ANGIOTENSIN CONVERTING ENZYME 2 IN TYPE 2 DIABETES MELLITUS PATIENTS.
Should We Be Concerned about the Association of Diabetes Mellitus and Periodontal Disease in the Risk of Infection by SARS-CoV-2? A Systematic Review and Hypothesis.
The influence of angiotensin-converting enzyme 2 gene polymorphisms on type 2 diabetes mellitus and coronary heart disease.
Urinary angiotensin converting enzyme 2 is strongly related to urinary nephrin in type 2 diabetes patients.
[Relationship of angiotensin-converting enzyme 2 gene polymorphisms and vulnerability to coronary heart disease in patients with type 2 diabetes mellitus]
Diabetic Cardiomyopathies
Angiotensin 1-7 Ameliorates Diabetic Cardiomyopathy and Diastolic Dysfunction in db/db Mice by Reducing Lipotoxicity and Inflammation.
Diabetic Ketoacidosis
Type 1 Diabetes Mellitus in the SARS-CoV-2 Pandemic: Oxidative Stress as a Major Pathophysiological Mechanism Linked to Adverse Clinical Outcomes.
Diabetic Nephropathies
A review of urinary angiotensin converting enzyme 2 in diabetes and diabetic nephropathy.
ACE2 as therapy for glomerular disease: the devil is in the detail.
Advances in the renin-angiotensin-aldosterone system: relevance to diabetic nephropathy.
Angiotensin 1-7 mediates renoprotection against diabetic nephropathy by reducing oxidative stress, inflammation and lipotoxicity.
Angiotensin-converting enzyme 2 amplification limited to the circulation does not protect mice from development of diabetic nephropathy.
Angiotensin-Converting Enzyme 2 Overexpression Remarkably Ameliorated Glomerular Injury in a Rat Model of Diabetic Nephropathy: A Comparison with ACE Inhibition.
Angiotensin-converting enzyme 2: enhancing the degradation of angiotensin II as a potential therapy for diabetic nephropathy.
Assessment of diabetic nephropathy in the akita mouse.
Characterization of renal angiotensin-converting enzyme 2 in diabetic nephropathy.
Gonadectomy prevents the increase in blood pressure and glomerular injury in angiotensin-converting enzyme 2 knockout diabetic male mice. Effects on renin-angiotensin system.
Mesenchymal stem cells modified with angiotensin-converting enzyme 2 are superior for amelioration of glomerular fibrosis in diabetic nephropathy.
New aspects of the renin-angiotensin system: angiotensin-converting enzyme 2 - a potential target for treatment of hypertension and diabetic nephropathy.
Olmesartan Blocks Advanced Glycation End Products-induced VCAM-1 Gene Expression in Mesangial Cells by Restoring Angiotensin-converting Enzyme 2 Level.
Overexpression of the Severe Acute Respiratory Syndrome Coronavirus-2 Receptor, Angiotensin-Converting Enzyme 2, in Diabetic Kidney Disease: Implications for Kidney Injury in Novel Coronavirus Disease 2019.
Podocyte-specific overexpression of human angiotensin-converting enzyme 2 attenuates diabetic nephropathy in mice.
Urinary angiotensin converting enzyme 2 increases in patients with type 2 diabetic mellitus.
Urinary angiotensin-converting enzyme 2 increases in diabetic nephropathy by angiotensin II type 1 receptor blocker olmesartan.
[Association between angiotensin-converting enzyme 2 gene polymorphisms and childhood primary nephrotic syndrome].
Diabetic Retinopathy
Loss of Angiotensin-Converting Enzyme 2 Exacerbates Diabetic Retinopathy by Promoting Bone Marrow Dysfunction.
Down Syndrome
Cloning of the TMPRSS2 gene, which encodes a novel serine protease with transmembrane, LDLRA, and SRCR domains and maps to 21q22.3.
Drug-Related Side Effects and Adverse Reactions
Mechanisms and treatments of myocardial injury in patients with corona virus disease 2019.
Dysgeusia
Oral lesions in patients with SARS-CoV-2 infection: could the oral cavity be a target organ?
The Impact of COVID-19 in Gastroenterology and Hepatology.
Dyspnea
Diagnostic and prognostic properties of procalcitonin in patients with acute dyspnea: Data from the ACE 2 Study.
Eclampsia
Advances in the renin angiotensin system focus on angiotensin-converting enzyme 2 and angiotensin-(1-7).
Embolic Stroke
Angiotensin-Converting Enzyme 2 Activity Is Associated With Embolic Stroke of Undetermined Source.
Embolism
Obesity considerations during the COVID-19 outbreak.
Encephalitis
De Novo Movement Disorders and COVID-19: Exploring the Interface.
Encephalitis, Japanese
Resolving genetic diversity in Australasian Culex mosquitoes: incongruence between the mitochondrial cytochrome c oxidase I and nuclear acetylcholine esterase 2.
Encephalomyelitis
Human and novel coronavirus infections in children: a review.
Endometrial Neoplasms
Pan?cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS?CoV?2 infection leading to COVID-19.
Enterocolitis
Cytomegalovirus haemorrhagic enterocolitis associated with severe infection with COVID-19.
Eosinophilic Esophagitis
Type 2 Immunity and Age Modify Gene Expression of Coronavirus-induced Disease 2019 Receptors in Eosinophilic Gastrointestinal Disorders.
Epistaxis
Severe Epistaxis after Tissue Plasminogen Activator administration for Acute Ischemic Stroke in SARS-COV-2 Infection.
Essential Hypertension
ACE2 gene polymorphism and essential hypertension: an updated meta-analysis involving 11,051 subjects.
Advances in the renin angiotensin system focus on angiotensin-converting enzyme 2 and angiotensin-(1-7).
Association of ACE, ACE2 and UTS2 polymorphisms with essential hypertension in Han and Dongxiang populations from north-western China.
Association of angiotensin-converting enzyme 2 gene polymorphism and enzymatic activity with essential hypertension in different gender: A case-control study.
Association of angiotensin-converting enzyme and angiotensin-converting enzyme-2 gene polymorphisms with essential hypertension in the population of Odisha, India.
Association study of angiotensin-converting enzyme 2 gene (ACE2) polymorphisms and essential hypertension in northern Han Chinese.
Lack of Association of ACE2 G8790A Gene Mutation with Essential Hypertension in the Chinese Population: A Meta-Analysis Involving 5260 Subjects.
No association of angiotensin-converting enzyme 2 gene (ACE2) polymorphisms with essential hypertension.
Relationship between genetic variants of ACE2 gene and circulating levels of ACE2 and its metabolites.
The association between angiotensin-converting enzyme 2 polymorphisms and essential hypertension risk: A meta-analysis involving 14,122 patients.
[Correlation of angiotensin-converting enzyme 2 gene polymorphisms to essential hypertension and ischemic stroke.]
[Relationship of angiotensin-converting enzyme 2 gene polymorphism with the prognosis of hypertensive stroke patients]
Exocrine Pancreatic Insufficiency
SARS-CoV-2 Entry Genes Expression in Relation with Interferon Response in Cystic Fibrosis Patients.
Eye Infections
EyeDiseases: an integrated resource for dedicating to genetic variants, gene expression and epigenetic factors of human eye diseases.
Fatty Liver
Impact of hepatic immunoreactivity of angiotensin-converting enzyme 2 on liver fibrosis due to non-alcoholic steatohepatitis.
Pioglitazone upregulates hepatic angiotensin converting enzyme 2 expression in rats with steatohepatitis.
Fetal Growth Retardation
Angiotensin-converting enzyme 2 deficiency is associated with impaired gestational weight gain and fetal growth restriction.
Photoacoustic imaging for in vivo quantification of placental oxygenation in mice.
Gallbladder Neoplasms
Loss of angiotensin-converting enzyme 2 promotes growth of gallbladder cancer.
Gastritis
Type 2 Immunity and Age Modify Gene Expression of Coronavirus-induced Disease 2019 Receptors in Eosinophilic Gastrointestinal Disorders.
Gastrointestinal Neoplasms
Pan-cancer analysis of RNA expression of ANGIOTENSIN-I-CONVERTING ENZYME 2 reveals high variability and possible impact on COVID-19 clinical outcomes.
Genetic Diseases, Inborn
Similarities in Risk for COVID-19 and Cancer Disparities.
Glaucoma
Antiglaucomatous effects of the activation of intrinsic Angiotensin-converting enzyme 2.
Ocular Inserts for Sustained Release of the Angiotensin-Converting Enzyme 2 Activator, Diminazene Aceturate, to Treat Glaucoma in Rats.
Glaucoma, Open-Angle
Aqueous humor renin, angiotensin I, and angiotensin II activity in primary open-angle glaucoma.
Glomerulonephritis, IGA
Glomerular angiotensin-converting enzyme 2 in pediatric IgA nephropathy.
Glucose Intolerance
Angiotensin-Converting Enzyme 2 Deficiency Aggravates Glucose Intolerance via Impairment of Islet Microvascular Density in Mice with High-Fat Diet.
Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes.
Head and Neck Neoplasms
TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients.
Heart Arrest
Cardiac arrest and COVID-19: inflammation, angiotensin-converting enzyme 2, and the destabilization of non-significant coronary artery disease-a case report.
Screening strategy of TMPRSS2 inhibitors by FRET-based enzymatic activity for TMPRSS2-based cancer and COVID-19 treatment.
Heart Defects, Congenital
Determinants of soluble angiotensin-converting enzyme 2 concentrations in adult patients with complex congenital heart disease.
The changes of serum angiotensin-converting enzyme 2 in patients with pulmonary arterial hypertension due to congenital heart disease.
Heart Diseases
A Dual-Route Perspective of SARS-CoV-2 Infection: Lung- vs. Gut-specific Effects of ACE-2 Deficiency.
Cardiovascular disease during the COVID-19 pandemic: Think ahead, protect hearts, reduce mortality.
Challenge of post-COVID era: management of cardiovascular complications in asymptomatic carriers of SARS-CoV-2.
Circulating cardiovascular microRNAs in critically ill COVID-19 patients.
Effect of angiotensin receptor blockers and angiotensin-converting enzyme 2 on plasma equilibrium angiotensin peptide concentrations in cats with heart disease.
Plasma and tissue angiotensin-converting enzyme 2 activity and plasma equilibrium concentrations of angiotensin peptides in dogs with heart disease.
Prioritizing potential ACE2 inhibitors in the COVID-19 pandemic: Insights from a molecular mechanics-assisted structure-based virtual screening experiment.
Heart Failure
Angiotensin (1-7) and other angiotensin peptide.
Angiotensin converting enzyme 2 gene expression increased compensatory for left ventricular remodeling in patients with end-stage heart failure.
Angiotensin-converting enzyme 2 as a therapeutic target for heart failure.
Angiotensin-converting enzyme 2 overexpression improves central nitric oxide-mediated sympathetic outflow in chronic heart failure.
Angiotensin-converting enzyme 2: a double-edged sword in COVID-19 patients with an increased risk of heart failure.
Balance between angiotensin converting enzyme and angiotensin converting enzyme 2 in patients with chronic heart failure.
Brain-selective overexpression of angiotensin-converting enzyme 2 attenuates sympathetic nerve activity and enhances baroreflex function in chronic heart failure.
Cardiac and renal distribution of ACE and ACE-2 in rats with heart failure.
Changes of myocardial gene expression and protein composition in patients with dilated cardiomyopathy after immunoadsorption with subsequent immunoglobulin substitution.
Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin-angiotensin-aldosterone inhibitors.
Clinical impact of echocardiography parameters and molecular biomarkers in heart failure: Correlation of ACE2 and MCP-1 polymorphisms with echocardiography parameters: A comparative study.
Commenting on "Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from ACE 2 study" by Jacob A. Winther and colleagues.
Detection of soluble angiotensin-converting enzyme 2 in heart failure: insights into the endogenous counter-regulatory pathway of the renin-angiotensin-aldosterone system.
Heterodimerization of apelin receptor and neurotensin receptor 1 induces phosphorylation of ERK(1/2) and cell proliferation via G?q-mediated mechanism.
High-sensitivity cardiac troponin T and N-terminal pro-B-type natriuretic peptide in acute heart failure: Data from the ACE 2 study.
Increasing serum soluble Angiotensin-converting enzyme 2 activity after intensive medical therapy is associated with better prognosis in acute decompensated heart failure.
Loss of angiotensin-converting enzyme 2 exacerbates myocardial injury via activation of the CTGF-fractalkine signaling pathway.
Manipulating angiotensin metabolism with angiotensin converting enzyme 2 (ACE2) in heart failure.
Mineralocorticoid receptor blocker increases angiotensin-converting enzyme 2 activity in congestive heart failure patients.
N-Terminal Pro-Brain Natriuretic Peptide and Angiotensin-Converting Enzyme-2 Levels and Their Association With Postoperative Cardiac Complications After Emergency Orthopedic Surgery.
Neuronal nitric oxide synthase and sympathetic nerve activity in neurovascular and metabolic systems.
New Perspectives in the Renin-Angiotensin-Aldosterone System (RAAS) IV: Circulating ACE2 as a Biomarker of Systolic Dysfunction in Human Hypertension and Heart Failure.
Plasma angiotensin-converting enzyme 2: novel biomarker in heart failure with implications for COVID-19.
Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from the ACE 2 study.
Prognostic and diagnostic significance of mid-regional pro-atrial natriuretic peptide in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from the ACE 2 Study.
Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2 and ADAM17 in rats with heart failure: Potential implication for COVID-19 disease.
Recombinant human Angiotensin-converting enzyme 2 as a new Renin-Angiotensin system peptidase for heart failure therapy.
Revealing the synergistic mechanism of Shenfu Decoction for anti-heart failure through network pharmacology strategy.
Serum angiotensin-converting enzyme 2 concentration and angiotensin-(1-7) concentration in patients with acute heart failure patients requiring emergency hospitalization.
Soluble angiotensin converting enzyme 2 levels in chronic heart failure is associated with decreased exercise capacity and increased oxidative stress-mediated endothelial dysfunction.
Soluble angiotensin-converting enzyme 2 in human heart failure: relation with myocardial function and clinical outcomes.
Soluble Angiotensin-Converting Enzyme 2, Cardiac Biomarkers, Structure, and Function, and Cardiovascular Events (From the Atherosclerosis Risk in Communities Study).
The Case Fatality Rate in COVID-19 Patients With Cardiovascular Disease: Global Health Challenge and Paradigm in the Current Pandemic.
The serum angiotensin-converting enzyme 2 and angiotensin-(1-7) concentrations after optimal therapy for acute decompensated heart failure with reduced ejection fraction.
[Cloning of ACE-2 gene encoding the functional receptor for the SARS coronavirus and its expression in eukaryotic cells]
[Role of ACE2-Ang (1-7)-Mas receptor axis in heart failure with preserved ejection fraction with hypertension].
Heart Failure, Systolic
Soluble angiotensin converting enzyme 2 levels in chronic heart failure is associated with decreased exercise capacity and increased oxidative stress-mediated endothelial dysfunction.
Soluble angiotensin-converting enzyme 2 in human heart failure: relation with myocardial function and clinical outcomes.
Hemangioma
?-elemene affects angiogenesis of infantile hemangioma by regulating angiotensin-converting enzyme 2 and hypoxia-inducible factor-1 alpha.
Hematologic Neoplasms
Coronavirus in Hematologic Malignancies: Targeting Molecules Beyond the Angiotensin-Converting Enzyme 2 (ACE2) Wall in COVID-19.
Hematuria
The role of Interleukin-4 in COVID-19 associated male infertility - A hypothesis.
Hemorrhagic Stroke
COVID-19-Related Intracerebral Hemorrhage.
Potential mechanisms of hemorrhagic stroke in elderly COVID-19 patients.
Hepatitis
Highlights in the fight against COVID-19: does autophagy play a role in SARS-CoV-2 infection?
Hepatitis B
A decoy strategy to activate the immune system.
Hepatitis C
Computational drug repurposing study elucidating simultaneous inhibition of entry and replication of novel corona virus by Grazoprevir.
The use of hepatitis C virus NS3/4A and secreted alkaline phosphatase to quantitate cell-cell membrane fusion mediated by severe acute respiratory syndrome coronavirus S protein and the receptor angiotensin-converting enzyme 2.
Transmembrane serine protease TMPRSS2 activates hepatitis C virus infection.
Herpes Zoster
The Adrenal Cortex, an Underestimated Site of SARS-CoV-2 Infection.
HIV Infections
HIV infection drives interferon signaling within intestinal SARS-CoV-2 target cells.
Hyperaldosteronism
Aldosterone and cortisol synthesis regulation by angiotensin-(1-7) and angiotensin-converting enzyme 2 in the human adrenal cortex.
Hyperalgesia
TMPRSS2, a novel membrane-anchored mediator in cancer pain.
Hyperandrogenism
[Androgens and Antiandrogens influence on COVID-19 disease in men].
Hypercholesterolemia
Cholesterol in Relation to COVID-19: Should We Care about It?
Hyperglycemia
Activation of endogenous angiotensin converting enzyme 2 prevents early injuries induced by hyperglycemia in rat retina.
Coronavirus Disease 2019 and Diabetes: The Epidemic and the Korean Diabetes Association Perspective.
COVID-19 in Relation to Hyperglycemia and Diabetes Mellitus.
Factors leading to high morbidity and mortality of COVID-19 in patients with type 2 diabetes.
Increased ACE 2 and decreased ACE protein in renal tubules from diabetic mice: a renoprotective combination?
Metabolic Perturbations and Severe COVID-19 Disease: Implication of Molecular Pathways.
New onset diabetes, type 1 diabetes and COVID-19.
Potential mechanisms of cerebrovascular diseases in COVID-19 patients.
Hypersensitivity
Alternative antibiotic feed additives alleviate pneumonia with inhibiting ACE-2 expression in the respiratory system of piglets.
COVID-19 Susceptibility in Bronchial Asthma.
Hypertension
A Dual-Route Perspective of SARS-CoV-2 Infection: Lung- vs. Gut-specific Effects of ACE-2 Deficiency.
A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension.
A role of glycation and methylation for SARS-CoV-2 infection in diabetes?
ACE2 activation confers endothelial protection and attenuates neointimal lesions in prevention of severe pulmonary arterial hypertension in rats.
ACE2: angiotensin II/angiotensin-(1-7) balance in cardiac and renal injury.
Administration of 17?-estradiol to ovariectomized obese female mice reverses obesity-hypertension through an ACE2-dependent mechanism.
Alterations in circulatory and renal angiotensin-converting enzyme and angiotensin-converting enzyme 2 in fetal programmed hypertension.
Angiotensin converting enzyme 2 and angiotensin (1-7) axis in pulmonary arterial hypertension.
Angiotensin converting enzyme 2 contributes to sex differences in the development of obesity hypertension in C57BL/6 mice.
Angiotensin converting enzyme-2 (ACE2) and its possible roles in hypertension, diabetes and cardiac function.
Angiotensin Converting Enzyme-2 (ACE2) and its Possible Roles in Hypertension, Diabetes and Cardiac Function.
Angiotensin-(1-7) prevents systemic hypertension, attenuates oxidative stress and tubulointerstitial fibrosis, and normalizes renal angiotensin-converting enzyme 2 and Mas receptor expression in diabetic mice.
Angiotensin-converting enzyme 2 (ACE2) and ACE activities display tissue-specific sensitivity to undernutrition-programmed hypertension in the adult rat.
Angiotensin-converting enzyme 2 A1075G polymorphism is associated with survival in an acute coronary syndromes cohort.
Angiotensin-converting enzyme 2 activation ameliorates pulmonary endothelial dysfunction in rats with pulmonary arterial hypertension through mediating phosphorylation of endothelial nitric oxide synthase.
Angiotensin-converting enzyme 2 activation protects against pulmonary arterial hypertension through improving early endothelial function and mediating cytokines levels.
Angiotensin-converting enzyme 2 activation suppresses pulmonary vascular remodeling by inducing apoptosis through the Hippo signaling pathway in rats with pulmonary arterial hypertension.
Angiotensin-converting enzyme 2 alleviates pulmonary artery hypertension through inhibition of focal adhesion kinase expression.
Angiotensin-converting enzyme 2 as a novel target for gene therapy for hypertension.
Angiotensin-Converting Enzyme 2 in the Rostral Ventrolateral Medulla Regulates Cholinergic Signaling and Cardiovascular and Sympathetic Responses in Hypertensive Rats.
Angiotensin-converting enzyme 2 is an essential regulator of heart function.
Angiotensin-converting enzyme 2: a new target for neurogenic hypertension.
Angiotensin-converting enzyme 2: possible role in hypertension and kidney disease.
Angiotensin-converting enzyme and Angiotensin-converting enzyme 2 are involved in sinoaortic denervation-induced cardiovascular hypertrophy in rats.
Antenatal maternal low protein diet: ACE-2 in the mouse lung and sexually dimorphic programming of hypertension.
Association of angiotensin-converting enzyme 2 gene A/G polymorphism and elevated blood pressure in Chinese patients with metabolic syndrome.
Biological Context Linking Hypertension and Higher Risk for COVID-19 Severity.
Brain ACE2 overexpression reduces DOCA-salt hypertension independently of endoplasmic reticulum stress.
Brain ACE2 Shedding Contributes to the Development of Neurogenic Hypertension.
Brain-selective overexpression of human Angiotensin-converting enzyme type 2 attenuates neurogenic hypertension.
Brain-targeted Angiotensin-converting enzyme 2 overexpression attenuates neurogenic hypertension by inhibiting cyclooxygenase-mediated inflammation.
Cardiovascular medications and regulation of COVID-19 receptors expression.
Chronic sleep restriction during pregnancy--repercussion on cardiovascular and renal functioning of male offspring.
Clinical Management of Hypertension, Inflammation and Thrombosis in Hospitalized COVID-19 Patients: Impact on Survival and Concerns.
Clinical Relevance and Role of Neuronal AT1 Receptors in ADAM17-Mediated ACE2 Shedding in Neurogenic Hypertension.
Collectrin, an X-Linked, ACE2 Homologue Causes Hypertension in a Rat Strain through Gene-Gene and Gene-Environment Interactions: Relevance to Human Hypertension.
Coronavirus Disease 2019 and Hypertension: The Role of Angiotensin-Converting Enzyme 2 and the Renin-Angiotensin System.
Correlation of angiotensin-converting enzyme 2 gene polymorphisms with stage 2 hypertension in Han Chinese.
Effect of Prolonged Infusion of Alamandine on Cardiovascular Parameters and Cardiac ACE2 Expression in a Rat Model of Renovascular Hypertension.
FGF21 Prevents Angiotensin II-Induced Hypertension and Vascular Dysfunction by Activation of ACE2/Angiotensin-(1-7) Axis in Mice.
Heart Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 Gene Expression Associated With Male Sex and Salt-Sensitive Hypertension in the Dahl Rat.
Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney.
Impairment of the angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas axis contributes to the acceleration of two-kidney, one-clip Goldblatt hypertension.
In Silico Comparison of Separate or Combinatorial Effects of Potential Inhibitors of the SARS-CoV-2 Binding Site of ACE2.
Insufficient hypothalamic angiotensin-converting enzyme 2 is associated with hypertension in SHR rats.
Loss of Collectrin, an ACE2 Homologue, Uncouples Endothelial Nitric Oxide Synthase and Causes Hypertension and Vascular Dysfunction.
Lower Gene Expression of Angiotensin Converting Enzyme 2 Receptor in Lung Tissues of Smokers with COVID-19 Pneumonia.
Maternal endothelial dysfunction in HIV-associated preeclampsia comorbid with COVID-19: a review.
MDM2-Mediated Ubiquitination of Angiotensin-Converting Enzyme 2 Contributes to the Development of Pulmonary Arterial Hypertension.
Measuring Blood Pressure Using a Noninvasive Tail Cuff Method in Mice.
Multiple faces of fibroblast growth factor-23.
Murine Recombinant Angiotensin-Converting Enzyme 2: Effect on Angiotensin II-Dependent Hypertension and Distinctive Angiotensin-Converting Enzyme 2 Inhibitor Characteristics on Rodent and Human Angiotensin-Converting Enzyme 2.
Neuronal nitric oxide synthase and sympathetic nerve activity in neurovascular and metabolic systems.
New aspects of the renin-angiotensin system: angiotensin-converting enzyme 2 - a potential target for treatment of hypertension and diabetic nephropathy.
New Perspectives in the Renin-Angiotensin-Aldosterone System (RAAS) IV: Circulating ACE2 as a Biomarker of Systolic Dysfunction in Human Hypertension and Heart Failure.
Nicotine modulates the Renin-Angiotensin system of cultured neurons and glial cells from cardiovascular brain areas of wistar kyoto and spontaneously hypertensive rats.
No association of angiotensin-converting enzyme 2 gene (ACE2) polymorphisms with essential hypertension.
Outcomes in Patients with COVID-19 Infection Taking ACEI/ARB.
Overexpression of angiotensin-converting enzyme 2 attenuates tonically active glutamatergic input to the rostral ventrolateral medulla in hypertensive rats.
Overexpression of angiotensin-converting enzyme 2 by renin-angiotensin system inhibitors. Truth or myth? A systematic review of animal studies.
Physiological Relevance of Angiotensin Converting Enzyme 2 As a Metabolic Linker and Therapeutic Implication of Mesenchymal Stem Cells in COVID-19 and Hypertension.
Polymorphisms of angiotensin-converting enzyme 2 gene confer a risk to lone atrial fibrillation in Chinese male patients.
Prediction of death status on the course of treatment in SARS-COV-2 patients with deep learning and machine learning methods.
Propofol increases angiotensin-converting enzyme 2 expression in human pulmonary artery endothelial cells.
Role of angiotensin-converting enzyme 2 and angiotensin(1-7) in 17beta-oestradiol regulation of renal pathology in renal wrap hypertension in rats.
Soluble Angiotensin-Converting Enzyme 2, Cardiac Biomarkers, Structure, and Function, and Cardiovascular Events (From the Atherosclerosis Risk in Communities Study).
Spironolactone may provide protection from SARS-CoV-2: Targeting androgens, angiotensin converting enzyme 2 (ACE2), and renin-angiotensin-aldosterone system (RAAS).
Targeting the degradation of angiotensin II with recombinant angiotensin-converting enzyme 2: prevention of angiotensin II-dependent hypertension.
The Case Fatality Rate in COVID-19 Patients With Cardiovascular Disease: Global Health Challenge and Paradigm in the Current Pandemic.
The changes of serum angiotensin-converting enzyme 2 in patients with pulmonary arterial hypertension due to congenital heart disease.
The Ineluctable Role of ACE-2 Receptors in SARS COV-2 Infection and Drug Repurposing as a Plausible SARS COV-2 Therapy : A Concise Treatise.
The interaction between the endocannabinoid system and the renin angiotensin system and its potential implication for COVID-19 infection.
The interplay of hypertension, ACE-2 and SARS-CoV-2: Emerging data as the "Ariadne's thread" for the "labyrinth" of COVID-19.
The role of hypertension on the severity of COVID-19: a review.
Transgenic angiotensin-converting enzyme 2 overexpression in vessels of SHRSP rats reduces blood pressure and improves endothelial function.
[An experimental study of expression of angiotension converting enzyme 2 in myocardium and effect of telmisartan treatment in pressure-overloaded rats]
[Association between angiotensin-converting enzyme 2 gene polymorphisms and childhood primary nephrotic syndrome].
[Cardiac Involvement in COVID-19].
[Effect of puerarin injection on the mRNA expressions of AT1 and ACE2 in spontaneous hypertension rats]
[Role of ACE2-Ang (1-7)-Mas receptor axis in heart failure with preserved ejection fraction with hypertension].
Hypertension, Portal
Activation of the Alternate Renin-Angiotensin System Correlates with the Clinical Status in Human Cirrhosis and Corrects Post Liver Transplantation.
Hypertension, Pulmonary
Angiotensin-converting enzyme 2 activation for treatment of pulmonary hypertension.
Angiotensin-Converting Enzyme 2 Activator Ameliorates Severe Pulmonary Hypertension in a Rat Model of Left Pneumonectomy Combined With VEGF Inhibition.
Diminazene attenuates pulmonary hypertension and improves angiogenic progenitor cell functions in experimental models.
Evidence for Angiotensin Converting Enzyme 2 as a Therapeutic Target for the Prevention of Pulmonary Hypertension.
MiRNA let-7b promotes the development of hypoxic pulmonary hypertension by targeting ACE2.
Oral delivery of Angiotensin-converting enzyme 2 and Angiotensin-(1-7) bioencapsulated in plant cells attenuates pulmonary hypertension.
Prevention of pulmonary hypertension by Angiotensin-converting enzyme 2 gene transfer.
Recombinant angiotensin-converting enzyme 2 improves pulmonary blood flow and oxygenation in lipopolysaccharide-induced lung injury in piglets.
The changes of serum angiotensin-converting enzyme 2 in patients with pulmonary arterial hypertension due to congenital heart disease.
Hypertension, Renovascular
Beneficial Effects of the Angiotensin-Converting Enzyme 2 Activator Dize in Renovascular Hypertension.
Hyperthyroidism
Cardiac ACE2/angiotensin 1-7/Mas receptor axis is activated in thyroid hormone-induced cardiac hypertrophy.
Hypertrophy, Left Ventricular
Angiotensin-converting enzyme 2 A1075G polymorphism is associated with survival in an acute coronary syndromes cohort.
Association of angiotensin-converting enzyme 2 (ACE2) gene polymorphisms with parameters of left ventricular hypertrophy in men Results of the MONICA Augsburg echocardiographic substudy.
Genetic variation in angiotensin-converting enzyme 2 gene is associated with extent of left ventricular hypertrophy in hypertrophic cardiomyopathy.
Hypertension and hypertensive left ventricular hypertrophy are associated with ACE2 genetic polymorphism.
Multiple faces of fibroblast growth factor-23.
Polymorphisms of angiotensin-converting enzyme 2 gene associated with magnitude of left ventricular hypertrophy in male patients with hypertrophic cardiomyopathy.
Polymorphisms of angiotensin-converting enzyme 2 gene confer a risk to lone atrial fibrillation in Chinese male patients.
Hypoalbuminemia
Clinical features resembling subcutaneous insulin resistance observed in a patient with type 2 diabetes and severe COVID-19-associated pneumonia: a case report.
Osmotic Adaptation by Na+-Dependent Transporters and ACE2: Correlation with Hemostatic Crisis in COVID-19.
Hypogonadism
A virus-free cellular model recapitulates several features of severe COVID-19.
Hypokalemia
Assessment of Hypokalemia and Clinical Characteristics in Patients With Coronavirus Disease 2019 in Wenzhou, China.
Osmotic Adaptation by Na+-Dependent Transporters and ACE2: Correlation with Hemostatic Crisis in COVID-19.
Hypotension
Intradialytic hypotension: beyond hemodynamics.
Idiopathic Pulmonary Fibrosis
Angiotensin-converting enzyme 2 expression in COPD and IPF fibroblasts: the forgotten cell in COVID-19.
Cell cycle-dependence of ACE-2 explains downregulation in Idiopathic pulmonary fibrosis.
Single Cell RNA-seq Data Analysis Reveals the Potential Risk of SARS-CoV-2 Infection Among Different Respiratory System Conditions.
Upregulation of ACE2 and TMPRSS2 by particulate matter and idiopathic pulmonary fibrosis: a potential role in severe COVID-19.
Infections
A Case-Control Study of the 2019 Influenza Vaccine and Incidence of COVID-19 Among Healthcare Workers.
A Comprehensive Review of COVID-19 Associated Neurological Manifestations.
A computational study of the interface interaction between SARS-CoV-2 RBD and ACE2 from human, cat, dog, and ferret.
A Cytopathic Effect-Based Tissue Culture Method for HCoV-OC43 Titration Using TMPRSS2-Expressing VeroE6 Cells.
A dramatic rise in serum ACE2 activity in a critically ill COVID-19 patient.
A human antibody of potent efficacy against SARS-CoV-2 in rhesus macaques showed strong blocking activity to B.1.351.
A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry in vitro.
A mouse model of lethal respiratory dysfunction for SARS-CoV-2 infection.
A Mouse Model of SARS-CoV-2 Infection and Pathogenesis.
A Multi-Targeting Approach to Fight SARS-CoV-2 Attachment.
A novel pseudovirus-based mouse model of SARS-CoV-2 infection to test COVID-19 interventions.
A Novel Soluble ACE2 Variant with Prolonged Duration of Action Neutralizes SARS-CoV-2 Infection in Human Kidney Organoids.
A Review on Expression, Pathological Roles, and Inhibition of TMPRSS2, the Serine Protease Responsible for SARS-CoV-2 Spike Protein Activation.
A SARS-CoV-2 Spike Binding DNA Aptamer that Inhibits Pseudovirus Infection by an RBD-Independent Mechanism*.
A SARS-CoV-2 Spike Binding DNA Aptamer that Inhibits Pseudovirus Infection by an RBD-Independent Mechanism.
A super-potent tetramerized ACE2 protein displays enhanced neutralization of SARS-CoV-2 virus infection.
A surrogate virus neutralization test to quantify antibody-mediated inhibition of SARS-CoV-2 in finger stick dried blood spot samples.
A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity.
ACE-2 Downregulation and Incidence of Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) Infection.
ACE2 and TMPRSS2 expression by clinical, HLA, immune, and microbial correlates across 34 human cancers and matched normal tissues: implications for SARS-CoV-2 COVID-19.
ACE2 and TMPRSS2 polymorphisms in various diseases with special reference to its impact on COVID-19 disease.
ACE2 as a Therapeutic Target for COVID-19; its Role in Infectious Processes and Regulation by Modulators of the RAAS System.
ACE2 imbalance as a key player for the poor outcomes in COVID-19 patients with age-related comorbidities - Role of gut microbiota dysbiosis.
ACE2, TMPRSS2 and L-SIGN expression in placentae from HIV-positive pregnancies exposed to antiretroviral therapy-implications for SARS-CoV-2 placental infection.
Acute Kidney Injury in a Case Series of Patients with Confirmed COVID-19 (Coronavirus Disease 2019): Role of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Blockade.
Acute mesenteric ischemia and small bowel imaging findings in COVID-19: A comprehensive review of the literature.
Age-Related Differences in Immunological Responses to SARS-CoV-2.
Air pollution by NO2 and PM2.5 explains COVID-19 infection severity by overexpression of angiotensin-converting enzyme 2 in respiratory cells: a review.
Alert to US physicians: DHEA, widely used as an OTC androgen supplement, may exacerbate COVID-19.
Alteration in angiotensin-converting enzyme 2 by PM1 during the development of emphysema in rats.
An ACE2 Microbody Containing a Single Immunoglobulin Fc Domain Is a Potent Inhibitor of SARS-CoV-2.
An ACE2 Triple Decoy that neutralizes SARS-CoV-2 shows enhanced affinity for virus variants.
An Enzymatic TMPRSS2 Assay for Assessment of Clinical Candidates and Discovery of Inhibitors as Potential Treatment of COVID-19.
An Immunological Perspective: What Happened to Pregnant Women After Recovering From COVID-19?
An insight into the inhibitory mechanism of phytochemicals and FDA-approved drugs on the ACE2-Spike complex of SARS-CoV-2 using computational methods.
Analysis of ACE2 in polarized epithelial cells: surface expression and function as receptor for severe acute respiratory syndrome-associated coronavirus.
Anchor-Locker Binding Mechanism of the Coronavirus Spike Protein to Human ACE2: Insights from Computational Analysis.
Androgen Deprivation Therapy in Men With Prostate Cancer Does Not Affect Risk of Infection With SARS-CoV-2.
Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men.
Angiotensin Converting Enzyme-2 (ACE2) receptors, asthma and severe COVID-19 infection risk.
Angiotensin-Converting Enzyme 2 (ACE2) in the Context of Respiratory Diseases and Its Importance in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection.
Angiotensin-converting enzyme 2 (ACE2) levels in relation to risk factors for COVID-19 in two large cohorts of patients with atrial fibrillation.
Angiotensin-converting enzyme 2 gene expression in human male urological tissues: implications for pathogenesis and virus transmission pathways.
Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections.
Angiotensin-converting enzyme 2: The old door for new severe acute respiratory syndrome coronavirus 2 infection.
Animal Models of COVID-19 II. Comparative Immunology.
Are the cutaneous manifestations during or due to SARS-CoV-2 infection/COVID-19 frequent or not? Revision of possible pathophysiologic mechanisms.
Assessment of risk conferred by coding and regulatory variations of TMPRSS2 and CD26 in susceptibility to SARS-CoV-2 infection in human.
Asthma and severe acute respiratory syndrome coronavirus 2019: current evidence and knowledge gaps.
Azithromycin Downregulates Gene Expression of IL-1? and Pathways Involving TMPRSS2 and TMPRSS11D Required by SARS-CoV-2.
Bacterial modification of the host glycosaminoglycan heparan sulfate modulates SARS-CoV-2 infectivity.
Bioactive Alkaloids from Genus Aspergillus: Mechanistic Interpretation of Their Antimicrobial and Potential SARS-CoV-2 Inhibitory Activity Using Molecular Modelling.
Blocking of the High-Affinity Interaction-Synapse Between SARS-CoV-2 Spike and Human ACE2 Proteins Likely Requires Multiple High-Affinity Antibodies: An Immune Perspective.
Camostat mesylate against SARS-CoV-2 and COVID-19-Rationale, dosing and safety.
Can SARS-CoV-2 infect the central nervous system via the olfactory bulb or the blood-brain barrier?
Can SARS-CoV-2 infect the eye? An overview of the receptor status in ocular tissue.
Cardiorenal Tissues Express SARS-CoV-2 Entry Genes and Basigin (BSG/CD147) Increases With Age in Endothelial Cells.
Cardiovascular disease management during the coronavirus disease 2019 pandemic.
Cathepsins B and L activate Ebola but not Marburg virus glycoproteins for efficient entry into cell lines and macrophages independent of TMPRSS2 expression.
Caution in the management of SARS-CoV-2 infection in males.
Characterisation of animal angiotensin-converting enzyme 2 receptors and use of pseudotyped virus to correlate receptor binding with susceptibility of SARS-CoV infection.
Characterization of changes in global gene expression in the hearts and kidneys of transgenic mice overexpressing human angiotensin-converting enzyme 2.
Cigarette Smoke Stimulates SARS-CoV-2 Internalization by Activating AhR and Increasing ACE2 Expression in Human Gingival Epithelial Cells.
Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity.
Cleavage and activation of the severe acute respiratory syndrome coronavirus spike protein by human airway trypsin-like protease.
Clinical Implications of SARS-CoV-2 Interaction With Renin Angiotensin System: JACC Review Topic of the Week.
Clinical-Pathological Correlation of the Pathophysiology and Mechanism of Action of COVID-19 - a Primer for Clinicians.
Co-expression of SARS-CoV-2 entry genes in the superficial adult human conjunctival, limbal and corneal epithelium suggests an additional route of entry via the ocular surface.
Co?expression of peripheral olfactory receptors with SARS?CoV?2 infection mediators: Potential implications beyond loss of smell as a COVID?19 symptom.
Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study.
Combination and tricombination therapy to destabilize the structural integrity of COVID-19 by some bioactive compounds with antiviral drugs: insights from molecular docking study.
Common determinants of severe Covid-19 infection are explicable by SARS-CoV-2 secreted glycoprotein interaction with the CD33-related Siglecs, Siglec-3 and Siglec-5/14.
Comparative analyses of ACE2 and TMPRSS2 gene: Implications for the risk to which vertebrate animals are susceptible to SARS-CoV-2.
Comparative phylogenetic analysis of SARS-CoV-2 spike protein-possibility effect on virus spillover.
Comparative transcriptomic analysis of SARS-CoV-2 infected cell model systems reveals differential innate immune responses.
Computational design of ultrashort peptide inhibitors of the receptor-binding domain of the SARS-CoV-2 S protein.
Computational drug repurposing strategy predicted peptide-based drugs that can potentially inhibit the interaction of SARS-CoV-2 spike protein with its target (humanACE2).
Computational optimization of angiotensin-converting enzyme 2 for SARS-CoV-2 Spike molecular recognition.
Consideration on TMPRSS2 and the risk of COVID-19 infection in Cushing's syndrome.
Construction of a Human Cell Landscape of COVID-19 Infection at Single-cell Level.
Contribution of SARS-CoV-2 Accessory Proteins to Viral Pathogenicity in K18 Human ACE2 Transgenic Mice.
Coronavirus Disease 2019 Infection among Children: Pathogenesis, Treatment, and Outcome.
Coronavirus Disease 2019: Coronaviruses and Kidney Injury.
Correlation between renin-angiotensin system and Severe Acute Respiratory Syndrome Coronavirus 2 infection: What do we know?
Correspondence: Angiotensin-converting enzyme 2 coated nanoparticles containing respiratory masks, chewing gums and nasal filters may be used for protection against COVID-19 infection.
Covid 19 and its cardiovascular effects.
COVID-19 and bronchial asthma: current perspectives.
COVID-19 and Cardiovascular Disease.
COVID-19 and developmental origins of health and disease.
COVID-19 and Kidney Injury.
COVID-19 and the gastrointestinal tract: Source of infection or merely a target of the inflammatory process following SARS-CoV-2 infection?
COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects.
Covid-19 pathogenesis in prostatic cancer and TMPRSS2-ERG regulatory genetic pathway.
COVID-19 Vasculopathy: Mounting Evidence for an Indirect Mechanism of Endothelial Injury.
COVID-19, Renin-Angiotensin System and Endothelial Dysfunction.
COVID-19-associated diarrhea.
COVID-19-Associated Nonocclusive Fibrin Microthrombi in the Heart.
Crystal structure of inhibitor-bound human MSPL that can activate high pathogenic avian influenza.
Current Findings Regarding Natural Components With Potential Anti-2019-nCoV Activity.
Cyclooxgenase-2 is induced by SARS-CoV-2 infection but does not affect viral entry or replication.
Cytomegalovirus haemorrhagic enterocolitis associated with severe infection with COVID-19.
Deamidation drives molecular aging of the SARS-CoV-2 spike protein receptor-binding motif.
Decreased Mortality Rate Among COVID-19 Patients Prescribed Statins: Data From Electronic Health Records in the US.
Deep mutagenesis in the study of COVID-19: a technical overview for the proteomics community.
Defusing SARS-CoV-2: Emergency Brakes in a Vaccine Failure Scenario.
Design and biological activities of novel inhibitory peptides for SARS-CoV spike protein and angiotensin-converting enzyme 2 interaction.
Development of a nano-luciferase based assay to measure the binding of SARS-CoV-2 spike receptor binding domain to ACE-2.
Differential Dynamic Behavior of Prefusion Spike Proteins of SARS Coronaviruses 1 and 2.
Differential sensitivity of bat cells to infection by enveloped RNA viruses: coronaviruses, paramyxoviruses, filoviruses, and influenza viruses.
Differential virological and immunological outcome of severe acute respiratory syndrome coronavirus infection in susceptible and resistant transgenic mice expressing human angiotensin-converting enzyme 2.
Disequilibrium between the classic renin-angiotensin system and its opposing arm in SARS-CoV-2-related lung injury.
Distribution of the ACE1 D Allele in the Bosnian-Herzegovinian Population and its Possible Role in the Regional Epidemiological Picture of COVID-19.
Do inflammaging and coagul-aging play a role as conditions contributing to the co-occurrence of the severe hyper-inflammatory state and deadly coagulopathy during COVID-19 in older people?
Dodging COVID-19 infection: low expression and localization of ACE2 and TMPRSS2 in multiple donor-derived lines of human umbilical cord-derived mesenchymal stem cells.
Drug Repurposing Strategy (DRS): Emerging Approach to Identify Potential Therapeutics for Treatment of Novel Coronavirus Infection.
Drug Weaponry to Fight Against SARS-CoV-2.
Dual role for angiotensin-converting enzyme 2 in Severe Acute Respiratory Syndrome Coronavirus 2 infection and cardiac fat.
Dysbalance of ACE2 levels - a possible cause for severe COVID-19 outcome in COPD.
Effect of ramipril on kidney, lung and heart ACE2 in a diabetic mice model.
Effective ACE2 peptide-nanoparticle conjugation and its binding with the SARS-Cov-2 RBD quantified by dynamic light scattering.
Efficient activation of SARS coronavirus spike protein by the transmembrane protease, TMPRSS2.
Emerging of composition variations of SARS-CoV-2 spike protein and human ACE2 contribute to the level of infection: in silico approaches.
Endocrine and metabolic aspects of COVID-19.
Endothelial dysfunction in COVID-19: a position paper of the ESC Working Group for Atherosclerosis and Vascular Biology, and the ESC Council of Basic Cardiovascular Science.
Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2.
Epidemiological Study of Betacoronaviruses in Captive Malayan Pangolins.
Epigallocatechin gallate from green tea effectively blocks infection of SARS-CoV-2 and new variants by inhibiting spike binding to ACE2 receptor.
Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19.
Evaluation of the susceptibility and fatality of lung cancer patients towards the COVID-19 infection: A systemic approach through analyzing the ACE2, CXCL10 and their co-expressed genes.
Evidence Regarding Vitamin D and Risk of COVID-19 and Its Severity.
Exploring G protein-coupled receptors and yeast surface display strategies for viral detection in baker's yeast: SARS-CoV-2 as a case study.
Exploring the Demographics and Clinical Characteristics Related to the Expression of Angiotensin-Converting Enzyme 2, a Receptor of SARS-CoV-2.
Expression Analyses of MicroRNAs in Hamster Lung Tissues Infected by SARS-CoV-2.
Expression and co-expression analyses of TMPRSS2, a key element in COVID-19.
Expression of ACE2 and TMPRSS2 proteins in the upper and lower aerodigestive tracts of rats: implications on COVID 19 infections.
Expression of ACE2 in airways: implication for COVID-19 risk and disease management in patients with chronic inflammatory respiratory diseases.
Expression of Endogenous Angiotensin-Converting Enzyme 2 in Human Induced Pluripotent Stem Cell-Derived Retinal Organoids.
Expression of SARS-CoV-2 receptor ACE2 and the protease TMPRSS2 suggests susceptibility of the human embryo in the first trimester.
Expression of SARS-CoV-2-related Receptors in Cells of the Neurovascular Unit: Implications for HIV-1 Infection.
Expression of SARS-CoV-2-related receptors in cells of the neurovascular unit: implications for HIV-1 infection.
Expression of severe acute respiratory syndrome coronavirus 2 cell entry genes, angiotensin-converting enzyme 2 and transmembrane protease serine 2, in the placenta across gestation and at the maternal-fetal interface in pregnancies complicated by preterm birth or preeclampsia.
Extracellular vesicles carry SARS-CoV-2 spike protein and serve as decoys for neutralizing antibodies.
Extrapulmonary Clinical Manifestations in COVID-19 Patients.
EyeDiseases: an integrated resource for dedicating to genetic variants, gene expression and epigenetic factors of human eye diseases.
FDA-approved thiol-reacting drugs that potentially bind into the SARS-CoV-2 main protease, essential for viral replication.
Feminising hormone therapy reduces testicular ACE-2 receptor expression: Implications for treatment or prevention of COVID-19 infection in men.
Free SARS-CoV-2 Spike Protein S1 Particles May Play a Role in the Pathogenesis of COVID-19 Infection.
Functional comparison of SARS-CoV-2 with closely related pangolin and bat coronaviruses.
Gender susceptibility to COVID-19: a review of the putative role of sex hormones and X chromosome.
Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue.
Genetic Control of Human Infection with SARS-CoV-2.
Genetic Risk Factors for the Development of COVID-19 Coronavirus Infection.
Genetic variation analyses indicate conserved SARS-CoV-2-host interaction and varied genetic adaptation in immune response factors in modern human evolution.
H1N1 exposure during the convalescent stage of SARS-CoV-2 infection results in enhanced lung pathologic damage in hACE2 transgenic mice.
H2 influenza A virus is not pathogenic in Tmprss2 knock-out mice.
Hemagglutinins of avian influenza viruses are proteolytically activated by TMPRSS2 in human and murine airway cells.
Hesperidin Is a Potential Inhibitor against SARS-CoV-2 Infection.
High-throughput human primary cell-based airway model for evaluating influenza, coronavirus, or other respiratory viruses in vitro.
Highly susceptible SARS-CoV-2 model in CAG promoter-driven hACE2 transgenic mice.
Host serine proteases TMPRSS2 and TMPRSS11D mediate proteolytic activation and trypsin-independent infection in group A rotaviruses.
Human coronavirus NL63 utilizes heparan sulfate proteoglycans for attachment to target cells.
Human Immunodeficiency Viruses Pseudotyped with SARS-CoV-2 Spike Proteins Infect a Broad Spectrum of Human Cell Lines through Multiple Entry Mechanisms.
Human SARS CoV-2 spike protein mutations.
Human Stem Cell Models of SARS-CoV-2 Infection in the Cardiovascular System.
Humanized COVID-19 decoy antibody effectively blocks viral entry and prevents SARS-CoV-2 infection.
Hypotheses about sub-optimal hydration in the weeks before coronavirus disease (COVID-19) as a risk factor for dying from COVID-19.
Immune Interaction Map of Human SARS-CoV-2 Target Genes: Implications for Therapeutic Avenues.
Immunization with an attenuated severe acute respiratory syndrome coronavirus deleted in E protein protects against lethal respiratory disease.
Impact of diminazene aceturate on renin-angiotensin system, infectious myocarditis and skeletal myositis in mice: An in vitro and in vivo study.
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19.
In vitro characterization of TMPRSS2 inhibition in IPEC-J2 cells.
In-silico analysis of angiotensin converting enzyme 2 (ACE2) of livestock, pet and poultry animals to determine its susceptibility to SARS-CoV- 2 infection.
Inhibition of S-protein RBD and hACE2 Interaction for Control of SARSCoV- 2 Infection (COVID-19).
Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2.
Insights into disparities observed with COVID-19.
Insights to SARS-CoV-2 life cycle, pathophysiology, and rationalized treatments that target COVID-19 clinical complications.
Instigators of COVID-19 in Immune Cells are Increased in Tobacco Cigarette Smokers and Electronic Cigarette Vapers Compared to Non-smokers.
Integrated Bioinformatics Analysis Reveals Key Candidate Genes and Cytokine Pathways Involved in COVID-19 After Rhinovirus Infection in Asthma Patients.
Integrative analysis of miRNA and mRNA sequencing data reveals potential regulatory mechanisms of ACE2 and TMPRSS2.
Interaction Between Coronavirus S-Protein and Human ACE2: Hints for Exploring Efficient Therapeutic Targets to Treat COVID-19.
Interaction of SARS-CoV-2 spike protein with angiotensin converting enzyme inhibitors and selected compounds from the chemical entities of biological interest.
Interaction of severe acute respiratory syndrome-coronavirus and NL63 coronavirus spike proteins with angiotensin converting enzyme-2.
Interplay of Opposing Effects of the WNT/?-Catenin Pathway and PPAR? and Implications for SARS-CoV2 Treatment.
Investigation of Interaction between the Spike Protein of SARS-CoV-2 and ACE2-Expressing Cells Using an In Vitro Cell Capturing System.
Is SARS-CoV-2 infection a risk factor for early pregnancy loss? ACE2 and TMPRSS2 co-expression and persistent replicative infection in primitive trophoblast.
Is There an Association Between COVID-19 Mortality and the Renin-Angiotensin System? A Call for Epidemiologic Investigations.
Kidney ACE2 expression: Implications for chronic kidney disease.
Lack of Association Between Genetic Variants at ACE2 and TMPRSS2 Genes Involved in SARS-CoV-2 Infection and Human Quantitative Phenotypes.
Lack of Evidence of Angiotensin-Converting Enzyme 2 Expression and Replicative Infection by SARS-CoV-2 in Human Endothelial Cells.
Lethal infection of K18-hACE2 mice infected with severe acute respiratory syndrome coronavirus.
Leveraging coronavirus binding to gangliosides for innovative vaccine and therapeutic strategies against COVID-19.
Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions.
Low plasma angiotensin-converting enzyme 2 level in diabetics increases the risk of severe COVID-19 infection.
Lower Gene Expression of Angiotensin Converting Enzyme 2 Receptor in Lung Tissues of Smokers with COVID-19 Pneumonia.
Maternal endothelial dysfunction in HIV-associated preeclampsia comorbid with COVID-19: a review.
Mechanisms and evidence of vertical transmission of infections in pregnancy including SARS-CoV-2.
Mechanisms of host defense following severe acute respiratory syndrome-coronavirus (SARS-CoV) pulmonary infection of mice.
Mice transgenic for human angiotensin-converting enzyme 2 provide a model for SARS coronavirus infection.
Mice with induced pulmonary morbidities display severe lung inflammation and mortality following exposure to SARS-CoV-2.
MicroRNAs targeting the SARS-CoV-2 entry receptor ACE2 in cardiomyocytes.
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Infection Mediated by the Transmembrane Serine Protease TMPRSS2.
Mild SARS-CoV-2 infections in children might be based on evolutionary biology and linked with host reactive oxidative stress and antioxidant capabilities.
Molecular Insights into Human Transmembrane Protease Serine-2 (TMPS2) Inhibitors against SARS-CoV2: Homology Modelling, Molecular Dynamics, and Docking Studies.
Molecular PET/CT Profiling of ACE2 Expression In Vivo: Implications for Infection and Outcome from SARS-CoV-2.
Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling.
Mouse Model of SARS-CoV-2 Reveals Inflammatory Role of Type I Interferon Signaling.
Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling.
mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2.
Multidisciplinary Approaches Identify Compounds that Bind to Human ACE2 or SARS-CoV-2 Spike Protein as Candidates to Block SARS-CoV-2-ACE2 Receptor Interactions.
Multiple Expression Assessments of ACE2 and TMPRSS2 SARS-CoV-2 Entry Molecules in the Urinary Tract and Their Associations with Clinical Manifestations of COVID-19.
Murine-?-coronavirus-induced neuropathogenesis sheds light on CNS pathobiology of SARS-CoV2.
Mutational heterogeneity in spike glycoproteins of severe acute respiratory syndrome coronavirus 2.
Mutations derived from horseshoe bat ACE2 orthologs enhance ACE2-Fc neutralization of SARS-CoV-2.
Mutations from bat ACE2 orthologs markedly enhance ACE2-Fc neutralization of SARS-CoV-2.
MVA Vector Vaccines Inhibit SARS CoV-2 Replication in Upper and Lower Respiratory Tracts of Transgenic Mice and Prevent Lethal Disease.
Neurovirulent Murine Coronavirus JHM.SD Uses Cellular Zinc Metalloproteases for Virus Entry and Cell-Cell Fusion.
Neutralizing activity of Sputnik V vaccine sera against SARS-CoV-2 variants.
Neutralizing antibodies for the prevention and treatment of COVID-19.
Non-RBM Mutations Impaired SARS-CoV-2 Spike Protein Regulated to the ACE2 Receptor Based on Molecular Dynamic Simulation.
Non-steroidal anti-inflammatory drugs dampen the cytokine and antibody response to SARS-CoV-2 infection.
Obesity and Outcomes in COVID-19: When an Epidemic and Pandemic Collide.
Ocular pathology and occasionally detectable intraocular SARS-CoV-2 RNA in five fatal COVID-19 cases.
Ogilvie Syndrome and COVID-19 Infection.
One or two injections of MVA-vectored vaccine shields hACE2 transgenic mice from SARS-CoV-2 upper and lower respiratory tract infection.
Opposing activities of IFITM proteins in SARS-CoV-2 infection.
Optimized pseudotyping conditions for the SARS COV-2 Spike glycoprotein.
Oral antiseptics against coronavirus: in-vitro and clinical evidence.
Overexpression of the Severe Acute Respiratory Syndrome Coronavirus-2 Receptor, Angiotensin-Converting Enzyme 2, in Diabetic Kidney Disease: Implications for Kidney Injury in Novel Coronavirus Disease 2019.
Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2.
Pathology and pathogenesis of severe acute respiratory syndrome.
Pathology of experimental SARS coronavirus infection in cats and ferrets.
Peptide Platform as a Powerful Tool in the Fight against COVID-19.
Pernio (Chilblains), SARS-CoV-2, and COVID Toes Unified Through Cutaneous and Systemic Mechanisms.
Persistent infection of SARS coronavirus in colonic cells in vitro.
Perspective: the nose and the stomach play a critical role in the NZACE2-P?tari* (modified ACE2) drug treatment project of SARS-CoV-2 infection.
Phytopharmaceuticals mediated Furin and TMPRSS2 receptor blocking: can it be a potential therapeutic option for Covid-19?
Plasma ACE2 predicts outcome of COVID-19 in hospitalized patients.
Plasma ACE2 species are differentially altered in COVID-19 patients.
PM2.5, NO2, wildfires, and other environmental exposures are linked to higher Covid 19 incidence, severity, and death rates.
Potential chimeric peptides to block the SARS-CoV-2 spike receptor-binding domain.
Potential inhibitors of angiotensin converting enzyme 2 receptor of COVID-19 by Corchorus olitorius Linn using docking, molecular dynamics, conceptual DFT investigation and pharmacophore mapping.
Potential mechanisms of cerebrovascular diseases in COVID-19 patients.
Potential mechanisms of hemorrhagic stroke in elderly COVID-19 patients.
Potential pathophysiological mechanisms leading to increased COVID-19 susceptibility and severity in obesity.
Potential repurposing of the HDAC inhibitor valproic acid for patients with COVID-19.
Predicting susceptibility to SARS-CoV-2 infection based on structural differences in ACE2 across species.
Prediction and mitigation of mutation threats to COVID-19 vaccines and antibody therapies.
Protein Footprinting, Conformational Dynamics, and Core Interface-Adjacent Neutralization "Hotspots" in the SARS-CoV-2 Spike Protein Receptor Binding Domain/Human ACE2 Interaction.
Proteolytic activation of the 1918 influenza virus hemagglutinin.
Q493K and Q498H substitutions in Spike promote adaptation of SARS-CoV-2 in mice.
RAAS, ACE2 and COVID-19; a mechanistic review.
Rapid generation of circulating and mucosal decoy ACE2 using mRNA nanotherapeutics for the potential treatment of SARS-CoV-2.
Rapid single cell evaluation of human disease and disorder targets using REVEAL: SingleCell™.
Reconstitution of the receptor-binding motif of the SARS coronavirus.
Relative Abundance of SARS-CoV-2 Entry Genes in the Enterocytes of the Lower Gastrointestinal Tract.
Renal Injury by SARS-CoV-2 Infection: A Systematic Review.
Renin-angiotensin system blockers and severe acute respiratory syndrome coronavirus 2.
Revealing the mechanism of SARS-CoV-2 spike protein binding with ACE2.
Role of ACE2 polymorphism in COVID-19: impact of age.
Role of angiotensin-converting enzyme 2 and pericytes in cardiac complications of COVID-19 infection.
Role of indoor aerosols for COVID-19 viral transmission: a review.
Role of Structural and Non-Structural Proteins and Therapeutic Targets of SARS-CoV-2 for COVID-19.
Roles of steroid receptors in the lung and COVID-19.
S19W, T27W, and N330Y mutations in ACE2 enhance SARS-CoV-2 S-RBD binding toward both wild-type and antibody-resistant viruses and its molecular basis.
SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo.
SARS-CoV-2 infection: physiological and environmental gift factors at high altitude.
SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes.
SARS-CoV-2 Innate Effector Associations and Viral Load in Early Nasopharyngeal Infection.
SARS-CoV-2 innate effector associations and viral load in early nasopharyngeal infection.
SARS-CoV-2 presence in seminal fluid: Myth or reality.
SARS-CoV-2 spike promotes inflammation and apoptosis through autophagy by ROS-suppressed PI3K/AKT/mTOR signaling.
Sars-CoV-2: A clinical update - II.
SARS-CoV-2 cell receptor gene ACE2 -mediated immunomodulation in breast cancer subtypes.
SARS-CoV2 infectivity is potentially modulated by host redox status.
Scientific Hypothesis for Treatment of COVID-19's Lung Lesions by Adjusting ACE/ACE2 Imbalance.
Screening strategy of TMPRSS2 inhibitors by FRET-based enzymatic activity for TMPRSS2-based cancer and COVID-19 treatment.
Serine 477 plays a crucial role in the interaction of the SARS-CoV-2 spike protein with the human receptor ACE2.
Severe acute respiratory syndrome coronavirus 2 infection, angiotensin-converting enzyme 2 and treatment with angiotensin-converting enzyme inhibitors or angiotensin II type 1 receptor blockers.
Severe acute respiratory syndrome coronavirus infection of human ciliated airway epithelia: role of ciliated cells in viral spread in the conducting airways of the lungs.
Severe Acute Respiratory Syndrome Coronavirus Replication Is Severely Impaired by MG132 due to Proteasome-Independent Inhibition of M-Calpain.
Severe acute respiratory syndrome coronavirus-2 and the deduction effect of angiotensin-converting enzyme 2 in pregnancy.
Simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry.
Single cell resolution of SARS-CoV-2 tropism, antiviral responses, and susceptibility to therapies in primary human airway epithelium.
Single Cell RNA-seq Data Analysis Reveals the Potential Risk of SARS-CoV-2 Infection Among Different Respiratory System Conditions.
Single-cell expression profiles of ACE2 and TMPRSS2 reveals potential vertical transmission and fetus infection of SARS-CoV-2.
Single-cell RNA expression profiling of ACE2 and TMPRSS2 in the human trophectoderm and placenta.
Single-cell RNA sequencing of SARS-CoV-2 cell entry factors in the preconceptional human endometrium.
Site-specific characterisation of SARS-CoV-2 spike glycoprotein receptor binding domain.
Small molecule therapeutics to destabilize the ACE2-RBD complex: A molecular dynamics study.
Small Molecules to Destabilize the ACE2-RBD Complex: A Molecular Dynamics Study for Potential COVID-19 Therapeutics.
Soluble ACE2 as a potential therapy for COVID-19.
Spike Proteins of SARS-CoV and SARS-CoV-2 Utilize Different Mechanisms to Bind With Human ACE2.
Stapled Peptides Based on Human Angiotensin-Converting Enzyme 2 (ACE2) Potently Inhibit SARS-CoV-2 Infection In Vitro.
Stroke in patients infected by the novel coronavirus and its causal mechanisms: A narrative review.
Structural analysis of major species barriers between humans and palm civets for severe acute respiratory syndrome coronavirus infections.
Structural and simulation analysis of hotspot residues interactions of SARS-CoV 2 with human ACE2 receptor.
Structural Basis for the Understanding of Entry Inhibitors Against SARS Viruses.
Structural basis of severe acute respiratory syndrome coronavirus 2 infection.
Structural Behavior of Monomer of SARS-CoV-2 Spike Protein during Initial Stage of Adsorption on Graphene.
Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia.
Structure-based phylogeny identifies avoralstat as a TMPRSS2 inhibitor that prevents SARS-CoV-2 infection in mice.
SUMO pathway, blood coagulation and oxidative stress in SARS-CoV-2 infection.
Susceptibility Factors of Stomach for SARS-CoV-2 and Treatment Implication of Mucosal Protective Agent in COVID-19.
Susceptibility of different eukaryotic cell lines to SARS-coronavirus.
Susceptibility of livestock and companion animals to COVID-19.
Susceptibility of white-tailed deer (Odocoileus virginianus) to SARS-CoV-2.
Susceptibility to COVID-19 in populations with health disparities: Posited involvement of mitochondrial disorder, socioeconomic stress, and pollutants.
Susceptibility to SARS coronavirus S protein-driven infection correlates with expression of angiotensin converting enzyme 2 and infection can be blocked by soluble receptor.
Susceptibility to SARS-CoV-2 of Cell Lines and Substrates Commonly Used to Diagnose and Isolate Influenza and Other Viruses.
Sustained decrease in pediatric asthma emergency visits during the first year of the COVID-19 pandemic.
Synergistic block of SARS-CoV-2 infection by combined drug inhibition of the host entry factors PIKfyve kinase and TMPRSS2 protease.
Tackling Covid-19 using disordered-to-order transition of residues in the spike protein upon angiotensin-converting enzyme 2 binding.
Targeting ACE2 for COVID-19 Therapy: Opportunities and Challenges.
Targeting Crucial Host Factors of SARS-CoV-2.
Targeting host cell proteases to prevent SARS-CoV-2 invasion.
Targeting SARS-CoV-2 spike protein by stapled hACE2 peptides.
Testing of natural products in clinical trials targeting the SARS-CoV-2 (Covid-19) viral spike protein-angiotensin converting enzyme-2 (ACE2) interaction.
Tetracycline as an inhibitor to the SARS-CoV-2.
The age-dependent decline of the extracellular thiol-disulfide balance and its role in SARS-CoV-2 infection.
The Benefits of Vitamin D Supplementation for Athletes: Better Performance and Reduced Risk of COVID-19.
The big challenge of SARS-CoV-2 latency: testes as reservoir.
The cardiovascular aspect of COVID-19.
The Cellular basis of the loss of smell in 2019-nCoV-infected individuals.
The COVID-19 Pandemic: A Global Health Crisis.
The Dynamic Expression of Potential Mediators of Severe Acute Respiratory Syndrome Coronavirus 2 Cellular Entry in Fetal, Neonatal, and Adult Rhesus Monkeys.
The Effects of COVID-19 on Placenta and Pregnancy: What Do We Know So Far?
The emergence of human coronavirus EMC: how scared should we be?
The Expression and Polymorphism of Entry Machinery for COVID-19 in Human: Juxtaposing Population Groups, Gender, and Different Tissues.
The expression of hACE2 receptor protein and its involvement in SARS-CoV-2 entry, pathogenesis, and its application as potential therapeutic target.
The Fight against COVID-19 on the Multi-Protease Front and Surroundings: Could an Early Therapeutic Approach with Repositioning Drugs Prevent the Disease Severity?
The gut microbiome: an under-recognised contributor to the COVID-19 pandemic?
The host protease TMPRSS2 plays a major role for in vivo replication of emerging H7N9 and seasonal influenza viruses.
The Impact of Angiotensin-Converting Enzyme 2 (ACE2) Expression on the Incidence and Severity of COVID-19 Infection.
The impact of spike mutated variants of SARS-CoV2 [Alpha, Beta, Gamma, Delta, and Lambda] on the efficacy of subunit recombinant vaccines.
The Ineluctable Role of ACE-2 Receptors in SARS COV-2 Infection and Drug Repurposing as a Plausible SARS COV-2 Therapy : A Concise Treatise.
The mechanistic overview of SARS-CoV-2 using angiotensin-converting enzyme 2 to enter the cell for replication: possible treatment options related to the renin-angiotensin system.
The Microvillar and Solitary Chemosensory Cells as the Novel Targets of Infection of SARS-CoV-2 in Syrian Golden Hamsters.
The ocular surface, coronaviruses and COVID-19.
The proteolytic activation of A (H3N2) Influenza virus hemagglutinin is facilitated by different type II transmembrane serine proteases.
The rapid diagnosis and effective inhibition of coronavirus using spike antibody attached gold nanoparticles.
The renin-angiotensin system and specifically angiotensin-converting enzyme 2 as a potential therapeutic target in SARS-CoV-2 infections.
The Renin-Angiotensin-Aldosterone System and Coronavirus Disease 2019.
The Role of Angiotensin Converting Enzyme 2 in Modulating Gut Microbiota, Intestinal Inflammation, and Coronavirus Infection.
The role of angiotensin-converting enzyme 2 in coronaviruses/influenza viruses and cardiovascular disease.
The role of angiotensin-converting enzyme 2 in the pathogenesis of COVID-19: the villain or the hero?
The roles of nausea and vomiting in COVID-19: did we miss something?
The roles of vitamin D in increasing the body's immunity and reducing injuries due to viral infections: With an emphasis on its possible role in SARS-CoV-2 (COVID-19).
The SARS-CoV-2 receptor ACE2 expression of maternal-fetal interface and fetal organs by single-cell transcriptome study.
The secret identities of TMPRSS2: Fertility factor, virus trafficker, inflammation moderator, prostate protector and tumor suppressor.
The spike-protein of the emerging betacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2 and is targeted by neutralizing antibodies.
The tetraspanin CD9 facilitates MERS-coronavirus entry by scaffolding host cell receptors and proteases.
The TMPRSS2 Inhibitor Nafamostat Reduces SARS-CoV-2 Pulmonary Infection in Mouse Models of COVID-19.
The Two Faces of ACE2: The Role of ACE2 Receptor and Its Polymorphisms in Hypertension and COVID-19.
The use of negative oxygen ion clusters [O2-(H2O)n] and bicarbonate ions [HCO3-] as the supportive treatment of COVID-19 infections: A possibility.
Tissue-specific expression of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2, in mouse models of chronic kidney disease.
TMPRSS2 activates hemagglutinin-esterase glycoprotein of influenza C virus.
TMPRSS2 activates the human coronavirus 229E for cathepsin-independent host cell entry and is expressed in viral target cells in the respiratory epithelium.
TMPRSS2 and ACE2 Coexpression in SARS-CoV-2 Salivary Glands Infection.
TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention?
TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection.
TMPRSS2 Correlated With Immune Infiltration Serves as a Prognostic Biomarker in Prostatic Adenocarcinoma: Implication for the COVID-2019.
TMPRSS2 expression dictates the entry route used by SARS-CoV-2 to infect host cells.
Tmprss2 is essential for influenza H1N1 virus pathogenesis in mice.
Tmprss2 specific miRNAs as promising regulators for SARS-CoV-2 entry checkpoint.
Transmembrane serine protease TMPRSS2 activates hepatitis C virus infection.
TWIRLS, a knowledge-mining technology, suggests a possible mechanism for the pathological changes in the human host after coronavirus infection via ACE2.
Type-2 diabetes, a co-morbidity in Covid-19: does insulin signaling matter?
Underlying Mechanisms and Candidate Drugs for COVID-19 Based on the Connectivity Map Database.
Unveiling COVID-19-associated organ-specific cell types and cell-specific pathway cascade.
Update on SARS-CoV-2 infection in children.
Use of pioglitazone in people with type 2 diabetes mellitus with coronavirus disease 2019 (COVID-19): Boon or bane?
Variants in ACE2 and TMPRSS2 Genes Are Not Major Determinants of COVID-19 Severity in UK Biobank Subjects.
Viral, host and environmental factors that favor anthropozoonotic spillover of coronaviruses: An opinionated review, focusing on SARS-CoV, MERS-CoV and SARS-CoV-2.
What Is the Role of Angiotensin-Converting Enzyme 2 (ACE2) in COVID-19 Infection in Hypertensive Patients With Diabetes?
What is the significance of the conjunctiva as a potential transmission route for SARS-CoV-2 infections?
What solid organ transplant healthcare providers should know about renin-angiotensin-aldosterone system inhibitors and COVID-19.
Which animals are at risk? Predicting species susceptibility to Covid-19.
Zinc supplementation augments the suppressive effects of repurposed NF-?B inhibitors on ACE2 expression in human lung cell lines.
[A review on the role of angiotensin-converting enzyme 2 in children with coronavirus disease 2019].
[A special on epidemic prevention and control: analysis on expression of 2019-nCoV related ACE2 and TMPRSS2 in eye tissues].
[Association of age distribution with the expression of angiotensin-converting enzyme 2 in lung tissues in severe acute respiratory syndrome coronavirus 2 infection: reflections from the study of RAS pathway expression in mice].
[Association of hypertension and antihypertensive agents and the severity of COVID-19 pneumonia. A monocentric French prospective study].
[Can SARS-CoV-2 infect the eye?-An overview of the receptor status in ocular tissue].
[RISK ASSESSMENT FOR AEROSOL INFECTION BY THE NEW CORONA VIRUS AND PROTECTION BY RESPIRATORS].
[What is the importance of the conjunctiva as a potential transmission pathway for SARS-CoV-2 infections?]
Infertility
Histopathology and Ultrastructural Findings of Fatal COVID-19 Infections on Testis.
Understanding the cross-talk between mediators of infertility and COVID-19.
Infertility, Male
In Silico Identification of miRNA-lncRNA Interactions in Male Reproductive Disorder Associated with COVID-19 Infection.
Testis and blood-testis barrier in Covid-19 infestation: role of angiotensin-converting enzyme 2 in male infertility.
Inflammatory Bowel Diseases
A Network Medicine Approach to Investigation and Population-based Validation of Disease Manifestations and Drug Repurposing for COVID-19.
A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19.
Age, Inflammation, and Disease Location Are Critical Determinants of Intestinal Expression of SARS-CoV-2 Receptor ACE2 and TMPRSS2 in Inflammatory Bowel Disease.
Anti-Inflammatory Action of Angiotensin 1-7 in Experimental Colitis.
Benign Evolution of SARS-Cov2 Infections in Children With Inflammatory Bowel Disease: Results From Two International Databases.
TNF?-antagonist use and mucosal inflammation are associated with increased intestinal expression of SARS-CoV-2 host protease TMPRSS2 in patients with inflammatory bowel disease.
Influenza in Birds
Angiotensin-converting enzyme 2 protects from lethal avian influenza A H5N1 infections.
Crystal structure of inhibitor-bound human MSPL that can activate high pathogenic avian influenza.
Hemagglutinins of avian influenza viruses are proteolytically activated by TMPRSS2 in human and murine airway cells.
Influenza, Human
A Case-Control Study of the 2019 Influenza Vaccine and Incidence of COVID-19 Among Healthcare Workers.
A Mutant H3N2 Influenza Virus Uses an Alternative Activation Mechanism in TMPRSS2 Knockout Mice by Loss of an Oligosaccharide in the Hemagglutinin Stalk Region.
Activation of influenza A viruses by host proteases from swine airway epithelium.
Activation of influenza viruses by proteases from host cells and bacteria in the human airway epithelium.
Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury.
Camostat mesylate against SARS-CoV-2 and COVID-19-Rationale, dosing and safety.
Cleavage of influenza virus hemagglutinin by airway proteases TMPRSS2 and HAT differs in subcellular localization and susceptibility to protease inhibitors.
Comparative Study of SARS-CoV-2, SARS-CoV-1, MERS-CoV, HCoV-229E and Influenza Host Gene Expression in Asthma: Importance of Sex, Disease Severity, and Epithelial Heterogeneity.
Computational drug repurposing strategy predicted peptide-based drugs that can potentially inhibit the interaction of SARS-CoV-2 spike protein with its target (humanACE2).
Coupled CRC 2D and ALI 3D Cultures Express Receptors of Emerging Viruses and Are More Suitable for the Study of Viral Infections Compared to Conventional Cell Lines.
Defensin 5 for prevention of SARS-CoV-2 invasion and Covid-19 disease.
DESC1 and MSPL activate influenza A viruses and emerging coronaviruses for host cell entry.
Downregulation of angiotensin-converting enzyme 2 by the neuraminidase protein of influenza A (H1N1) virus.
Efficient activation of SARS coronavirus spike protein by the transmembrane protease, TMPRSS2.
Establishment of MDCK Stable Cell Lines Expressing TMPRSS2 and MSPL and Their Applications in Propagating Influenza Vaccine Viruses in Absence of Exogenous Trypsin.
Evidence that TMPRSS2 activates the SARS-coronavirus spike-protein for membrane fusion and reduces viral control by the humoral immune response.
Exchange of amino acids in the H1-haemagglutinin to H3 residues is required for efficient influenza A virus replication and pathology in Tmprss2 knock-out mice.
H2 influenza A virus is not pathogenic in Tmprss2 knock-out mice.
Hemagglutinin activating host cell proteases provide promising drug targets for the treatment of influenza A and B virus infections.
Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation.
Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza.
In vitro characterization of TMPRSS2 inhibition in IPEC-J2 cells.
Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts.
Inhibition of Influenza A virus propagation by benzoselenoxanthenes stabilizing TMPRSS2 Gene G-quadruplex and hence down-regulating TMPRSS2 expression.
Inhibition of influenza virus infection in human airway cell cultures by an antisense peptide-conjugated morpholino oligomer targeting the hemagglutinin-activating protease TMPRSS2.
Innate Immune Signaling and Proteolytic Pathways in the Resolution or Exacerbation of SARS-CoV-2 in Covid-19: Key Therapeutic Targets?
Matriptase proteolytically activates influenza virus and promotes multicycle replication in the human airway epithelium.
Matriptase, HAT, and TMPRSS2 activate the hemagglutinin of H9N2 influenza A viruses.
MDCK cells that express proteases TMPRSS2 and HAT provide a cell system to propagate influenza viruses in the absence of trypsin and to study cleavage of HA and its inhibition.
Non-human primate orthologues of TMPRSS2 cleave and activate the influenza virus hemagglutinin.
Novel insights into proteolytic cleavage of influenza virus hemagglutinin.
Prostate adenocarcinoma and COVID-19: The possible impacts of TMPRSS2 expressions in susceptibility to SARS-CoV-2.
Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium.
Proteolytic activation of the 1918 influenza virus hemagglutinin.
SPINT2 inhibits proteases involved in activation of both influenza viruses and metapneumoviruses.
The Hemagglutinin of Bat-Associated Influenza Viruses Is Activated by TMPRSS2 for pH-Dependent Entry into Bat but Not Human Cells.
The host protease TMPRSS2 plays a major role for in vivo replication of emerging H7N9 and seasonal influenza viruses.
The human Transmembrane Protease Serine 2 is necessary for the production of Group 2 influenza A virus pseudotypes.
The proteolytic activation of A (H3N2) Influenza virus hemagglutinin is facilitated by different type II transmembrane serine proteases.
The role of angiotensin-converting enzyme 2 in coronaviruses/influenza viruses and cardiovascular disease.
TMPRSS2 activates hemagglutinin-esterase glycoprotein of influenza C virus.
TMPRSS2 and TMPRSS4 facilitate trypsin-independent spread of influenza virus in Caco-2 cells.
TMPRSS2 Independency for Haemagglutinin Cleavage In Vivo Differentiates Influenza B Virus from Influenza A Virus.
TMPRSS2 Is a Host Factor That Is Essential for Pneumotropism and Pathogenicity of H7N9 Influenza A Virus in Mice.
Tmprss2 is essential for influenza H1N1 virus pathogenesis in mice.
TMPRSS2 is the major activating protease of influenza A virus in primary human airway cells and influenza B virus in human type II pneumocytes.
TMPRSS2 Isoform 1 Activates Respiratory Viruses and Is Expressed in Viral Target Cells.
Tmprss2 knock-out mice are resistant to H10 influenza A virus pathogenesis.
TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections.
Transmembrane serine protease 2 Polymorphisms and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Type 2 Infection: A German Case-Control Study.
Viral Pandemics of the Last Four Decades: Pathophysiology, Health Impacts and Perspectives.
[Protease-dependent virus tropism and pathogenicity: The role for TMPRSS2].
Insulin Resistance
Angiotensin Converting Enzyme 2 Activator DIZE Modulates Metabolic Profile in Mice Decreasing Lipogenesis.
Ginsenoside Rc Ameliorates Endothelial Insulin Resistance via Upregulation of Angiotensin-Converting Enzyme 2.
Loss of ACE 2 Exaggerates High-Calorie Diet-Induced Insulin Resistance by Reduction of GLUT4 in Mice.
Metabolic impact of weight loss induced reduction of adipose ACE-2 - Potential implication in COVID-19 infections?
The Efficacy and Potential Mechanisms of Metformin in the Treatment of COVID-19 in the Diabetics: A Systematic Review.
Ischemic Stroke
Activation of the Neuroprotective Angiotensin-Converting Enzyme 2 in Rat Ischemic Stroke.
Centrally administered angiotensin-(1-7) increases the survival of stroke-prone spontaneously hypertensive rats.
Human placenta mesenchymal stem cell protection in ischemic stroke is angiotensin converting enzyme-2 and masR receptor-dependent.
Serum activity of angiotensin converting enzyme 2 is decreased in patients with acute ischemic stroke.
[Correlation of angiotensin-converting enzyme 2 gene polymorphisms to essential hypertension and ischemic stroke.]
Keratoconus
EyeDiseases: an integrated resource for dedicating to genetic variants, gene expression and epigenetic factors of human eye diseases.
Keratosis, Actinic
ACE and ACE2 expression in normal and malignant skin lesions.
Kidney Diseases
A Dual-Route Perspective of SARS-CoV-2 Infection: Lung- vs. Gut-specific Effects of ACE-2 Deficiency.
ACE2 as therapy for glomerular disease: the devil is in the detail.
Angiotensin-converting enzyme 2 and kidney diseases in the era of coronavirus disease 2019.
Angiotensin-converting enzyme 2: implications for blood pressure and kidney disease.
Angiotensin-converting enzyme 2: possible role in hypertension and kidney disease.
Circulating plasma angiotensin-converting enzyme 2 concentration is elevated in patients with kidney disease and diabetes.
Circulating plasma angiotensin-converting enzyme 2 concentrations in patients with kidney disease.
New aspects of the renin-angiotensin system: angiotensin-converting enzyme 2 - a potential target for treatment of hypertension and diabetic nephropathy.
Sex and kidney ACE2 expression in primary focal segmental glomerulosclerosis: A NEPTUNE study.
Kidney Failure, Chronic
Neuronal nitric oxide synthase and sympathetic nerve activity in neurovascular and metabolic systems.
Kidney Neoplasms
Downregulation of ACE2 expression by SARS-CoV-2 worsens the prognosis of KIRC and KIRP patients via metabolism and immunoregulation.
Leiomyoma
Angiotensin-converting enzyme 2, the SARS-CoV-2 cellular receptor, is widely expressed in human myometrium and uterine leiomyoma.
Leukemia
A meta-analysis of comorbidities in COVID-19: Which diseases increase the susceptibility of SARS-CoV-2 infection?
Liver Cirrhosis
ACE2 Therapy Using Adeno-associated Viral Vector Inhibits Liver Fibrosis in Mice.
Expression of angiotensin-converting enzyme 2 in CCL4-induced rat liver fibrosis.
Impact of hepatic immunoreactivity of angiotensin-converting enzyme 2 on liver fibrosis due to non-alcoholic steatohepatitis.
The small molecule drug diminazene aceturate inhibits liver injury and biliary fibrosis in mice.
[Expression and correlation of angiotensin-converting enzyme 2 in CCl4-induced rat liver fibrosis].
Liver Diseases
Angiotensin-converting enzyme 2 inhibits endoplasmic reticulum stress-associated pathway to preserve nonalcoholic fatty liver disease.
Angiotensin-converting enzyme 2 receptors, chronic liver diseases, common medications, and clinical outcomes in coronavirus disease 2019 patients.
Hepatic complications of COVID-19 and its treatment.
Hepatic Fibrosis and the Renin-Angiotensin System.
Single-Cell RNA-seq Reveals Angiotensin-Converting Enzyme 2 and Transmembrane Serine Protease 2 Expression in TROP2+ Liver Progenitor Cells: Implications in Coronavirus Disease 2019-Associated Liver Dysfunction.
Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) levels in experimental biliary fibrosis.
Lung Diseases
Alternative Roles of STAT3 and MAPK Signaling Pathways in the MMPs Activation and Progression of Lung Injury Induced by Cigarette Smoke Exposure in ACE2 Knockout Mice.
Angiotensin-Converting Enzyme 2 (ACE2) as a Potential Diagnostic and Prognostic Biomarker for Chronic Inflammatory Lung Diseases.
Angiotensin-converting enzyme 2 (ACE2) haplotypes are associated with pulmonary disease phenotypes in sarcoidosis patients.
Angiotensin-converting enzyme 2 in lung diseases.
Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg9 bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration.
Diminazene attenuates pulmonary hypertension and improves angiogenic progenitor cell functions in experimental models.
Evidence for Angiotensin Converting Enzyme 2 as a Therapeutic Target for the Prevention of Pulmonary Hypertension.
Hyperoxia Downregulates Angiotensin Converting Enzyme-2 (ACE-2) in Human Fetal Lung Fibroblasts.
Influenza virus infection increases ACE2 expression and shedding in human small airway epithelial cells.
Instigators of COVID-19 in Immune Cells are Increased in Tobacco Cigarette Smokers and Electronic Cigarette Vapers Compared to Non-smokers.
Pulmonary Angiotensin-Converting Enzyme 2 (ACE2) and Inflammatory Lung Disease.
Roles of the Angiotensin System in Neonatal Lung Injury and Disease.
SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo.
Temporal changes in soluble angiotensin-converting enzyme 2 associated with metabolic health, body composition, and proteome dynamics during a weight loss diet intervention: a randomized trial with implications for the COVID-19 pandemic.
Lung Diseases, Interstitial
A Mouse Model of SARS-CoV-2 Infection and Pathogenesis.
Lung Injury
A brief review of interplay between vitamin D and angiotensin-converting enzyme 2: Implications for a potential treatment for COVID-19.
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury.
A multi-center phase II randomized clinical trial of losartan on symptomatic outpatients with COVID-19.
Angiotensin converting enzyme 2 abrogates bleomycin-induced lung injury.
Angiotensin converting enzyme-2 as therapeutic target in COVID-19.
Angiotensin II type-1 receptor A1166C polymorphism is associated with increased risk of ischemic stroke in hypertensive smokers.
Angiotensin-Converting Enzyme 2 Attenuates Bleomycin-Induced Lung Fibrosis in Mice.
Angiotensin-converting enzyme 2 attenuates inflammatory response and oxidative stress in hyperoxic lung injury by regulating NF-?B and Nrf2 pathways.
Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus.
Angiotensin-Converting Enzyme Gene Polymorphism and Severe Lung Injury in Patients with Coronavirus Disease 2019.
Angiotensin-converting enzyme inhibition attenuates lipopolysaccharide-induced lung injury by regulating the balance between Angiotensin-converting enzyme and Angiotensin-converting enzyme 2 and inhibiting mitogen-activated protein kinase activation.
COVID-19 and Renal Diseases: An Update.
Diabetes and COVID-19: evidence, current status and unanswered research questions.
LPS-Stimulated Cytokine Production in Type I Cells is Modulated by the Renin-Angiotensin System.
Mesenchymal Stem Cells Overexpressing Angiotensin-Converting Enzyme 2 Rescue Lipopolysaccharide-Induced Lung Injury.
Perspective: Vitamin D deficiency and COVID-19 severity - plausibly linked by latitude, ethnicity, impacts on cytokines, ACE2 and thrombosis.
Prediction of repurposed drugs for treating lung injury in COVID-19.
Recombinant angiotensin-converting enzyme 2 improves pulmonary blood flow and oxygenation in lipopolysaccharide-induced lung injury in piglets.
Roles of the Angiotensin System in Neonatal Lung Injury and Disease.
Soluble Angiotensin Converting Enzyme 2 (ACE2) Is Upregulated and Soluble Endothelial Nitric Oxide Synthase (eNOS) Is Downregulated in COVID-19-induced Acute Respiratory Distress Syndrome (ARDS).
The role of angiotensin-converting enzyme 2 in COVID-19 induced lung injury.
The role of Interleukin-4 in COVID-19 associated male infertility - A hypothesis.
[Protective Effect of Angiotensin Converting Enzyme 2 (ACE2) Against Chronic Intermittent Hypoxia-induced Pulmonary Oxidative Stress Injury in Rats].
Lung Neoplasms
A meta-analysis of comorbidities in COVID-19: Which diseases increase the susceptibility of SARS-CoV-2 infection?
ACE2 inhibits breast cancer angiogenesis via suppressing the VEGFa/VEGFR2/ERK pathway.
ACE2: At the crossroad of COVID-19 and lung cancer.
Angiotensin-converting enzyme 2 attenuates the metastasis of non-small cell lung cancer through inhibition of epithelial-mesenchymal transition.
Association between Serum Angiotensin-converting Enzyme 2 Level with Postoperative Morbidity and Mortality after Major Pulmonary Resection in Non-small Cell Lung Cancer Patients.
Association of Cigarette Smoking, COPD, and Lung Cancer With Expression of SARS-CoV-2 Entry Genes in Human Airway Epithelial Cells.
Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19.
Epithelial-mesenchymal transition induced by SARS-CoV-2 required transcriptional upregulation of Snail.
Evaluation of the susceptibility and fatality of lung cancer patients towards the COVID-19 infection: A systemic approach through analyzing the ACE2, CXCL10 and their co-expressed genes.
High Expression of ACE2 and TMPRSS2 at the Resection Margin Makes Lung Cancer Survivors Susceptible to SARS-CoV-2 With Unfavorable Prognosis.
Identification of angiotensin-converting enzyme 2 (ACE2) protein as the potential biomarker in SARS-CoV-2 infection-related lung cancer using computational analysis.
Identification of Novel MicroRNAs Targeting SARS-CoV-2 through the Regulation of TMPRSS2/PI3K/AKT/PTEN Alignment in Lung Cancer: An in Silico Analysis.
In silico analysis identifies neuropilin-1 as a potential therapeutic target for SARS-Cov-2 infected lung cancer patients.
SARS-CoV-2 Infection and Lung Cancer: Potential Therapeutic Modalities.
Single Cell RNA-seq Data Analysis Reveals the Potential Risk of SARS-CoV-2 Infection Among Different Respiratory System Conditions.
The angiotensin-converting enzyme 2 in tumor growth and tumor-associated angiogenesis in non-small cell lung cancer.
TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients.
Lymphatic Metastasis
TMPRSS2:ERG Fusion-Associated Deletions Provide Insight into the Heterogeneity of Prostate Cancer.
Lymphoma, B-Cell
Protective effect of recombinant Lactobacillus plantarum against H2O2-induced oxidative stress in HUVEC cells.
Malaria
Implications of COVID-19 Pandemic on Evolution of Diabetes in Malaria-Endemic African Region.
Malnutrition
Protein Malnutrition Alters Tryptophan and Angiotensin-Converting Enzyme 2 Homeostasis and Adaptive Immune Responses in Human Rotavirus-Infected Gnotobiotic Pigs with Human Infant Fecal Microbiota Transplant.
Meconium Aspiration Syndrome
Degradation of Lung Protective Angiotensin Converting Enzyme-2 by Meconium in Human Alveolar Epithelial Cells: A Potential Pathogenic Mechanism in Meconium Aspiration Syndrome.
Melanoma
Expression of innate immune response genes in upper airway samples of SARS-CoV-2 infected patients: A preliminary study.
Expression of the COVID-19 receptor ACE2 in the human conjunctiva.
Methylation Changes of Primary Tumors, Monolayer, and Spheroid Tissue Culture Environments in Malignant Melanoma and Breast Carcinoma.
Meningomyelocele
Study of serum and urinary markers of the renin-angiotensin-aldosterone system in myelomeningocele patients with renal injury detected by DMSA.
Mesenteric Ischemia
Acute mesenteric ischemia and small bowel imaging findings in COVID-19: A comprehensive review of the literature.
Metabolic Diseases
Angiotensin 1-7: A peptide for preventing and treating metabolic syndrome.
Metabolic Syndrome
Association of angiotensin-converting enzyme 2 gene A/G polymorphism and elevated blood pressure in Chinese patients with metabolic syndrome.
[Effect of Astragali Radix in improving early renal damage in metabolic syndrome rats through ACE2/Mas pathway].
Migraine Disorders
Are Migraine Patients at Increased Risk for Symptomatic Coronavirus Disease 2019 Due to Shared Comorbidities?
Movement Disorders
De Novo Movement Disorders and COVID-19: Exploring the Interface.
Mucocutaneous Lymph Node Syndrome
Human and novel coronavirus infections in children: a review.
Is multisystem inflammatory syndrome related with coronavirus disease 2019, Kawasaki disease, and angiotensin-converting enzyme 2 in children?
Update on SARS-CoV-2 infection in children.
Multiple Sclerosis
ACE2, TMPRSS2, and Furin variants and SARS-CoV-2 infection in Madrid, Spain.
Muscle Weakness
Angiotensin-converting enzyme 2 deficiency accelerates and angiotensin 1-7 restores age-related muscle weakness in mice.
Different effects of the deletion of angiotensin converting enzyme 2 and chronic activation of the renin-angiotensin system on muscle weakness in middle-aged mice.
Myalgia
Sars-CoV-2: A clinical update - II.
Myocardial Infarction
ACE2 Overexpression Improves Left Ventricular Remodeling and Function in Rats with Myocardial Infarction.
Arg972 Insulin receptor substrate-1 is associated with decreased serum angiotensin-converting enzyme 2 levels in acute myocardial infarction patients: in vivo and in vitro evidence.
Association between serum angiotensin-converting enzyme 2 levels and postoperative myocardial infarction following coronary artery bypass grafting.
Cardiovascular Complications Associated with COVID-19 and Potential Therapeutic~Strategies.
Clinically Suspected Myocarditis in the Course of Severe Acute Respiratory Syndrome Novel Coronavirus-2 Infection: Fact or Fiction?
Combination renin-angiotensin system blockade and angiotensin-converting enzyme 2 in experimental myocardial infarction: implications for future therapeutic directions.
Differences in the expression of the renin angiotensin system and the kallikrein-kinin system during the course of myocardial infarction in male and female Wistar rats.
Diminazene aceturate enhances Angiotensin-converting enzyme 2 activity and attenuates ischemia-induced cardiac pathophysiology.
Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction.
N-Terminal Pro-Brain Natriuretic Peptide and Angiotensin-Converting Enzyme-2 Levels and Their Association With Postoperative Cardiac Complications After Emergency Orthopedic Surgery.
Postconditioning attenuates coronary perivascular and interstitial fibrosis through modulating angiotensin II receptors and angiotensin-converting enzyme 2 after myocardial infarction.
Role of circulating angiotensin converting enzyme 2 in left ventricular remodeling following myocardial infarction: a prospective controlled study.
The ACE 2 activator diminazene aceturate (DIZE) improves left ventricular diastolic dysfunction following myocardial infarction in rats.
Upregulation of angiotensin-converting enzyme 2 after myocardial infarction by blockade of angiotensin II receptors.
Myocarditis
Cardiovascular Considerations in Coronavirus Disease 2019 with a Special Focus on Arrhythmia.
Phytochemicals as Potential Therapeutics for SARS-CoV-2-Induced Cardiovascular Complications: Thrombosis and Platelet Perspective.
Potential mechanisms of cardiac injury and common pathways of inflammation in patients with COVID-19.
Myositis
Impact of diminazene aceturate on renin-angiotensin system, infectious myocarditis and skeletal myositis in mice: An in vitro and in vivo study.
Neoplasm Metastasis
Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis.
Angiotensin-converting enzyme 2 attenuates the metastasis of non-small cell lung cancer through inhibition of epithelial-mesenchymal transition.
Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia.
Expression and Clinical Significance of SARS-CoV-2 Human Targets in Neoplastic and Non-Neoplastic Lung Tissues.
Functional analysis of the TMPRSS2:ERG fusion gene in cisplatin?induced cell death.
In vitro characterization of TMPRSS2 inhibition in IPEC-J2 cells.
Inhibition of TMPRSS2 by HAI-2 reduces prostate cancer cell invasion and metastasis.
Insights into the mechanism of organ-specific cancer metastasis.
Prostate cancer: TMPRSS2 promotes metastasis through proteolysis.
Regression of Castration-Resistant Prostate Cancer by a Novel Compound HG122.
The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis.
The androgen-regulated type II serine protease TMPRSS2 is differentially expressed and mislocalized in prostate adenocarcinoma.
The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells.
TMPRSS2:ERG Fusion-Associated Deletions Provide Insight into the Heterogeneity of Prostate Cancer.
Neoplasms
A combinational approach to restore cytokine balance and to inhibit virus growth may promote patient recovery in severe COVID-19 cases.
A multiplex model of combining gene-based, protein-based, and metabolite-based with positive and negative markers in urine for the early diagnosis of prostate cancer.
A variant TMPRSS2 isoform and ERG fusion product in prostate cancer with implications for molecular diagnosis.
Aberrant TGF-? Signaling Drives Castration-Resistant Prostate Cancer in a Male Mouse Model of Prostate Tumorigenesis.
ACE2 and TMPRSS2 expression by clinical, HLA, immune, and microbial correlates across 34 human cancers and matched normal tissues: implications for SARS-CoV-2 COVID-19.
ACE2 and TMPRSS2 Potential Involvement in Genetic Susceptibility to SARS-COV-2 in Cancer Patients.
Acute Kidney Injury in COVID-19: a Brief Review.
An investigation into the molecular basis of cancer comorbidities in coronavirus infection.
Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (N = 4532).
Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis.
Androgen-induced TMPRSS2:ERG fusion in non-malignant prostate epithelial cells.
Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements.
Angiotensin-(1-7) Attenuates Kidney Injury Due to Obstructive Nephropathy in Rats.
Angiotensin-converting enzyme 2 connects COVID-19 with cancer and cancer immunotherapy.
Association of imputed prostate cancer transcriptome with disease risk reveals novel mechanisms.
Association of TMPRSS2 and KLK11 gene expression levels with clinical progression of human prostate cancer.
Bone Cell Activity in Clinical Prostate Cancer Bone Metastasis and Its Inverse Relation to Tumor Cell Androgen Receptor Activity.
Calcium Channel Blocker Use and Risk of Prostate Cancer by TMPRSS2:ERG Gene Fusion Status.
Cancer progression in COVID-19: integrating the roles of renin angiotensin aldosterone system, angiopoietin-2, heat shock protein-27 and epithelial mesenchymal transition.
Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia.
Chromosome rearrangement associated inactivation of tumour suppressor genes in prostate cancer.
Co?expression of peripheral olfactory receptors with SARS?CoV?2 infection mediators: Potential implications beyond loss of smell as a COVID?19 symptom.
Colorectal Cancer that Highly Express Both ACE2 and TMPRSS2, Suggesting Severe Symptoms to SARS-CoV-2 Infection.
Commentary on "ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients." Baena E, Shao Z, Linn DE, Glass K, Hamblen MJ, Fujiwara Y, Kim J, Nguyen M, Zhang X, Godinho FJ, Bronson RT, Mucci LA, Loda M, Yuan GC, Orkin SH, Li Z, Division of Hematology and Oncology, Boston Children's Hospital, Boston, MA, USA.: Genes Dev 2013;27(6):683-98.
Comparative RNA-seq analysis reveals dys-regulation of major canonical pathways in ERG-inducible LNCaP cell progression model of prostate cancer.
Comprehensive analysis of two potential novel SARS-CoV-2 entries, TMPRSS2 and IFITM3, in healthy individuals and cancer patients.
Correlation between ERG Fusion Protein and Androgen Receptor Expression by Immunohistochemistry in Prostate, Possible Role in Diagnosis and Therapy.
COVID-19 and Malignancy: Exploration of the possible genetic and epigenetic interlinks and overview of the vaccination scenario.
COVID19-inhibitory activity of withanolides involves targeting of the host cell surface receptor ACE2: insights from computational and biochemical assays.
Decreased expression of Angiotensin-converting enzyme 2 in pancreatic ductal adenocarcinoma is associated with tumor progression.
Design, synthesis and biological evaluation of novel 1, 3-thiazolidine-2, 4-diones as anti-prostate cancer agents.
Detection of TMPRSS2 gene deletions and translocations in carcinoma, intraepithelial neoplasia, and normal epithelium of the prostate by direct fluorescence in situ hybridization.
Differential expression and immune correlation analysis of COVID-19 receptor ACE2 and TMPRSS2 genes in all normal and tumor tissues.
Distinct transcriptional repertoire of the androgen receptor in ETS fusion-negative prostate cancer.
Does the compromised sleep and circadian disruption of night and shiftworkers make them highly vulnerable to 2019 coronavirus disease (COVID-19)?
Downregulation of ACE2 expression by SARS-CoV-2 worsens the prognosis of KIRC and KIRP patients via metabolism and immunoregulation.
Effects of COVID-19 on male sex function and its potential sexual transmission.
Epigenetic underpinnings of inflammation: Connecting the dots between pulmonary diseases, lung cancer and COVID-19.
ERG rearrangement is specific to prostate cancer and does not occur in any other common tumor.
Estrogen and Androgen Receptor Inhibitors: Unexpected Allies in the Fight Against COVID-19.
ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients.
Expression and Clinical Significance of SARS-CoV-2 Human Targets in Neoplastic and Non-Neoplastic Lung Tissues.
Expression of innate immune response genes in upper airway samples of SARS-CoV-2 infected patients: A preliminary study.
Expression of renin-angiotensin system (RAS) components in endometrial cancer.
Expression of the SAR2-Cov-2 receptor ACE2 reveals the susceptibility of COVID-19 in non-small cell lung cancer.
Functional analysis of the TMPRSS2:ERG fusion gene in cisplatin?induced cell death.
Fusion between TMPRSS2 and ETS family members (ERG, ETV1, ETV4) in prostate cancers from northern China.
Gastrointestinal cancers, ACE-2/TMPRSS2 expression and susceptibility to COVID-19.
Genetic alteration, RNA expression, and DNA methylation profiling of coronavirus disease 2019 (COVID-19) receptor ACE2 in malignancies: a pan-cancer analysis.
Genetic Susceptibility of ACE2 and TMPRSS2 in Six Common Cancers and Possible Impacts on COVID-19.
Genome-wide CpG island methylation analysis implicates novel genes in the pathogenesis of renal cell carcinoma.
Heterogeneity of TMPRSS2 gene rearrangements in multifocal prostate adenocarcinoma: molecular evidence for an independent group of diseases.
High expression of ACE2 and TMPRSS2 and clinical characteristics of COVID-19 in colorectal cancer patients.
Highlights in the fight against COVID-19: does autophagy play a role in SARS-CoV-2 infection?
Human and novel coronavirus infections in children: a review.
Hypotheses about sub-optimal hydration in the weeks before coronavirus disease (COVID-19) as a risk factor for dying from COVID-19.
Identification of cell lines CL-14, CL-40 and CAL-51 as suitable models for SARS-CoV-2 infection studies.
Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation.
Imatinib (STI571) Inhibits the Expression of Angiotensin-Converting Enzyme 2 and Cell Entry of the SARS-CoV-2-Derived Pseudotyped Viral Particles.
Immune Interaction Map of Human SARS-CoV-2 Target Genes: Implications for Therapeutic Avenues.
In silico analysis identifies neuropilin-1 as a potential therapeutic target for SARS-Cov-2 infected lung cancer patients.
Inhibition of TMPRSS2 by HAI-2 reduces prostate cancer cell invasion and metastasis.
Insights into the mechanism of organ-specific cancer metastasis.
Integrated Bioinformatic Analysis of SARS-CoV-2 Infection Related Genes ACE2, BSG and TMPRSS2 in Aerodigestive Cancers.
Integrative analysis of miRNA and mRNA sequencing data reveals potential regulatory mechanisms of ACE2 and TMPRSS2.
Landscape Profiling Analysis of DPP4 in Malignancies: Therapeutic Implication for Tumor Patients With Coronavirus Disease 2019.
Loss of CDCP1 triggers FAK activation in detached prostate cancer cells.
Malignancy going viral: ACE2 and TMPRSS2 expression in conjunctival neoplastic diseases.
Methylation Changes of Primary Tumors, Monolayer, and Spheroid Tissue Culture Environments in Malignant Melanoma and Breast Carcinoma.
Molecular Pathology of the Genitourinary Tract: Prostate and Bladder.
Monoallelic expression of TMPRSS2/ERG in prostate cancer stem cells.
More light on cancer and COVID-19 reciprocal interaction.
Mutation analyses of 268 candidate genes in human tumor cell lines.
Neuronal nitric oxide synthase and sympathetic nerve activity in neurovascular and metabolic systems.
New insights into genetic susceptibility of COVID-19: an ACE2 and TMPRSS2 polymorphism analysis.
NKX3.1 Suppresses TMPRSS2-ERG Gene Rearrangement and Mediates Repair of Androgen Receptor-Induced DNA Damage.
Novel Case of Isolated Peritoneal Carcinomatosis from Metastatic Prostate Cancer Carrying a Pathogenic BRCA Mutation Treated with Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy.
Pan-Cancer Analysis of Genomic and Prognostic Characteristics Associated With Coronavirus Disease 2019 Regulators.
Pan-cancer analysis of RNA expression of ANGIOTENSIN-I-CONVERTING ENZYME 2 reveals high variability and possible impact on COVID-19 clinical outcomes.
Pan?cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS?CoV?2 infection leading to COVID-19.
Pericellular regulation of prostate cancer expressed kallikrein-related peptidases and matrix metalloproteinases by cell surface serine proteases.
Prevalence of TMPRSS2-ERG and SLC45A3-ERG gene fusions in a large prostatectomy cohort.
Prognostic and predictive molecular biological markers in prostate cancer - significance of expression of genes PCA3 and TMPRSS2.
Prostate adenocarcinoma and COVID-19: The possible impacts of TMPRSS2 expressions in susceptibility to SARS-CoV-2.
Protocols for Studies on TMPRSS2/ERG in Prostate Cancer.
Pyrrole-imidazole polyamide targeted to break fusion sites in TMPRSS2 and ERG gene fusion represses prostate tumor growth.
Quantitative expression of TMPRSS2 transcript in prostate tumor cells reflects TMPRSS2-ERG fusion status.
Recombinant angiotensin-converting enzyme 2 improves pulmonary blood flow and oxygenation in lipopolysaccharide-induced lung injury in piglets.
SARS-CoV-2 and cancer: Are they really partners in crime?
SARS-CoV-2 cell receptor gene ACE2 -mediated immunomodulation in breast cancer subtypes.
Screening strategy of TMPRSS2 inhibitors by FRET-based enzymatic activity for TMPRSS2-based cancer and COVID-19 treatment.
Selective and Specific Regulation of Ectodomain Shedding of Angiotensin-converting Enzyme 2 by Tumor Necrosis Factor {alpha}-converting Enzyme.
Significance of the TMPRSS2:ERG gene fusion in prostate cancer.
Similarities in Risk for COVID-19 and Cancer Disparities.
Sirt1 Activity in PBMCs as a Biomarker of Different Heart Failure Phenotypes.
Soluble angiotensin-converting enzyme 2 is transiently elevated in COVID-19 and correlates with specific inflammatory and endothelial markers.
Tannic acid suppresses SARS-CoV-2 as a dual inhibitor of the viral main protease and the cellular TMPRSS2 protease.
The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis.
The androgen-regulated type II serine protease TMPRSS2 is differentially expressed and mislocalized in prostate adenocarcinoma.
The angiotensin-converting enzyme 2 in tumor growth and tumor-associated angiogenesis in non-small cell lung cancer.
The association of renin-angiotensin system genes with the progression of hepatocellular carcinoma.
The Deadly Duo of COVID-19 and Cancer!
The Landscape of Coronavirus Disease 2019 (COVID-19) and Integrated Analysis SARS-CoV-2 Receptors and Potential Inhibitors in Lung Adenocarcinoma Patients.
The management of patients with metastatic prostate cancer during the COVID-19 pandemic.
The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells.
The role of Interleukin-4 in COVID-19 associated male infertility - A hypothesis.
The secret identities of TMPRSS2: Fertility factor, virus trafficker, inflammation moderator, prostate protector and tumor suppressor.
The TMPRSS2 gene encoding transmembrane serine protease is overexpressed in a majority of prostate cancer patients: detection of mutated TMPRSS2 form in a case of aggressive disease.
The Transcription Factor ERG Regulates Super-Enhancers Associated With an Endothelial-Specific Gene Expression Program.
The ubiquitin ligase TRIM25 targets ERG for degradation in prostate cancer.
TMPRSS2 Correlated With Immune Infiltration Serves as a Prognostic Biomarker in Prostatic Adenocarcinoma: Implication for the COVID-2019.
TMPRSS2 fusions with oncogenic ETS factors in prostate cancer involve unbalanced genomic rearrangements and are associated with HDAC1 and epigenetic reprogramming.
TMPRSS2, a novel membrane-anchored mediator in cancer pain.
TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients.
TMPRSS2, a Serine Protease Expressed in the Prostate on the Apical Surface of Luminal Epithelial Cells and Released into Semen in Prostasomes, Is Misregulated in Prostate Cancer Cells.
Tumor markers as an entry for SARS-CoV-2 infection?
Underlying mechanisms behind the protective effect of angiotensin (1-7) in experimental rat model of ovarian ischemia reperfusion injury.
Unexpected tumor reduction in metastatic colorectal cancer patients during SARS-Cov-2 infection: effect of ACE-2 expression on tumor cells or molecular mimicry phenomena? Two not mutually exclusive hypotheses.
Words of wisdom. Re: duplication of the fusion of TMPRSS2 to ERG sequences identifies fatal human prostate cancer.
[A review on the role of angiotensin-converting enzyme 2 in children with coronavirus disease 2019].
[Relationship between TMPRSS2: ERG and the pathological grade of prostate cancer].
[TMPRSS2-ETS gene fusion in prostate cancer]
[What's new in 2009 in prostate cancer: highlights from ASTRO, EAU, ASCO and AUA meetings]
Neoplastic Cells, Circulating
Loss of CDCP1 triggers FAK activation in detached prostate cancer cells.
Nephritis, Hereditary
ACE2 as therapy for glomerular disease: the devil is in the detail.
Nephrotic Syndrome
Evidence for a role of angiotensin converting enzyme 2 in proteinuria of idiopathic nephrotic syndrome.
Neuralgia
Downregulation of spinal angiotensin converting enzyme 2 is involved in neuropathic pain associated with type 2 diabetes mellitus in mice.
The Implications of Angiotensin-Converting Enzymes and Their Modulators in Neurodegenerative Disorders: Current and Future Perspectives.
Neurodegenerative Diseases
Role of angiotensin-converting enzyme 2 in neurodegenerative diseases during the COVID-19 pandemic.
Neuroinflammatory Diseases
CNS implications of COVID-19: a comprehensive review.
Targeting Neurological Manifestations of Coronaviruses by Candidate Phytochemicals: A Mechanistic Approach.
Neurologic Manifestations
Coronavirus Disease 2019: Latest Data on Neuroinvasive Potential.
Emerging neurotropic features of SARS-CoV-2.
Neurological manifestations of coronavirus infections: role of angiotensin-converting enzyme 2 in COVID-19.
Non-alcoholic Fatty Liver Disease
A meta-analysis of comorbidities in COVID-19: Which diseases increase the susceptibility of SARS-CoV-2 infection?
Angiotensin-converting enzyme 2 inhibits endoplasmic reticulum stress-associated pathway to preserve nonalcoholic fatty liver disease.
Pioglitazone upregulates angiotensin converting enzyme 2 expression in insulin-sensitive tissues in rats with high-fat diet-induced nonalcoholic steatohepatitis.
Obesity
A Dual-Route Perspective of SARS-CoV-2 Infection: Lung- vs. Gut-specific Effects of ACE-2 Deficiency.
Angiotensin converting enzyme 2 contributes to sex differences in the development of obesity hypertension in C57BL/6 mice.
Circulating Soluble ACE2 and Upstream microRNA Expressions in Serum of Type 2 Diabetes Mellitus Patients.
COVID-19 and Obesity: Role of Ectopic Visceral and Epicardial Adipose Tissues in Myocardial Injury.
Increased ACE 2 and decreased ACE protein in renal tubules from diabetic mice: a renoprotective combination?
Irisin modulates genes associated with severe coronavirus disease (COVID-19) outcome in human subcutaneous adipocytes cell culture.
Nutritional status, diet and viral respiratory infections: perspectives for SARS-CoV-2.
Obesity alters Ace2 and Tmprss2 expression in lung, trachea, and esophagus in a sex-dependent manner: Implications for COVID-19.
Obesity and COVID-19: ACE 2, the Missing Tile.
Regulation of Angiotensin- Converting Enzyme 2 in Obesity: Implications for COVID-19.
SARS-CoV-2 infection: physiological and environmental gift factors at high altitude.
Spironolactone may provide protection from SARS-CoV-2: Targeting androgens, angiotensin converting enzyme 2 (ACE2), and renin-angiotensin-aldosterone system (RAAS).
The Role of Adipocytes and Adipocyte-Like Cells in the Severity of COVID-19 Infections.
Understanding the Co-Epidemic of Obesity and COVID-19: Current Evidence, Comparison with Previous Epidemics, Mechanisms, and Preventive and Therapeutic Perspectives.
Oral Manifestations
How to deal with coronavirus disease 2019: A comprehensive narrative review about oral involvement of the disease.
Orchitis
COVID-19 and male reproductive system: pathogenic features and possible mechanisms.
Orthomyxoviridae Infections
Tmprss2 is essential for influenza H1N1 virus pathogenesis in mice.
Ovarian Neoplasms
The oncogenic gene fusion TMPRSS2: ERG is not a diagnostic or prognostic marker for ovarian cancer.
Pancreatic Neoplasms
Angiotensin-converting enzyme 2 acts as a potential molecular target for pancreatic cancer therapy.
Pancreatitis, Chronic
Structural Basis of Covalent Inhibitory Mechanism of TMPRSS2-Related Serine Proteases by Camostat.
Papilloma
Expression of the COVID-19 receptor ACE2 in the human conjunctiva.
Paramyxoviridae Infections
TMPRSS2 Is an Activating Protease for Respiratory Parainfluenza Viruses.
peptidyl-dipeptidase a deficiency
Serum Renin Levels Increase With Age in Boys Resulting in Higher Renin Levels in Young Men Compared to Young Women, and Soluble Angiotensin-Converting Enzyme 2 Correlates With Renin and Body Mass Index.
Periodontal Diseases
Making a complex dental care tailored to the person: population health in focus of predictive, preventive and personalised (3P) medical approach.
Periodontal Pocket
Role of NLRP3 inflammasome in COVID-19 and periodontitis: Possible protective effect of melatonin.
Periodontitis
COVID-19 and periodontitis: reflecting on a possible association.
Pneumonia
A brief review of interplay between vitamin D and angiotensin-converting enzyme 2: Implications for a potential treatment for COVID-19.
Alternative antibiotic feed additives alleviate pneumonia with inhibiting ACE-2 expression in the respiratory system of piglets.
Analysis of the involvement of the thyroid gland using computed tomography in patients with suspected SARS-CoV-2 infection: a retrospective study.
Case Report: Ischemic Colitis in Severe COVID-19 Pneumonia: An Unforeseen Gastrointestinal Complication.
COVID-19 post-mortem findings: how the departed can teach us.
COVID-19: an update and cardiac involvement.
Dermatological aspects of SARS-CoV-2 infection: mechanisms and manifestations.
Effects of Smoking on ACE2 Expression Pattern: Risk and Severity of SARS-CoV-2 Infection.
Impact of angiotensin-converting enzyme 2 levels on postoperative pneumonia after esophagectomy.
Lower Gene Expression of Angiotensin Converting Enzyme 2 Receptor in Lung Tissues of Smokers with COVID-19 Pneumonia.
Mesenchymal stem cell immunomodulation and regeneration therapeutics as an ameliorative approach for COVID-19 pandemics.
Neurological Consequences of SARS-CoV-2 Infection and Concurrence of Treatment-Induced Neuropsychiatric Adverse Events in COVID-19 Patients: Navigating the Uncharted.
Positive association of angiotensin II receptor blockers, not angiotensin-converting enzyme inhibitors, with an increased vulnerability to SARS-CoV-2 infection in patients hospitalized for suspected COVID-19 pneumonia.
SARS-CoV-2 and helminth co-infections, and environmental pollution exposure: An epidemiological and immunological perspective.
Searching therapeutic strategy of new coronavirus pneumonia from angiotensin-converting enzyme 2: the target of COVID-19 and SARS-CoV.
Pneumonia, Viral
Inhibitors of endosomal acidification suppress SARS-CoV-2 replication and relieve viral pneumonia in hACE2 transgenic mice.
Vitamin A in resistance to and recovery from infection: relevance to SARS-CoV2.
Post-Exercise Hypotension
Angiotensin converting enzyme 2 polymorphisms and postexercise hypotension in hypertensive medicated individuals.
Postural Orthostatic Tachycardia Syndrome
Defects in cutaneous angiotensin-converting enzyme 2 and angiotensin-(1-7) production in postural tachycardia syndrome.
Pre-Eclampsia
Angiotensin Converting Enzyme 2 (ACE2) in Pregnancy: Preeclampsia and Small for Gestational Age.
Corrigendum: Angiotensin Converting Enzyme 2 (ACE2) in Pregnancy: Preeclampsia and Small for Gestational Age.
Expression of severe acute respiratory syndrome coronavirus 2 cell entry genes, angiotensin-converting enzyme 2 and transmembrane protease serine 2, in the placenta across gestation and at the maternal-fetal interface in pregnancies complicated by preterm birth or preeclampsia.
Is highly expressed ACE 2 in pregnant women "a curse" in times of COVID-19 pandemic?
Prehypertension
Is hypertension in African-descent populations contributed to by an imbalance in the activities of the ACE2/Ang-(1-7)/Mas and the ACE/Ang II/AT1 axes?
Premature Birth
Expression of severe acute respiratory syndrome coronavirus 2 cell entry genes, angiotensin-converting enzyme 2 and transmembrane protease serine 2, in the placenta across gestation and at the maternal-fetal interface in pregnancies complicated by preterm birth or preeclampsia.
Primary Dysautonomias
Characterization of cardiac autonomic function in COVID-19 using heart rate variability: a hospital based preliminary observational study.
Prostatic Diseases
Quantitative expression of TMPRSS2 transcript in prostate tumor cells reflects TMPRSS2-ERG fusion status.
Prostatic Hyperplasia
Diagnostic and prognostic scoring system for prostate cancer using urine and plasma biomarkers.
The androgen-regulated type II serine protease TMPRSS2 is differentially expressed and mislocalized in prostate adenocarcinoma.
The TMPRSS2 gene encoding transmembrane serine protease is overexpressed in a majority of prostate cancer patients: detection of mutated TMPRSS2 form in a case of aggressive disease.
Prostatic Intraepithelial Neoplasia
Detection of TMPRSS2 gene deletions and translocations in carcinoma, intraepithelial neoplasia, and normal epithelium of the prostate by direct fluorescence in situ hybridization.
Prostatic Neoplasms
1{alpha},25-Dihydroxyvitamin D3 inhibits growth of VCaP prostate cancer cells despite inducing the growth-promoting TMPRSS2:ERG gene fusion.
3beta-hydroxysteroid dehydrogenase is a possible pharmacological target in the treatment of castration-resistant prostate cancer.
5' UTR Control of Native ERG and of Tmprss2:ERG Variants Activity in Prostate Cancer.
A DNA methylation microarray-based study identifies ERG as a gene commonly methylated in prostate cancer.
A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth.
A high-density tissue microarray from patients with clinically localized prostate cancer reveals ERG and TATI exclusivity in tumor cells.
A novel four-color fluorescence in situ hybridization assay for the detection of TMPRSS2 and ERG rearrangements in prostate cancer.
A Tmprss2-CreERT2 Knock-In Mouse Model for Cancer Genetic Studies on Prostate and Colon.
A variant TMPRSS2 isoform and ERG fusion product in prostate cancer with implications for molecular diagnosis.
ACE2 and TMPRSS2 polymorphisms in various diseases with special reference to its impact on COVID-19 disease.
Activation of NF-{kappa}B by TMPRSS2/ERG Fusion Isoforms through Toll-Like Receptor-4.
An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression.
Androgen Deprivation Therapy in Men With Prostate Cancer Does Not Affect Risk of Infection With SARS-CoV-2.
Androgen Receptor-Activated Enhancers Simultaneously Regulate Oncogene TMPRSS2 and lncRNA PRCAT38 in Prostate Cancer.
Androgen Regulation of ETS Gene Fusion Transcripts in Prostate Cancer.
Androgen regulation of the TMPRSS2 gene and the effect of a SNP in an androgen response element.
Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (N = 4532).
Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis.
Androgen-induced TMPRSS2:ERG fusion in non-malignant prostate epithelial cells.
Androgens Induce Functional CXCR4 through ERG Factor Expression in TMPRSS2-ERG Fusion-Positive Prostate Cancer Cells.
Association between TMPRSS2:ERG fusion gene and the prostate cancer: systematic review and meta-analysis.
Association of pre-diagnostic blood metabolomics with prostate cancer defined by ERG or PTEN molecular subtypes.
Association of TMPRSS2 and KLK11 gene expression levels with clinical progression of human prostate cancer.
Base pair resolution analysis of TMPRSS2-ERG rearrangements in prostate cancer.
Binding of TMPRSS2-ERG to BAF Chromatin Remodeling Complexes Mediates Prostate Oncogenesis.
Catalytic cleavage of the androgen-regulated TMPRSS2 protease results in its secretion by prostate and prostate cancer epithelia.
Cellular and Molecular Mechanisms Underlying Prostate Cancer Development: Therapeutic Implications.
Characterization of ERG, AR and PTEN gene status in circulating tumor cells from patients with castration-resistant prostate cancer.
Characterization of TMPRSS2-ETS gene aberrations in androgen-independent metastatic prostate cancer.
Clinical implications of TMPRSS2-ERG gene fusion expression in patients with prostate cancer treated with radical prostatectomy.
Colorimetric TMPRSS2-ERG Gene Fusion Detection in Prostate Cancer Urinary Samples via Recombinase Polymerase Amplification.
Comparative evaluation of urinary PCA3 and TMPRSS2: ERG scores and serum PHI in predicting prostate cancer aggressiveness.
Comprehensive assessment of TMPRSS2 and ETS family gene aberrations in clinically localized prostate cancer.
Correlation of ERG expression and DNA methylation biomarkers with adverse clinicopathologic features of prostate cancer.
COVID-19 and androgen-targeted therapy for prostate cancer patients.
Covid-19 pathogenesis in prostatic cancer and TMPRSS2-ERG regulatory genetic pathway.
Defining the molecular action of HDAC inhibitors and synergism with androgen deprivation in ERG-positive prostate cancer.
Deletion of Interstitial Genes between TMPRSS2 and ERG Promotes Prostate Cancer Progression.
Detection of TMPRSS2 gene deletions and translocations in carcinoma, intraepithelial neoplasia, and normal epithelium of the prostate by direct fluorescence in situ hybridization.
Detection of TMPRSS2-ERG Fusion Gene Expression in Prostate Cancer Specimens by a Novel Assay Using Branched DNA.
Detection of TMPRSS2-ERG translocations in human prostate cancer by expression profiling using GeneChip Human Exon 1.0 ST arrays.
Development of a peptide-based vaccine targeting TMPRSS2:ERG fusion-positive prostate cancer.
Discovery of non-ETS gene fusions in human prostate cancer using next-generation RNA sequencing.
Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer.
Distinct transcriptional repertoire of the androgen receptor in ETS fusion-negative prostate cancer.
Do Anti-androgens Have Potential as Therapeutics for COVID-19?
Duplication of the fusion of TMPRSS2 to ERG sequences identifies fatal human prostate cancer.
Dynamic nucleosome-depleted regions at androgen receptor enhancers in the absence of ligand in prostate cancer cells.
Effects of COVID-19 on male sex function and its potential sexual transmission.
Emerging biological observations in prostate cancer.
Enzalutamide response in a panel of prostate cancer cell lines reveals a role for glucocorticoid receptor in enzalutamide resistant disease.
Epigenetic alterations in human prostate cancers.
ERG induces androgen receptor-mediated regulation of SOX9 in prostate cancer.
ERG Is a Critical Regulator of Wnt/LEF1 Signaling in Prostate Cancer.
ERG monoclonal antibody in the diagnosis and biological stratification of prostate cancer: delineation of minimal epitope, critical residues for binding, and molecular basis of specificity.
ERG rearrangement in local recurrences compared to distant metastases of castration-resistant prostate cancer.
ERG rearrangement is specific to prostate cancer and does not occur in any other common tumor.
ETS fusion genes in prostate cancer.
ETS gene fusions and prostate cancer.
ETS Gene Fusions in Prostate Cancer: From Discovery to Daily Clinical Practice.
ETS rearrangements and prostate cancer initiation.
Ets Related Gene and Smad3 Proteins Collaborate to Activate Transforming Growth Factor-Beta Mediated Signaling Pathway in ETS Related Gene-Positive Prostate Cancer Cells.
ETS-TMPRSS2 Fusion Gene Products in Prostate Cancer.
ETV1 is a novel androgen receptor-regulated gene that mediates prostate cancer cell invasion.
Evaluation of ERG responsive proteome in prostate cancer.
Evaluation of the TMPRSS2:ERG fusion for the detection of prostate cancer: a systematic review and meta-analysis.
Expression of the Androgen-Regulated Fusion Gene TMPRSS2-ERG Does Not Predict Response to Endocrine Treatment in Hormone-Naïve, Node-Positive Prostate Cancer.
Expression of the TMPRSS2:ERG fusion gene predicts cancer recurrence after surgery for localised prostate cancer.
Expression of TMPRSS2:ERG gene fusion in prostate cancer cells is an important prognostic factor for cancer progression.
Expression of Variant TMPRSS2/ERG Fusion Messenger RNAs Is Associated with Aggressive Prostate Cancer.
Functional analysis of the TMPRSS2:ERG fusion gene in cisplatin?induced cell death.
Functional antagonism of TMPRSS2-ERG splice variants in prostate cancer.
Fusion between TMPRSS2 and ETS family members (ERG, ETV1, ETV4) in prostate cancers from northern China.
Fusion in the ETS gene family and prostate cancer.
Gene fusions between TMPRSS2 and ETS family genes in prostate cancer: frequency and transcript variant analysis by RT-PCR and FISH on paraffin-embedded tissues.
Gene of the month: TMPRSS2 (transmembrane serine protease 2).
Genetic interaction between Tmprss2-ERG gene fusion and Nkx3.1-loss does not enhance prostate tumorigenesis in mouse models.
Genetic variation in the upstream region of ERG and prostate cancer.
Genome-wide linkage analysis of TMPRSS2-ERG fusion in familial prostate cancer.
Highly specific targeting of the TMPRSS2/ERG fusion gene using liposomal nanovectors.
Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells.
Histone deacetylases are required for androgen receptor function in hormone-sensitive and castrate-resistant prostate cancer.
Hormonal intervention for the treatment of veterans with COVID-19 requiring hospitalization (HITCH): a multicenter, phase 2 randomized controlled trial of best supportive care vs best supportive care plus degarelix: study protocol for a randomized controlled trial.
Hormone-sensitive prostate cancer: a case of ETS gene fusion heterogeneity.
Hypermethylation-mediated transcriptional repression of TMPRSS2 in androgen receptor-negative prostate cancer cells.
Immunohistochemical expression of ERG in the molecular epidemiology of fatal prostate cancer study.
Inactivation of ATM/ATR DNA damage checkpoint promotes androgen induced chromosomal instability in prostate epithelial cells.
Induced chromosomal proximity and gene fusions in prostate cancer.
Inflammation-Induced Oxidative Stress Mediates Gene Fusion Formation in Prostate Cancer.
Inhibition of TMPRSS2 by HAI-2 reduces prostate cancer cell invasion and metastasis.
Inhibition of tumor cell motility by the interferon-inducible GTPase MxA.
Involvement of different mechanisms for the association of CAG repeat length polymorphism in androgen receptor gene with prostate cancer.
KLK3 and TMPRSS2 for molecular lymph-node staging in prostate cancer patients undergoing radical prostatectomy.
Loss of SLC45A3 protein (prostein) expression in prostate cancer is associated with SLC45A3-ERG gene rearrangement and an unfavorable clinical course.
Loss of the NKX3.1 tumorsuppressor promotes the TMPRSS2-ERG fusion gene expression in prostate cancer.
Marked heterogeneity of ERG expression in large primary prostate cancers.
miR-145 suppress the androgen receptor in prostate cancer cells and correlates to prostate cancer prognosis.
miR-30 as a tumor suppressor connects EGF/Src signal to ERG and EMT.
Molecular characterization of TMPRSS2-ERG gene fusion in the NCI-H660 prostate cancer cell line: a new perspective for an old model.
Molecular genetic analyses of the TMPRSS2-ERG and TMPRSS2-ETV1 gene fusions in 50 cases of prostate cancer.
Molecular Mechanism of Activation of Transforming Growth Factor Beta/Smads Signaling Pathway in Ets Related Gene-Positive Prostate Cancers.
Molecular Pathology of the Genitourinary Tract: Prostate and Bladder.
Monoallelic expression of TMPRSS2/ERG in prostate cancer stem cells.
Morphological features of TMPRSS2: ERG fusion prostate cancer.
MRGBP promotes AR-mediated transactivation of KLK3 and TMPRSS2 via acetylation of histone H2A.Z in prostate cancer cells.
Multiple genomic alterations on 21q22 predict various TMPRSS2/ERG fusion transcripts in human prostate cancers.
N-myc downstream regulated gene 1 (NDRG1) is fused to ERG in prostate cancer.
Next-generation sequencing reveals novel rare fusion events with functional implication in prostate cancer.
NKX3.1 Suppresses TMPRSS2-ERG Gene Rearrangement and Mediates Repair of Androgen Receptor-Induced DNA Damage.
Noninvasive detection of TMPRSS2:ERG fusion transcripts in the urine of men with prostate cancer.
Overexpression of Prostate-Specific TMPRSS2(exon 0)-ERG Fusion Transcripts Corresponds with Favorable Prognosis of Prostate Cancer.
Predisposition for TMPRSS2-ERG Fusion in Prostate Cancer by Variants in DNA Repair Genes.
Prevalence of TMPRSS2-ERG and SLC45A3-ERG gene fusions in a large prostatectomy cohort.
Prevalence of TMPRSS2-ERG fusion prostate cancer among men undergoing prostate biopsy in the United States.
Prevention, complementary therapies, and new scientific developments in the field of prostate cancer.
Prognostic and predictive molecular biological markers in prostate cancer - significance of expression of genes PCA3 and TMPRSS2.
Prostaglandin 15d-PGJ(2) inhibits androgen receptor signaling in prostate cancer cells.
Prostate adenocarcinoma and COVID-19: The possible impacts of TMPRSS2 expressions in susceptibility to SARS-CoV-2.
Prostate cancer prevention.
Prostate cancer: TMPRSS2 promotes metastasis through proteolysis.
Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2.
Prostatic adenocarcinoma CNS parenchymal and dural metastases: alterations in ERG, CHD1 and MAP3K7 expression.
Protocols for Studies on TMPRSS2/ERG in Prostate Cancer.
Racial differences in prediction of time to prostate cancer diagnosis in a prospective screening cohort of high-risk men: effect of TMPRSS2 Met160Val.
Re: Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.
Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.
RNA splicing and splicing regulator changes in prostate cancer pathology.
Role of dutasteride in pre-clinical ETS fusion-positive prostate cancer models.
Screening strategy of TMPRSS2 inhibitors by FRET-based enzymatic activity for TMPRSS2-based cancer and COVID-19 treatment.
Secreted Frizzled-Related Protein 4 (SFRP4) Is an Independent Prognostic Marker in Prostate Cancers Lacking TMPRSS2: ERG Fusions.
Significance of the TMPRSS2:ERG gene fusion in prostate cancer.
SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression.
Status of TMPRSS2-ERG fusion in prostate cancer patients from India: correlation with clinico-pathological details and TMPRSS2 Met160Val polymorphism.
Tannic acid suppresses SARS-CoV-2 as a dual inhibitor of the viral main protease and the cellular TMPRSS2 protease.
The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis.
The androgen-regulated type II serine protease TMPRSS2 is differentially expressed and mislocalized in prostate adenocarcinoma.
The end of the road for prostate specific antigen testing?
The lysine specific demethylase-1 (LSD1/KDM1A) regulates VEGF-A expression in prostate cancer.
The management of patients with metastatic prostate cancer during the COVID-19 pandemic.
The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells.
The pivotal role of TMPRSS2 in coronavirus disease 2019 and prostate cancer.
The role of TMPRSS2:ERG in molecular stratification of PCa and its association with tumor aggressiveness: a study in Brazilian patients.
The secret identities of TMPRSS2: Fertility factor, virus trafficker, inflammation moderator, prostate protector and tumor suppressor.
The TMPRSS2 gene encoding transmembrane serine protease is overexpressed in a majority of prostate cancer patients: detection of mutated TMPRSS2 form in a case of aggressive disease.
The Transcription Factor ERG Regulates Super-Enhancers Associated With an Endothelial-Specific Gene Expression Program.
TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention?
TMPRSS2 fusions with oncogenic ETS factors in prostate cancer involve unbalanced genomic rearrangements and are associated with HDAC1 and epigenetic reprogramming.
TMPRSS2 Met160Val polymorphism: Significant association with sporadic prostate cancer, but not with latent prostate cancer in Japanese men.
TMPRSS2, a Serine Protease Expressed in the Prostate on the Apical Surface of Luminal Epithelial Cells and Released into Semen in Prostasomes, Is Misregulated in Prostate Cancer Cells.
TMPRSS2- Driven ERG Expression In Vivo Increases Self-Renewal and Maintains Expression in a Castration Resistant Subpopulation.
TMPRSS2-ERG and PTEN loss in prostate cancer.
TMPRSS2-ERG Fusion Gene Expression in Prostate Tumor Cells and Its Clinical and Biological Significance in Prostate Cancer Progression.
TMPRSS2-ERG gene fusion is not associated with outcome in patients treated by prostatectomy.
TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model.
TMPRSS2:ERG fusion by translocation or interstitial deletion is highly relevant in androgen-dependent prostate cancer, but is bypassed in late-stage androgen receptor-negative prostate cancer.
TMPRSS2:ERG fusion transcripts in urine from prostate cancer patients correlate with a less favorable prognosis.
TMPRSS2:ERG Fusion-Associated Deletions Provide Insight into the Heterogeneity of Prostate Cancer.
TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer Tomlins SA, Mehra R, Rhodes DR, Smith LR, Roulston D, Helgeson BE, Cao X, Wei JT, Rubin MA, Shah RB, Chinnaiyan AM, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI.
TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer.
Truncated ERG proteins affect the aggressiveness of prostate cancer.
Two unique novel prostate-specific and androgen-regulated fusion partners of ETV4 in prostate cancer.
Urine Exosomes for Non-Invasive Assessment of Gene Expression and Mutations of Prostate Cancer.
Urine TMPRSS2: ERG Fusion Transcript as a Biomarker for Prostate Cancer: Literature Review.
Weaker ERG expression in patients with ERG-positive prostate cancer is associated with advanced disease and weaker androgen receptor expression: An Indian outlook.
What is the molecular pathology of low-risk prostate cancer?
Words of wisdom. Re: duplication of the fusion of TMPRSS2 to ERG sequences identifies fatal human prostate cancer.
Y08197 is a novel and selective CBP/EP300 bromodomain inhibitor for the treatment of prostate cancer.
[Detection and significance of fusion gene between TMPRSS2 and ETS transcription factor genes in fresh prostatic cancer tissues in Chinese patients].
[Frequency and transcript variant analysis of gene fusions between TMPRSS2 and ETS transcription factor genes in prostate cancer]
[Relationship between TMPRSS2: ERG and the pathological grade of prostate cancer].
Proteinuria
ACE2 as therapy for glomerular disease: the devil is in the detail.
Evidence for a role of angiotensin converting enzyme 2 in proteinuria of idiopathic nephrotic syndrome.
The role of Interleukin-4 in COVID-19 associated male infertility - A hypothesis.
Psoriasis
A meta-analysis of comorbidities in COVID-19: Which diseases increase the susceptibility of SARS-CoV-2 infection?
Pterygium
Expression of SARS-CoV-2 receptor ACE2 and TMPRSS2 in human primary conjunctival and pterygium cell lines and in mouse cornea.
Pulmonary Arterial Hypertension
A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension.
ACE2 activation confers endothelial protection and attenuates neointimal lesions in prevention of severe pulmonary arterial hypertension in rats.
Angiotensin converting enzyme 2 and angiotensin (1-7) axis in pulmonary arterial hypertension.
Angiotensin-converting enzyme 2 activation ameliorates pulmonary endothelial dysfunction in rats with pulmonary arterial hypertension through mediating phosphorylation of endothelial nitric oxide synthase.
Angiotensin-converting enzyme 2 activation protects against pulmonary arterial hypertension through improving early endothelial function and mediating cytokines levels.
Angiotensin-converting enzyme 2 activation suppresses pulmonary vascular remodeling by inducing apoptosis through the Hippo signaling pathway in rats with pulmonary arterial hypertension.
MDM2-Mediated Ubiquitination of Angiotensin-Converting Enzyme 2 Contributes to the Development of Pulmonary Arterial Hypertension.
Propofol increases angiotensin-converting enzyme 2 expression in human pulmonary artery endothelial cells.
The changes of serum angiotensin-converting enzyme 2 in patients with pulmonary arterial hypertension due to congenital heart disease.
Pulmonary Disease, Chronic Obstructive
ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19.
Age-dependent assessment of genes involved in cellular senescence, telomere and mitochondrial pathways in human lung tissue of smokers, COPD and IPF: Associations with SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 axis.
Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis.
Airways Expression of SARS-CoV-2 Receptor, ACE2, and TMPRSS2 Is Lower in Children Than Adults and Increases with Smoking and COPD.
Angiotensin-converting enzyme 2 expression in COPD and IPF fibroblasts: the forgotten cell in COVID-19.
Angiotensin-converting enzyme-2 overexpression attenuates inflammation in rat model of chronic obstructive pulmonary disease.
Association of Cigarette Smoking, COPD, and Lung Cancer With Expression of SARS-CoV-2 Entry Genes in Human Airway Epithelial Cells.
Commenting on "Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from ACE 2 study" by Jacob A. Winther and colleagues.
Dysbalance of ACE2 levels - a possible cause for severe COVID-19 outcome in COPD.
Identification of the SARS-CoV-2 Entry Receptor ACE2 as a Direct Target for Transcriptional Repression by Miz1.
Paradoxical effects of cigarette smoke and COPD on SARS-CoV2 infection and disease.
Prognostic and diagnostic significance of copeptin in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from the ACE 2 study.
Prognostic and diagnostic significance of mid-regional pro-atrial natriuretic peptide in acute exacerbation of chronic obstructive pulmonary disease and acute heart failure: data from the ACE 2 Study.
Pulmonary Edema
The Reasons for Higher Mortality Rate in Opium Addicted Patients with COVID-19: A Narrative Review.
Pulmonary Embolism
RhoA-Rho associated kinase signaling leads to renin-angiotensin system imbalance and angiotensin converting enzyme 2 has a protective role in acute pulmonary embolism.
Pulmonary Fibrosis
COVID-19 and pulmonary fibrosis: therapeutics in clinical trials, repurposing, and potential development.
Evidence for Angiotensin Converting Enzyme 2 as a Therapeutic Target for the Prevention of Pulmonary Hypertension.
Osthole Alleviates Bleomycin-Induced Pulmonary Fibrosis via Modulating Angiotensin-Converting Enzyme 2/Angiotensin-(1-7) Axis and Decreasing Inflammation Responses in Rats.
The angiotensin-converting enzyme 2/angiotensin (1-7)/Mas axis protects against lung fibroblast migration and lung fibrosis by inhibiting the NOX4-derived ROS-mediated RhoA/Rho kinase pathway.
The renin angiotensin system in liver and lung: impact and therapeutic potential in organ fibrosis.
Upregulation of ACE2 and TMPRSS2 by particulate matter and idiopathic pulmonary fibrosis: a potential role in severe COVID-19.
Renal Insufficiency, Chronic
Angiotensin-converting enzyme 2 activity in patients with chronic kidney disease.
Circulating angiotensin converting enzyme 2 activity as a biomarker of silent atherosclerosis in patients with chronic kidney disease.
Circulating angiotensin-converting enzyme 2 activity in patients with chronic kidney disease without previous history of cardiovascular disease.
Circulating miR-421 Targeting Leucocytic Angiotensin Converting Enzyme 2 Is Elevated in Patients with Chronic Kidney Disease.
Intrarenal Distributions and Changes of Angiotensin-Converting Enzyme and Angiotensin-Converting Enzyme 2 in Feline and Canine Chronic Kidney Disease.
Is hypertension in African-descent populations contributed to by an imbalance in the activities of the ACE2/Ang-(1-7)/Mas and the ACE/Ang II/AT1 axes?
Kidney ACE2 expression: Implications for chronic kidney disease.
Loss of ACE2 Exacerbates Murine Renal Ischemia-Reperfusion Injury.
Monocytic angiotensin-converting enzyme 2 relates to atherosclerosis in patients with chronic kidney disease.
The role of Interleukin-4 in COVID-19 associated male infertility - A hypothesis.
Tissue-specific expression of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2, in mouse models of chronic kidney disease.
Reperfusion Injury
Combination therapy with human umbilical cord mesenchymal stem cells and angiotensin-converting enzyme 2 is superior for the treatment of acute lung ischemia-reperfusion injury in rats.
Hepatic complications of COVID-19 and its treatment.
The functional study of human umbilical cord mesenchymal stem cells harbouring angiotensin-converting enzyme 2 in rat acute lung ischemia-reperfusion injury model.
[Angiotensin-converting enzyme 2 gene transfer attenuates neointimal formation after carotid artery ischemia-reperfusion injury in rats].
Respiratory Distress Syndrome
A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome.
Angiotensin-converting enzyme 2 in acute respiratory distress syndrome.
Computational drug repurposing strategy predicted peptide-based drugs that can potentially inhibit the interaction of SARS-CoV-2 spike protein with its target (humanACE2).
Effects of Recombinant Human Angiotensin-Converting Enzyme 2 on Response to Acute Hypoxia and Exercise: A Randomised, Placebo-Controlled Study.
Human and novel coronavirus infections in children: a review.
Imbalance between pulmonary angiotensin-converting enzyme and angiotensin-converting enzyme 2 activity in acute respiratory distress syndrome.
Impact of cytokine storm and systemic inflammation on liver impairment patients infected by SARS-CoV-2: Prospective therapeutic challenges.
Mesenchymal stem cell immunomodulation and regeneration therapeutics as an ameliorative approach for COVID-19 pandemics.
New insights on possible vaccine development against SARS-CoV-2.
Pharmacovigilance in patients with diabetes: A data-driven analysis identifying specific RAS antagonists with adverse pulmonary safety profiles that have implications for COVID-19 morbidity and mortality.
Potential harmful effects of discontinuing ACE-inhibitors and ARBs in COVID-19 patients.
Recombinant angiotensin-converting enzyme 2 improves pulmonary blood flow and oxygenation in lipopolysaccharide-induced lung injury in piglets.
Research Progress of Genetic Structure, Pathogenic Mechanism, Clinical Characteristics, and Potential Treatments of Coronavirus Disease 2019.
Soluble Angiotensin Converting Enzyme 2 (ACE2) Is Upregulated and Soluble Endothelial Nitric Oxide Synthase (eNOS) Is Downregulated in COVID-19-induced Acute Respiratory Distress Syndrome (ARDS).
The role of angiotensin-converting enzyme 2 in the pathogenesis of COVID-19: the villain or the hero?
Update on SARS-CoV-2 infection in children.
[Lessons from SARS: a new potential therapy for acute respiratory distress syndrome (ARDS) with angiotensin converting enzyme 2 (ACE2)]
Respiratory Insufficiency
Acute Kidney Injury in COVID-19: a Brief Review.
Modulation of TNF-alpha-converting enzyme by the spike protein of SARS-CoV and ACE2 induces TNF-alpha production and facilitates viral entry.
Nebulised surfactant for the treatment of severe COVID-19 in adults (COV-Surf): A structured summary of a study protocol for a randomized controlled trial.
Potential harmful effects of discontinuing ACE-inhibitors and ARBs in COVID-19 patients.
The Ineluctable Role of ACE-2 Receptors in SARS COV-2 Infection and Drug Repurposing as a Plausible SARS COV-2 Therapy : A Concise Treatise.
Respiratory Tract Infections
Evidence Regarding Vitamin D and Risk of COVID-19 and Its Severity.
One or two injections of MVA-vectored vaccine shields hACE2 transgenic mice from SARS-CoV-2 upper and lower respiratory tract infection.
Rheumatic Fever
Update on SARS-CoV-2 infection in children.
Rhinitis, Allergic
Type 2 inflammation modulates ACE2 and TMPRSS2 in airway epithelial cells.
Sarcoidosis
Angiotensin-converting enzyme 2 (ACE2) haplotypes are associated with pulmonary disease phenotypes in sarcoidosis patients.
Sarcoma, Ewing
ERG rearrangement is specific to prostate cancer and does not occur in any other common tumor.
Sepsis
Influence of Herbal Medicines on HMGB1 Release, SARS-CoV-2 Viral Attachment, Acute Respiratory Failure, and Sepsis. A Literature Review.
Severe Acute Respiratory Syndrome
"Molecular Masks" for ACE2 to Effectively and Safely Block SARS-CoV-2 Virus Entry.
A brand-new cardiorenal syndrome in the COVID-19  setting.
A comprehensive guide to the pharmacologic regulation of angiotensin converting enzyme 2 (ACE2), the SARS-CoV-2 entry receptor.
A Comprehensive Review of COVID-19 Associated Neurological Manifestations.
A data-driven approach to identify risk profiles and protective drugs in COVID-19.
A dramatic rise in serum ACE2 activity in a critically ill COVID-19 patient.
A human antibody of potent efficacy against SARS-CoV-2 in rhesus macaques showed strong blocking activity to B.1.351.
A Hydrophobic-Interaction-Based Mechanism Triggers Docking between the SARS-CoV-2 Spike and Angiotensin-Converting Enzyme 2.
A hypothesis on the role of the human immune system in covid-19.
A Multifunctional Peptide From Bacillus Fermented Soybean for Effective Inhibition of SARS-CoV-2 S1 Receptor Binding Domain and Modulation of Toll Like Receptor 4: A Molecular Docking Study.
A Narrative Review of a Pulmonary Aerosolized Formulation or a Nasal Drop Using Sera Containing Neutralizing Antibodies Collected from COVID-19-Recovered Patients as a Probable Therapy for COVID-19.
A novel soluble ACE2 protein totally protects from lethal disease caused by SARS-CoV-2 infection.
A potential impact of SARS-CoV-2 on pituitary glands and pituitary neuroendocrine tumors.
A pressor dose of angiotensin II has no influence on the angiotensin-converting enzyme 2 and other molecules associated with SARS-CoV-2 infection in mice.
A review on SARS-CoV-2 and stroke pathogenesis and outcome.
A Review on the Neurological Manifestations of COVID-19 Infection: a Mechanistic View.
A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2.
A Snapshot of the Global Race for Vaccines Targeting SARS-CoV-2 and the COVID-19 Pandemic.
A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry.
A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent.
Abdominal Imaging Findings in COVID-19: Preliminary Observations.
Abnormal apelin-ACE2 and SGLT2 signaling contribute to adverse cardiorenal injury in patients with COVID-19.
ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study.
ACE2 (Angiotensin-Converting Enzyme 2) in Cardiopulmonary Diseases: Ramifications for the Control of SARS-CoV-2.
ACE2 and TMPRSS2 expression by clinical, HLA, immune, and microbial correlates across 34 human cancers and matched normal tissues: implications for SARS-CoV-2 COVID-19.
ACE2 as a Therapeutic Target for COVID-19; its Role in Infectious Processes and Regulation by Modulators of the RAAS System.
ACE2 chromogenic immunostaining protocol optimized for formalin-fixed paraffin-embedded human tissue sections.
ACE2 in the second act of COVID-19 syndrome: Peptide dysregulation and possible correction with oestrogen.
ACE2 models of frequently contacted animals provide clues of their SARS-CoV-2 S protein affinity and viral susceptibility.
ACE2 mouse models: a toolbox for cardiovascular and pulmonary research.
ACE2 Protein Landscape in the Head and Neck Region: The Conundrum of SARS-CoV-2 Infection.
ACE2 role in SARS-CoV-2 infectivity and Covid-19 severity.
Acid pH Increases SARS-CoV-2 Infection and the Risk of Death by COVID-19.
Acidic preconditioning reduces lipopolysaccharide-induced acute lung injury by upregulating the expression of angiotensin-converting enzyme 2.
Acute Ischemic and Hemorrhagic Stroke in COVID-19: Mounting Evidence.
Advanced-glycation end-products axis: A contributor to the risk of severe illness from COVID-19 in diabetes patients.
Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 Axis.
Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 disease severity.
Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity.
AI-based spectroscopic monitoring of real-time interactions between SARS-CoV-2 and human ACE2.
Air contamination with SARS-CoV-2 in the operating room.
Air pollution by NO2 and PM2.5 explains COVID-19 infection severity by overexpression of angiotensin-converting enzyme 2 in respiratory cells: a review.
Airways Expression of SARS-CoV-2 Receptor, ACE2, and TMPRSS2 Is Lower in Children Than Adults and Increases with Smoking and COPD.
Akt-independent effects of triciribine on ACE2 expression in human lung epithelial cells: Potential benefits in restricting SARS-CoV2 infection.
Alteration in angiotensin-converting enzyme 2 by PM1 during the development of emphysema in rats.
Altered Intestinal ACE2 Levels Are Associated With Inflammation, Severe Disease, and Response to Anti-Cytokine Therapy in Inflammatory Bowel Disease.
Ambroxol Hydrochloride Inhibits the Interaction between Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein's Receptor Binding Domain and Recombinant Human ACE2.
Amino acid substitutions in the s2 region enhance severe acute respiratory syndrome coronavirus infectivity in rat angiotensin-converting enzyme 2-expressing cells.
An ACE2 Microbody Containing a Single Immunoglobulin Fc Domain Is a Potent Inhibitor of SARS-CoV-2.
An Engineered Receptor-Binding Domain Improves the Immunogenicity of Multivalent SARS-CoV-2 Vaccines.
An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
Analysis of ACE2 Genetic Variability among Populations Highlights a Possible Link with COVID-19-Related Neurological Complications.
Analysis of Gastrointestinal and Hepatic Manifestations of SARS-CoV-2 Infection in 892 Patients in Queens, NY.
Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (N = 4532).
Angiotensin converting enzyme 2 at the interface between renin-angiotensin system inhibition and coronavirus disease 2019.
Angiotensin converting enzyme 2 is a novel target of the ?-secretase complex.
Angiotensin Converting Enzyme-2 (ACE-2) role in disease and future in research.
Angiotensin-converting enzyme 2 (ACE2) from raccoon dog can serve as an efficient receptor for the spike protein of severe acute respiratory syndrome coronavirus.
Angiotensin-Converting Enzyme 2 (ACE2) in the Context of Respiratory Diseases and Its Importance in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection.
Angiotensin-converting enzyme 2 (ACE2) is upregulated in Alzheimer's disease brain.
Angiotensin-converting enzyme 2 (ACE2) receptor and SARS-CoV-2: Potential therapeutic targeting.
Angiotensin-converting enzyme 2 (ACE2), SARS-CoV-2 and the pathophysiology of coronavirus disease 2019 (COVID-19).
Angiotensin-converting enzyme 2 and COVID-19 in cardiorenal diseases.
Angiotensin-converting enzyme 2 ectodomain shedding cleavage-site identification: determinants and constraints.
Angiotensin-converting enzyme 2 expression is not induced by the renin-angiotensin system in the lung.
Angiotensin-Converting Enzyme 2 Gene Expression in Breast Tissue.
Angiotensin-converting enzyme 2 gene expression in human male urological tissues: implications for pathogenesis and virus transmission pathways.
Angiotensin-converting enzyme 2 in severe acute respiratory syndrome coronavirus and SARS-CoV-2: A double-edged sword?
Angiotensin-converting enzyme 2 receptors, chronic liver diseases, common medications, and clinical outcomes in coronavirus disease 2019 patients.
Angiotensin-converting Enzyme 2 Specific Cell Subset Identification in Oral Tissues: A Need of the Hour in COVID-19 Research.
Angiotensin-converting enzyme 2: The old door for new severe acute respiratory syndrome coronavirus 2 infection.
Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers: potential allies in the COVID-19 pandemic instead of a threat?
Angiotensin-Converting Enzyme Inhibitors or Angiotensin Receptor Blockers Use and COVID-19 Infection Among 824 650 Patients With Hypertension From a US Integrated Healthcare System.
Antihypertensive drug treatment and susceptibility to SARS-CoV-2 infection in human PSC-derived cardiomyocytes and primary endothelial cells.
Antiviral drug design based on the opening mechanism of spike glycoprotein in SARS-CoV-2.
Aromatic amino acids in the juxtamembrane domain of severe acute respiratory syndrome coronavirus spike glycoprotein are important for receptor-dependent virus entry and cell-cell fusion.
Assessment of Hypokalemia and Clinical Characteristics in Patients With Coronavirus Disease 2019 in Wenzhou, China.
Azithromycin and ambroxol as potential pharmacotherapy for SARS-CoV-2.
Bacterial modification of the host glycosaminoglycan heparan sulfate modulates SARS-CoV-2 infectivity.
Benign Evolution of SARS-Cov2 Infections in Children With Inflammatory Bowel Disease: Results From Two International Databases.
Binding of SARS-CoV-2 spike protein to ACE2 is disabled by thiol-based drugs; evidence from in vitro SARS-CoV-2 infection studies.
Biological plausibility for interactions between dietary fat, resveratrol, ACE2, and SARS-CoV illness severity.
Biomechanical characterization of SARS-CoV-2 spike RBD and human ACE2 protein-protein interaction.
Biophysical properties of the isolated spike protein binding helix of human ACE2.
Blocking Effect of Demethylzeylasteral on the Interaction between Human ACE2 Protein and SARS-CoV-2 RBD Protein Discovered Using SPR Technology.
Camostat Mesylate May Reduce Severity of Coronavirus Disease 2019 Sepsis: A First Observation.
Cardiac arrest and COVID-19: inflammation, angiotensin-converting enzyme 2, and the destabilization of non-significant coronary artery disease-a case report.
Cardiorenal Tissues Express SARS-CoV-2 Entry Genes and Basigin (BSG/CD147) Increases With Age in Endothelial Cells.
Cardiovascular Pharmacology in the Time of COVID-19: A Focus on Angiotensin-Converting Enzyme 2.
Case Report: An Unusual Case of Biventricular Thrombosis in a COVID-19 Patient With Ischemic Dilated Cardiomyopathy: Assessment of Mass Mobility and Embolic Risk by Tissue Doppler Imaging.
Case Report: B Lymphocyte Disorders Under COVID-19 Inflammatory Pressure.
CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus.
Central Nervous System Manifestations Associated with COVID-19.
Cigarette Smoke Stimulates SARS-CoV-2 Internalization by Activating AhR and Increasing ACE2 Expression in Human Gingival Epithelial Cells.
Circulating cardiovascular microRNAs in critically ill COVID-19 patients.
Circulating Soluble ACE2 and Upstream microRNA Expressions in Serum of Type 2 Diabetes Mellitus Patients.
Classical and Counter-Regulatory Renin-Angiotensin System: Potential Key Roles in COVID-19 Pathophysiology.
Clinical Isolates of Human Coronavirus 229E Bypass the Endosome for Cell Entry.
Clinical significance of angiotensin-converting enzyme 2 receptors for severe acute respiratory syndrome coronavirus 2 (COVID-19) on peripheral small-fiber sensory neurons is unknown today.
Cognitive disorders associated with hospitalization of COVID-19: Results from an observational cohort study.
Comparative analysis of ACE2 protein expression in rodent, non-human primate, and human respiratory tract at baseline and after injury: A conundrum for COVID-19 pathogenesis.
Comparative phylogenetic analysis of SARS-CoV-2 spike protein-possibility effect on virus spillover.
Comparison of SARS-CoV-2 variant lethality in human angiotensin-converting enzyme 2 transgenic mice.
Computational and experimental insights on the interaction of artemisinin, dihydroartemisinin and chloroquine with SARS-CoV-2 spike protein receptor-binding domain (RBD).
Computational Identification of a Putative Allosteric Binding Pocket in TMPRSS2.
Computational optimization of the SARS-CoV-2 receptor-binding-motif affinity for human ACE2.
Controversial Roles of the Renin Angiotensin System and Its Modulators During the COVID-19 Pandemic.
Coronavirus Disease 2019 (COVID-19) in Children - What We Know So Far and What We Do Not.
Coronavirus Disease 2019 and the Cerebrovascular-Cardiovascular Systems: What Do We Know So Far?
Coronavirus Disease 2019-Associated Thrombosis and Coagulopathy: Review of the Pathophysiological Characteristics and Implications for Antithrombotic Management.
Coronavirus Disease 2019: A Gastroenterologist's Perspective in May 2020.
Coronavirus disease 2019: acute Fanconi syndrome precedes acute kidney injury.
Coronavirus disease and the cardiovascular system: a narrative review of the mechanisms of injury and management implications.
Correlation Between Clinical and Pathological Findings of Liver Injury in 27 Patients With Lethal COVID-19 Infections in Brazil.
Could Anti-Hypertensive Drug Therapy Affect the Clinical Prognosis of Hypertensive Patients With COVID-19 Infection? Data From Centers of Southern Italy.
COVID-19 and bronchial asthma: current perspectives.
COVID-19 and Cardiovascular Disease.
COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives.
COVID-19 and diabetes; Possible role of polymorphism and rise of telemedicine.
COVID-19 and heart failure: from infection to inflammation and angiotensin II stimulation. Searching for evidence from a new disease.
COVID-19 and human reproduction: A pandemic that packs a serious punch.
COVID-19 and metabolic comorbidities: An update on emerging evidences for optimal therapies.
COVID-19 and Multiorgan Response.
COVID-19 and the gastrointestinal tract: Source of infection or merely a target of the inflammatory process following SARS-CoV-2 infection?
COVID-19 and the Kidneys, Implications and Outcomes.
COVID-19 in gastroenterology and hepatology: Lessons learned and questions to be answered.
COVID-19 preclinical models: human angiotensin-converting enzyme 2 transgenic mice.
COVID-19: an update and cardiac involvement.
COVID-19: Current Understanding of Pathophysiology.
Critical ACE2 Determinants of SARS-CoV-2 and Group 2B Coronavirus Infection and Replication.
Critical Interactions Between the SARS-CoV-2 Spike Glycoprotein and the Human ACE2 Receptor.
Crosstalk between coronavirus disease 2019 and cardiovascular disease and its treatment.
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Cytokine-Induced Modulation of SARS-CoV2 Receptor Expression in Primary Human Nasal Epithelial Cells.
De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2.
Deleterious Effects of SARS-CoV-2 Infection on Human Pancreatic Cells.
Design of an engineered ACE2 as a novel therapeutics against COVID-19.
Development of flexible electrochemical impedance spectroscopy-based biosensing platform for rapid screening of SARS-CoV-2 inhibitors.
Development of spike receptor-binding domain nanoparticle as a vaccine candidate against SARS-CoV-2 infection in ferrets.
Development of Spike Receptor-Binding Domain Nanoparticles as a Vaccine Candidate against SARS-CoV-2 Infection in Ferrets.
Diabetes and COVID-19: evidence, current status and unanswered research questions.
Diesel Particulate Matter 2.5 Induces Epithelial-to-Mesenchymal Transition and Upregulation of SARS-CoV-2 Receptor during Human Pluripotent Stem Cell-Derived Alveolar Organoid Development.
Difference in receptor usage between severe acute respiratory syndrome (SARS) coronavirus and SARS-like coronavirus of bat origin.
Differential virological and immunological outcome of severe acute respiratory syndrome coronavirus infection in susceptible and resistant transgenic mice expressing human angiotensin-converting enzyme 2.
Discovery of Small Anti-ACE2 Peptides to Inhibit SARS-CoV-2 Infectivity.
Disequilibrium between the classic renin-angiotensin system and its opposing arm in SARS-CoV-2-related lung injury.
Distinct disease severity between children and older adults with COVID-19: Impacts of ACE2 expression, distribution, and lung progenitor cells.
Distinct expression of SARS-CoV-2 receptor ACE2 correlates with endotypes of chronic rhinosinusitis with nasal polyps.
Distribution of the ACE1 D Allele in the Bosnian-Herzegovinian Population and its Possible Role in the Regional Epidemiological Picture of COVID-19.
Do Anti-androgens Have Potential as Therapeutics for COVID-19?
Do genetic polymorphisms in angiotensin converting enzyme 2 (ACE2) gene play a role in coronavirus disease 2019 (COVID-19)?
Do SARS-CoV-2 Infection (COVID-19) and the Medications Administered for Its Treatment Impair Testicular Functions?
Does hereditary angioedema make COVID-19 worse?
Does infection of 2019 novel coronavirus cause acute and/or chronic sialadenitis?
Does severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) cause orchitis in patients with coronavirus disease 2019 (COVID-19)?
Downregulation of ACE2 expression by SARS-CoV-2 worsens the prognosis of KIRC and KIRP patients via metabolism and immunoregulation.
Drug screening and development from the affinity of S protein of new coronavirus with ACE2.
Dual role for angiotensin-converting enzyme 2 in Severe Acute Respiratory Syndrome Coronavirus 2 infection and cardiac fat.
Dysregulation of COVID-19 related gene expression in the COPD lung.
Effect of COVID-19 on hereditary angioedema activity and quality of life.
Effects of SARS-CoV-2 infection on male sex-related hormones in recovering patients.
Effects of SARS-CoV-2 on Cardiovascular System: The Dual Role of Angiotensin-Converting Enzyme 2 (ACE2) as the Virus Receptor and Homeostasis Regulator-Review.
Efficient activation of SARS coronavirus spike protein by the transmembrane protease, TMPRSS2.
Efficient replication of severe acute respiratory syndrome coronavirus in mouse cells is limited by murine angiotensin-converting enzyme 2.
EMMPRIN/BASIGIN as a biological modulator of oral cancer and COVID-19 interaction: Novel propositions.
Endocrine Significance of SARS-CoV-2's Reliance on ACE2.
Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2.
Enhanced receptor binding of SARS-CoV-2 through networks of hydrogen-bonding and hydrophobic interactions.
Estrogen regulates the expression of SARS-CoV-2 receptor ACE2 in differentiated airway epithelial cells.
Evaluating angiotensin-converting enzyme 2-mediated SARS-CoV-2 entry across species.
Evidence for Use or Disuse of Renin-Angiotensin System Modulators in Patients Having COVID-19 With an Underlying Cardiorenal Disorder.
Exercise Training and Cardiac Rehabilitation in COVID-19 Patients with Cardiovascular Complications: State of Art.
Existence of SARS-CoV-2 Entry Molecules in the Oral Cavity.
Exploring the pathogenesis of severe acute respiratory syndrome (SARS): the tissue distribution of the coronavirus (SARS-CoV) and its putative receptor, angiotensin-converting enzyme 2 (ACE2).
Exposure to particulate matter upregulates ACE2 and TMPRSS2 expression in the murine lung.
Expression of ACE2 in Human Neurons Supports the Neuro-Invasive Potential of COVID-19 Virus.
Expression of ACE2, TMPRSS2, and Furin in Mouse Ear Tissue, and the Implications for SARS-CoV-2 Infection.
Expression of Endogenous Angiotensin-Converting Enzyme 2 in Human Induced Pluripotent Stem Cell-Derived Retinal Organoids.
Expression of severe acute respiratory syndrome coronavirus 2 cell entry genes, angiotensin-converting enzyme 2 and transmembrane protease serine 2, in the placenta across gestation and at the maternal-fetal interface in pregnancies complicated by preterm birth or preeclampsia.
Factors Behind the Higher COVID-19 Risk in Diabetes: A Critical Review.
Food Enrichment with Glycyrrhiza glabra Extract Suppresses ACE2 mRNA and Protein Expression in Rats-Possible Implications for COVID-19.
Functional importance of the D614G mutation in the SARS-CoV-2 spike protein.
Gene Expression of Angiotensin-Converting Enzyme 2 Receptor in Skin and the Implications for COVID-19.
Generation of enzymatically competent SARS-CoV-2 decoy receptor ACE2-Fc in glycoengineered Nicotiana benthamiana.
Genetic variations in the human severe acute respiratory syndrome coronavirus receptor ACE2 and serine protease TMPRSS2.
HDL-scavenger receptor B type 1 facilitates SARS-CoV-2 entry.
Heparin prevents in vitro glycocalyx shedding induced by plasma from COVID-19 patients.
Hepatic complications of COVID-19 and its treatment.
Hesperidin Is a Potential Inhibitor against SARS-CoV-2 Infection.
Highlights in the fight against COVID-19: does autophagy play a role in SARS-CoV-2 infection?
Highly Conserved Homotrimer Cavity Formed by the SARS-CoV-2 Spike Glycoprotein: A Novel Binding Site.
Highly conserved regions within the spike proteins of human coronaviruses 229E and NL63 determine recognition of their respective cellular receptors.
Human and novel coronavirus infections in children: a review.
Human coronavirus NL63 utilizes heparan sulfate proteoglycans for attachment to target cells.
Human Type II Taste Cells Express Angiotensin-Converting Enzyme 2 and Are Infected by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
Humanized COVID-19 decoy antibody effectively blocks viral entry and prevents SARS-CoV-2 infection.
Hypernatremia-A Manifestation of COVID-19: A Case Series.
Hypertension and Electrolyte Disorders in Patients with COVID-19.
Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney.
Hypokalaemic Paralysis Associated with COVID-19 Infection.
iBioProVis: interactive visualization and analysis of compound bioactivity space.
Ibuprofen and COVID-19 disease: separating the myths from facts.
Identification of natural compounds as SARS-CoV-2 entry inhibitors by molecular docking-based virtual screening with bio-layer interferometry.
Identification of pulmonary Oct-4+ stem/progenitor cells and demonstration of their susceptibility to SARS coronavirus (SARS-CoV) infection in vitro.
Identification of residues in the receptor-binding domain (RBD) of the spike protein of human coronavirus NL63 that are critical for the RBD-ACE2 receptor interaction.
Identification of the SARS-CoV-2 Entry Receptor ACE2 as a Direct Target for Transcriptional Repression by Miz1.
IMAGING FINDINGS IN A CASE OF MYO-PERICARDITIS ASSOCIATED WITH SARS CoV-2 DISEASE.
Impact of sex and gender on COVID-19 outcomes in Europe.
Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload.
Implications of SARS-CoV-2 infection for neurogastroenterology.
In silico screening of potential anti-COVID-19 bioactive natural constituents from food sources by molecular docking.
In Silico Structure-Based Repositioning of Approved Drugs for Spike Glycoprotein S2 Domain Fusion Peptide of SARS-CoV-2: Rationale from Molecular Dynamics and Binding Free Energy Calculations.
Inappropriate Heart Rate Response to Hypotension in Critically Ill COVID-19-Associated Acute Kidney Injury.
Increased ACE2 Expression in Bronchial Epithelium of COPD Patients who are Overweight.
Individual variation of the SARS-CoV-2 receptor ACE2 gene expression and regulation.
Influence of androgen deprivation therapy on the severity of COVID-19 in prostate cancer patients.
Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2.
Inpatient Omission of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers Is Associated With Morbidity and Mortality in Coronavirus Disease 2019.
Interferons and viruses induce a novel primate-specific isoform dACE2 and not the SARS-CoV-2 receptor ACE2.
Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor.
Intestinal expression of ACE2 in mice with high-fat diet-induced obesity and neonates exposed to maternal high-fat diet.
Investigation of Interaction between the Spike Protein of SARS-CoV-2 and ACE2-Expressing Cells Using an In Vitro Cell Capturing System.
Investigation of the genetic variation in ACE2 on the structural recognition by the novel coronavirus (SARS-CoV-2).
Involvement of digestive system in COVID-19: manifestations, pathology, management and challenges.
Is Low Alveolar Type II Cell SOD3 in the Lungs of Elderly Linked to the Observed Severity of COVID-19?
Is There an Association Between COVID-19 Mortality and the Renin-Angiotensin System? A Call for Epidemiologic Investigations.
Is there an association between the level of ambient air pollution and COVID-19?
Isoelectric point determination by imaged CIEF of commercially available SARS-CoV-2 proteins and the hACE2 receptor.
Key Aspects in Nutritional Management of COVID-19 Patients.
Kidney ACE2 expression: Implications for chronic kidney disease.
Let's talk about sex in the context of COVID-19.
Level of the SARS-CoV-2 receptor ACE2 activity is highly elevated in old-aged patients with aortic stenosis: implications for ACE2 as a biomarker for the severity of COVID-19.
Linking ACE2 and angiotensin II to pulmonary immunovascular dysregulation in SARS-CoV-2 infection.
Low serum neutralizing anti-SARS-CoV-2 S antibody levels in mildly affected COVID-19 convalescent patients revealed by two different detection methods.
Lung and Kidney ACE2 and TMPRSS2 in Renin-Angiotensin System Blocker-Treated Comorbid Diabetic Mice Mimicking Host Factors That Have Been Linked to Severe COVID-19.
Lung Cancer Models Reveal Severe Acute Respiratory Syndrome Coronavirus 2-Induced Epithelial-to-Mesenchymal Transition Contributes to Coronavirus Disease 2019 Pathophysiology.
Male pituitary-gonadal axis dysfunction in post-acute COVID-19 syndrome-Prevalence and associated factors: A Mediterranean case series.
Mendelian randomization analysis provides causality of smoking on the expression of ACE2, a putative SARS-CoV-2 receptor.
Metformin Use in Diabetes Prior to Hospitalization: Effects on Mortality in Covid-19.
Mice transgenic for human angiotensin-converting enzyme 2 provide a model for SARS coronavirus infection.
Micronutrients and bioactive substances: Their potential roles in combating COVID-19.
MicroRNA Mimics or Inhibitors as Antiviral Therapeutic Approaches Against COVID-19.
miR-98 Regulates TMPRSS2 Expression in Human Endothelial Cells: Key Implications for COVID-19.
Molecular docking of compounds from Clinacanthus nutans extract detected by GC-MS analysis with the SARS-CoV-2 main protease and ACE2 protein.
Molecular Dynamics Reveals Complex Compensatory Effects of Ionic Strength on the Severe Acute Respiratory Syndrome Coronavirus 2 Spike/Human Angiotensin-Converting Enzyme 2 Interaction.
Molecular PET/CT Profiling of ACE2 Expression In Vivo: Implications for Infection and Outcome from SARS-CoV-2.
Monoclonal antibodies for the S2 subunit of spike of SARS-CoV-1 cross-react with the newly-emerged SARS-CoV-2.
mRNA induced expression of human angiotensin-converting enzyme 2 in mice for the study of the adaptive immune response to severe acute respiratory syndrome coronavirus 2.
Mutations derived from horseshoe bat ACE2 orthologs enhance ACE2-Fc neutralization of SARS-CoV-2.
Mutations from bat ACE2 orthologs markedly enhance ACE2-Fc neutralization of SARS-CoV-2.
Neurological Complications of COVID-19 and Possible Neuroinvasion Pathways: A Systematic Review.
Neurological Consequences of SARS-CoV-2 Infection and Concurrence of Treatment-Induced Neuropsychiatric Adverse Events in COVID-19 Patients: Navigating the Uncharted.
Neuropathology of COVID-19 (neuro-COVID): clinicopathological update.
Neutralizing antibodies for the prevention and treatment of COVID-19.
Neutralizing Aptamers Block S/RBD-ACE2 Interactions and Prevent Host Cell Infection.
New onset diabetes, type 1 diabetes and COVID-19.
New perspectives on angiotensin-converting enzyme 2 and its related diseases.
NMR Based SARS-CoV-2 Antibody Screening.
No evidence of severe acute respiratory syndrome-coronavirus 2 in semen of males recovering from coronavirus disease 2019.
Novel Evidence of Acute Kidney Injury in COVID-19.
Obesity and Outcomes in COVID-19: When an Epidemic and Pandemic Collide.
Ogilvie Syndrome and COVID-19 Infection.
Oral lesions in patients with SARS-CoV-2 infection: could the oral cavity be a target organ?
Overexpression of the SARS-CoV-2 receptor ACE2 is induced by cigarette smoke in bronchial and alveolar epithelia.
Overexpression of the Severe Acute Respiratory Syndrome Coronavirus-2 Receptor, Angiotensin-Converting Enzyme 2, in Diabetic Kidney Disease: Implications for Kidney Injury in Novel Coronavirus Disease 2019.
Paediatric COVID-19 and the GUT.
Pernio (Chilblains), SARS-CoV-2, and COVID Toes Unified Through Cutaneous and Systemic Mechanisms.
Physical Exercise and the Renin Angiotensin System: Prospects in the COVID-19.
Physiological implications of COVID-19 in reproduction: angiotensin-converting enzyme 2 a key player.
Plasma ACE2 predicts outcome of COVID-19 in hospitalized patients.
Population-Specific ACE2 Single-Nucleotide Polymorphisms Have Limited Impact on SARS-CoV-2 Infectivity In Vitro.
Positive association of angiotensin II receptor blockers, not angiotensin-converting enzyme inhibitors, with an increased vulnerability to SARS-CoV-2 infection in patients hospitalized for suspected COVID-19 pneumonia.
Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features.
Potential benefits of dietary seaweeds as protection against COVID-19.
Potential detrimental role of soluble ACE2 in severe COVID-19 comorbid patients.
Potential effects of COVID-19 on reproductive systems and fertility; assisted reproductive technology guidelines and considerations: a review.
Potential mechanisms of cerebrovascular diseases in COVID-19 patients.
Potential mechanisms of hemorrhagic stroke in elderly COVID-19 patients.
Potential Mechanisms of the SARS-CoV-2-induced AKI Progression to CKD: A Forward-Looking Perspective.
Potential pathogenesis of severe acute respiratory syndrome coronavirus 2.
Prior Routine Use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Important Outcomes in Hospitalised Patients with COVID-19.
Prior Statin Use and Risk of Mortality and Severe Disease From Coronavirus Disease 2019: A Systematic Review and Meta-analysis.
Prognostic Significance of COVID-19 Receptor ACE2 and Recommendation for Antihypertensive Drug in Renal Cell Carcinoma.
Protein Expression of Angiotensin-Converting Enzyme 2 (ACE2) is Upregulated in Brains with Alzheimer's Disease.
Pulmonary ACE2 expression in neonatal and adult rats.
Pulmonary vascular endothelial injury and acute pulmonary hypertension caused by COVID-19: the fundamental cause of refractory hypoxemia?
Quantifying the adhesive strength between the SARS-CoV-2 S-proteins and human receptor and its effect in therapeutics.
Quercetin and Its Metabolites Inhibit Recombinant Human Angiotensin-Converting Enzyme 2 (ACE2) Activity.
Rapid and Sensitive Inhibitor Screening Using Magnetically Modulated Biosensors.
Recent advances in the angiotensin-converting enzyme 2-angiotensin(1-7)-Mas axis.
Recovery scenario and immunity in COVID-19 disease: A new strategy to predict the potential of reinfection.
Relationship Between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and the Etiology of Acute Kidney Injury (AKI).
Renin-angiotensin system blockade in the COVID-19 pandemic.
Renin-angiotensin system blockers and severe acute respiratory syndrome coronavirus 2.
Renin-angiotensin system inhibition and risk of infection and mortality in COVID-19: a systematic review and meta-analysis.
Renin-angiotensin system inhibitors in COVID-19.
Renin-Angiotensin-Aldosterone System Inhibitors in COVID-19: A Review.
Replication-dependent downregulation of cellular angiotensin-converting enzyme 2 protein expression by human coronavirus NL63.
Retroviruses pseudotyped with the severe acute respiratory syndrome coronavirus spike protein efficiently infect cells expressing angiotensin-converting enzyme 2.
Rhesus angiotensin converting enzyme 2 supports entry of severe acute respiratory syndrome coronavirus in Chinese macaques.
Role and mechanism of angiotensin-converting enzyme 2 in acute lung injury in coronavirus disease 2019.
Role of gastrointestinal system on transmission and pathogenesis of SARS-CoV-2.
Roux-en-Y Gastric Bypass Downregulates Angiotensin-Converting Enzyme 2 (ACE2) Gene Expression in Subcutaneous White Adipose Tissue: A Putative Protective Mechanism Against Severe COVID-19.
SAMHD1 as the Potential Link Between SARS-CoV-2 Infection and Neurological Complications.
SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS.
SARS-CoV-2 cell entry receptor ACE2 mediated endothelial dysfunction leads to vascular thrombosis in COVID-19 patients.
SARS-CoV-2 Cellular Entry Is Independent of the ACE2 Cytoplasmic Domain Signaling.
SARS-CoV-2 Entry Factors: ACE2 and TMPRSS2 Are Expressed in Peri-Implantation Embryos and the Maternal-Fetal Interface.
SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2.
SARS-CoV-2 Host Receptor ACE2 Protein Expression Atlas in Human Gastrointestinal Tract.
SARS-CoV-2 Infection: A Role for S1P/S1P Receptor Signaling in the Nervous System?
SARS-CoV-2 Infectivity and Neurological Targets in the Brain.
SARS-CoV-2 may hijack GPCR signaling pathways to dysregulate lung ion and fluid transport.
SARS-CoV-2 Receptor ACE2 Gene Is Associated with Hypertension and Severity of COVID 19: Interaction with Sex, Obesity, and Smoking.
SARS-CoV-2 Spike Protein Induces Degradation of Junctional Proteins That Maintain Endothelial Barrier Integrity.
SARS-CoV-2 spike protein-mediated cell signaling in lung vascular cells.
SARS-CoV-2 Viral Persistence Based on Cycle Threshold Value and Liver Injury in Patients With COVID-19.
SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats (Rousettus aegyptiacus).
scRNA-seq Profiling of Human Testes Reveals the Presence of the ACE2 Receptor, A Target for SARS-CoV-2 Infection in Spermatogonia, Leydig and Sertoli Cells.
Serum ACE2, Angiotensin II, and Aldosterone Levels Are Unchanged in Patients With COVID-19.
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-Induced Cardiovascular Syndrome: Etiology, Outcomes, and Management.
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response.
Severe Acute Respiratory Syndrome Coronavirus 2 Attachment Receptor Angiotensin-Converting Enzyme 2 Is Decreased in Crohn's Disease and Regulated By Microbial and Inflammatory Signaling.
Severe acute respiratory syndrome coronavirus 2 infection, angiotensin-converting enzyme 2 and treatment with angiotensin-converting enzyme inhibitors or angiotensin II type 1 receptor blockers.
Severe acute respiratory syndrome coronavirus infection of mice transgenic for the human Angiotensin-converting enzyme 2 virus receptor.
Severe acute respiratory syndrome coronavirus-2 and the deduction effect of angiotensin-converting enzyme 2 in pregnancy.
Severe acute respiratory syndrome: an update.
Sex Hormones and Hormone Therapy during COVID-19 Pandemic: Implications for Patients with Cancer.
Sex steroids skew ACE2 expression in human airway: A contributing factor to sex differences in COVID-19?
Short-term effects of COVID-19 on semen parameters: A multicenter study of 69 cases.
Simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry.
Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics.
Single-cell RNA analysis on ACE2 expression provides insights into SARS-CoV-2 potential entry into the bloodstream and heart injury.
Single-Cell RNA-seq Reveals Angiotensin-Converting Enzyme 2 and Transmembrane Serine Protease 2 Expression in TROP2+ Liver Progenitor Cells: Implications in Coronavirus Disease 2019-Associated Liver Dysfunction.
Soluble angiotensin-converting enzyme 2 is transiently elevated in COVID-19 and correlates with specific inflammatory and endothelial markers.
Structural analysis of ACE2 variant N720D demonstrates a higher binding affinity to TMPRSS2.
Structural basis of severe acute respiratory syndrome coronavirus 2 infection.
Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia.
Structural Variability, Expression Profile, and Pharmacogenetic Properties of TMPRSS2 Gene as a Potential Target for COVID-19 Therapy.
Structure of severe acute respiratory syndrome coronavirus receptor-binding domain complexed with neutralizing antibody.
Structure, Dynamics, Receptor Binding, and Antibody Binding of the Fully Glycosylated Full-Length SARS-CoV-2 Spike Protein in a Viral Membrane.
Structure-based discovery of a novel angiotensin-converting enzyme 2 inhibitor.
Susceptibility to SARS coronavirus S protein-driven infection correlates with expression of angiotensin converting enzyme 2 and infection can be blocked by soluble receptor.
Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity.
Targeting the intestinal TMPRSS2 protease to prevent SARS-CoV-2 entry into enterocytes-prospects and challenges.
Targeting transcriptional regulation of SARS-CoV-2 entry factors ACE2 and TMPRSS2.
The Altered Anatomical Distribution of ACE2 in the Brain With Alzheimer's Disease Pathology.
The Anticoagulant Nafamostat Potently Inhibits SARS-CoV-2 S Protein-Mediated Fusion in a Cell Fusion Assay System and Viral Infection In Vitro in a Cell-Type-Dependent Manner.
The Biology of Lactoferrin, an Iron-Binding Protein That Can Help Defend Against Viruses and Bacteria.
The chaperone GRP78 is a host auxiliary factor for SARS-CoV-2 and GRP78 depleting antibody blocks viral entry and infection.
The Contribution of Biophysics and Structural Biology to Current Advances in COVID-19.
The COVID-19 Menace.
The COVID-19 pandemic, heart and cardiovascular diseases: What we have learned.
The Effects of A?1-42 Binding to the SARS-CoV-2 Spike Protein S1 Subunit and Angiotensin-Converting Enzyme 2.
The emergence of human coronavirus EMC: how scared should we be?
The evolutionary history of ACE2 usage within the coronavirus subgenus Sarbecovirus.
The Fight against COVID-19 on the Multi-Protease Front and Surroundings: Could an Early Therapeutic Approach with Repositioning Drugs Prevent the Disease Severity?
The fight against COVID-19: Striking a balance in the renin-angiotensin system.
The flexibility of ACE2 in the context of SARS-CoV-2 infection.
The four horsemen of a viral Apocalypse: The pathogenesis of SARS-CoV-2 infection (COVID-19).
The genetic sequence, origin, and diagnosis of SARS-CoV-2.
The identification of novel inhibitors of human angiotensin-converting enzyme 2 and main protease of Sars-Cov-2: A combination of in silico methods for treatment of COVID-19.
The Impact of Angiotensin-Converting Enzyme 2 (ACE2) Expression Levels in Patients with Comorbidities on COVID-19 Severity: A Comprehensive Review.
The important herbal pair for the treatment of COVID-19 and its possible mechanisms.
The interaction between the endocannabinoid system and the renin angiotensin system and its potential implication for COVID-19 infection.
The interaction of the severe acute respiratory syndrome coronavirus 2 spike protein with drug-inhibited angiotensin converting enzyme 2 studied by molecular dynamics simulation.
The interferon-stimulated exosomal hACE2 potently inhibits SARS-CoV-2 replication through competitively blocking the virus entry.
The mechanism and treatment of gastrointestinal symptoms in patients with COVID-19.
The overlooked chamber in coronavirus disease 2019.
The Pivotal Role of Adipocyte-Na K peptide in Reversing Systemic Inflammation in Obesity and COVID-19 in the Development of Heart Failure.
The Possible Double-Edged Sword Effects of Vitamin D on COVID-19: A Hypothesis.
The potential involvement of JAK-STAT signaling pathway in the COVID-19 infection assisted by ACE2.
The Rationale for Angiotensin Receptor Neprilysin Inhibitors in a Multi-Targeted Therapeutic Approach to COVID-19.
The Rhinolophus affinis bat ACE2 and multiple animal orthologs are functional receptors for bat coronavirus RaTG13 and SARS-CoV-2.
The role of androgens in COVID-19.
The Role of Angiotensin Converting Enzyme 2 in Modulating Gut Microbiota, Intestinal Inflammation, and Coronavirus Infection.
The Role of Chest Radiograph, Procalcitonin and Moxifloxacin in Diagnosis and Management of Breast Cancer Patients with COVID-19.
The role of nicotinic receptors in SARS-CoV-2 receptor ACE2 expression in intestinal epithelia.
The Role of Pulmonary Surfactants in the Treatment of Acute Respiratory Distress Syndrome in COVID-19.
The Spatial and Cell-Type Distribution of SARS-CoV-2 Receptor ACE2 in the Human and Mouse Brains.
The Spike Glycoprotein of SARS-CoV-2 Binds to ?1 Integrins Expressed on the Surface of Lung Epithelial Cells.
The TMPRSS2 Inhibitor Nafamostat Reduces SARS-CoV-2 Pulmonary Infection in Mouse Models of COVID-19.
The Two Faces of ACE2: The Role of ACE2 Receptor and Its Polymorphisms in Hypertension and COVID-19.
The use of hepatitis C virus NS3/4A and secreted alkaline phosphatase to quantitate cell-cell membrane fusion mediated by severe acute respiratory syndrome coronavirus S protein and the receptor angiotensin-converting enzyme 2.
Thermodynamics of the Interaction between the Spike Protein of Severe Acute Respiratory Syndrome Coronavirus-2 and the Receptor of Human Angiotensin-Converting Enzyme 2. Effects of Possible Ligands.
Thromboplasminflammation in COVID-19 Coagulopathy: Three Viewpoints for Diagnostic and Therapeutic Strategies.
Thyroid complications of SARS and coronavirus disease 2019 (COVID-19).
Tissue-specific and interferon-inducible expression of nonfunctional ACE2 through endogenous retroelement co-option.
Tissue-specific expression of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2, in mouse models of chronic kidney disease.
TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein.
TMPRSS2 Isoform 1 Activates Respiratory Viruses and Is Expressed in Viral Target Cells.
Transmission of Severe Acute Respiratory Syndrome Coronavirus 2 via Close Contact and Respiratory Droplets Among Human Angiotensin-Converting Enzyme 2 Mice.
TRIM28 regulates SARS-CoV-2 cell entry by targeting ACE2.
TRP channels in COVID-19 disease: Potential targets for prevention and treatment.
Two important controversial risk factors in SARS-CoV-2 infection: Obesity and smoking.
Underlying Mechanisms and Candidate Drugs for COVID-19 Based on the Connectivity Map Database.
Update on COVID-19: A teleconference with the Paediatric Virology Study Group (Review).
Update on SARS-CoV-2 infection in children.
Usage of peptidases by SARS-CoV-2 and several human coronaviruses as receptors: A mysterious story.
Use of Renin-Angiotensin-Aldosterone System Inhibitors and Severe COVID-19 Outcomes in Patients with Hypertension: A Nationwide Cohort Study.
Using genetics to understand the role of antihypertensive drugs modulating angiotensin-converting enzyme in immune function and inflammation.
Vesicular stomatitis virus pseudotyped with severe acute respiratory syndrome coronavirus spike protein.
Viral stimulation modulates endotype-related ACE2 expression in eosinophilic chronic rhinosinusitis.
What Do Influenza and COVID-19 Represent for Patients With Inflammatory Bowel Disease?
What solid organ transplant healthcare providers should know about renin-angiotensin-aldosterone system inhibitors and COVID-19.
Why blood group A individuals are at risk whereas blood group O individuals are protected from SARS-CoV-2 (COVID-19) infection: A hypothesis regarding how the virus invades the human body via ABO(H) blood group-determining carbohydrates.
Zinc supplementation augments the suppressive effects of repurposed NF-?B inhibitors on ACE2 expression in human lung cell lines.
[Association of age distribution with the expression of angiotensin-converting enzyme 2 in lung tissues in severe acute respiratory syndrome coronavirus 2 infection: reflections from the study of RAS pathway expression in mice].
[Cloning of ACE-2 gene encoding the functional receptor for the SARS coronavirus and its expression in eukaryotic cells]
[Expression of severe acute respiratory syndrome coronavirus receptors, ACE2 and CD209L in different organ derived microvascular endothelial cells]
Shock, Septic
Update on SARS-CoV-2 infection in children.
Silicosis
ACE2 Attenuates Epithelial-Mesenchymal Transition in MLE-12 Cells Induced by Silica.
Skin Neoplasms
An investigation into the molecular basis of cancer comorbidities in coronavirus infection.
Sleep Deprivation
Does the compromised sleep and circadian disruption of night and shiftworkers make them highly vulnerable to 2019 coronavirus disease (COVID-19)?
Squamous Cell Carcinoma of Head and Neck
Structural Basis of Covalent Inhibitory Mechanism of TMPRSS2-Related Serine Proteases by Camostat.
TMPRSS2, a SARS-CoV-2 internalization protease is downregulated in head and neck cancer patients.
Stroke
A review on SARS-CoV-2 and stroke pathogenesis and outcome.
Activation of the Neuroprotective Angiotensin-Converting Enzyme 2 in Rat Ischemic Stroke.
Altered COVID-19 receptor ACE2 expression in a higher risk group for cerebrovascular disease and ischemic stroke.
Assessing the effects of Ang-(1-7) therapy following transient middle cerebral artery occlusion.
Large Vessel Stroke Following Multiple Other Strokes and Cardiomyopathy in a Forty-Nine-Year-Old COVID-19 Patient.
Serum activity of angiotensin converting enzyme 2 is decreased in patients with acute ischemic stroke.
Stages in Discovery: Angiotensin-Converting Enzyme Type 2 and Stroke.
Stroke in patients infected by the novel coronavirus and its causal mechanisms: A narrative review.
[Relationship of angiotensin-converting enzyme 2 gene polymorphism with the prognosis of hypertensive stroke patients]
Superinfection
Paracetamol-Induced Glutathione Consumption: Is There a Link With Severe COVID-19 Illness?
Tachycardia
Defects in cutaneous angiotensin-converting enzyme 2 and angiotensin-(1-7) production in postural tachycardia syndrome.
Tachypnea
Sars-CoV-2: A clinical update - II.
Thrombocytopenia
Hemostatic abnormalities in COVID-19: A guided review.
Thromboembolism
Endothelial Immunity Trained by Coronavirus Infections, DAMP Stimulations and Regulated by Anti-Oxidant NRF2 May Contribute to Inflammations, Myelopoiesis, COVID-19 Cytokine Storms and Thromboembolism.
Thromboinflammation
Potential mechanisms of cerebrovascular diseases in COVID-19 patients.
Thrombophilia
Acute Kidney Injury in COVID-19: The Chinese Experience.
Cardiovascular Considerations in Coronavirus Disease 2019 with a Special Focus on Arrhythmia.
Hemostatic abnormalities in COVID-19: A guided review.
Obesity considerations during the COVID-19 outbreak.
Potential mechanisms of cerebrovascular diseases in COVID-19 patients.
SARS-CoV-2 and Acute Cerebrovascular Events: An Overview.
Understanding the Co-Epidemic of Obesity and COVID-19: Current Evidence, Comparison with Previous Epidemics, Mechanisms, and Preventive and Therapeutic Perspectives.
Thrombosis
A review of acute limb ischemia in COVID-positive patients.
Cardiac manifestations of COVID-19.
Cardiovascular Complications Associated with COVID-19 and Potential Therapeutic~Strategies.
COVID-19 - Endothelial Axis and Coronary Artery Bypass Graft Patency: a Target for Therapeutic Intervention?
COVID-19 Encephalopathy in Adults.
COVID-19: the role of excessive cytokine release and potential ACE2 down-regulation in promoting hypercoagulable state associated with severe illness.
Immunogenetic Predictors of Severe COVID-19.
Pathogeny of cerebral venous thrombosis in SARS-Cov-2 infection: Case reports.
Potential mechanisms of cerebrovascular diseases in COVID-19 patients.
SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19.
The angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas receptor axis: a potential target for treating thrombotic diseases.
Thyroid Neoplasms
An investigation into the molecular basis of cancer comorbidities in coronavirus infection.
Thyroiditis, Subacute
Detection of SARS-COV-2 receptor ACE-2 mRNA in thyroid cells: a clue for COVID-19-related subacute thyroiditis.
Trypanosomiasis
Diminazene aceturate--An antiparasitic drug of antiquity: Advances in pharmacology & therapeutics.
Ureteral Obstruction
Altered regulation of renin-angiotensin, endothelin and natriuretic peptide systems in rat kidney with chronic unilateral ureteral obstruction.
Urinary Bladder, Neurogenic
Study of serum and urinary markers of the renin-angiotensin-aldosterone system in myelomeningocele patients with renal injury detected by DMSA.
Uveitis
AAV8-Mediated Angiotensin-Converting Enzyme 2 Gene Delivery Prevents Experimental Autoimmune Uveitis by Regulating MAPK, NF-?B and STAT3 Pathways.
Angiotensin-converting enzyme 2 (ACE2) activator diminazene aceturate ameliorates endotoxin-induced uveitis in mice.
Topical administration of diminazene aceturate decreases inflammation in endotoxin-induced uveitis.
Vascular Diseases
rhACE2 Therapy Modifies Bleomycin-Induced Pulmonary Hypertension via Rescue of Vascular Remodeling.
Vascular System Injuries
Lower Gene Expression of Angiotensin Converting Enzyme 2 Receptor in Lung Tissues of Smokers with COVID-19 Pneumonia.
Temporal changes in soluble angiotensin-converting enzyme 2 associated with metabolic health, body composition, and proteome dynamics during a weight loss diet intervention: a randomized trial with implications for the COVID-19 pandemic.
Vasculitis
SARS-CoV-2 leads to a small vessel endotheliitis in the heart.
Ventricular Dysfunction
Enalapril attenuates downregulation of Angiotensin-converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat.
Ventricular Dysfunction, Left
The beneficial effects of angiotensin-converting enzyme II (ACE2) activator in pulmonary hypertension secondary to left ventricular dysfunction.
Vesicular Stomatitis
Evaluation of Cell-Based and Surrogate SARS-CoV-2 Neutralization Assays.
Neutralizing activity of Sputnik V vaccine sera against SARS-CoV-2 variants.
Viremia
An Update on Coronavirus Disease 2019 (COVID-19) and Pregnancy.
Assessment of Maternal and Neonatal SARS-CoV-2 Viral Load, Transplacental Antibody Transfer, and Placental Pathology in Pregnancies During the COVID-19 Pandemic.
Coronavirus Disease 2019 Transmission: Blood Viremia and Aerosol Generation from Spinal Surgery. Is There an Increased Risk to the Surgical Team?
Endothelial Immunity Trained by Coronavirus Infections, DAMP Stimulations and Regulated by Anti-Oxidant NRF2 May Contribute to Inflammations, Myelopoiesis, COVID-19 Cytokine Storms and Thromboembolism.
Virus Diseases
1,2,3,4,6-Pentagalloyl Glucose, a RBD-ACE2 Binding Inhibitor to Prevent SARS-CoV-2 Infection.
17?-estradiol reduces SARS-CoV-2 infection in vitro.
A potential peptide inhibitor of SARS-CoV-2?S and human ACE2 complex.
ACE2 Expression Is Upregulated in Inflammatory Corneal Epithelial Cells and Attenuated by Resveratrol.
ACE2, TMPRSS2 distribution and extrapulmonary organ injury in patients with COVID-19.
Active components in Ephedra sinica stapf disrupt the interaction between ACE2 and SARS-CoV-2 RBD: Potent COVID-19 therapeutic agents.
Acute Kidney Injury in COVID-19.
Advanced-glycation end-products axis: A contributor to the risk of severe illness from COVID-19 in diabetes patients.
Alpha-1-antitrypsin: A possible host protective factor against Covid-19.
Aptamer Conjugated Gold Nanostar-Based Distance-Dependent Nanoparticle Surface Energy Transfer Spectroscopy for Ultrasensitive Detection and Inactivation of Corona Virus.
CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells.
Cerebral Venous Sinus Thrombosis in COVID-19 Infection: A Case Series and Review of The Literature.
Chest CT Features from 58 Patients with COVID-19 Pneumonia from the Perspective of ACE2.
Computational drug repurposing strategy predicted peptide-based drugs that can potentially inhibit the interaction of SARS-CoV-2 spike protein with its target (humanACE2).
Computational Identification of a Putative Allosteric Binding Pocket in TMPRSS2.
Convalescent Memory T Cell Immunity in Individuals with Mild or Asymptomatic SARS-CoV-2 Infection May Result from an Evolutionarily Adapted Immune Response to Coronavirus and the 'Common Cold'.
Covid-19 pathogenesis in prostatic cancer and TMPRSS2-ERG regulatory genetic pathway.
COVID-19-related Genes in Sputum Cells in Asthma. Relationship to Demographic Features and Corticosteroids.
COVID?19 and SARS?CoV?2 host cell entry mediators: Expression profiling of TMRSS4 in health and disease.
Cross-species recognition of SARS-CoV-2 to bat ACE2.
Defining the Immune Responses for SARS-CoV-2-Human Macrophage Interactions.
Dependence of SARS-CoV-2 infection on cholesterol-rich lipid raft and endosomal acidification.
Detection of viral RNA fragments in human iPSC cardiomyocytes following treatment with extracellular vesicles from SARS-CoV-2 coding sequence overexpressing lung epithelial cells.
Detection of Viral RNA Fragments in Human iPSC-Cardiomyocytes following Treatment with Extracellular Vesicles from SARS-CoV-2 Coding-Sequence-Overexpressing Lung Epithelial Cells.
Development of potent and effective synthetic SARS-CoV-2 neutralizing nanobodies.
Distinct infection process of SARS-CoV-2 in human bronchial epithelial cells line.
Dodging COVID-19 infection: low expression and localization of ACE2 and TMPRSS2 in multiple donor-derived lines of human umbilical cord-derived mesenchymal stem cells.
Drug screening and development from the affinity of S protein of new coronavirus with ACE2.
Effect of Angiotensin Converting Enzyme Inhibitors/Angiotensin Receptor Blockers on COVID-19 outcome: A Record Based Observational Study in West Bengal.
Efficacy of GC-376 against SARS-CoV-2 virus infection in the K18 hACE2 transgenic mouse model.
Efficient activation of SARS coronavirus spike protein by the transmembrane protease, TMPRSS2.
Endocrine Involvement in COVID-19: Mechanisms, Clinical Features, and Implications for Care.
Focus on clinical practice: angiotensin-converting enzyme 2 and corona virus disease 2019: pathophysiology and clinical implications.
Gender susceptibility to COVID-19: a review of the putative role of sex hormones and X chromosome.
Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue.
Generation of SARS-CoV-2 Spike Pseudotyped Virus for Viral Entry and Neutralization Assays: A 1-Week Protocol.
Genome interaction of the virus and the host genes and non-coding RNAs in SARS-CoV-2 infection.
Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin.
Histopathological features of SARS-CoV-2 infection and relationships with organoid technology.
Identification of potential SARS-CoV-2 entry inhibitors by targeting the interface region between the spike RBD and human ACE2.
Identification of SARS-CoV-2 Receptor Binding Inhibitors by In Vitro Screening of Drug Libraries.
Immune response to SARS-CoV-2 in the nasal mucosa in children and adults.
In-silico design of a potential inhibitor of SARS-CoV-2 S protein.
Increased susceptibility of human endothelial cells to infections by SARS-CoV-2 variants.
Influenza virus activating host proteases: Identification, localization and inhibitors as potential therapeutics.
Inhibition of Influenza A virus propagation by benzoselenoxanthenes stabilizing TMPRSS2 Gene G-quadruplex and hence down-regulating TMPRSS2 expression.
Inhibition of influenza virus infection in human airway cell cultures by an antisense peptide-conjugated morpholino oligomer targeting the hemagglutinin-activating protease TMPRSS2.
Irisin modulates genes associated with severe coronavirus disease (COVID-19) outcome in human subcutaneous adipocytes cell culture.
Korean traditional foods as antiviral and respiratory disease prevention and treatments: A detailed review.
Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2.
Neutralizing Aptamers Block S/RBD-ACE2 Interactions and Prevent Host Cell Infection.
Pathophysiological Association of Endothelial Dysfunction with Fatal Outcome in COVID-19.
Perspectives and Challenges in the Fight Against COVID-19: The Role of Genetic Variability.
Plasma proteomics reveals tissue-specific cell death and mediators of cell-cell interactions in severe COVID-19 patients.
Potential antiviral activity of isorhamnetin against SARS-CoV-2 spike pseudotyped virus in vitro.
Potential detrimental role of soluble ACE2 in severe COVID-19 comorbid patients.
Potential protease inhibitors and their combinations to block SARS-CoV-2.
Profiling COVID-19 Genetic Research: A Data-Driven Study Utilizing Intelligent Bibliometrics.
Protective Role of a TMPRSS2 Variant on Severe COVID-19 Outcome in Young Males and Elderly Women.
Rapid generation of circulating and mucosal decoy ACE2 using mRNA nanotherapeutics for the potential treatment of SARS-CoV-2.
Regulation of the ACE2 locus in human airways cells.
SARS-CoV-2 can infect the placenta and is not associated with specific placental histopathology: a series of 19 placentas from COVID-19-positive mothers.
SARS-CoV-2 Cellular Entry Is Independent of the ACE2 Cytoplasmic Domain Signaling.
SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice.
SARS-CoV-2: Understanding the Transcriptional Regulation of ACE2 and TMPRSS2 and the Role of Single Nucleotide Polymorphism (SNP) at Codon 72 of p53 in the Innate Immune Response against Virus Infection.
Scientific Hypothesis for Treatment of COVID-19's Lung Lesions by Adjusting ACE/ACE2 Imbalance.
Severe acute respiratory syndrome coronavirus infection of human ciliated airway epithelia: role of ciliated cells in viral spread in the conducting airways of the lungs.
Strong Binding of Leupeptin with TMPRSS2 Protease May Be an Alternative to Camostat and Nafamostat for SARS-CoV-2 Repurposed Drug: Evaluation from Molecular Docking and Molecular Dynamics Simulations.
Supplementation with vitamin D in the COVID-19 pandemic?
The contrasting role of nasopharyngeal angiotensin converting enzyme 2 (ACE2) transcription in SARS-CoV-2 infection: A cross-sectional study of people tested for COVID-19 in British Columbia, Canada.
The Expression and Polymorphism of Entry Machinery for COVID-19 in Human: Juxtaposing Population Groups, Gender, and Different Tissues.
The renin-angiotensin system and specifically angiotensin-converting enzyme 2 as a potential therapeutic target in SARS-CoV-2 infections.
The role of nicotinic receptors in SARS-CoV-2 receptor ACE2 expression in intestinal epithelia.
The scRNA-seq Expression Profiling of the Receptor ACE2 and the Cellular Protease TMPRSS2 Reveals Human Organs Susceptible to SARS-CoV-2 Infection.
TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention?
TNF-? Blockers Showed Prophylactic Effects in Preventing COVID-19 in Patients with Rheumatoid Arthritis and Seronegative Spondyloarthropathies: A Case-Control Study.
Transmembrane serine protease 2 Polymorphisms and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Type 2 Infection: A German Case-Control Study.
Transmembrane serine protease TMPRSS2 activates hepatitis C virus infection.
Vitamin D Deficiency
Understanding the Co-Epidemic of Obesity and COVID-19: Current Evidence, Comparison with Previous Epidemics, Mechanisms, and Preventive and Therapeutic Perspectives.