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ATP + 1D-myo-inositol
ADP + 1D-myo-inositol 1-phosphate
-
-
-
-
?
ATP + D-tagatose
?
-
-
-
?
ATP + D-xylulose
?
-
-
-
?
ATP + myo-inositol
ADP + 1D-myo-inositol 3-phosphate
ATP + myo-inositol
ADP + 1L-myo-inositol 1-phosphate
-
-
-
?
ATP + myo-inositol
ADP + myo-inositol 1-phosphate
CTP + myo-inositol
CDP + myo-inositol 1-phosphate
GTP + myo-inositol
GDP + myo-inositol 1-phosphate
UTP + myo-inositol
UDP + myo-inositol 1-phosphate
additional information
?
-
ATP + myo-inositol
ADP + 1D-myo-inositol 3-phosphate
-
-
-
-
?
ATP + myo-inositol
ADP + 1D-myo-inositol 3-phosphate
-
-
-
?
ATP + myo-inositol
ADP + 1D-myo-inositol 3-phosphate
-
-
-
-
?
ATP + myo-inositol
ADP + myo-inositol 1-phosphate
-
-
-
?
ATP + myo-inositol
ADP + myo-inositol 1-phosphate
-
-
-
?
ATP + myo-inositol
ADP + myo-inositol 1-phosphate
-
-
-
?
ATP + myo-inositol
ADP + myo-inositol 1-phosphate
-
-
-
?
ATP + myo-inositol
ADP + myo-inositol 1-phosphate
-
biosynthesis of phytic acid
-
-
?
ATP + myo-inositol
ADP + myo-inositol 1-phosphate
-
-
-
?
ATP + myo-inositol
ADP + myo-inositol 1-phosphate
-
-
-
?
ATP + myo-inositol
ADP + myo-inositol 1-phosphate
-
-
-
?
ATP + myo-inositol
ADP + myo-inositol 1-phosphate
-
-
-
?
ATP + myo-inositol
ADP + myo-inositol 1-phosphate
-
-
-
?
CTP + myo-inositol
CDP + myo-inositol 1-phosphate
-
weak activity
-
?
CTP + myo-inositol
CDP + myo-inositol 1-phosphate
-
weak activity
-
?
CTP + myo-inositol
CDP + myo-inositol 1-phosphate
-
weak activity
-
?
CTP + myo-inositol
CDP + myo-inositol 1-phosphate
-
weak activity
-
?
GTP + myo-inositol
GDP + myo-inositol 1-phosphate
-
no actiity with TTP
-
?
GTP + myo-inositol
GDP + myo-inositol 1-phosphate
-
no actiity with TTP
-
?
GTP + myo-inositol
GDP + myo-inositol 1-phosphate
-
no actiity with TTP
-
?
GTP + myo-inositol
GDP + myo-inositol 1-phosphate
-
no actiity with TTP
-
?
UTP + myo-inositol
UDP + myo-inositol 1-phosphate
-
-
-
?
UTP + myo-inositol
UDP + myo-inositol 1-phosphate
-
-
-
?
UTP + myo-inositol
UDP + myo-inositol 1-phosphate
-
-
-
?
UTP + myo-inositol
UDP + myo-inositol 1-phosphate
-
-
-
?
additional information
?
-
no activity with glycerol, DL-threitol, L-iditol, dulcitol, volemitol, D-lactitol monohydrate, maltitol, D-glucosamine, N-acetyl-D-glucosamine, maltose and lactose, D-erythrose, D-threose, D-erythrulose, L-arabinose, L-fructose, L-glucose, D-ribulose, D-galactose, fructose 1-phosphate, fructose 6-phosphate, glucose 1-phosphate, glucose 6-phosphate, ribose 1-phosphate, ribose 5-phosphate, tagatose 6-phosphate, adenosine, uridine, guanosine, cytidine, thymidine, and inosine
-
-
?
additional information
?
-
-
no activity with glycerol, DL-threitol, L-iditol, dulcitol, volemitol, D-lactitol monohydrate, maltitol, D-glucosamine, N-acetyl-D-glucosamine, maltose and lactose, D-erythrose, D-threose, D-erythrulose, L-arabinose, L-fructose, L-glucose, D-ribulose, D-galactose, fructose 1-phosphate, fructose 6-phosphate, glucose 1-phosphate, glucose 6-phosphate, ribose 1-phosphate, ribose 5-phosphate, tagatose 6-phosphate, adenosine, uridine, guanosine, cytidine, thymidine, and inosine
-
-
?
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Adenocarcinoma of Lung
Alternate paths from epidermal growth factor receptor to Akt in malignant versus nontransformed lung epithelial cells: ErbB3 versus Gab1.
Breast Neoplasms
MICAL1 facilitates breast cancer cell proliferation via ROS-sensitive ERK/cyclin D pathway.
Breast Neoplasms
Phosphatidyl inositol 3-kinase (PI3K)-mTOR inhibitor PKI-402 inhibits breast cancer induced osteolysis.
Breast Neoplasms
Targeting the Phosphatidyl Inositol 3-Kinase Signaling Pathway in Breast Cancer.
Breast Neoplasms
The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer.
Carcinogenesis
Inhibition of midkine by metformin can contribute to its anticancer effects in malignancies: A proposal mechanism of action of metformin in context of endometrial cancer prevention and therapy.
Carcinogenesis
Roles of EGFR, PI3K, AKT, and mTOR in Heavy Metal-Induced Cancer.
Carcinoma
[The expression of PIK3CA in nasopharyngeal carcinoma].
Colorectal Neoplasms
FOXQ1 promotes cancer metastasis by PI3K/AKT signaling regulation in colorectal carcinoma.
Diabetes Mellitus, Type 1
Tuning in to the "right" calcium channel regulation in experimental models of diabetes.
Encephalomyelitis
Corrigendum.
Encephalomyelitis
Suppression of CD4+ T lymphocyte activation in vitro and experimental encephalomyelitis in vivo by the phosphatidyl inositol 3-kinase inhibitor PIK-75.
Fetal Growth Retardation
[Study on the mechanism of insulin resistance in rats born with intrauterine growth retardation]
Infections
Old world arenaviruses enter the host cell via the multivesicular body and depend on the endosomal sorting complex required for transport.
Insulin Resistance
The Mechanism by Which Amentoflavone Improves Insulin Resistance in HepG2 Cells.
Insulin Resistance
[Study on the mechanism of insulin resistance in rats born with intrauterine growth retardation]
Lymphoma
B-cell activating factor-receptor specific activation of tumor necrosis factor receptor associated factor 6 and the phosphatidyl inositol 3-kinase pathway in lymphoma B cells.
Lymphoma
Exosomes from Dendritic Cells Loaded with Chaperone-Rich Cell Lysates Elicit a Potent T Cell Immune Response Against Intracranial Glioma in Mice.
Lymphoma
Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members.
Lymphoma, B-Cell
Shikonin inhibits TNF-?-induced growth and invasion of rat aortic vascular smooth muscle cells.
Lymphoma, B-Cell
Sphingosine kinase-1 enhances endothelial cell survival through a PECAM-1-dependent activation of PI-3K/Akt and regulation of Bcl-2 family members.
Melanoma
The phosphatidyl inositol 3-kinase pathway is central to the pathogenesis of Kit-activated melanoma.
Nasopharyngeal Carcinoma
[The expression of PIK3CA in nasopharyngeal carcinoma].
Neoplasms
?-Estradiol Enhanced Secretion of Lipoprotein Lipase from Mouse Mammary Tumor FM3A Cells.
Neoplasms
AKT in thyroid tumorigenesis and progression.
Neoplasms
Association between Genetic and Immunological Background of Hepatocellular Carcinoma and Expression of Programmed Cell Death-1.
Neoplasms
B-cell activating factor-receptor specific activation of tumor necrosis factor receptor associated factor 6 and the phosphatidyl inositol 3-kinase pathway in lymphoma B cells.
Neoplasms
Chronic inflammation and pathogenesis of GI and pancreatic cancers.
Neoplasms
Differential radio-adaptive responses in BALB/c and C57BL/6 mice: pivotal role of calcium and nitric oxide signalling.
Neoplasms
Expression, localization, and phosphorylation of Akt1 in benign and malignant thyroid lesions.
Neoplasms
Focal adhesion kinase negatively regulates neuronal insulin resistance.
Neoplasms
Influence of hepatic artery occlusion on tumor growth and metastatic potential in a human orthotopic hepatoma nude mouse model: Relevance of epithelial-mesenchymal transition.
Neoplasms
Inhibition of midkine by metformin can contribute to its anticancer effects in malignancies: A proposal mechanism of action of metformin in context of endometrial cancer prevention and therapy.
Neoplasms
INPP4B exerts a dual function in the stemness of colorectal cancer stem-like cells through regulating Sox2 and Nanog expression.
Neoplasms
INPP4B inhibits cell proliferation, invasion and chemoresistance in human hepatocellular carcinoma.
Neoplasms
Lupeol modulates NF-kappaB and PI3K/Akt pathways and inhibits skin cancer in CD-1 mice.
Neoplasms
PI3K/PTEN signaling in tumorigenesis and angiogenesis.
Neoplasms
Quercetin enhances susceptibility to NK cell-mediated lysis of tumor cells through induction of NKG2D ligands and suppression of HSP70.
Neoplasms
Regulation of signal transduction and role of platelets in liver regeneration.
Neoplasms
Roles of EGFR, PI3K, AKT, and mTOR in Heavy Metal-Induced Cancer.
Neoplasms
Using Molecular Docking Analysis to Discovery Dregea sinensis Hemsl. Potential Mechanism of Anticancer, Antidepression, and Immunoregulation.
Neoplasms
Vasculogenic mimicry and tumor metastasis.
Neoplasms
Wortmannin induces MCF-7 breast cancer cell death via the apoptotic pathway, involving chromatin condensation, generation of reactive oxygen species, and membrane blebbing.
Neoplasms
[The expression of PIK3CA in nasopharyngeal carcinoma].
Osteolysis
Phosphatidyl inositol 3-kinase (PI3K)-mTOR inhibitor PKI-402 inhibits breast cancer induced osteolysis.
Osteosarcoma
Long non-coding RNA CCAT1/miR-148a axis promotes osteosarcoma proliferation and migration through regulating PIK3IP1.
Ovarian Neoplasms
[Effects of PTEN over-expression on phosphatidyl inositol 3-kinase/protein kinase B signal pathway in ovarian epithelial cancer cells].
Prostatic Neoplasms
The role of fibroblast growth factors and their receptors in prostate cancer.
Status Epilepticus
Expression of Bcl-2 and Bad in hippocampus of status epileptic rats and molecular mechanism of intervened recombinant human erythropoietin.
Thymoma
FOXQ1 promotes cancer metastasis by PI3K/AKT signaling regulation in colorectal carcinoma.
Thyroid Neoplasms
Suppressor of cytokine signaling 3 sensitizes anaplastic thyroid cancer to standard chemotherapy.
Thyroid Neoplasms
XB130, a novel adaptor protein, promotes thyroid tumor growth.
Triple Negative Breast Neoplasms
[Molecular mechanisms of resistance to phosphatidyl inositol 3-kinase inhibitors in triple-negative breast cancer cells].
Tuberculosis
Regulation of matrix metalloproteinase-1, -3, and -9 in Mycobacterium tuberculosis-dependent respiratory networks by the rapamycin-sensitive PI3K/p70S6K cascade.
Whooping Cough
Signal transduction pathways involved in soluble fractalkine-induced monocytic cell adhesion.
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English, P.D.; Dietz, M.; Albersheim, P.
Myoinositol kinase: partial purification and identification of product
Science
151
198-199
1966
Vigna radiata var. radiata, Spinacia oleracea, Triticum aestivum
brenda
Molinari, E.; Hoffmann-Ostenhof, O.
Studies on the biosynthesis of cyclitols. XXI. An enzyme system capable of phosphorylating myo-inositol to phytic acid
Hoppe-Seyler's Z. Physiol. Chem.
349
1797-1799
1968
Lemna gibba
brenda
Loewus, M.W.; Sasaki, K.; Leavitt, A.L.; Munsell, L.; Sherman, W.R.; Loewus, F.A.
Enantiomeric form of myo-inositol-1-phosphate produced by myo-inositol-1-phosphate synthase and myo-inositol kinase in higher plants
Plant Physiol.
70
1661-1663
1982
Triticum aestivum
brenda
Dietz, M.; Albersheim, P.
The enzymic phosphorylation of myo-inositol
Biochem. Biophys. Res. Commun.
19
598-603
1965
Acer pseudoplatanus, Bos taurus, Escherichia coli, Vigna radiata var. radiata
brenda
Shi, J.; Wang, H.; Hazebroek, J.; Ertl, D.S.; Harp, T.
The maize low-phytic acid 3 encodes a myo-inositol kinase that plays a role in phytic acid biosynthesis in developing seeds
Plant J.
42
708-719
2005
Zea mays
brenda
Nagata, R.; Fujihashi, M.; Sato, T.; Atomi, H.; Miki, K.
Crystal structure and product analysis of an archaeal myo-inositol kinase reveal substrate recognition mode and 3-OH phosphorylation
Biochemistry
54
3494-3503
2015
Thermococcus kodakarensis (Q5JDA3), Thermococcus kodakarensis
brenda
Sato, T.; Fujihashi, M.; Miyamoto, Y.; Kuwata, K.; Kusaka, E.; Fujita, H.; Miki, K.; Atomi, H.
An uncharacterized member of the ribokinase family in Thermococcus kodakarensis exhibits myo-inositol kinase activity
J. Biol. Chem.
288
20856-20867
2013
Thermococcus kodakarensis (Q5JDA3), Thermococcus kodakarensis
brenda
Moure, M.J.; Zhuo, Y.; Boons, G.J.; Prestegard, J.H.
Perdeuterated and 13C-enriched myo-inositol for DNP assisted monitoring of enzymatic phosphorylation by inositol-3-kinase
Chem. Commun. (Camb.)
53
12398-12401
2017
Thermococcus kodakarensis
brenda