Substrates: in the absence of an amino group acceptor, part of the ureidoglycine donates its amino group to the enzyme in a half-transamination reaction, and part of the ureidoglycine undergoes decay, producing the substrate necessary to complete the reaction. The enzyme is able to use various keto acids. No substrates: Ala, Asp, Glu, Ser, Val Products: -
PucG catalyzes the transamination between an unstable intermediate ((S)-ureidoglycine) and the end product of purine catabolism (glyoxylate) to yield oxalurate and glycine. This activity enables soil and gut bacteria to use the animal purine waste as a source of carbon and nitrogen. The same substrate provides both the amino group donor and, via its spontaneous decay, the amino group acceptor
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CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
to 2.05 A resolution. The crystal shows a dimer. The pyridoxal 5'-phosphate cofactor binds at the dimer interface, forming a Schiff base with residue K200
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