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Information on EC 2.5.1.44 - homospermidine synthase

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EC Tree
IUBMB Comments
The reaction of this bacterial enzyme occurs in three steps, with some of the intermediates presumably remaining enzyme-bound: (a) NAD+-dependent dehydrogenation of either putrescine or spermidine, forming 4-iminobutan-1-amine or (E)-(4-aminobutylidene)(3-aminopropyl)amine, respectively, (b) attack by water forming 4-aminobutanal (and releasing ammonia or propane-1,3-diamine, respectively), and (c) condensation of 4-aminobutanal with putrescine, which forms homospermidine and restores NAD+. Differs from the eukaryotic enzyme EC 2.5.1.45, homospermidine synthase (spermidine-specific), which cannot use putrescine as donor of the aminobutyl group.
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Word Map
  • 2.5.1.44
  • knee
  • arthroplasty
  • postoperative
  • pain
  • tibial
  • osteoarthritis
  • acquity
  • preoperative
  • fracture
  • acetonitrile
  • radiograph
  • formic
  • medial
  • femoral
  • radiological
  • osteotomy
  • loosening
  • flexion
  • varus
  • ultra-performance
  • satisfaction
  • inter-day
  • humic
  • womac
  • cement
  • radiolucent
  • cruciate
  • patella
  • mcmaster
  • arthroscopic
  • unicompartmental
  • uhplc
  • prostheses
  • lysholm
  • hepatosplenic
  • leadership
  • tegner
  • heterostructures
  • cementless
  • deoxyhypusine
  • malalignment
  • kellgren-lawrence
  • resurface
  • condylar
  • nonunion
  • precisions
  • posterolateral
  • meniscal
  • curricula
  • patellofemoral
The enzyme appears in viruses and cellular organisms
Synonyms
hss, homospermidine synthase, bvhss, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 putrescine = sym-homospermidine + NH3 + H+
show the reaction diagram
putrescine + spermidine = sym-homospermidine + propane-1,3-diamine
show the reaction diagram
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