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(2E,6E)-farnesyl diphosphate + homogentisate
diphosphate + (3-(2E,6E)-farnesyl-2,5-dihydroxyphenyl)acetate
-
no decarboxylation of product, 95% of the total prenylated reaction products formed are carboxylic acids
-
?
all-trans-nonaprenyl diphosphate + homogentisate
diphosphate + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2
farnesyl diphosphate + homogentisate
diphosphate + (3-(2E,6E)-farnesyl-2,5-dihydroxyphenyl)acetate
geranyl diphosphate + homogentisate
diphosphate + (3-geranyl-2,5-dihydroxyphenyl)acetate
geranylgeranyl diphosphate + homogentisate
diphosphate + (3-geranylgeranyl-2,5-dihydroxyphenyl)acetate
solanesyl diphosphate + homogentisate
diphosphate + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2
solanesyl diphosphate + homogentisate
diphosphate + 2-methyl-6-solanesyl-1,4-benzoquinol + CO2
additional information
?
-
all-trans-nonaprenyl diphosphate + homogentisate
diphosphate + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2
the enzyme is involved in biosynthesis pathway of plastoquinol-9
-
-
?
all-trans-nonaprenyl diphosphate + homogentisate
diphosphate + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2
highest activities with solanesyl diphosphate, hardly active with phytyl diphosphat
2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol i.e. 2-methyl-6-solanesylbenzene-1,4-diol
-
?
all-trans-nonaprenyl diphosphate + homogentisate
diphosphate + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2
the enzyme is involved in biosynthesis pathway of plastoquinol-9
-
-
?
all-trans-nonaprenyl diphosphate + homogentisate
diphosphate + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2
highest activity with solanesyl diphosphate, hardly active with phytyl diphosphat
2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol i.e. 2-methyl-6-solanesylbenzene-1,4-diol
-
?
all-trans-nonaprenyl diphosphate + homogentisate
diphosphate + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2
the enzyme is involved in biosynthesis pathway of plastoquinol-9
-
-
?
all-trans-nonaprenyl diphosphate + homogentisate
diphosphate + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2
highest activity with solanesyl diphosphate, hardly active with phytyl diphosphat
2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol i.e. 2-methyl-6-solanesylbenzene-1,4-diol
-
?
farnesyl diphosphate + homogentisate
diphosphate + (3-(2E,6E)-farnesyl-2,5-dihydroxyphenyl)acetate
-
-
-
?
farnesyl diphosphate + homogentisate
diphosphate + (3-(2E,6E)-farnesyl-2,5-dihydroxyphenyl)acetate
-
-
-
-
?
farnesyl diphosphate + homogentisate
diphosphate + (3-(2E,6E)-farnesyl-2,5-dihydroxyphenyl)acetate
-
no decarboxylation of product, 95% of the total prenylated reaction products formed are carboxylic acids
-
?
farnesyl diphosphate + homogentisate
diphosphate + (3-(2E,6E)-farnesyl-2,5-dihydroxyphenyl)acetate
-
-
no decarboxylation of product, 95% of the total prenylated reaction products formed are carboxylic acids
-
?
geranyl diphosphate + homogentisate
diphosphate + (3-geranyl-2,5-dihydroxyphenyl)acetate
-
no decarboxylation of product, 95% of the total prenylated reaction products formed are carboxylic acids
-
?
geranyl diphosphate + homogentisate
diphosphate + (3-geranyl-2,5-dihydroxyphenyl)acetate
-
no decarboxylation of product, 95% of the total prenylated reaction products formed are carboxylic acids
-
?
geranyl diphosphate + homogentisate
diphosphate + (3-geranyl-2,5-dihydroxyphenyl)acetate
-
-
no decarboxylation of product, 95% of the total prenylated reaction products formed are carboxylic acids
-
?
geranylgeranyl diphosphate + homogentisate
diphosphate + (3-geranylgeranyl-2,5-dihydroxyphenyl)acetate
-
no decarboxylation of product, 95% of the total prenylated reaction products formed are carboxylic acids
-
?
geranylgeranyl diphosphate + homogentisate
diphosphate + (3-geranylgeranyl-2,5-dihydroxyphenyl)acetate
-
no decarboxylation of product, 95% of the total prenylated reaction products formed are carboxylic acids
-
?
geranylgeranyl diphosphate + homogentisate
diphosphate + (3-geranylgeranyl-2,5-dihydroxyphenyl)acetate
-
-
no decarboxylation of product, 95% of the total prenylated reaction products formed are carboxylic acids
-
?
solanesyl diphosphate + homogentisate
diphosphate + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2
-
-
-
?
solanesyl diphosphate + homogentisate
diphosphate + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2
-
-
-
?
solanesyl diphosphate + homogentisate
diphosphate + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2
-
-
-
?
solanesyl diphosphate + homogentisate
diphosphate + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2
-
-
-
-
?
solanesyl diphosphate + homogentisate
diphosphate + 2-methyl-6-solanesyl-1,4-benzoquinol + CO2
-
-
-
?
solanesyl diphosphate + homogentisate
diphosphate + 2-methyl-6-solanesyl-1,4-benzoquinol + CO2
-
-
-
-
?
solanesyl diphosphate + homogentisate
diphosphate + 2-methyl-6-solanesyl-1,4-benzoquinol + CO2
-
-
-
?
solanesyl diphosphate + homogentisate
diphosphate + 2-methyl-6-solanesyl-1,4-benzoquinol + CO2
-
-
-
?
additional information
?
-
enzyme uses not only solanesyl diphosphate but also short chain prenyl diphosphates of 10-20 carbon atoms as prenyl donors. With these donors, prenyl transfer is largely decoupled from decarboxylation, and thus the major products are 6-prenyl-1,4-benzoquinol-2-methylcarboxylates rather than 2-methyl-6-prenyl-1,4-benzoquinols. The 6-prenyl-1,4-benzoquinol-2-methylcarboxylates are not substrates for homogentisate prenyl transferase-catalyzed decarboxylation, and the enzyme kinetics associated with forming these products appears quite distinct from those for 2-methyl-6-prenyl-1,4-benzoquinol formation. A model for mechanism is as follows: prenyl diphosphate binds to homogentisate prenyl transferase to form at least two alternative complexes that go on to react differently with homogentisate and prenylate it either with or without it first being decarboxylated. It is supposed that solanesyl diphosphate binds tightly and preferentially in the mode that compels prenylation with decarboxylation
-
-
?
additional information
?
-
no substrate: phythyl diphosphate
-
-
?
additional information
?
-
enzyme uses not only solanesyl diphosphate but also short chain prenyl diphosphates of 10-20 carbon atoms as prenyl donors. With these donors, prenyl transfer is largely decoupled from decarboxylation, and thus the major products are 6-prenyl-1,4-benzoquinol-2-methylcarboxylates rather than 2-methyl-6-prenyl-1,4-benzoquinols. The 6-prenyl-1,4-benzoquinol-2-methylcarboxylates are not substrates for homogentisate prenyl transferase-catalyzed decarboxylation, and the enzyme kinetics associated with forming these products appears quite distinct from those for 2-methyl-6-prenyl-1,4-benzoquinol formation. A model for mechanism is as follows: prenyl diphosphate binds to homogentisate prenyl transferase to form at least two alternative complexes that go on to react differently with homogentisate and prenylate it either with or without it first being decarboxylated. It is supposed that solanesyl diphosphate binds tightly and preferentially in the mode that compels prenylation with decarboxylation
-
-
?
additional information
?
-
-
enzyme uses not only solanesyl diphosphate but also short chain prenyl diphosphates of 10-20 carbon atoms as prenyl donors. With these donors, prenyl transfer is largely decoupled from decarboxylation, and thus the major products are 6-prenyl-1,4-benzoquinol-2-methylcarboxylates rather than 2-methyl-6-prenyl-1,4-benzoquinols. The 6-prenyl-1,4-benzoquinol-2-methylcarboxylates are not substrates for homogentisate prenyl transferase-catalyzed decarboxylation, and the enzyme kinetics associated with forming these products appears quite distinct from those for 2-methyl-6-prenyl-1,4-benzoquinol formation. A model for mechanism is as follows: prenyl diphosphate binds to homogentisate prenyl transferase to form at least two alternative complexes that go on to react differently with homogentisate and prenylate it either with or without it first being decarboxylated. It is supposed that solanesyl diphosphate binds tightly and preferentially in the mode that compels prenylation with decarboxylation
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
all-trans-nonaprenyl diphosphate + homogentisate
diphosphate + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2
solanesyl diphosphate + homogentisate
diphosphate + 2-methyl-6-solanesyl-1,4-benzoquinol + CO2
all-trans-nonaprenyl diphosphate + homogentisate
diphosphate + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2
the enzyme is involved in biosynthesis pathway of plastoquinol-9
-
-
?
all-trans-nonaprenyl diphosphate + homogentisate
diphosphate + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2
the enzyme is involved in biosynthesis pathway of plastoquinol-9
-
-
?
all-trans-nonaprenyl diphosphate + homogentisate
diphosphate + 2-methyl-6-all-trans-nonaprenylbenzene-1,4-diol + CO2
the enzyme is involved in biosynthesis pathway of plastoquinol-9
-
-
?
solanesyl diphosphate + homogentisate
diphosphate + 2-methyl-6-solanesyl-1,4-benzoquinol + CO2
-
-
-
?
solanesyl diphosphate + homogentisate
diphosphate + 2-methyl-6-solanesyl-1,4-benzoquinol + CO2
-
-
-
-
?
solanesyl diphosphate + homogentisate
diphosphate + 2-methyl-6-solanesyl-1,4-benzoquinol + CO2
-
-
-
?
solanesyl diphosphate + homogentisate
diphosphate + 2-methyl-6-solanesyl-1,4-benzoquinol + CO2
-
-
-
?
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
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Sadre, R.; Gruber, J.; Frentzen, M.
Characterization of homogentisate prenyltransferases involved in plastoquinone-9 and tocochromanol biosynthesis
FEBS Lett.
580
5357-5362
2006
Chlamydomonas reinhardtii (A1JHN0), Chlamydomonas reinhardtii, Arabidopsis thaliana (Q9SF04), Arabidopsis thaliana, Chlamydomonas reinhardtii CC-1690 (A1JHN0)
brenda
Sadre, R.; Frentzen, M.; Saeed, M.; Hawkes, T.
Catalytic reactions of the homogentisate prenyl transferase involved in plastoquinone-9 biosynthesis
J. Biol. Chem.
285
18191-18198
2010
Spinacia oleracea, Chlamydomonas reinhardtii (A1JHN0), Arabidopsis thaliana (Q1ACB3)
brenda
Tian, L.; DellaPenna, D.; Dixon, R.A.
The pds2 mutation is a lesion in the Arabidopsis homogentisate solanesyltransferase gene involved in plastoquinone biosynthesis
Planta
226
1067-73
2007
Arabidopsis thaliana (Q9SF04)
brenda
Chao, Y.; Kang, J.; Zhang, T.; Yang, Q.; Gruber, M.Y;, Sun, Y.
Disruption of the homogentisate solanesyltransferase gene results in albino and dwarf phenotypes and root, trichome and stomata defects in Arabidopsis thaliana
PLoS One
9
e94031
2014
Arabidopsis thaliana (F4J8K0), Arabidopsis thaliana
brenda
Liu, M.; Lu, S.
Plastoquinone and ubiquinone in plants Biosynthesis, physiological function and metabolic engineering
Front. Plant Sci.
7
1898
2016
Chlamydomonas reinhardtii (A1JHN0), Arabidopsis thaliana (Q1ACB3)
brenda
Shino, M.; Hamada, T.; Shigematsu, Y.; Hirase, K.; Banba, S.
Action mechanism of bleaching herbicide cyclopyrimorate, a novel homogentisate solanesyltransferase inhibitor
J. Pestic. Sci.
43
233-239
2018
Arabidopsis thaliana (Q1ACB3), Arabidopsis thaliana
brenda
Shino, M.; Hamada, T.; Shigematsu, Y.; Banba, S.
In vivo and in vitro evidence for the inhibition of homogentisate solanesyltransferase by cyclopyrimorate
Pest Manag. Sci.
76
3389-3394
2019
Arabidopsis thaliana (Q1ACB3), Arabidopsis thaliana
brenda