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EC Tree
IUBMB CommentsSee also EC 2.4.1.15 [alpha,alpha-trehalose-phosphate synthase (UDP-forming)].
Word Map
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2.4.1.36
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proto-oncogene
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met
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pp2
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nsclc
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non-small
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autocrine
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pp60c-src
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invasiveness
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integrins
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hgf-induced
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sarcoma
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3-kinase
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autophosphorylation
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paracrine
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osteoclast
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phosphotyrosine
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nonreceptor
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paxillin
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crizotinib
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protein-tyrosine
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motogenic
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mitogenesis
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line-derived
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dasatinib
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c-src-dependent
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gefitinib
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tyrosine-phosphorylated
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mesenchymal-epithelial
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atp-competitive
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connexin43
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cortactin
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hgf-mediated
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juxtamembrane
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anti-hgf
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hgf-stimulated
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cabozantinib
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vegfr-2
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erlotinib
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
alpha,alpha-trehalose-phosphate synthase,
more
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alpha,alpha-trehalose-phosphate synthase
GDP glucose-glucosephosphate glucosyltransferase
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GDP-glucose-glucose-phosphate glucosyltransferase
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glucosyltransferase, guanosine diphosphoglucose-glucose phosphate
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guanosine diphosphoglucose-glucose phosphate glucosyltransferase
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trehalose phosphate synthase (GDP-forming)
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trehalose-6-phosphate synthase
alpha,alpha-trehalose-phosphate synthase
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alpha,alpha-trehalose-phosphate synthase
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OtsA
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trehalose-6-phosphate synthase
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trehalose-6-phosphate synthase
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GDP-glucose + glucose 6-phosphate = GDP + alpha,alpha-trehalose 6-phosphate
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hexosyl group transfer
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GDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase
See also EC 2.4.1.15 [alpha,alpha-trehalose-phosphate synthase (UDP-forming)].
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ADP-glucose + glucose 6-phosphate
ADP + alpha,alpha-trehalose 6-phosphate
GDP-glucose + glucose 6-phosphate
GDP + alpha,alpha-trehalose 6-phosphate
additional information
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ADP-glucose + glucose 6-phosphate
ADP + alpha,alpha-trehalose 6-phosphate
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ADP-glucose + glucose 6-phosphate
ADP + alpha,alpha-trehalose 6-phosphate
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GDP-glucose + glucose 6-phosphate
GDP + alpha,alpha-trehalose 6-phosphate
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GDP-glucose + glucose 6-phosphate
GDP + alpha,alpha-trehalose 6-phosphate
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GDP-glucose + glucose 6-phosphate
GDP + alpha,alpha-trehalose 6-phosphate
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GDP-glucose + glucose 6-phosphate
GDP + alpha,alpha-trehalose 6-phosphate
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GDP-glucose + glucose 6-phosphate
GDP + alpha,alpha-trehalose 6-phosphate
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GDP-glucose + glucose 6-phosphate
GDP + alpha,alpha-trehalose 6-phosphate
the enzyme has a preference for GDP-glucose
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GDP-glucose + glucose 6-phosphate
GDP + alpha,alpha-trehalose 6-phosphate
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GDP-glucose + glucose 6-phosphate
GDP + alpha,alpha-trehalose 6-phosphate
the enzyme has a preference for GDP-glucose
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additional information
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overview on biosynthesis of trehalose
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additional information
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overview on biosynthesis of trehalose
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additional information
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overview on biosynthesis of trehalose
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GDP-glucose + glucose 6-phosphate
GDP + alpha,alpha-trehalose 6-phosphate
additional information
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GDP-glucose + glucose 6-phosphate
GDP + alpha,alpha-trehalose 6-phosphate
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GDP-glucose + glucose 6-phosphate
GDP + alpha,alpha-trehalose 6-phosphate
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GDP-glucose + glucose 6-phosphate
GDP + alpha,alpha-trehalose 6-phosphate
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additional information
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overview on biosynthesis of trehalose
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additional information
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overview on biosynthesis of trehalose
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additional information
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overview on biosynthesis of trehalose
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0.44
ADP-glucose
pH and temperature not specified in the publication
0.12
GDP-glucose
pH and temperature not specified in the publication
0.9 - 0.93
glucose 6-phosphate
0.9
glucose 6-phosphate
with 2.5 mM ADP-glucose as cosubstrate, pH and temperature not specified in the publication
0.93
glucose 6-phosphate
with 0.5 mM GDP-glucose as cosubstrate, pH and temperature not specified in the publication
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29
ADP-glucose
pH and temperature not specified in the publication
139
GDP-glucose
pH and temperature not specified in the publication
26 - 123
glucose 6-phosphate
26
glucose 6-phosphate
with 2.5 mM ADP-glucose as cosubstrate, pH and temperature not specified in the publication
123
glucose 6-phosphate
with 0.5 mM GDP-glucose as cosubstrate, pH and temperature not specified in the publication
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67
ADP-glucose
pH and temperature not specified in the publication
1143
GDP-glucose
pH and temperature not specified in the publication
29 - 132
glucose 6-phosphate
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glucose 6-phosphate
with 2.5 mM ADP-glucose as cosubstrate, pH and temperature not specified in the publication
132
glucose 6-phosphate
with 0.5 mM GDP-glucose as cosubstrate, pH and temperature not specified in the publication
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UniProt
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UniProt
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G9BXT0_9AGAR
126
0
13700
TrEMBL
other Location (Reliability: 2)
A0A1J1LCV4_9CYAN
261
0
29679
TrEMBL
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A0A7Z9BQM5_9CYAN
245
0
27512
TrEMBL
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A0A1T4ZNJ0_9CYAN
245
0
27688
TrEMBL
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K7VW10_9NOST
247
0
28227
TrEMBL
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A0A7Z9BN44_9CYAN
245
0
27645
TrEMBL
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F2RH01_STRVP
Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745)
452
0
49583
TrEMBL
other Location (Reliability: 2)
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homodimer
2 * 51000, calculated from amino acid sequence
homodimer
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2 * 51000, calculated from amino acid sequence
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additional information
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overview
additional information
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overview
additional information
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overview
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nickel affinity column chromatography and Superdex 200 gel filtration
overview
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expressed in Escherichia coli SoluBL21 cells
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Elbein, A.D.
Carbohydrate metabolism in Streptomyces hygroscopicus. I. Enzymatic synthesis of trehalose phosphate from guanosine diphosphate D-glucose-14C
J. Biol. Chem.
242
403-406
1967
Streptomyces hygroscopicus
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Elbein, A.D.; Pan, Y.T.; Pastuszak, I.; Carroll, D.
New insights on trehalose: a multifunctional molecule
Glycobiology
13
17-27
2003
Saccharomyces cerevisiae, Streptomyces sp., insecta
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brenda
Diez, M.; Miah, F.; Stevenson, C.; Lawson, D.; Iglesias, A.; Bornemann, S.
The production and utilization of GDP-glucose in the biosynthesis of trehalose 6-phosphate by Streptomyces venezuelae
J. Biol. Chem.
292
945-954
2017
Streptomyces venezuelae (F2RH01), Streptomyces venezuelae ATCC 10712 (F2RH01)
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