We're sorry, but BRENDA doesn't work properly without JavaScript. Please make sure you have JavaScript enabled in your browser settings.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments Converts xanthotoxol into xanthotoxin, which has therapeutic potential in the treatment of psoriasis as it has photosensitizing and antiproliferative activities . Methylates the 8-hydroxy group of some hydroxy- and methylcoumarins, but has little activity on non-coumarin phenols (see also EC 2.1.1.69, 5-hydroxyfuranocoumarin 5-O-methyltransferase).
The enzyme appears in viruses and cellular organisms
Synonyms
EC 2.1.1.93, furanocoumarin 8-methyltransferase, furanocoumarin 8-O-methyl-transferase, methyltransferase, xanthotoxol, XMT,
more
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
EC 2.1.1.93
-
-
formerly
-
furanocoumarin 8-methyltransferase
-
-
-
-
furanocoumarin 8-O-methyl-transferase
-
-
-
-
methyltransferase, xanthotoxol
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
S-adenosyl-L-methionine + 8-hydroxyfurocoumarin = S-adenosyl-L-homocysteine + 8-methoxyfurocoumarin
-
-
-
-
S-adenosyl-L-methionine + xanthotoxol = S-adenosyl-L-homocysteine + xanthotoxin
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
methyl group transfer
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
S-adenosyl-L-methionine:8-hydroxyfurocoumarin 8-O-methyltransferase
Converts xanthotoxol into xanthotoxin, which has therapeutic potential in the treatment of psoriasis as it has photosensitizing and antiproliferative activities [4]. Methylates the 8-hydroxy group of some hydroxy- and methylcoumarins, but has little activity on non-coumarin phenols (see also EC 2.1.1.69, 5-hydroxyfuranocoumarin 5-O-methyltransferase).
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
S-adenosyl-L-methionine + 5-hydroxyxanthotoxin
S-adenosyl-L-homocysteine + isopimpinellin
-
0.7% of the activity with xanthotoxol
-
?
S-adenosyl-L-methionine + 7,8-dihydroxycoumarin
?
-
-
-
-
?
S-adenosyl-L-methionine + 8-hydroxybergapten
S-adenosyl-L-homocysteine + isopimpinellin
S-adenosyl-L-methionine + bergaptol
S-adenosyl-L-homocysteine + bergapten
-
0.5% of the activity with xanthotoxol
-
?
S-adenosyl-L-methionine + daphnetin
S-adenosyl-L-homocysteine + hydrangetin
-
0.6% of the activity with xanthotoxol
-
?
S-adenosyl-L-methionine + xanthotoxol
S-adenosyl-L-homocysteine + xanthotoxin
S-adenosyl-L-methionine + 8-hydroxybergapten
S-adenosyl-L-homocysteine + isopimpinellin
-
-
-
-
?
S-adenosyl-L-methionine + 8-hydroxybergapten
S-adenosyl-L-homocysteine + isopimpinellin
-
-
-
-
?
S-adenosyl-L-methionine + 8-hydroxybergapten
S-adenosyl-L-homocysteine + isopimpinellin
-
2% of the activity with xanthotoxol
-
?
S-adenosyl-L-methionine + 8-hydroxybergapten
S-adenosyl-L-homocysteine + isopimpinellin
-
-
-
-
?
S-adenosyl-L-methionine + xanthotoxol
S-adenosyl-L-homocysteine + xanthotoxin
-
-
-
-
?
S-adenosyl-L-methionine + xanthotoxol
S-adenosyl-L-homocysteine + xanthotoxin
-
-
-
-
?
S-adenosyl-L-methionine + xanthotoxol
S-adenosyl-L-homocysteine + xanthotoxin
-
-
-
?
S-adenosyl-L-methionine + xanthotoxol
S-adenosyl-L-homocysteine + xanthotoxin
-
-
-
-
?
S-adenosyl-L-methionine + xanthotoxol
S-adenosyl-L-homocysteine + xanthotoxin
-
final methylation in the biosynthesis of the furanocoumarin xanthotoxin
-
-
?
S-adenosyl-L-methionine + xanthotoxol
S-adenosyl-L-homocysteine + xanthotoxin
-
-
-
-
?
S-adenosyl-L-methionine + xanthotoxol
S-adenosyl-L-homocysteine + xanthotoxin
-
furanocoumarin biosynthesis
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
S-adenosyl-L-methionine + xanthotoxol
S-adenosyl-L-homocysteine + xanthotoxin
S-adenosyl-L-methionine + xanthotoxol
S-adenosyl-L-homocysteine + xanthotoxin
-
final methylation in the biosynthesis of the furanocoumarin xanthotoxin
-
-
?
S-adenosyl-L-methionine + xanthotoxol
S-adenosyl-L-homocysteine + xanthotoxin
-
furanocoumarin biosynthesis
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
S-adenosyl-L-methionine
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
kinetin
-
strong inhibition
p-chloromercuribenzoic acid
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.0044
S-adenosyl-L-methionine
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.000033
-
8-hydroxybergapten
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Michx.
-
-
brenda
Michx.
-
-
brenda
-
-
-
brenda
-
-
-
brenda
cv Hamburger Schnitt
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
-
brenda
-
from leaf petiole, cells treated with an elicitor from Phytophtora megasperma, no activity in untreated cells
brenda
-
activity decreases from high activity in young cotyledons to low activity in late stages of cotyledon development
brenda
-
cell suspension culture
brenda
-
young shoots of field-grown plants
brenda
-
-
brenda
-
-
-
brenda
-
sterile leaf cell culture
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
enzyme activity is stimulated by elicitor treatment of protoplasts, increase in activity up to 30 h post treatment, no activity is detected in untreated or UV-irradiated protoplasts
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
COMTS_PEUPR
364
0
39979
Swiss-Prot
other Location (Reliability: 2 )
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
34000
-
2 * 34000, SDS-PAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
dimer
-
2 * 34000, SDS-PAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
5
-
30 min, inactivation below
485668
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2-mercaptoethanol stabilizes during purification and storage
-
marked loss of activity against xanthotoxol after resalting
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-20°C, stable for 20 days in 50% v/v glycerol
-
-20°C, stored and refrozen, activity against xanthotoxol falls rapidly to less than half of the initial value in 1 week and to only 10% after 4 weeks
-
0°C, stored below undesalted, 40% loss of activity after 5 weeks
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Sharma, S.K.; Garrett, J.M.; Brown, S.A.
Separation of the S-adenosylmethionine: 5-and 8-hydroxyfuranocoumarin O-methyltransferases of Ruta graveolens L. by general ligand affinity chromatography
Z. Naturforsch. C
34
387-391
1979
Ruta graveolens
-
brenda
Thompson, H.J.; Sharma, S.K.; Brown, S.A.
O-Methyltransferases of furanocoumarin biosynthesis
Arch. Biochem. Biophys.
188
272-281
1978
Heracleum maximum, Ruta graveolens, Heracleum maximum Michx.
brenda
Sharma, S.K.; Brown, S.A.
Affinity chromatography of Ruta graveolens L. O-methyltransferases. Studies demonstrating the potential of the technique in the mechanistic investigation of O-methyltransferases
Can. J. Biochem.
57
986-995
1979
Ruta graveolens
brenda
Hauffe, K.D.; Hahlbrock, K.; Scheel, D.
Elicitor-stimulated furanocoumarin biosynthesis in cultured parsley cells: S-adenosyl-L-methionine:bergaptol and S-adenosyl-L-methionine:xanthotoxol O-methyltransferase
Z. Naturforsch. C
41
228-239
1986
Petroselinum crispum
-
brenda
Dangl, J.L.; Hauffe, K.D.; Lipphardt, S.; Hahlbrock, K.; Scheel, D.
Parsley protoplasts retain differential responsiveness to u.v. light and fungal elicitor
EMBO J.
6
2551-2556
1987
Petroselinum crispum
brenda
Knogge, W.; Kombrink, E.; Schmelzer, E.; Hahlbrock, K.
Occurence of phytoalexins and other putative defense-related substances in uninfected parsley plants
Planta
171
279-287
1987
Petroselinum crispum
brenda
Select items on the left to see more content.
html completed