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The enzyme appears in viruses and cellular organisms
Synonyms dimethylthetin-homocysteine methyltransferase, methyltransferase, dimethylthetin-homocysteine, More, thetin-homocysteine methylpherase, more
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dimethylthetin-homocysteine methyltransferase
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methyltransferase, dimethylthetin-homocysteine
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thetin-homocysteine methylpherase
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additional information
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cf. EC 2.1.1.5, probably one enzyme
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dimethylsulfonioacetate + L-homocysteine = (methylsulfanyl)acetate + L-methionine
dimethylsulfonioacetate + L-homocysteine = (methylsulfanyl)acetate + L-methionine
mechanism
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dimethylsulfonioacetate + L-homocysteine = (methylsulfanyl)acetate + L-methionine
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methyl group transfer
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dimethylsulfonioacetate:L-homocysteine S-methyltransferase
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dimethylsulfonioacetate + DL-homocysteine
(methylsulfanyl)acetate + L-methionine
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Substrates: - Products: -
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dimethylthetin + L-homocysteine
S-methylthioglycolate + L-methionine
additional information
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Substrates: methyl group donors are ethylmethylthetin, dimethyl-alpha- and dimethyl-beta-propiothetin, ethylmethyl-beta-propiothetin, dimethyl-gamma-butyrothetin, methionine methylsulfonium, trimethylsulfonium, ethyldimethylsulfonium or butyldimethylsulfonium, no acceptors are cysteamine, 2-mercaptoethanol, DL-homocystine, sodium mercaptoacetate Products: -
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dimethylthetin + L-homocysteine
S-methylthioglycolate + L-methionine
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Substrates: - Products: -
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dimethylthetin + L-homocysteine
S-methylthioglycolate + L-methionine
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Substrates: i.e. dimethylsulfonioacetate, specific for L-homocysteine Products: i.e. methylthioacetate
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dimethylthetin + L-homocysteine
S-methylthioglycolate + L-methionine
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Substrates: - Products: -
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additional information
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no activation by metal ions
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Sodium mercaptoacetate
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additional information
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no inhibition by dimethylthetin, sulfocholine (up to 0.1 M), mercaptoethanol, cysteine, Na2SO4, Li+, Cs+, Ca2+, Mg2+, NaN3, NaCN, NaF, EDTA, semicarbazide, iodoacetate
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brenda
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Highest Expressing Human Cell Lines
Filter by:
Cell Line Links
Gene Links
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M2Y826_GALSU
788
0
90616
TrEMBL
other Location (Reliability: 2 )
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Maw, G.A.
Thetin-homocysteine transmethylase: some further characteristics of the enzyme from rat liver
Biochem. J.
70
168-173
1958
Rattus norvegicus
brenda
Maw, G.A.
Thetin-homocysteine transmethylase: a preliminary manometric study of the enzyme from rat liver
Biochem. J.
63
116-124
1956
Rattus norvegicus
brenda
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