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The enzyme appears in viruses and cellular organisms
Synonyms
DIB O-methyltransferase (3,5-diiodo-4-hydroxy-benzoic acid), iodophenol methyltransferase, more
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DIB O-methyltransferase (3,5-diiodo-4-hydroxy-benzoic acid)
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iodophenol methyltransferase
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S-adenosyl-L-methionine + 2-iodophenol = S-adenosyl-L-homocysteine + 2-iodophenol methyl ether
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methyl group transfer
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S-adenosyl-L-methionine:2-iodophenol O-methyltransferase
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3,5,3',5'-tetraiodothyroacetic acid + S-adenosyl-L-methionine
[4-(4-methoxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-acetic acid + S-adenosyl-L-homocysteine
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Substrates: -
Products: -
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3,5,3'-triiodo-L-thyronine + S-adenosyl-L-methionine
3,5,3'-triiodo-O-methyl-L-thyronine + S-adenosyl-L-homocysteine
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Substrates: poor substrate
Products: -
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3,5,3'-triiodothyroacetic acid + S-adenosyl-L-methionine
[3,5-diiodo-4-(3-iodo-4-methoxyphenoxy)phenyl]-acetic acid + S-adenosyl-L-homocysteine
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Substrates: poor substrate
Products: -
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3,5-diiodo-4-hydroxybenzoic acid + S-adenosyl-L-methionine
3,5-diiodo-4-methoxybenzoic acid + S-adenosyl-L-homocysteine
L-thyroxine + S-adenosyl-L-methionine
3,5,3'5'-tetraiodo-O'-methyl-L-thyronine + S-adenosyl-L-homocysteine
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Substrates: poor substrate
Products: -
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3,5-diiodo-4-hydroxybenzoic acid + S-adenosyl-L-methionine
3,5-diiodo-4-methoxybenzoic acid + S-adenosyl-L-homocysteine
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Substrates: DIB is the most effective substrate
Products: -
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3,5-diiodo-4-hydroxybenzoic acid + S-adenosyl-L-methionine
3,5-diiodo-4-methoxybenzoic acid + S-adenosyl-L-homocysteine
Pigeon
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Substrates: DIB is the most effective substrate
Products: -
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3,5-diiodo-4-hydroxybenzoic acid + S-adenosyl-L-methionine
3,5-diiodo-4-methoxybenzoic acid + S-adenosyl-L-homocysteine
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Substrates: DIB is the most effective substrate
Products: -
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3,5-Diiodo-4-hydroxybenzoic acid
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substrate inhibition above 0.2 mM
additional information
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activity is suppressed by extract from microsomal fraction
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0.0034
3,5-Diiodo-4-hydroxybenzoic acid
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0.0015
S-adenosyl-L-methionine
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0.0002
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purified enzyme with 3,5-diiodo-4-hydroxybenzoic acid as substrate
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no activity in Cavia porcellus
liver
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brenda
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brenda
Pigeon
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brenda
Sprague-Dawley rat
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brenda
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brenda
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brenda
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brenda
Pigeon
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brenda
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brenda
additional information
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no activity found in muscle
brenda
additional information
Pigeon
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no activity found in muscle
brenda
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brenda
Highest Expressing Human Cell Lines
Cell Line Links
Gene Links
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Tonita, K.; Cha, M.C.; Lardy, H.A.
Enzymic O-methylation of iodinated phenols and thyroide hormones
J. Biol. Chem.
239
1202-1207
1964
no activity in Cavia porcellus, Oryctolagus cuniculus, Pigeon, Rattus norvegicus
brenda
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