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Information on EC 1.8.3.5 - prenylcysteine oxidase

for references in articles please use BRENDA:EC1.8.3.5

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IUBMB Comments

A flavoprotein (FAD). Cleaves the thioether bond of S-prenyl-L-cysteines, such as S-farnesylcysteine and S-geranylgeranylcysteine. N-Acetyl-prenylcysteine and prenylcysteinyl peptides are not substrates. May represent the final step in the degradation of prenylated proteins in mammalian tissues. Originally thought to be a simple lyase so it had been classified as EC 4.4.1.18.

The enzyme appears in viruses and cellular organisms
  • 1.8.3.5
  • polycaprolactone
  • posterior
  • ligament
  • cruciate
  • knee
  • fabric
  • electrospun
  • fiber
  • biocompatibility
  • electrospinning
  • tibial
  • nanofibers
  • porous
  • copolymer
  • blend
  • film
  • flexion
  • modulus
  • tensile
  • biomaterials
  • femoral
  • nanofibrous
  • arthroscopic
  • porosity
  • biomechanical
  • polyepsilon-caprolactone
  • tendon
  • tear
  • laxity
  • arthroplasty
  • kinematics
  • posterolateral
  • avulsion
  • posteromedial
  • lysholm
  • polyester
  • autograft
  • bioresorbable
  • hamstring
  • osteoconductive
  • meniscal
  • wettabl
  • varus
  • diblock
  • cytocompatibility
  • condyle
  • anterolateral
  • polylactic
  • wettability
  • tissue-engineered

Synonyms
pcl, prenylcysteine lyase, pcyox1, fc lyase, prenylcysteine oxidase 1, prenylcysteine oxidase1, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
an S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2
show the reaction diagram
PATHWAY SOURCE
PATHWAYS
MetaCyc
farnesylcysteine salvage pathway
Highest Expressing Human Cell Lines
Cell Line Links Gene Links