Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2 GSH + NADP+
GSSG + NADPH + H+
-
-
-
-
?
2-hydroxyethyl disulfide + NADPH + H+
?
-
-
-
-
?
5,5'-dithio-bis(2-nitrobenzoic acid) + NADPH + H+
5'-thionitrobenzoic acid + NADP+
-
-
-
-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH
2-nitro-5-thiobenzoate + NADP+
-
-
-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH
?
-
-
-
-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
?
-
-
-
-
?
beta-hydroxyethyl disulfide + NADPH + H+
2 2-sulfanylethan-1-ol + NADP+
-
-
-
-
?
cytosolic thioredoxin + NADP+
cytosolic thioredoxin disulfide + NADPH
-
-
-
-
r
glutaredoxin + NADPH + H+
?
-
-
-
-
?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
glutathione disulfide + NADPH + H+
glutathione + NADP+
glutathione-hydroxyethyl disulfide + NADPH + H+
glutathione + 2-sulfanylethan-1-ol + NADP+
-
-
-
-
?
GSSG + NADPH + H+
glutathione + NADP+
GSSG + NADPH + H+
GSH + NADP+
hydroxyethyl disulfide + NADPH + H+
?
-
-
-
-
?
insulin disulfide + NADPH + H+
insulin + NADP+
-
-
-
-
?
mitochondrial thioredoxin + NADP+
mitochondrial thioredoxin disulfide + NADPH
-
-
-
-
r
oxidized insulin + NADPH + H+
reduced insulin + NADP+
-
-
-
-
?
thioredoxin + NADP+
thioredoxin disulfide + NADPH
-
-
-
-
?
thioredoxin + NADP+
thioredoxin disulfide + NADPH + H+
thioredoxin disulfide + NADPH
thioredoxin + NADP+
-
absolute specificity for NADPH as electron donor
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
additional information
?
-
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
-
-
-
-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
-
-
-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
-
-
-
-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
-
-
-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
-
-
-
-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
-
-
-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
-
-
-
-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
-
-
-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
-
-
-
-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
-
absolute specificity for NADPH as electron donor
-
-
?
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+
2-nitro-5-thiobenzoate + NADP+
-
-
-
-
?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
-
-
-
?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
-
-
-
-
?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
-
enzyme displays hysteretic behavior
-
-
?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
-
the enzyme plays an essential role in maintaining the redox homeostasis and antioxidant defenses in the parasite Fasciola gigantica. Parasitic flukes have a limited set of antioxidant proteins in contrast to their mammalian hosts. In platyhelminthic parasites, the two systems (glutathione/glutaredoxin system and thioredoxin system) are replaced by a single system of a multifunctional flavin containing chimeric selenoenzyme known as thioredoxin glutathione reductase, which donates electrons to both thioredoxin disulfide and glutathione disulfide in these parasites
-
-
?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
-
-
-
?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
-
-
-
?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
-
-
-
-
?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
-
-
-
-
?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
-
-
-
-
?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
-
the enzyme of the parasite essential for the survival of schistosomes in the mammalian host
-
-
?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
-
-
-
-
?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
-
the enzyme follows a two-site ping-pong bi bi kinetic mechanism, in which both substrates and products are bound in rapid equilibrium fashion
-
-
?
glutathione disulfide + NADPH + H+
2 glutathione + NADP+
-
-
-
-
?
glutathione disulfide + NADPH + H+
glutathione + NADP+
-
-
-
-
?
glutathione disulfide + NADPH + H+
glutathione + NADP+
-
-
-
-
?
GSSG + NADPH + H+
glutathione + NADP+
-
-
-
-
?
GSSG + NADPH + H+
glutathione + NADP+
-
-
-
?
GSSG + NADPH + H+
glutathione + NADP+
-
absolute specificity for NADPH as electron donor
-
-
?
GSSG + NADPH + H+
GSH + NADP+
-
-
-
-
?
GSSG + NADPH + H+
GSH + NADP+
-
-
-
-
?
GSSG + NADPH + H+
GSH + NADP+
-
-
-
?
GSSG + NADPH + H+
GSH + NADP+
-
-
-
?
GSSG + NADPH + H+
GSH + NADP+
-
-
-
?
GSSG + NADPH + H+
GSH + NADP+
-
-
-
-
?
GSSG + NADPH + H+
GSH + NADP+
-
-
-
-
?
GSSG + NADPH + H+
GSH + NADP+
-
-
-
?
GSSG + NADPH + H+
GSH + NADP+
-
-
-
-
?
thioredoxin + NADP+
thioredoxin disulfide + NADPH + H+
-
-
-
-
?
thioredoxin + NADP+
thioredoxin disulfide + NADPH + H+
-
-
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
-
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
-
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
-
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
-
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
-
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
-
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
-
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
the enzyme of the parasite essential for the survival of schistosomes in the mammalian host
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
-
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
the enzyme follows a two-site ping-pong bi bi kinetic mechanism, in which both substrates and products are bound in rapid equilibrium fashion
-
-
?
thioredoxin disulfide + NADPH + H+
thioredoxin + NADP+
-
Escherichia coli thioredoxin disulfide
-
-
?
additional information
?
-
-
the glutathione reductase activity of TGR exhibits hysteretic behavior regulated by the [GSSG]/[GSH] ratio. This behavior is associated with glutathionylation by GSSG and abolished by deglutathionylation
-
-
?
additional information
?
-
-
TGR promotes isomerization of disulfide bonds formed between glutathione peroxidase 4 and certain sperm proteins, generating a 46-kDa species containing glutathione peroxidase 4 from high molecular weight nonspecific cross-links
-
-
?
additional information
?
-
-
the parasite-specific enzyme thioredoxin glutathione reductase is a component of the defense system
-
-
?
additional information
?
-
-
low catalytic efficiency with H2O2
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(2-oxido-1,2,5-oxadiazole-3,4-diyl)bis(2-furylmethanone)
-
-
(2-oxido-1,2,5-oxadiazole-3,4-diyl)bis(2-thienylmethanone)
-
-
(2-oxido-1,2,5-oxadiazole-3,4-diyl)bis[(1,3-dimethyl-1H-pyrazol-4-yl)methanone]
-
-
(2-oxido-1,2,5-oxadiazole-3,4-diyl)bis[(4-methoxyphenyl)methanone]
-
-
(3R,5R,8R) 5-(((3-carboxy-4-nitrophenyl)disulfanyl)methyl)tetrahydro-2H-thiazolo[4,3-b]thiazole-3-carboxylic acid
-
1,3,4-oxadiazole-2-sulfone
-
1,8-naphthyridine-2 carboxylate
mixed inhibition. 1,8-Naphthyridine-2 carboxylate prevents Tyr296 from rotating, a process necessary for NADPH binding and enzyme reduction. It inhibits by stabilizing a protein conformation whose affinity for NADPH is greatly reduced
-
2-((4-chlorophenyl)sulfonal)-6-methoxy-3-nitropyridine
-
2-(4-chlorobenzene-1-sulfonyl)-6-methoxy-3-nitropyridine
-
-
-
2-(4-chlorophenoxy)-6-methyl-2,3-dihydro-1,3,2-diazaphosphinin-4(1H)-one 2-oxide
-
-
2-(4-ethoxyphenoxy)-6-methyl-2,3-dihydro-1,3,2-diazaphosphinin-4(1H)-one 2-oxide
-
-
3-bromo-5-butoxy-6H-anthra[1,9-cd]isoxazol-6-one
-
-
3-DAP
-
0.05 mM, complete inhibition
4-aminopiazthiole
inhibit the enzyme in a NADPH-dependent manner, and the inhibition appears to be irreversible even upon extensive dilution of the inhibited protein
-
4-chloro-5-[4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl]-2-phenylpyridazin-3(2H)-one
4-phenyl-1,2,5-oxadiazole-3-carbonitrile 2-oxide
-
-
5-(((3-carboxy-4-nitrophenyl)disulfanyl)methyl) (2RS,5RS)-3,3a-dihydro-benzo[d]thiazolo[4,3-b]thiazole
-
5-bromo-N-ethyl-3,4-dinitrothiophen-2-amine
-
at 0.005 microM, 100 % larval death at 48 hours
5-chloro-N-[4-[ethyl(phenyl)sulfamoyl]phenyl]-2-(methanesulfonyl)pyrimidine-4-carboxamide
-
-
-
5-[[3-(trifluoromethyl)anilino]methyl]quinolin-8-ol
-
-
-
6-methyl-2-phenoxy-2,3-dihydro-1,3,2-diazaphosphinin-4(1H)-one 2-oxide
-
-
6-nitro-1H-1-benzothiophene-1,1-dione
6-nitrobenzo[b]thiophene-1,1-dioxide
-
7-[(4-methoxyphenyl)[(4-methylpyridin-2-yl)amino]methyl]-2-methylquinolin-8-ol
-
-
-
AuI-pyridine-2-thiol N-oxide
a potent inhibitor that achieves 75% inhibition at a 1:1 thioredoxin glutathione reductase:Au ratio and efficiently kills Echinococcus granulosus in vitro
-
aurothioglucose
-
0.05 mM, complete inhibition
aurothiomalate
-
0.05 mM, complete inhibition
bis-demethoxycurcumin
-
inhibits in the micromolar concentration range
-
CDE16-2
-
0.05 mM, 98% inhibition
CDE4
-
0.05 mM, 99% inhibition
curcumin
-
time-dependent process. An intermediary compound of curcumin oxidation, probably spiroepoxide, is responsible. Preincubation of curcumin in the presence of NADPH results in the loss of its inhibitory ability. Preincubation of curcumin with sulfhydryl compounds fully protected the enzyme from inhibition
demethoxycurcumin
-
inhibits in the micromolar concentration range
diethyl (3-bromo-6-oxo-6H-anthra[1,9-cd]isoxazol-5-yl)propanedioate
-
-
diethyl 2-(3-bromo-6-oxo-6H-anthra[1,9-cd][1,2]oxazol-4-yl)-3-oxobutanedioate
-
-
-
dimethyl (3-bromo-6-oxo-6H-anthra[1,9-cd]isoxazol-5-yl)propanedioate
-
-
glutathione disulfide
-
substrate inhibition at moderate or high concentrations. Noncompetitive mode of inhibition in which the disulfide behaves as an affinity label-like reagent through its binding and reduction at an alternative site, leading the enzyme into an inactive state
indole-3-carbinol
inhibit the enzyme in a NADPH-dependent manner, and the inhibition appears to be irreversible even upon extensive dilution of the inhibited protein
JD159
-
0.05 mM, complete inhibition
LS826
-
0.05 mM, 95% inhibition
methyl (5-[1-[(tert-butoxycarbonyl)amino]-2-phenylethyl]-1,3,4-oxadiazole-2-sulfonyl)acetate
-
-
-
naphthazarin
-
0.05 mM, complete inhibition
NOC-7
-
i.e. 1-hydroxy-2-oxo-3-(N-3-methyl-aminopropyl)-3-methyl-1-triazene, complete inhibition at 0.1 mM
OPZ
-
0.05 mM, 87% inhibition
P-1,3-benzothiazol-2-yl-N-(2-fluorophenyl)-P-phenylphosphinic amide
-
-
P-1,3-benzothiazol-2-yl-N-(5-chloropyridin-2-yl)-P-phenylphosphinic amide
-
-
P-1,3-benzothiazol-2-yl-P-phenyl-N-1,3-thiazol-2-ylphosphinic amide
-
-
PAT
-
0.05 mM, complete inhibition
potassium antimony tartrate
-
-
RMA35
-
0.05 mM, 98% inhibition
[mu-[1-(hydroxy-1kappaO)-2-(sulfanyl-1kappaS)pyridin-1-iumato(2-)]]-[mu-[1-(hydroxy-2kappaO)-2-(sulfanyl-1kappaS)pyridin-1-iumato(2-)]]bis(triphenylphosphane)digold
-
a single gold atom binds to Cys519 and Cys573 in the AuI-enzyme complex. 7580% inhibition of thioredoxin and glutathione reductase activities is achieved at a 1:1 concentration ratio of inhibitor:enzyme
additional information
-
the recombinant plasmid DNA vaccine pVAX1/SjTGR lowers enzymatic activity in vivo and in vitro
-
1,3,4-oxadiazole-2-sulfone
-
shows potent schistomicidal activity (LD50 above 0.01 mM) against Schistosoma mansoni, Schistosoma japonicum and Schistosoma hematobium, particularly against immature flukes. The compounds exceeds the standard set by WHO for antischistosome lead compounds. Kills schistosomes within 1 h of administration
-
1,3,4-oxadiazole-2-sulfone
-
shows potent schistomicidal activity (LD50 above 0.01 mM) against Schistosoma mansoni, Schistosoma japonicum and Schistosoma hematobium, particularly against immature flukes. The compounds exceeds the standard set by WHO for antischistosome lead compounds. Kills schistosomes within 1 h of administration
-
1,3,4-oxadiazole-2-sulfone
-
shows potent schistomicidal activity (LD50 above 0.01 mM) against Schistosoma mansoni, Schistosoma japonicum and Schistosoma hematobium, particularly against immature flukes. The compounds exceeds the standard set by WHO for antischistosome lead compounds. Kills schistosomes within 1 h of administration
-
2-((4-chlorophenyl)sulfonal)-6-methoxy-3-nitropyridine
-
shows potent schistomicidal activity (LD50 above 0.01 mM) against Schistosoma mansoni, Schistosoma japonicum and Schistosoma hematobium, particularly against immature flukes. Kills schistosomes within 1 h of administration
-
2-((4-chlorophenyl)sulfonal)-6-methoxy-3-nitropyridine
-
shows potent schistomicidal activity (LD50 above 0.01 mM) against Schistosoma mansoni, Schistosoma japonicum and Schistosoma hematobium, particularly against immature flukes. Kills schistosomes within 1 h of administration
-
2-((4-chlorophenyl)sulfonal)-6-methoxy-3-nitropyridine
-
shows potent schistomicidal activity (LD50 above 0.01 mM) against Schistosoma mansoni, Schistosoma japonicum and Schistosoma hematobium, particularly against immature flukes. Kills schistosomes within 1 h of administration
-
4-chloro-5-[4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl]-2-phenylpyridazin-3(2H)-one
-
at 0.010 microM, 100 % larval death at 48 hours
4-chloro-5-[4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl]-2-phenylpyridazin-3(2H)-one
-
-
6-nitro-1H-1-benzothiophene-1,1-dione
-
at 0.010 microM, 100 % larval death at 48 hours
6-nitro-1H-1-benzothiophene-1,1-dione
-
-
6-nitrobenzo[b]thiophene-1,1-dioxide
-
shows potent schistomicidal activity (LD50 above 0.01 mM) against Schistosoma mansoni, Schistosoma japonicum and Schistosoma hematobium, particularly against immature flukes. The compounds exceeds the standard set by WHO for antischistosome lead compounds. Kills schistosomes within 1 h of administration
-
6-nitrobenzo[b]thiophene-1,1-dioxide
-
shows potent schistomicidal activity (LD50 above 0.01 mM) against Schistosoma mansoni, Schistosoma japonicum and Schistosoma hematobium, particularly against immature flukes. The compounds exceeds the standard set by WHO for antischistosome lead compounds. Kills schistosomes within 1 h of administration
-
6-nitrobenzo[b]thiophene-1,1-dioxide
-
shows potent schistomicidal activity (LD50 above 0.01 mM) against Schistosoma mansoni, Schistosoma japonicum and Schistosoma hematobium, particularly against immature flukes. The compounds exceeds the standard set by WHO for antischistosome lead compounds. Kills schistosomes within 1 h of administration
-
auranofin
-
the TGR inhibitor, killes larval worms in vitro
auranofin
inhibition in a dose-dependent manner. The inhibitor expresses a lethal toxic effect on both newly excysted juveniles and adult worms of Opisthorchis viverrini in vitro
auranofin
-
auranofin at 0.005 mg/ml (0.0074 mM) reduces 57.1% of the thioredoxin reductase activity and 71% of the glutathione reductase activity in the Schistosoma japonicum adult worms
auranofin
-
0.05 mM, complete inhibition
auranofin
very potent inhibitor, nearly compete inhibition at 0.01 mM
auranofin
-
complete inhibition at 0.7 nM
auranofin
-
both cytolsolic and mitochondrial isoform
furoxan
-
-
furoxan
i.e. oxadiazole-3-carbonitrile-2-oxide, potent inhibitor
pyrazine-3-one
-
shows potent schistomicidal activity (LD50 above 0.01 mM) against Schistosoma mansoni, Schistosoma japonicum and Schistosoma hematobium, particularly against immature flukes. The compounds exceeds the standard set by WHO for antischistosome lead compounds. Kills schistosomes within 1 h of administration
-
pyrazine-3-one
-
shows potent schistomicidal activity (LD50 above 0.01 mM) against Schistosoma mansoni, Schistosoma japonicum and Schistosoma hematobium, particularly against immature flukes. The compounds exceeds the standard set by WHO for antischistosome lead compounds. Kills schistosomes within 1 h of administration
-
pyrazine-3-one
-
shows potent schistomicidal activity (LD50 above 0.01 mM) against Schistosoma mansoni, Schistosoma japonicum and Schistosoma hematobium, particularly against immature flukes. The compounds exceeds the standard set by WHO for antischistosome lead compounds. Kills schistosomes within 1 h of administration
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2.792
2-hydroxyethyl disulfide
-
at 25°C in 0.1 M potassium phosphate (pH 7.4)
0.033 - 0.038
5,5'-dithio-bis(2-nitrobenzoic acid)
0.00434 - 0.71
5,5'-dithiobis(2-nitrobenzoic acid)
0.034
cytosolic thioredoxin
-
pH 7.0, 25°C, wild-type enzyme
0.004 - 0.0612
glutathione disulfide
0.184 - 0.41
glutathione-hydroxyethyl disulfide
1.698
GSH
-
at 25°C in 0.1 M potassium phosphate (pH 7.4)
0.0095 - 0.012
mitochondial thioredoxin
0.0031 - 0.017
thioredoxin
0.00087 - 0.067
thioredoxin disulfide
additional information
additional information
-
kinetic properties of the Grx domain of TGR
-
0.033
5,5'-dithio-bis(2-nitrobenzoic acid)
-
mutant C574S, pH 7.0, temperature not specified in the publication
0.034
5,5'-dithio-bis(2-nitrobenzoic acid)
-
mutant C519S, pH 7.0, temperature not specified in the publication
0.038
5,5'-dithio-bis(2-nitrobenzoic acid)
-
wild-type, pH 7.0, temperature not specified in the publication
0.00434
5,5'-dithiobis(2-nitrobenzoic acid)
-
pH 7.5, 25°C
0.00434
5,5'-dithiobis(2-nitrobenzoic acid)
-
pH not specified in the publication, temperature not specified in the publication
0.0345
5,5'-dithiobis(2-nitrobenzoic acid)
-
at pH 7.8 and 25°C
0.043
5,5'-dithiobis(2-nitrobenzoic acid)
-
mutant enzyme C31A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.045
5,5'-dithiobis(2-nitrobenzoic acid)
-
mitochondrial isoform, pH 7.8, temperature not specified in the publication
0.049
5,5'-dithiobis(2-nitrobenzoic acid)
-
pH 7.8, 25°C
0.088
5,5'-dithiobis(2-nitrobenzoic acid)
-
cytosolic isoform, pH 7.8, temperature not specified in the publication
0.107
5,5'-dithiobis(2-nitrobenzoic acid)
-
mutant enzyme U597C, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.114
5,5'-dithiobis(2-nitrobenzoic acid)
-
pH 7.4, 25°C
0.1451
5,5'-dithiobis(2-nitrobenzoic acid)
-
at 25°C in 0.1 M potassium phosphate (pH 7.4)
0.169
5,5'-dithiobis(2-nitrobenzoic acid)
-
mutant enzyme C31S, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.187
5,5'-dithiobis(2-nitrobenzoic acid)
-
mutant enzyme C520A/C574A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.23
5,5'-dithiobis(2-nitrobenzoic acid)
-
mutant enzyme C28A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.23
5,5'-dithiobis(2-nitrobenzoic acid)
-
mutant enzyme C574A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.319
5,5'-dithiobis(2-nitrobenzoic acid)
-
wild type enzyme, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.375
5,5'-dithiobis(2-nitrobenzoic acid)
-
mutant enzyme C520A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.406
5,5'-dithiobis(2-nitrobenzoic acid)
-
mutant enzyme C28A/C31A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.71
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
0.004
glutathione disulfide
-
mitochondrial isoform, pH 7.8, temperature not specified in the publication
0.0063
glutathione disulfide
-
cytosolic isoform, pH 7.8, temperature not specified in the publication
0.00809
glutathione disulfide
pH 7.4, 25°C
0.012
glutathione disulfide
-
mutant C519S, pH 7.0, temperature not specified in the publication
0.013
glutathione disulfide
-
mutant C574S, pH 7.0, temperature not specified in the publication
0.0144
glutathione disulfide
-
pH 7.8, 25°C
0.015
glutathione disulfide
-
wild-type, pH 7.0, temperature not specified in the publication
0.0208
glutathione disulfide
recombinant wild-type enzyme, pH 6.9, 25°C
0.0612
glutathione disulfide
-
pH not specified in the publication, temperature not specified in the publication
0.184
glutathione-hydroxyethyl disulfide
-
cytosolic isoform, pH 7.8, temperature not specified in the publication
0.41
glutathione-hydroxyethyl disulfide
-
mitochondrial isoform, pH 7.8, temperature not specified in the publication
0.013
GSSG
-
mutant enzyme C31A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.015
GSSG
-
pH 7.8, 25°C
0.016
GSSG
-
mutant enzyme C28A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.023
GSSG
-
mutant enzyme C28A/C31A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.024
GSSG
-
mutant enzyme C520A/C574A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.031
GSSG
-
mutant enzyme C520A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.036
GSSG
-
mutant enzyme C574A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.041
GSSG
-
at pH 7.8 and 25°C
0.042
GSSG
-
wild type enzyme, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.04955
GSSG
-
at 25°C in 0.1 M potassium phosphate (pH 7.4)
0.071
GSSG
-
mutant enzyme U597C, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.0715
GSSG
-
pH 7.4, 25°C
0.189
GSSG
-
mutant enzyme C31S, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.0095
mitochondial thioredoxin
-
pH 7.0, 25°C, wild-type enzyme
0.012
mitochondial thioredoxin
-
pH 7.0, 25°C, Sec-to-Cys mutant enzyme
0.0016
NADPH
-
mitochondrial isoform, pH 7.8, temperature not specified in the publication
0.003
NADPH
-
pH 7.8, 25°C
0.0035
NADPH
-
pH 7.8, 25°C
0.0051
NADPH
mutant enzyme U642C, cosubstrate: thioredoxin disulfide, pH 7.4, 25°C
0.01097
NADPH
-
with glutaredoxin as cosubstrate, at 25°C in 0.1 M potassium phosphate (pH 7.4)
0.0137
NADPH
-
pH 7.4, 25°C
0.0166
NADPH
recombinant wild-type enzyme, cosubstrate: thioredoxin disulfide, pH 7.4, 25°C
0.019
NADPH
-
at pH 7.8 and 25°C
0.0208
NADPH
recombinant wild-type enzyme, cosubstrate: glutathione disulfide, pH 6.9, 25°C
0.02142
NADPH
-
with 5,5'-dithiobis(2-nitrobenzoic acid) as cosubstrate, at 25°C in 0.1 M potassium phosphate (pH 7.4)
0.048
NADPH
-
cytosolic isoform, pH 7.8, temperature not specified in the publication
0.08324
NADPH
-
with GSSG as cosubstrate, at 25°C in 0.1 M potassium phosphate (pH 7.4)
0.0031
thioredoxin
-
pH 7.8, temperature not specified in the publication
0.017
thioredoxin
-
pH 7.8, 25°C
0.00087
thioredoxin disulfide
-
at pH 7.8 and 25°C
0.00324
thioredoxin disulfide
-
at 25°C in 0.1 M potassium phosphate (pH 7.4)
0.007
thioredoxin disulfide
-
mutant enzyme C520A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.007
thioredoxin disulfide
-
mutant enzyme C574A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.0075
thioredoxin disulfide
recombinant wild-type enzyme, pH 7.4, 25°C
0.008
thioredoxin disulfide
-
mutant enzyme C31A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.008
thioredoxin disulfide
-
mutant enzyme C31S, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.008
thioredoxin disulfide
-
wild type enzyme, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.01374
thioredoxin disulfide
pH 7.4, 25°C
0.015
thioredoxin disulfide
-
mutant enzyme C520A/C574A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.015
thioredoxin disulfide
-
mutant enzyme U597C, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.019
thioredoxin disulfide
-
mutant enzyme C28A/C31A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.0205
thioredoxin disulfide
mutant enzyme U642C, pH 7.4, 25°C
0.022
thioredoxin disulfide
-
mutant enzyme C28A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.067
thioredoxin disulfide
-
cytosolic isoform, pH 7.8, temperature not specified in the publication
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
8.65
2-hydroxyethyl disulfide
-
at 25°C in 0.1 M potassium phosphate (pH 7.4)
10.2 - 55
5,5'-dithio-bis(2-nitrobenzoic acid)
0.17 - 118
5,5'-dithiobis(2-nitrobenzoic acid)
197
cytosolic thioredoxin
-
pH 7.0, 25°C, wild-type enzyme
0.11 - 61.04
glutathione disulfide
5.13 - 163.5
glutathione-hydroxyethyl disulfide
15.78
GSH
-
at 25°C in 0.1 M potassium phosphate (pH 7.4)
6.4 - 131
mitochondial thioredoxin
0.02 - 9
thioredoxin disulfide
10.2
5,5'-dithio-bis(2-nitrobenzoic acid)
-
mutant C574S, pH 7.0, temperature not specified in the publication
12
5,5'-dithio-bis(2-nitrobenzoic acid)
-
mutant C519S, pH 7.0, temperature not specified in the publication
55
5,5'-dithio-bis(2-nitrobenzoic acid)
-
wild-type, pH 7.0, temperature not specified in the publication
0.17
5,5'-dithiobis(2-nitrobenzoic acid)
-
pH 7.8, 25°C
0.3
5,5'-dithiobis(2-nitrobenzoic acid)
-
at pH 7.8 and 25°C
1.2
5,5'-dithiobis(2-nitrobenzoic acid)
-
-
1.85
5,5'-dithiobis(2-nitrobenzoic acid)
-
cytosolic isoform, pH 7.8, temperature not specified in the publication
4
5,5'-dithiobis(2-nitrobenzoic acid)
-
mutant enzyme U597C, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
5
5,5'-dithiobis(2-nitrobenzoic acid)
-
mutant enzyme C520A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
6
5,5'-dithiobis(2-nitrobenzoic acid)
-
mutant enzyme C28A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
6
5,5'-dithiobis(2-nitrobenzoic acid)
-
mutant enzyme C31A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
6
5,5'-dithiobis(2-nitrobenzoic acid)
-
mutant enzyme C520A/C574A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
6
5,5'-dithiobis(2-nitrobenzoic acid)
-
mutant enzyme C574A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
8
5,5'-dithiobis(2-nitrobenzoic acid)
-
mutant enzyme C28A/C31A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
8.16
5,5'-dithiobis(2-nitrobenzoic acid)
-
at 25°C in 0.1 M potassium phosphate (pH 7.4)
12.6
5,5'-dithiobis(2-nitrobenzoic acid)
-
mitochondrial isoform, pH 7.8, temperature not specified in the publication
16
5,5'-dithiobis(2-nitrobenzoic acid)
-
pH 7.4, 25°C
16
5,5'-dithiobis(2-nitrobenzoic acid)
-
mutant enzyme C31S, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
16
5,5'-dithiobis(2-nitrobenzoic acid)
-
wild type enzyme, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
118
5,5'-dithiobis(2-nitrobenzoic acid)
-
pH 7.0, 25°C, wild-type enzyme
0.11
glutathione disulfide
25°C, pH 6.9, recombinant wild-type enzyme
0.96
glutathione disulfide
-
cytosolic isoform, pH 7.8, temperature not specified in the publication
1.62
glutathione disulfide
-
mitochondrial isoform, pH 7.8, temperature not specified in the publication
2 - 8
glutathione disulfide
-
wild-type, pH 7.0, temperature not specified in the publication
5
glutathione disulfide
-
mutant C574S, pH 7.0, temperature not specified in the publication
5.6
glutathione disulfide
-
mutant C519S, pH 7.0, temperature not specified in the publication
12
glutathione disulfide
-
pH 7.8, 25°C
61.04
glutathione disulfide
pH 7.4, 25°C
5.13
glutathione-hydroxyethyl disulfide
-
cytosolic isoform, pH 7.8, temperature not specified in the publication
163.5
glutathione-hydroxyethyl disulfide
-
mitochondrial isoform, pH 7.8, temperature not specified in the publication
0.19
GSSG
-
-
0.6
GSSG
-
mutant enzyme C28A/C31A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.7
GSSG
-
mutant enzyme C28A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.84
GSSG
-
at pH 7.8 and 25°C
3.5
GSSG
-
mutant enzyme C31A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
4
GSSG
-
mutant enzyme U597C, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
5
GSSG
-
mutant enzyme C520A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
5
GSSG
-
mutant enzyme C520A/C574A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
5.35
GSSG
-
at 25°C in 0.1 M potassium phosphate (pH 7.4)
7
GSSG
-
mutant enzyme C574A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
19.4
GSSG
-
wild type enzyme, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
25
GSSG
-
mutant enzyme C31S, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
6.4
mitochondial thioredoxin
-
pH 7.0, 25°C, Sec-to-Cys mutant enzyme
131
mitochondial thioredoxin
-
pH 7.0, 25°C, wild-type enzyme
0.015
NADPH
25°C, pH 7.4, mutant enzyme U642C, cosubstrate: thioredoxin disulfide
0.14
NADPH
25°C, pH 6.9, recombinant wild-type enzyme, cosubstrate: thioredoxin disulfide
0.2
NADPH
25°C, pH 7.4, recombinant wild-type enzyme, cosubstrate: thioredoxin disulfide
1.64
NADPH
-
cytosolic isoform, pH 7.8, temperature not specified in the publication
4.87
NADPH
-
with GSSG as cosubstrate, at 25°C in 0.1 M potassium phosphate (pH 7.4)
10.92
NADPH
-
with 5,5'-dithiobis(2-nitrobenzoic acid) as cosubstrate, at 25°C in 0.1 M potassium phosphate (pH 7.4)
12.6
NADPH
-
mitochondrial isoform, pH 7.8, temperature not specified in the publication
14.93
NADPH
-
with glutaredoxin as cosubstrate, at 25°C in 0.1 M potassium phosphate (pH 7.4)
20.1
NADPH
-
pH 7.4, 25°C
10
thioredoxin
-
pH 7.8, temperature not specified in the publication
19.2
thioredoxin
-
pH 7.8, 25°C
0.02
thioredoxin disulfide
25°C, pH 7.4, mutant enzyme U642C
0.18
thioredoxin disulfide
25°C, pH 7.4, recombinant wild-type enzyme
0.35
thioredoxin disulfide
-
cytosolic isoform, pH 7.8, temperature not specified in the publication
0.47
thioredoxin disulfide
-
at pH 7.8 and 25°C
3.5
thioredoxin disulfide
-
mutant enzyme U597C, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
4.78
thioredoxin disulfide
-
at 25°C in 0.1 M potassium phosphate (pH 7.4)
8
thioredoxin disulfide
-
mutant enzyme C520A/C574A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
8
thioredoxin disulfide
-
mutant enzyme C574A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
8.79
thioredoxin disulfide
pH 7.4, 25°C
9
thioredoxin disulfide
-
mutant enzyme C520A, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
0.000025 - 0.000082
(2-oxido-1,2,5-oxadiazole-3,4-diyl)bis(2-furylmethanone)
0.00002 - 0.00051
(2-oxido-1,2,5-oxadiazole-3,4-diyl)bis(2-thienylmethanone)
0.00129 - 0.00408
(2-oxido-1,2,5-oxadiazole-3,4-diyl)bis[(1,3-dimethyl-1H-pyrazol-4-yl)methanone]
0.00006 - 0.00244
(2-oxido-1,2,5-oxadiazole-3,4-diyl)bis[(4-methoxyphenyl)methanone]
0.024
(3R,5R,8R) 5-(((3-carboxy-4-nitrophenyl)disulfanyl)methyl)tetrahydro-2H-thiazolo[4,3-b]thiazole-3-carboxylic acid
Echinococcus granulosus
pH 7.0, 25°C
0.00005
2-(4-chlorobenzene-1-sulfonyl)-6-methoxy-3-nitropyridine
Schistosoma mansoni
-
pH and temperature not specified in the publication, inhibition of GSSG reducing activity
-
0.00055
2-(4-chlorophenoxy)-6-methyl-2,3-dihydro-1,3,2-diazaphosphinin-4(1H)-one 2-oxide
Schistosoma mansoni
-
-
0.0006
2-(4-ethoxyphenoxy)-6-methyl-2,3-dihydro-1,3,2-diazaphosphinin-4(1H)-one 2-oxide
Schistosoma mansoni
-
-
0.00015
3-bromo-5-butoxy-6H-anthra[1,9-cd]isoxazol-6-one
Schistosoma mansoni
-
-
0.00249 - 0.0063
4-chloro-5-[4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl]-2-phenylpyridazin-3(2H)-one
0.00032 - 0.0018
4-phenyl-1,2,5-oxadiazole-3-carbonitrile 2-oxide
0.0129
4-vinylguaiacol
Taenia crassiceps
-
25°C, pH not specified in the publication
0.014
5-(((3-carboxy-4-nitrophenyl)disulfanyl)methyl) (2RS,5RS)-3,3a-dihydro-benzo[d]thiazolo[4,3-b]thiazole
Echinococcus granulosus
pH 7.0, 25°C
3.15
5-bromo-N-ethyl-3,4-dinitrothiophen-2-amine
Schistosoma mansoni
-
pH 7.5, 22°C
0.00023
5-chloro-N-[4-[ethyl(phenyl)sulfamoyl]phenyl]-2-(methanesulfonyl)pyrimidine-4-carboxamide
Schistosoma mansoni
-
pH and temperature not specified in the publication, inhibition of GSSG reducing activity
-
0.00013
5-[[3-(trifluoromethyl)anilino]methyl]quinolin-8-ol
Schistosoma mansoni
-
pH and temperature not specified in the publication, inhibition of GSSG reducing activity
-
0.004
6-methyl-2-phenoxy-2,3-dihydro-1,3,2-diazaphosphinin-4(1H)-one 2-oxide
Schistosoma mansoni
-
-
0.0022 - 0.0054
6-nitro-1H-1-benzothiophene-1,1-dione
0.00033
7-[(4-methoxyphenyl)[(4-methylpyridin-2-yl)amino]methyl]-2-methylquinolin-8-ol
Schistosoma mansoni
-
pH and temperature not specified in the publication, inhibition of GSSG reducing activity
-
0.0000032 - 0.00001
auranofin
0.00007 - 0.003
aurothioglucose
0.00005 - 0.00009
aurothiomalate
0.009
diethyl (3-bromo-6-oxo-6H-anthra[1,9-cd]isoxazol-5-yl)propanedioate
Schistosoma mansoni
-
-
0.00015
diethyl 2-(3-bromo-6-oxo-6H-anthra[1,9-cd][1,2]oxazol-4-yl)-3-oxobutanedioate
Schistosoma mansoni
-
pH and temperature not specified in the publication, inhibition of GSSG reducing activity
-
0.00008
dimethyl (3-bromo-6-oxo-6H-anthra[1,9-cd]isoxazol-5-yl)propanedioate
Schistosoma mansoni
-
-
0.465
ferulic acid
Taenia crassiceps
-
25°C, pH not specified in the publication
0.18
ferulic aldehyde
Taenia crassiceps
-
25°C, pH not specified in the publication
0.122
feruloylmethane
Taenia crassiceps
-
25°C, pH not specified in the publication
-
0.00039
methyl (5-[1-[(tert-butoxycarbonyl)amino]-2-phenylethyl]-1,3,4-oxadiazole-2-sulfonyl)acetate
Schistosoma mansoni
-
pH and temperature not specified in the publication, inhibition of GSSG reducing activity
-
0.0025 - 0.01
naphthazarin
0.012 - 0.0203
P-1,3-benzothiazol-2-yl-N-(2-fluorophenyl)-P-phenylphosphinic amide
0.000789 - 0.00154
P-1,3-benzothiazol-2-yl-N-(5-chloropyridin-2-yl)-P-phenylphosphinic amide
0.0000212 - 0.000121
P-1,3-benzothiazol-2-yl-P-phenyl-N-1,3-thiazol-2-ylphosphinic amide
0.000008 - 0.000045
potassium antimony tartrate
0.657
vanillic acid
Taenia crassiceps
-
25°C, pH not specified in the publication
0.127
Vanillin
Taenia crassiceps
-
25°C, pH not specified in the publication
0.000025
(2-oxido-1,2,5-oxadiazole-3,4-diyl)bis(2-furylmethanone)
Schistosoma mansoni
-
-
0.000038
(2-oxido-1,2,5-oxadiazole-3,4-diyl)bis(2-furylmethanone)
Schistosoma mansoni
-
pH 7, thioredoxin reductase activity
0.000082
(2-oxido-1,2,5-oxadiazole-3,4-diyl)bis(2-furylmethanone)
Schistosoma mansoni
-
pH 7, glutathione reductase activity
0.00002
(2-oxido-1,2,5-oxadiazole-3,4-diyl)bis(2-thienylmethanone)
Schistosoma mansoni
-
-
0.000042
(2-oxido-1,2,5-oxadiazole-3,4-diyl)bis(2-thienylmethanone)
Schistosoma mansoni
-
pH 7, thioredoxin reductase activity
0.00051
(2-oxido-1,2,5-oxadiazole-3,4-diyl)bis(2-thienylmethanone)
Schistosoma mansoni
-
pH 7, glutathione reductase activity
0.00129
(2-oxido-1,2,5-oxadiazole-3,4-diyl)bis[(1,3-dimethyl-1H-pyrazol-4-yl)methanone]
Schistosoma mansoni
-
pH 7, thioredoxin reductase activity
0.002
(2-oxido-1,2,5-oxadiazole-3,4-diyl)bis[(1,3-dimethyl-1H-pyrazol-4-yl)methanone]
Schistosoma mansoni
-
-
0.00408
(2-oxido-1,2,5-oxadiazole-3,4-diyl)bis[(1,3-dimethyl-1H-pyrazol-4-yl)methanone]
Schistosoma mansoni
-
pH 7, glutathione reductase activity
0.00006
(2-oxido-1,2,5-oxadiazole-3,4-diyl)bis[(4-methoxyphenyl)methanone]
Schistosoma mansoni
-
-
0.000105
(2-oxido-1,2,5-oxadiazole-3,4-diyl)bis[(4-methoxyphenyl)methanone]
Schistosoma mansoni
-
pH 7, thioredoxin reductase activity
0.00244
(2-oxido-1,2,5-oxadiazole-3,4-diyl)bis[(4-methoxyphenyl)methanone]
Schistosoma mansoni
-
pH 7, glutathione reductase activity
0.0005
3-DAP
Schistosoma mansoni
-
pH 7.4, 25°C, substrates: 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH
0.007
3-DAP
Schistosoma mansoni
-
pH 7.4, 25°C, substrates: GSSG + NADPH
0.00249
4-chloro-5-[4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl]-2-phenylpyridazin-3(2H)-one
Schistosoma mansoni
-
pH and temperature not specified in the publication, inhibition of GSSG reducing activity
0.0063
4-chloro-5-[4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl]-2-phenylpyridazin-3(2H)-one
Schistosoma mansoni
-
pH 7.5, 22°C
0.00032
4-phenyl-1,2,5-oxadiazole-3-carbonitrile 2-oxide
Schistosoma mansoni
-
pH 7, glutathione reductase activity
0.00167
4-phenyl-1,2,5-oxadiazole-3-carbonitrile 2-oxide
Schistosoma mansoni
-
pH 7, thioredoxin reductase activity
0.0018
4-phenyl-1,2,5-oxadiazole-3-carbonitrile 2-oxide
Schistosoma mansoni
-
-
0.0022
6-nitro-1H-1-benzothiophene-1,1-dione
Schistosoma mansoni
-
pH and temperature not specified in the publication, inhibition of GSSG reducing activity
0.0054
6-nitro-1H-1-benzothiophene-1,1-dione
Schistosoma mansoni
-
pH 7.5, 22°C
0.0000032
auranofin
Schistosoma mansoni
-
wild type enzyme, with 5,5'-dithiobis(2-nitrobenzoic acid) as substrate, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.0000054
auranofin
Schistosoma mansoni
-
wild type enzyme, with GSSG as substrate, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.000007
auranofin
Schistosoma mansoni
pH 7.0, 25°C, thioredoxin reductase activity
0.000007
auranofin
Schistosoma mansoni
-
pH 7.4, 25°C, substrates: 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH
0.0000083
auranofin
Schistosoma mansoni
-
wild type enzyme, with thioredoxin disulfide as substrate, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.000009
auranofin
Schistosoma mansoni
-
pH 7.4, 25°C, substrates: GSSG + NADPH
0.00001
auranofin
Schistosoma mansoni
pH 7.0, 37°C, glutathione reductase activity
0.00007
aurothioglucose
Schistosoma mansoni
-
pH 7.4, 25°C, substrates: 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH
0.003
aurothioglucose
Schistosoma mansoni
-
pH 7.4, 25°C, substrates: GSSG + NADPH
0.00005
aurothiomalate
Schistosoma mansoni
-
pH 7.4, 25°C, substrates: GSSG + NADPH
0.00009
aurothiomalate
Schistosoma mansoni
-
pH 7.4, 25°C, substrates: 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH
0.001
CDE16-2
Schistosoma mansoni
-
pH 7.4, 25°C, substrates: GSSG + NADPH
0.025
CDE16-2
Schistosoma mansoni
-
pH 7.4, 25°C, substrates: 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH
0.0005
CDE4
Schistosoma mansoni
-
pH 7.4, 25°C, substrates: GSSG + NADPH
0.007
CDE4
Schistosoma mansoni
-
pH 7.4, 25°C, substrates: 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH
0.003
furoxan
Schistosoma mansoni
-
wild type enzyme, with 5,5'-dithiobis(2-nitrobenzoic acid) as substrate, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.0032
furoxan
Schistosoma mansoni
-
wild type enzyme, with GSSG as substrate, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.0054
furoxan
Schistosoma mansoni
-
wild type enzyme, with thioredoxin disulfide as substrate, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.0005
JD159
Schistosoma mansoni
-
pH 7.4, 25°C, substrates: 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH
0.001
JD159
Schistosoma mansoni
-
pH 7.4, 25°C, substrates: GSSG + NADPH
0.008
LS826
Schistosoma mansoni
-
pH 7.4, 25°C, substrates: 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH
0.008
LS826
Schistosoma mansoni
-
pH 7.4, 25°C, substrates: GSSG + NADPH
0.0025
naphthazarin
Schistosoma mansoni
-
pH 7.4, 25°C, substrates: 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH
0.01
naphthazarin
Schistosoma mansoni
-
pH 7.4, 25°C, substrates: GSSG + NADPH
0.05
OPZ
Schistosoma mansoni
-
pH 7.4, 25°C, substrates: GSSG + NADPH
0.08
OPZ
Schistosoma mansoni
-
pH 7.4, 25°C, substrates: 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH
0.012
P-1,3-benzothiazol-2-yl-N-(2-fluorophenyl)-P-phenylphosphinic amide
Schistosoma mansoni
-
-
0.0151
P-1,3-benzothiazol-2-yl-N-(2-fluorophenyl)-P-phenylphosphinic amide
Schistosoma mansoni
-
pH 7, thioredoxin reductase activity
0.0203
P-1,3-benzothiazol-2-yl-N-(2-fluorophenyl)-P-phenylphosphinic amide
Schistosoma mansoni
-
pH 7, glutathione reductase activity
0.000789
P-1,3-benzothiazol-2-yl-N-(5-chloropyridin-2-yl)-P-phenylphosphinic amide
Schistosoma mansoni
-
pH 7, thioredoxin reductase activity
0.0008
P-1,3-benzothiazol-2-yl-N-(5-chloropyridin-2-yl)-P-phenylphosphinic amide
Schistosoma mansoni
-
-
0.00154
P-1,3-benzothiazol-2-yl-N-(5-chloropyridin-2-yl)-P-phenylphosphinic amide
Schistosoma mansoni
-
pH 7, glutathione reductase activity
0.0000212
P-1,3-benzothiazol-2-yl-P-phenyl-N-1,3-thiazol-2-ylphosphinic amide
Schistosoma mansoni
-
pH 7, thioredoxin reductase activity
0.000025
P-1,3-benzothiazol-2-yl-P-phenyl-N-1,3-thiazol-2-ylphosphinic amide
Schistosoma mansoni
-
-
0.000121
P-1,3-benzothiazol-2-yl-P-phenyl-N-1,3-thiazol-2-ylphosphinic amide
Schistosoma mansoni
-
pH 7, glutathione reductase activity
0.000037
PAT
Schistosoma mansoni
-
pH 7.4, 25°C, substrates: GSSG + NADPH
0.000051
PAT
Schistosoma mansoni
-
pH 7.4, 25°C, substrates: 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH
0.000008
potassium antimony tartrate
Schistosoma mansoni
-
wild type enzyme, with GSSG as substrate, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.000009
potassium antimony tartrate
Schistosoma mansoni
-
wild type enzyme, with 5,5'-dithiobis(2-nitrobenzoic acid) as substrate, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.000045
potassium antimony tartrate
Schistosoma mansoni
-
wild type enzyme, with thioredoxin disulfide as substrate, in 0.1 M potassium phosphate buffer and 10 mM EDTA (pH 7.4) at 25°C
0.004
RMA35
Schistosoma mansoni
-
pH 7.4, 25°C, substrates: 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH
0.006
RMA35
Schistosoma mansoni
-
pH 7.4, 25°C, substrates: GSSG + NADPH
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Su, D.; Novoselov, S.V.; Sun, Q.A.; Moustafa, M.E.; Zhou, Y.; Oko, R.; Hatfield, D.L.; Gladyshev, V.N.
Mammalian selenoprotein thioredoxin/glutathione reductase: roles in disulfide bond formation and sperm maturation
J. Biol. Chem.
280
26491-26498
2005
Mus musculus
brenda
Rendon, J.L.; del Arenal, I.P.; Guevara-Flores, A.; Uribe, A.; Plancarte, A.; Mendoza-Hernandez, G.
Purification, characterization and kinetic properties of the multifunctional thioredoxin-glutathione reductase from Taenia crassiceps metacestode (cysticerci)
Mol. Biochem. Parasitol.
133
61-69
2004
Taenia crassiceps
brenda
Lea, W.A.; Jadhav, A.; Rai, G.; Sayed, A.A.; Cass, C.L.; Inglese, J.; Williams, D.L.; Austin, C.P.; Simeonov, A.
A 1,536-well-based kinetic HTS assay for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase
Assay Drug Dev. Technol.
6
551-555
2008
Schistosoma mansoni
brenda
Sun, Q.A.; Su, D.; Novoselov, S.V.; Carlson, B.A.; Hatfield, D.L.; Gladyshev, V.N.
Reaction mechanism and regulation of mammalian thioredoxin/glutathione reductase
Biochemistry
44
14528-14537
2005
Bos taurus, Danio rerio, Gallus gallus, Homo sapiens, Mus musculus, no activity in Caenorhabditis elegans, no activity in Canis familiaris, no activity in Drosophila melanogaster, no activity in Sus scrofa, Pan troglodytes, Rattus norvegicus, Takifugu rubripes, Xenopus laevis, Tetraodon nigroviridis
brenda
Huang, H.H.; Arscott, L.D.; Ballou, D.P.; Williams, C.H.
Acid-base catalysis in the mechanism of thioredoxin reductase from Drosophila melanogaster
Biochemistry
47
1721-1731
2008
Drosophila melanogaster
brenda
Agorio, A.; Chalar, C.; Cardozo, S.; Salinas, G.
Alternative mRNAs arising from trans-splicing code for mitochondrial and cytosolic variants of Echinococcus granulosus thioredoxin glutathione reductase
J. Biol. Chem.
278
12920-12928
2003
Echinococcus granulosus (Q869D6), Echinococcus granulosus (Q869D7), Echinococcus granulosus
brenda
Jurado, J.; Prieto-Alamo, M.J.; Madrid-Risquez, J.; Pueyo, C.
Absolute gene expression patterns of thioredoxin and glutaredoxin redox systems in mouse
J. Biol. Chem.
278
45546-45554
2003
Mus musculus (Q99MD6)
brenda
Bonilla, M.; Denicola, A.; Novoselov, S.V.; Turanov, A.A.; Protasio, A.; Izmendi, D.; Gladyshev, V.N.; Salinas, G.
Platyhelminth mitochondrial and cytosolic redox homeostasis is controlled by a single thioredoxin glutathione reductase and dependent on selenium and glutathione
J. Biol. Chem.
283
17898-17907
2008
Echinococcus granulosus
brenda
Alger, H.M.; Williams, D.L.
The disulfide redox system of Schistosoma mansoni and the importance of a multifunctional enzyme, thioredoxin glutathione reductase
Mol. Biochem. Parasitol.
121
129-139
2002
Schistosoma mansoni (Q962Y6), Schistosoma mansoni
brenda
Sayed, A.A.; Simeonov, A.; Thomas, C.J.; Inglese, J.; Austin, C.P.; Williams, D.L.
Identification of oxadiazoles as new drug leads for the control of schistosomiasis
Nat. Med.
14
407-412
2008
Schistosoma mansoni
brenda
Kuntz Angela, N.; Davioud-Charvet, E.; Sayed Ahmed, A.; Califf Lindsay, L.; Dessolin, J.; Arner Elias, S.J.; Williams David, L.
Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target
PLoS Med.
4
e206
2007
Schistosoma mansoni
brenda
Simeonov, A.; Jadhav, A.; Sayed, A.A.; Wang, Y.; Nelson, M.E.; Thomas, C.J.; Inglese, J.; Williams, D.L.; Austin, C.P.
Quantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascade
PLoS Negl. Trop. Dis.
2
e127
2008
Schistosoma mansoni
brenda
Angelucci, F.; Miele, A.E.; Boumis, G.; Dimastrogiovanni, D.; Brunori, M.; Bellelli, A.
Glutathione reductase and thioredoxin reductase at the crossroad: the structure of Schistosoma mansoni thioredoxin glutathione reductase
Proteins
72
936-945
2008
Schistosoma mansoni
brenda
Salinas, G.; Selkirk, M.E.; Chalar, C.; Maizels, R.M.; Fernandez, C.
Linked thioredoxin-glutathione systems in platyhelminths
Trends Parasitol.
20
340-346
2004
Echinococcus granulosus (Q869D6), Echinococcus granulosus (Q869D7), Schistosoma mansoni (Q962Y6)
brenda
Huang, H.H.; Day, L.; Cass, C.L.; Ballou, D.P.; Williams, C.H.; Williams, D.L.
Investigations of the catalytic mechanism of thioredoxin glutathione reductase from Schistosoma mansoni
Biochemistry
50
5870-5882
2011
Schistosoma mansoni
brenda
Prast-Nielsen, S.; Huang, H.H.; Williams, D.L.
Thioredoxin glutathione reductase: its role in redox biology and potential as a target for drugs against neglected diseases
Biochim. Biophys. Acta
1810
1262-1271
2011
Schistosoma mansoni (Q962Y6)
brenda
Cao, Y.; Zhao, B.; Han, Y.; Zhang, J.; Li, X.; Qiu, C.; Wu, X.; Hong, Y.; Ai, D.; Lin, J.; Fu, Z.
Gene gun bombardment with DNA-coated golden particles enhanced the protective effect of a DNA vaccine based on thioredoxin glutathione reductase of Schistosoma japonicum
BioMed Res. Int.
2013
952416
2013
Schistosoma japonicum
brenda
Maggioli, G.; Silveira, F.; Martin-Alonso, J.M.; Salinas, G.; Carmona, C.; Parra, F.
A recombinant thioredoxin-glutathione reductase from Fasciola hepatica induces a protective response in rabbits
Exp. Parasitol.
129
323-330
2011
Fasciola hepatica (A8E0R8), Fasciola hepatica
brenda
Bonilla, M.; Denicola, A.; Marino, S.M.; Gladyshev, V.N.; Salinas, G.
Linked thioredoxin-glutathione systems in platyhelminth parasites: alternative pathways for glutathione reduction and deglutathionylation
J. Biol. Chem.
286
4959-4967
2011
Echinococcus granulosus
brenda
Guevara-Flores, A.; Del Arenal, I.P.; Mendoza-Hernandez, G.; Pardo, J.P.; Flores-Herrera, O.; Rendon, J.L.
Mitochondrial thioredoxin-glutathione reductase from larval Taenia crassiceps (Cysticerci)
J. Parasitol. Res.
2010
2010
2010
Taenia crassiceps
brenda
Han, Y.; Zhang, M.; Hong, Y.; Zhu, Z.; Li, D.; Li, X.; Fu, Z.; Lin, J.
Characterization of thioredoxin glutathione reductase in Schiotosoma japonicum
Parasitol. Int.
61
475-480
2012
Schistosoma japonicum (B5THG7), Schistosoma japonicum
brenda
Song, L.; Li, J.; Xie, S.; Qian, C.; Wang, J.; Zhang, W.; Yin, X.; Hua, Z.; Yu, C.
Thioredoxin glutathione reductase as a novel drug target: evidence from Schistosoma japonicum
PLoS ONE
7
e31456
2012
Schistosoma japonicum
brenda
Dobrovolska, O.; Shumilina, E.; Gladyshev, V.N.; Dikiy, A.
Structural analysis of glutaredoxin domain of Mus musculus thioredoxin glutathione reductase
PLoS ONE
7
e52914
2012
Mus musculus (Q99MD6), Mus musculus
brenda
Li, Y.; Wu, Q.; Peng, Y.; Huang, F.; Li, X.; Chen, L.; Shi, D.; Zhou, X.; Fan, X.
Expression, crystallization and preliminary X-ray diffraction analysis of thioredoxin glutathione reductase from Schistosoma japonicum in complex with FAD
Acta Crystallogr. Sect. F
70
92-96
2014
Schistosoma japonicum (Q5DE05), Schistosoma japonicum
brenda
Wu, Z.; Hou, Y.; Dai, Z.; Hu, C.A.; Wu, G.
Metabolism, nutrition, and redox signaling of hydroxyproline
Antioxid. Redox Signal.
30
674-682
2017
Echinococcus granulosus
brenda
Plancarte, A.; Nava, G.
Purification and kinetic analysis of cytosolic and mitochondrial thioredoxin glutathione reductase extracted from Taenia solium cysticerci
Exp. Parasitol.
149
65-73
2015
Taenia solium
brenda
Li, T.; Ziniel, P.D.; He, P.Q.; Kommer, V.P.; Crowther, G.J.; He, M.; Liu, Q.; Van Voorhis, W.C.; Williams, D.L.; Wang, M.W.
High-throughput screening against thioredoxin glutathione reductase identifies novel inhibitors with potential therapeutic value for schistosomiasis
Infect. Dis. Poverty
4
40
2015
Schistosoma mansoni
brenda
Gupta, A.; Kesherwani, M.; Velmurugan, D.; Tripathi, T.
Fasciola gigantica thioredoxin glutathione reductase Biochemical properties and structural modeling
Int. J. Biol. Macromol.
89
152-160
2016
Fasciola gigantica
brenda
El Gendy, A.; Rabie, I.; El Deeb, S.; El Amir, A.
Importance of Schistosoma mansoni thioredoxin glutathione reductase 1- evaluation of its role in schistosomiasis diagnosis in human
J. Med. Sci.
13
635-646
2013
Schistosoma mansoni
-
brenda
Saiz, C.; Castillo, V.; Fontan, P.; Bonilla, M.; Salinas, G.; Rodriguez-Haralambides, A.; Mahler, S.G.
Discovering Echinococcus granulosus thioredoxin glutathione reductase inhibitors through site-specific dynamic combinatorial chemistry
Mol. Divers.
18
1-12
2014
Echinococcus granulosus (F8QQF4), Echinococcus granulosus
brenda
Huang, J.; Hua, W.; Li, J.; Hua, Z.
Molecular docking to explore the possible binding mode of potential inhibitors of thioredoxin glutathione reductase
Mol. Med. Rep.
12
5787-5795
2015
Schistosoma japonicum (B5THG7), Schistosoma japonicum, Schistosoma mansoni (Q962Y6), Schistosoma mansoni
brenda
Martinez-Gonzalez, J.J.; Guevara-Flores, A.; Rendon, J.L.; Sosa-Peinado, A.; Del Arenal Mena, I.P.
Purification and characterization of Taenia crassiceps cysticerci thioredoxin insight into thioredoxin-glutathione-reductase (TGR) substrate recognition
Parasitol. Int.
64
194-201
2015
Taenia crassiceps
brenda
Changklungmoa, N.; Kueakhai, P.; Sangpairoj, K.; Chaichanasak, P.; Jaikua, W.; Riengrojpitak, S.; Sobhon, P.; Chaithirayanon, K.
Molecular cloning and characterization of Fasciola gigantica thioredoxin-glutathione reductase
Parasitol. Res.
114
2119-2127
2015
Fasciola gigantica
brenda
Gaba, S.; Jamal, S.; Drug Discovery Consortium, O.; Scaria, V.
Cheminformatics models for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase
Sci. World J.
2014
957107
2014
Schistosoma mansoni
brenda
Silvestri, I.; Lyu, H.; Fata, F.; Boumis, G.; Miele, A.E.; Ardini, M.; Ippoliti, R.; Bellelli, A.; Jadhav, A.; Lea, W.A.; Simeonov, A.; Cheng, Q.; Arner, E.S.J.; Thatcher, G.R.J.; Petukhov, P.A.; Williams, D.L.; Angelucci, F.
Fragment-based discovery of a regulatory site in thioredoxin glutathione reductase acting as ''Doorstop'' for NADPH Entry
ACS Chem. Biol.
13
2190-2202
2018
Schistosoma mansoni (Q962Y6), Schistosoma mansoni
brenda
Lyu, H.; Petukhov, P.A.; Banta, P.R.; Jadhav, A.; Lea, W.A.; Cheng, Q.; Arner, E.S.J.; Simeonov, A.; Thatcher, G.R.J.; Angelucci, F.; Williams, D.L.
Characterization of lead compounds targeting the selenoprotein thioredoxin glutathione reductase for treatment of Schistosomiasis
ACS Infect. Dis.
6
393-405
2020
Schistosoma mansoni
brenda
Tripathi, T.; Chetri, P.B.
Potent inhibitors of thioredoxin glutathione reductase grail of anti-Schistosome drug within reach?
ACS Infect. Dis.
6
893-895
2020
Schistosoma japonicum, Schistosoma mansoni, Schistosoma haematobium
brenda
Fata, F.; Silvestri, I.; Ardini, M.; Ippoliti, R.; Di Leandro, L.; Demitri, N.; Polentarutti, M.; Di Matteo, A.; Lyu, H.; Thatcher, G.R.J.; Petukhov, P.A.; Williams, D.L.; Angelucci, F.
Probing the surface of a parasite drug target thioredoxin glutathione reductase using small molecule fragments
ACS Infect. Dis.
7
1932-1944
2021
Schistosoma mansoni (A0A3Q0KFL1), Schistosoma mansoni
brenda
Prum, S.; Plumworasawat, S.; Chaiyadet, S.; Saichua, P.; Thanan, R.; Laha, T.; Laohaviroj, M.; Sripa, B.; Suttiprapa, S.
Characterization and in vitro functional analysis of thioredoxin glutathione reductase from the liver fluke Opisthorchis viverrini
Acta Trop.
210
105621
2020
Opisthorchis viverrini (A0A6C0NKS2), Opisthorchis viverrini
brenda
Salinas, G.; Gao, W.; Wang, Y.; Bonilla, M.; Yu, L.; Novikov, A.; Virginio, V.G.; Ferreira, H.B.; Vieites, M.; Gladyshev, V.N.; Gambino, D.; Dai, S.
The enzymatic and structural basis for inhibition of Echinococcus granulosus thioredoxin glutathione reductase by gold(I)
Antioxid. Redox Signal.
27
1491-1504
2017
Echinococcus granulosus (Q869D7), Echinococcus granulosus
brenda
Kalita, P.; Shukla, H.; Gadhave, K.; Giri, R.; Tripathi, T.
Role of the glutaredoxin domain and FAD in the stabilization of thioredoxin glutathione reductase
Arch. Biochem. Biophys.
656
38-45
2018
Fasciola gigantica
brenda
Kalita, P.; Shukla, H.; Das, K.C.; Tripathi, T.
Conserved Arg451 residue is critical for maintaining the stability and activity of thioredoxin glutathione reductase
Arch. Biochem. Biophys.
674
108098
2019
Fasciola gigantica
brenda
Kalita, P.; Shukla, H.; Shukla, R.; Tripathi, T.
Biochemical and thermodynamic comparison of the selenocysteine containing and non-containing thioredoxin glutathione reductase of Fasciola gigantica
Biochim. Biophys. Acta Gen. Subj.
1862
1306-1316
2018
Fasciola gigantica
brenda
Rendon, J.L.; Miranda-Leyva, M.; Guevara-Flores, A.; Martinez-Gonzalez, J.J.; Del Arenal, I.P.; Flores-Herrera, O.; Pardo, J.P.
Insight into the mechanistic basis of the hysteretic-like kinetic behavior of thioredoxin-glutathione reductase (TGR)
Enzyme Res.
2018
3215462
2018
Taenia crassiceps
brenda
Brandstaedter, C.; Fritz-Wolf, K.; Weder, S.; Fischer, M.; Hecker, B.; Rahlfs, S.; Becker, K.
Kinetic characterization of wild-type and mutant human thioredoxin glutathione reductase defines its reaction and regulatory mechanisms
FEBS J.
285
542-558
2018
Homo sapiens (Q86VQ6), Homo sapiens
brenda
Guevara-Flores, A.; Martinez-Gonzalez, J.J.; Herrera-Juarez, A.M.; Rendon, J.L.; Gonzalez-Andrade, M.; Torres Duran, P.V.; Enriquez-Habib, R.G.; Del Arenal Mena, I.P.
Effect of curcuminoids and curcumin derivate products on thioredoxin-glutathione reductase from Taenia crassiceps cysticerci. Evidence suggesting a curcumin oxidation product as a suitable inhibitor
PLoS ONE
14
e0220098
2019
Taenia crassiceps
brenda