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Information on EC 1.6.5.7 - 2-hydroxy-1,4-benzoquinone reductase
for references in articles please use BRENDA:EC1.6.5.7
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EC Tree 1 Oxidoreductases
1.6 Acting on NADH or NADPH
1.6.5 With a quinone or similar compound as acceptor
1.6.5.7 2-hydroxy-1,4-benzoquinone reductase
IUBMB Comments
A flavoprotein (FMN) that differs in substrate specificity from other quinone reductases. The enzyme in Burkholderia cepacia is inducible by 2,4,5-trichlorophenoxyacetate.
The enzyme appears in viruses and cellular organisms
showSynonyms
2-hydroxy-1,4-benzoquinone reductase, hydroxybenzoquinone reductase, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
1,2,4-trihydroxybenzene:NAD+ oxidoreductase
-
-
-
-
hydroxybenzoquinone reductase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
2-hydroxy-1,4-benzoquinone + NADH + H+ = hydroxyquinol + NAD+
-
-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
-
-
-
-
redox reaction
-
-
-
-
reduction
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
KEGG
MetaCyc
2,4,5-trichlorophenoxyacetate degradation, 4-nitrophenol degradation II
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SYSTEMATIC NAME
IUBMB Comments
2-hydroxy-1,4-benzoquinone:NADH oxidoreductase
A flavoprotein (FMN) that differs in substrate specificity from other quinone reductases. The enzyme in Burkholderia cepacia is inducible by 2,4,5-trichlorophenoxyacetate.
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CAS REGISTRY NUMBER
COMMENTARY
214466-94-1
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-hydroxy-[1,4]-benzoquinone + NADH
1,2,4-trihydroxybenzene + NAD+
-
Substrates: -
Products: -
Products: -
r
2-hydroxy-[1,4]-benzoquinone + NADH
1,2,4-trihydroxybenzene + NAD+
-
Substrates: -
Products: -
Products: -
r
2-hydroxy-[1,4]-benzoquinone + NADH
1,2,4-trihydroxybenzene + NAD+
-
Substrates: -
Products: -
Products: -
?
2-hydroxy-[1,4]-benzoquinone + NADH
1,2,4-trihydroxybenzene + NAD+
-
Substrates: -
Products: -
Products: -
?
5-chloro-2-hydroxy-[1,4]-benzoquinone + NADH
5-chloro-1,2,4-trihydroxybenzene + NAD+
-
Substrates: -
Products: -
Products: -
r
5-chloro-2-hydroxy-[1,4]-benzoquinone + NADH
5-chloro-1,2,4-trihydroxybenzene + NAD+
-
Substrates: -
Products: -
Products: -
r
additional information
?
-
-
Substrates: the purified enzyme shows a broad substrate specificity toward benzoquinones converting them to the corresponding 1,4-benzenediols
Products: -
Products: -
?
additional information
?
-
-
Substrates: the purified enzyme shows a broad substrate specificity toward benzoquinones converting them to the corresponding 1,4-benzenediols
Products: -
Products: -
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
metabolism
metabolism
-
iron-containing superoxide dismutase and 2-hydroxy-1,4-benzoquinone reductase together with 1,2,4-trihydroxybenzene 1,2-dioxygenase convert 1,2,4-trihydroxybenzene to maleylacetic acid
metabolism
-
iron-containing superoxide dismutase and 2-hydroxy-1,4-benzoquinone reductase together with 1,2,4-trihydroxybenzene 1,2-dioxygenase convert 1,2,4-trihydroxybenzene to maleylacetic acid
-
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). A0A6J5A557_9BURK
184
0
20210
TrEMBL
-
A0A346BBT2_9BURK
184
0
20308
TrEMBL
-
A0A6J5GTS3_9BURK
184
0
20503
TrEMBL
-
A0A645G504_9ZZZZ
98
0
10903
TrEMBL
other Location (Reliability: 3)
A0A645CVJ3_9ZZZZ
183
0
20252
TrEMBL
other Location (Reliability: 3)
A0A6V7DJ34_9XANT
184
0
19918
TrEMBL
-
A0A645D7F4_9ZZZZ
185
0
20179
TrEMBL
other Location (Reliability: 4)
B1FUL8_PARG4
Paraburkholderia graminis (strain ATCC 700544 / DSM 17151 / LMG 18924 / NCIMB 13744 / C4D1M)
184
0
20305
TrEMBL
-
A0A6J5K110_9BURK
184
0
20238
TrEMBL
-
A0A644YH21_9ZZZZ
88
0
9480
TrEMBL
other Location (Reliability: 3)
A0A644YGS9_9ZZZZ
187
0
20588
TrEMBL
other Location (Reliability: 5)
A0A645DF23_9ZZZZ
186
0
20789
TrEMBL
other Location (Reliability: 3)
A0A644YQT3_9ZZZZ
183
0
20202
TrEMBL
other Location (Reliability: 5)
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
dimer
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zaborina, O.; Daubaras, D.L.; Zago, A.; Xun, L.; Saido, K; Klem, T.; Nikolic, D.; Chakrabarty, A.M.
Novel pathway for conversion of chlorohydroxyquinol to maleylacetate in Burkholderia cepacia AC1100
J. Bacteriol.
180
4667-4675
1998
Burkholderia cepacia, Burkholderia cepacia AC1100
brenda
Takenaka, S.; Koshiya, J.; Okugawa, S.; Takata, A.; Murakami, S.; Aoki, K.
Fe-superoxide dismutase and 2-hydroxy-1,4-benzoquinone reductase preclude the auto-oxidation step in 4-aminophenol metabolism by Burkholderia sp. strain AK-5
Biodegradation
22
1-11
2011
Burkholderia sp., Burkholderia sp. AK-5
brenda
EXTERNAL LINKS (specific for EC-Number 1.6.5.7)
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Release 2023.1 (January 2023)
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