Any feedback?
No. of entries
Information on EC 1.5.99.B2 - proline dehydrogenase (acceptor)
for references in articles please use BRENDA:EC1.5.99.B2
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
preliminary BRENDA-supplied EC number
EC Tree 1 Oxidoreductases
1.5 Acting on the CH-NH group of donors
1.5.99 With unknown physiological acceptors
1.5.99.B2 proline dehydrogenase (acceptor)
The expected taxonomic range for this enzyme is: Archaea, Eukaryota, Bacteria
Reaction Schemes
showSynonyms
prodh2, pro dehydrogenase, l-prodh, more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
APE_1267.1
L-proDH
L-proline dehydrogenase
L-proline: FAD oxidoreductase
L-proline:FAD oxidoreductase
LPDH
PDH
PF1798
-
alphabetagammadelta-type beta subunit of L-proline dehydrogenase
PH1364
PH1751
POX
PRODH
ProDH2
proline dehydrogenase
proline oxidase
prub
PutA
TK0117
TK0122
TPpdhB
TPpdhB2
PH1751
-
alphabetagammadelta-type beta subunit of L-proline dehydrogenase
PH1751
-
alphabetagammadelta-type beta subunit of L-proline dehydrogenase
-
proline dehydrogenase
has also a 1-pyrroline-5-carboxylate dehydrogenase (EC 1.5.1.12) activity
TK0117
-
alpha4beta4-type beta subunit of L-proline dehydrogenase
-
TK0122
-
alphabetagammadelta-type beta subunit of L-proline dehydrogenase
TK0122
-
alphabetagammadelta-type beta subunit of L-proline dehydrogenase
-
TPpdhB
alphabetagammadelta-type beta subunit of L-proline dehydrogenase
TPpdhB
alphabetagammadelta-type beta subunit of L-proline dehydrogenase
-
TPpdhB2
alpha4beta4-type beta subunit of L-proline dehydrogenase
TPpdhB2
alpha4beta4-type beta subunit of L-proline dehydrogenase
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol
also active as 1-pyrroline-5-carboxylate dehydrogenase
-
L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol
-
-
-
-
L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor
-
-
-
-
L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor
ping-pong mechanism, the transfer of hydride from L-proline to FAD is rate-limiting for the reductive half-reaction, but the overall reaction is limited by reduced flavin reoxidation in the second half-reaction. Solvent and multiple kinetic isotope effects suggest that L-proline oxidation occurs in a stepwise rather than concerted mechanism
L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor
ping-pong mechanism, the transfer of hydride from L-proline to FAD is rate-limiting for the reductive half-reaction, but the overall reaction is limited by reduced flavin reoxidation in the second half-reaction. Solvent and multiple kinetic isotope effects suggest that L-proline oxidation occurs in a stepwise rather than concerted mechanism
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PATHWAY SOURCE
PATHWAYS
BRENDA
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
L-proline:acceptor oxidoreductase
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3,4-dehydro-L-proline + acceptor + H2O
? + reduced acceptor
Substrates: efficient substrate
Products: -
Products: -
?
4-methylene-L-proline + acceptor + H2O
DELTA1-pyrroline-3-methylene-5-carboxylic acid + reduced acceptor
-
Substrates: -
Products: -
Products: -
?
L-hydroxyproline + 2,6-dichlorophenolindophenol + H2O
? + reduced 2,6-dichlorophenolindophenol
L-hydroxyproline + 2,6-dichlorophenolindophenol + H2O
DELTA1-pyrroline-5-carboxylate + reduced 2,6-dichlorophenolindophenol
-
Substrates: 100% activity compared to L-proline
Products: -
Products: -
?
L-hydroxyproline + oxidized 2,6-dichlorophenolindophenol + H2O
?
-
Substrates: reaction rate is 39% of that with L-proline
Products: -
Products: -
?
L-leucine + 2,6-dichlorophenolindophenol + H2O
? + reduced 2,6-dichlorophenolindophenol
-
Substrates: 42% activity compared to L-proline
Products: -
Products: -
?
L-pipecolic acid + acceptor + H2O
? + reduced acceptor
-
Substrates: -
Products: -
Products: -
?
L-proline + 2,6-dichlorophenolindophenol
(S)-1-pyrroline-5-carboxylate + reduced 2,6-dichlorophenolindophenol
L-proline + 2,6-dichlorophenolindophenol + H2O
(S)-1-pyrroline-5-carboxylate + reduced 2,6-dichlorophenolindophenol
L-proline + 2,6-dichlorophenolindophenol + H2O
DELTA1-pyrroline-5-carboxylate + reduced 2,6-dichlorophenolindophenol
L-proline + 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyltetrazolium
DELTA1-pyrroline-5-carboxylate + reduced 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyltetrazolium
-
Substrates: -
Products: -
Products: -
?
L-proline + 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyltetrazolium + H2O
DELTA1-pyrroline-5-carboxylate + reduced 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyltetrazolium
L-proline + 4-iodonitrotetrazolium violet + H2O
DELTA1-pyrroline-5-carboxylate + reduced 4-iodonitrotetrazolium violet
L-proline + coenzyme Q1 + H2O
DELTA1-pyrroline-5-carboxylate + reduced coenzyme Q1
Substrates: -
Products: -
Products: -
?
L-proline + H2O
(S)-1-pyrroline-5-carboxylate + H2O2
Substrates: -
Products: -
Products: -
?
L-proline + menadione
(S)-1-pyrroline-5-carboxylate + menadiol
-
Substrates: -
Products: -
Products: -
r
L-proline + oxidized 2,6-dichlorophenolindophenol + H2O
(S)-1-pyrroline-5-carboxylate + reduced 2,6-dichlorophenolindophenol
-
Substrates: the enzyme does not utilize ferricyanide or 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide as the electron acceptor, activity with phenazine methosulfate-p-iodonitrotetrazolium violet is 10% of that with 2,6-dichlorophenolindophenol
Products: -
Products: -
?
L-proline + oxidized dichlorophenolindophenol
1-pyrroline-5-carboxylate + reduced dichlorophenolindophenol
L-proline + oxidized ferrocenecarboxylic acid
1-pyrroline-5-carboxylate + reduced ferrocenecarboxylic acid
L-proline + oxidized phenazine methosulfate
(S)-1-pyrroline-5-carboxylate + reduced phenazine methosulfate
-
Substrates: -
Products: -
Products: -
?
L-proline + p-iodonitrotetrazolium + H2O
(S)-1-pyrroline-5-carboxylate + reduced p-iodonitrotetrazolium
Substrates: -
Products: -
Products: -
?
L-serine + 2,6-dichlorophenolindophenol + H2O
? + reduced 2,6-dichlorophenolindophenol
-
Substrates: 55% activity compared to L-proline
Products: -
Products: -
?
L-threonine + 2,6-dichlorophenolindophenol + H2O
? + reduced 2,6-dichlorophenolindophenol
-
Substrates: 66% activity compared to L-proline
Products: -
Products: -
?
L-valine + 2,6-dichlorophenolindophenol + H2O
? + reduced 2,6-dichlorophenolindophenol
-
Substrates: 33% activity compared to L-proline
Products: -
Products: -
?
sarcosine + acceptor + H2O
? + reduced acceptor
-
Substrates: -
Products: -
Products: -
?
glycine + 2,6-dichlorophenolindophenol + H2O
? + reduced 2,6-dichlorophenolindophenol
-
Substrates: 52% activity compared to L-proline
Products: -
Products: -
?
glycine + 2,6-dichlorophenolindophenol + H2O
? + reduced 2,6-dichlorophenolindophenol
-
Substrates: 52% activity compared to L-proline
Products: -
Products: -
?
L-alanine + 2,6-dichlorophenolindophenol + H2O
? + reduced 2,6-dichlorophenolindophenol
-
Substrates: 48% activity compared to L-proline
Products: -
Products: -
?
L-alanine + 2,6-dichlorophenolindophenol + H2O
? + reduced 2,6-dichlorophenolindophenol
-
Substrates: 48% activity compared to L-proline
Products: -
Products: -
?
L-alanine + 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyltetrazolium + H2O
?
-
Substrates: weak activity
Products: -
Products: -
?
L-alanine + 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyltetrazolium + H2O
?
-
Substrates: weak activity
Products: -
Products: -
?
L-arginine + 2,6-dichlorophenolindophenol + H2O
? + reduced 2,6-dichlorophenolindophenol
-
Substrates: 62% activity compared to L-proline
Products: -
Products: -
?
L-arginine + 2,6-dichlorophenolindophenol + H2O
? + reduced 2,6-dichlorophenolindophenol
-
Substrates: 62% activity compared to L-proline
Products: -
Products: -
?
L-histidine + 2,6-dichlorophenolindophenol + H2O
? + reduced 2,6-dichlorophenolindophenol
-
Substrates: 72% activity compared to L-proline
Products: -
Products: -
?
L-histidine + 2,6-dichlorophenolindophenol + H2O
? + reduced 2,6-dichlorophenolindophenol
-
Substrates: 72% activity compared to L-proline
Products: -
Products: -
?
L-hydroxyproline + 2,6-dichlorophenolindophenol + H2O
? + reduced 2,6-dichlorophenolindophenol
-
Substrates: 72% activity compared to L-proline
Products: -
Products: -
?
L-hydroxyproline + 2,6-dichlorophenolindophenol + H2O
? + reduced 2,6-dichlorophenolindophenol
-
Substrates: 72% activity compared to L-proline
Products: -
Products: -
?
L-proline + 2,6-dichlorophenolindophenol
(S)-1-pyrroline-5-carboxylate + reduced 2,6-dichlorophenolindophenol
Substrates: artificial electron acceptor
Products: -
Products: -
?
L-proline + 2,6-dichlorophenolindophenol
(S)-1-pyrroline-5-carboxylate + reduced 2,6-dichlorophenolindophenol
Substrates: artificial electron acceptor
Products: -
Products: -
?
L-proline + 2,6-dichlorophenolindophenol
(S)-1-pyrroline-5-carboxylate + reduced 2,6-dichlorophenolindophenol
Substrates: artificial electron acceptor
Products: -
Products: -
?
L-proline + 2,6-dichlorophenolindophenol + H2O
(S)-1-pyrroline-5-carboxylate + reduced 2,6-dichlorophenolindophenol
-
Substrates: -
Products: -
Products: -
?
L-proline + 2,6-dichlorophenolindophenol + H2O
(S)-1-pyrroline-5-carboxylate + reduced 2,6-dichlorophenolindophenol
-
Substrates: -
Products: -
Products: -
?
L-proline + 2,6-dichlorophenolindophenol + H2O
(S)-1-pyrroline-5-carboxylate + reduced 2,6-dichlorophenolindophenol
Substrates: -
Products: -
Products: -
?
L-proline + 2,6-dichlorophenolindophenol + H2O
DELTA1-pyrroline-5-carboxylate + reduced 2,6-dichlorophenolindophenol
-
Substrates: -
Products: -
Products: -
?
L-proline + 2,6-dichlorophenolindophenol + H2O
DELTA1-pyrroline-5-carboxylate + reduced 2,6-dichlorophenolindophenol
-
Substrates: -
Products: -
Products: -
?
L-proline + 2,6-dichlorophenolindophenol + H2O
DELTA1-pyrroline-5-carboxylate + reduced 2,6-dichlorophenolindophenol
-
Substrates: 100% activity
Products: -
Products: -
?
L-proline + 2,6-dichlorophenolindophenol + H2O
DELTA1-pyrroline-5-carboxylate + reduced 2,6-dichlorophenolindophenol
-
Substrates: L-proline is the most preferred substrate and 2,6-dichlorophenolindophenol is the most preferred electron acceptor
Products: -
Products: -
?
L-proline + 2,6-dichlorophenolindophenol + H2O
DELTA1-pyrroline-5-carboxylate + reduced 2,6-dichlorophenolindophenol
-
Substrates: L-proline is the most preferred substrate and 2,6-dichlorophenolindophenol is the most preferred electron acceptor
Products: -
Products: -
?
L-proline + 2,6-dichlorophenolindophenol + H2O
DELTA1-pyrroline-5-carboxylate + reduced 2,6-dichlorophenolindophenol
-
Substrates: the alphabetagammadelta-type beta subunit of L-proline dehydrogenase prefers 2, 6-dichloroindophenol as electron acceptor
Products: -
Products: -
?
L-proline + 2,6-dichlorophenolindophenol + H2O
DELTA1-pyrroline-5-carboxylate + reduced 2,6-dichlorophenolindophenol
-
Substrates: the alphabetagammadelta-type beta subunit of L-proline dehydrogenase prefers 2, 6-dichloroindophenol as electron acceptor
Products: -
Products: -
?
L-proline + 2,6-dichlorophenolindophenol + H2O
DELTA1-pyrroline-5-carboxylate + reduced 2,6-dichlorophenolindophenol
-
Substrates: the alphabetagammadelta-type beta subunit of L-proline dehydrogenase prefers 2, 6-dichloroindophenol as electron acceptor
Products: -
Products: -
?
L-proline + 2,6-dichlorophenolindophenol + H2O
DELTA1-pyrroline-5-carboxylate + reduced 2,6-dichlorophenolindophenol
-
Substrates: the alphabetagammadelta-type beta subunit of L-proline dehydrogenase prefers 2, 6-dichloroindophenol as electron acceptor
Products: -
Products: -
?
L-proline + 2,6-dichlorophenolindophenol + H2O
DELTA1-pyrroline-5-carboxylate + reduced 2,6-dichlorophenolindophenol
-
Substrates: the alphabetagammadelta-type beta subunit of L-proline dehydrogenase prefers 2, 6-dichloroindophenol as electron acceptor
Products: -
Products: -
?
L-proline + 2,6-dichlorophenolindophenol + H2O
DELTA1-pyrroline-5-carboxylate + reduced 2,6-dichlorophenolindophenol
Substrates: the alphabetagammadelta-type beta subunit of L-proline dehydrogenase prefers 2, 6-dichloroindophenol as electron acceptor
Products: -
Products: -
?
L-proline + 2,6-dichlorophenolindophenol + H2O
DELTA1-pyrroline-5-carboxylate + reduced 2,6-dichlorophenolindophenol
Substrates: the alphabetagammadelta-type beta subunit of L-proline dehydrogenase prefers 2, 6-dichloroindophenol as electron acceptor
Products: -
Products: -
?
L-proline + 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyltetrazolium + H2O
DELTA1-pyrroline-5-carboxylate + reduced 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyltetrazolium
-
Substrates: -
Products: -
Products: -
?
L-proline + 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyltetrazolium + H2O
DELTA1-pyrroline-5-carboxylate + reduced 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyltetrazolium
-
Substrates: -
Products: -
Products: -
?
L-proline + 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyltetrazolium + H2O
DELTA1-pyrroline-5-carboxylate + reduced 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyltetrazolium
-
Substrates: -
Products: -
Products: -
?
L-proline + 4-iodonitrotetrazolium violet + H2O
DELTA1-pyrroline-5-carboxylate + reduced 4-iodonitrotetrazolium violet
-
Substrates: 9% activity compared to 2,6-dichlorophenolindophenol
Products: -
Products: -
?
L-proline + 4-iodonitrotetrazolium violet + H2O
DELTA1-pyrroline-5-carboxylate + reduced 4-iodonitrotetrazolium violet
-
Substrates: 9% activity compared to 2,6-dichlorophenolindophenol
Products: -
Products: -
?
L-proline + 4-iodonitrotetrazolium violet + H2O
DELTA1-pyrroline-5-carboxylate + reduced 4-iodonitrotetrazolium violet
-
Substrates: -
Products: -
Products: -
?
L-proline + 4-iodonitrotetrazolium violet + H2O
DELTA1-pyrroline-5-carboxylate + reduced 4-iodonitrotetrazolium violet
-
Substrates: -
Products: -
Products: -
?
L-proline + 4-iodonitrotetrazolium violet + H2O
DELTA1-pyrroline-5-carboxylate + reduced 4-iodonitrotetrazolium violet
-
Substrates: -
Products: -
Products: -
?
L-proline + 4-iodonitrotetrazolium violet + H2O
DELTA1-pyrroline-5-carboxylate + reduced 4-iodonitrotetrazolium violet
-
Substrates: -
Products: -
Products: -
?
L-proline + 4-iodonitrotetrazolium violet + H2O
DELTA1-pyrroline-5-carboxylate + reduced 4-iodonitrotetrazolium violet
-
Substrates: -
Products: -
Products: -
?
L-proline + 4-iodonitrotetrazolium violet + H2O
DELTA1-pyrroline-5-carboxylate + reduced 4-iodonitrotetrazolium violet
Substrates: -
Products: -
Products: -
?
L-proline + 4-iodonitrotetrazolium violet + H2O
DELTA1-pyrroline-5-carboxylate + reduced 4-iodonitrotetrazolium violet
Substrates: -
Products: -
Products: -
?
L-proline + acceptor
(S)-1-pyrroline-5-carboxylate + reduced acceptor
-
Substrates: -
Products: -
Products: -
?
L-proline + acceptor
(S)-1-pyrroline-5-carboxylate + reduced acceptor
Substrates: -
Products: -
Products: -
?
L-proline + acceptor
(S)-1-pyrroline-5-carboxylate + reduced acceptor
Substrates: -
Products: -
Products: -
?
L-proline + acceptor
(S)-1-pyrroline-5-carboxylate + reduced acceptor
Substrates: -
Products: -
Products: -
?
L-proline + acceptor + H2O
(S)-1-pyrroline-5-carboxylate + reduced acceptor
-
Substrates: -
Products: -
Products: -
?
L-proline + acceptor + H2O
(S)-1-pyrroline-5-carboxylate + reduced acceptor
-
Substrates: -
Products: -
Products: -
?
L-proline + acceptor + H2O
(S)-1-pyrroline-5-carboxylate + reduced acceptor
-
Substrates: -
Products: -
Products: -
?
L-proline + acceptor + H2O
(S)-1-pyrroline-5-carboxylate + reduced acceptor
-
Substrates: -
Products: -
Products: -
?
L-proline + acceptor + H2O
(S)-1-pyrroline-5-carboxylate + reduced acceptor
Substrates: -
Products: -
Products: -
ir
L-proline + acceptor + H2O
(S)-1-pyrroline-5-carboxylate + reduced acceptor
-
Substrates: -
Products: -
Products: -
?
L-proline + acceptor + H2O
(S)-1-pyrroline-5-carboxylate + reduced acceptor
-
Substrates: acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate, ferricyanide, menadione, cytochrome c
Products: -
Products: -
?
L-proline + acceptor + H2O
(S)-1-pyrroline-5-carboxylate + reduced acceptor
-
Substrates: -
Products: -
Products: -
?
L-proline + acceptor + H2O
(S)-1-pyrroline-5-carboxylate + reduced acceptor
-
Substrates: acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate, ferricyanide, menadione, cytochrome c
Products: -
Products: -
?
L-proline + acceptor + H2O
(S)-1-pyrroline-5-carboxylate + reduced acceptor
Substrates: -
Products: -
Products: -
?
L-proline + acceptor + H2O
(S)-1-pyrroline-5-carboxylate + reduced acceptor
-
Substrates: -
Products: -
Products: -
?
L-proline + acceptor + H2O
(S)-1-pyrroline-5-carboxylate + reduced acceptor
-
Substrates: -
Products: -
Products: -
?
L-proline + acceptor + H2O
(S)-1-pyrroline-5-carboxylate + reduced acceptor
-
Substrates: acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate, ferricyanide, menadione, cytochrome c
Products: -
Products: -
?
L-proline + acceptor + H2O
(S)-1-pyrroline-5-carboxylate + reduced acceptor
-
Substrates: highly specific for L-form of proline
Products: -
Products: -
?
L-proline + acceptor + H2O
(S)-1-pyrroline-5-carboxylate + reduced acceptor
-
Substrates: preferred substrate
Products: -
Products: -
?
L-proline + acceptor + H2O
(S)-1-pyrroline-5-carboxylate + reduced acceptor
-
Substrates: -
Products: -
Products: -
?
L-proline + acceptor + H2O
(S)-1-pyrroline-5-carboxylate + reduced acceptor
-
Substrates: acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate, ferricyanide, menadione, cytochrome c
Products: -
Products: -
?
L-proline + acceptor + H2O
(S)-1-pyrroline-5-carboxylate + reduced acceptor
-
Substrates: -
Products: -
Products: -
?
L-proline + acceptor + H2O
(S)-1-pyrroline-5-carboxylate + reduced acceptor
-
Substrates: acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate, ferricyanide, menadione, cytochrome c
Products: -
Products: -
?
L-proline + acceptor + H2O
(S)-1-pyrroline-5-carboxylate + reduced acceptor
-
Substrates: -
Products: -
Products: -
?
L-proline + acceptor + H2O
(S)-1-pyrroline-5-carboxylate + reduced acceptor
-
Substrates: acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate, ferricyanide, menadione, cytochrome c
Products: -
Products: -
?
L-proline + cytochrome c + H2O
(S)-1-pyrroline-5-carboxylate + reduced cytochrome c
-
Substrates: -
Products: -
Products: -
?
L-proline + cytochrome c + H2O
(S)-1-pyrroline-5-carboxylate + reduced cytochrome c
Substrates: -
Products: -
Products: -
?
L-proline + FAD
(S)-1-pyrroline-5-carboxylate + FADH2
Substrates: -
Products: -
Products: -
?
L-proline + FAD
(S)-1-pyrroline-5-carboxylate + FADH2
-
Substrates: -
Products: -
Products: -
r
L-proline + ferricyanide
DELTA1-pyrroline-5-carboxylate + ferrocyanide
-
Substrates: 93% activity compared to 2,6-dichlorophenolindophenol
Products: -
Products: -
?
L-proline + ferricyanide
DELTA1-pyrroline-5-carboxylate + ferrocyanide
-
Substrates: 93% activity compared to 2,6-dichlorophenolindophenol
Products: -
Products: -
?
L-proline + ferricyanide
DELTA1-pyrroline-5-carboxylate + ferrocyanide
-
Substrates: the alpha4beta4-type beta subunit of L-proline dehydrogenase utilizes ferricyanide as the most preferable electron acceptor
Products: -
Products: -
?
L-proline + ferricyanide
DELTA1-pyrroline-5-carboxylate + ferrocyanide
-
Substrates: the alpha4beta4-type beta subunit of L-proline dehydrogenase utilizes ferricyanide as the most preferable electron acceptor
Products: -
Products: -
?
L-proline + ferricyanide
DELTA1-pyrroline-5-carboxylate + ferrocyanide
-
Substrates: the alpha4beta4-type beta subunit of L-proline dehydrogenase utilizes ferricyanide as the most preferable electron acceptor
Products: -
Products: -
?
L-proline + ferricyanide
DELTA1-pyrroline-5-carboxylate + ferrocyanide
-
Substrates: the alpha4beta4-type beta subunit of L-proline dehydrogenase utilizes ferricyanide as the most preferable electron acceptor
Products: -
Products: -
?
L-proline + ferricyanide
DELTA1-pyrroline-5-carboxylate + ferrocyanide
-
Substrates: the alpha4beta4-type beta subunit of L-proline dehydrogenase utilizes ferricyanide as the most preferable electron acceptor
Products: -
Products: -
?
L-proline + ferricyanide
DELTA1-pyrroline-5-carboxylate + ferrocyanide
Substrates: the alpha4beta4-type beta subunit of L-proline dehydrogenase utilizes ferricyanide as the most preferable electron acceptor
Products: -
Products: -
?
L-proline + ferricyanide
DELTA1-pyrroline-5-carboxylate + ferrocyanide
Substrates: the alpha4beta4-type beta subunit of L-proline dehydrogenase utilizes ferricyanide as the most preferable electron acceptor
Products: -
Products: -
?
L-proline + oxidized dichlorophenolindophenol
1-pyrroline-5-carboxylate + reduced dichlorophenolindophenol
Substrates: -
Products: -
Products: -
?
L-proline + oxidized dichlorophenolindophenol
1-pyrroline-5-carboxylate + reduced dichlorophenolindophenol
Substrates: -
Products: -
Products: -
?
L-proline + oxidized ferrocenecarboxylic acid
1-pyrroline-5-carboxylate + reduced ferrocenecarboxylic acid
Substrates: -
Products: -
Products: -
?
L-proline + oxidized ferrocenecarboxylic acid
1-pyrroline-5-carboxylate + reduced ferrocenecarboxylic acid
Substrates: -
Products: -
Products: -
?
L-threonine + 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyltetrazolium + H2O
?
-
Substrates: weak activity
Products: -
Products: -
?
L-threonine + 2-(4-iodophenyl)-3-(4-nitrophenyl)-5-phenyltetrazolium + H2O
?
-
Substrates: weak activity
Products: -
Products: -
?
additional information
?
-
-
Substrates: no activity with: D-proline, glycine, L-glutamate, L-aspartate, L-arginine, L-lysine, L-serine, L-leucine, L-alanine, L-threonine, L-methionine,L-tryptophan, L-tyrosine
Products: -
Products: -
?
additional information
?
-
-
Substrates: no activity with D-proline, L-tryptophan, L-glutamate, and L-aspartate
Products: -
Products: -
?
additional information
?
-
-
Substrates: no activity with D-proline, L-tryptophan, L-glutamate, and L-aspartate
Products: -
Products: -
?
additional information
?
-
-
Substrates: D-proline, L-hydroxyproline, L-arginine, L-aspartate, and glycine are inert as substrates
Products: -
Products: -
?
additional information
?
-
-
Substrates: D-proline, L-hydroxyproline, L-arginine, L-aspartate, and glycine are inert as substrates
Products: -
Products: -
?
additional information
?
-
-
Substrates: sarcosine, D-proline, L-ornithine, L-glutamate, L-arginine, L-serine, L-leucine, L-valine, and L-alanine are inert as substrates. NAD+, NADP+, and bovine heart cytochrome c are inert as electron acceptors
Products: -
Products: -
?
additional information
?
-
-
Substrates: sarcosine, D-proline, L-ornithine, L-glutamate, L-arginine, L-serine, L-leucine, L-valine, and L-alanine are inert as substrates. NAD+, NADP+, and bovine heart cytochrome c are inert as electron acceptors
Products: -
Products: -
?
additional information
?
-
-
Substrates: does not reduce NAD+
Products: -
Products: -
?
additional information
?
-
-
Substrates: D-proline, L-hydroxyproline, pyrrolidone-5-carboxylate, sarcosine, and glycine are inert as substrates
Products: -
Products: -
?
additional information
?
-
-
Substrates: isoform PDH1, no substrate: L-hydroxyproline, D-proline, cis-4-hydroxy-D-proline, L-2-pyrrolidone-5-carboxylate, pyrrole-5-carboxylate, pipecolic acid
Products: -
Products: -
?
additional information
?
-
-
Substrates: D-proline, L-hydroxyproline, pyrrolidone-5-carboxylate, sarcosine, and glycine are inert as substrates
Products: -
Products: -
?
additional information
?
-
-
Substrates: D-proline, L-hydroxyproline, pyrrolidone-5-carboxylate, sarcosine, and glycine are inert as substrates
Products: -
Products: -
?
additional information
?
-
-
Substrates: isoform PDH1, no substrate: L-hydroxyproline, D-proline, cis-4-hydroxy-D-proline, L-2-pyrrolidone-5-carboxylate, pyrrole-5-carboxylate, pipecolic acid
Products: -
Products: -
?
additional information
?
-
-
Substrates: D-proline, L-hydroxyproline, pyrrolidone-5-carboxylate, sarcosine, and glycine are inert as substrates
Products: -
Products: -
?
additional information
?
-
-
Substrates: D-proline, L-hydroxyproline, pyrrolidone-5-carboxylate, sarcosine, and glycine are inert as substrates
Products: -
Products: -
?
additional information
?
-
Substrates: D-proline, L-hydroxyproline, pyrrolidone-5-carboxylate, sarcosine, and glycine are inert as substrates
Products: -
Products: -
?
additional information
?
-
Substrates: D-proline, L-hydroxyproline, pyrrolidone-5-carboxylate, sarcosine, and glycine are inert as substrates
Products: -
Products: -
?
additional information
?
-
Substrates: trans-4-hydroxy-L-proline, cis-4-hydroxy-L-proline, L-azetidine-2-carboxylic acid, and L-pipecolinic acid are no substrates of PRODH
Products: -
Products: -
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-proline + acceptor
(S)-1-pyrroline-5-carboxylate + reduced acceptor
-
Substrates: -
Products: -
Products: -
?
L-proline + acceptor
(S)-1-pyrroline-5-carboxylate + reduced acceptor
Substrates: -
Products: -
Products: -
?
L-proline + acceptor
(S)-1-pyrroline-5-carboxylate + reduced acceptor
Substrates: -
Products: -
Products: -
?
L-proline + acceptor
(S)-1-pyrroline-5-carboxylate + reduced acceptor
Substrates: -
Products: -
Products: -
?
L-proline + acceptor + H2O
(S)-1-pyrroline-5-carboxylate + reduced acceptor
-
Substrates: -
Products: -
Products: -
?
L-proline + acceptor + H2O
(S)-1-pyrroline-5-carboxylate + reduced acceptor
-
Substrates: -
Products: -
Products: -
?
L-proline + acceptor + H2O
(S)-1-pyrroline-5-carboxylate + reduced acceptor
-
Substrates: -
Products: -
Products: -
?
L-proline + acceptor + H2O
(S)-1-pyrroline-5-carboxylate + reduced acceptor
-
Substrates: -
Products: -
Products: -
?
L-proline + acceptor + H2O
(S)-1-pyrroline-5-carboxylate + reduced acceptor
-
Substrates: -
Products: -
Products: -
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
FAD
-
isoform PDH1, 1 mol per mol of beta subunit, alpha and beta subunits separatively produced in Escherichia coli cannot bind FAD
FAD
-
flavoprotein amine dehydrogenase, the holoenzyme contains one FAD per alphabeta complex
FAD
the beta subunit of the L-proline dehydrogenase complex is the catalytic component containing FAD as a cofactor
FAD
-
ProDH is a flavoenzyme, that can eventually transfer electrons to O2