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Information on EC 1.4.3.20 - L-lysine 6-oxidase

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IUBMB Comments

Differs from EC 1.4.3.13, protein-lysine 6-oxidase, by using free L-lysine rather than the protein-bound form. N2-Acetyl-L-lysine is also a substrate, but N6-acetyl-L-lysine, which has an acetyl group at position 6, is not a substrate. Also acts on L-ornithine, D-lysine and 4-hydroxy-L-lysine, but more slowly. The amines cadaverine and putrescine are not substrates .

The enzyme appears in viruses and cellular organisms

Synonyms
marinocine, l-lysine epsilon-oxidase, lysine-epsilon-oxidase, lysine-epsilon oxidase, l-lysine-epsilon-oxidase, marinocine antimicrobial protein, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-lysine + O2 + H2O = (S)-2-amino-6-oxohexanoate + H2O2 + NH3
show the reaction diagram
Differs from EC 1.4.3.13, protein-lysine 6-oxidase, by using free L-lysine rather than the protein-bound form. 2-N-Acetyl-L-lysine is also a substrate, but 6-N-acetyl-L-lysine, which has an acetyl group at position 6, is not a substrate. Also acts on L-ornithine, D-lysine and 4-hydroxy-L-lysine, but more slowly. The amines cadaverine and putrescine are not substrates
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