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Information on EC 1.4.1.28 - secondary-alkyl amine dehydrogenase [NAD(P)+]
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EC Tree
1.4.1.28 secondary-alkyl amine dehydrogenase [NAD(P)+]IUBMB Comments
The enzyme has been shown to react preferentially with short-chain ketones such as cyclohexanone, primary amine groups attached to secondary alkyl groups, or D- and L-amino acids. It also reduces aldehydes to primary amines. Cosubstrate preference depends on the substrate.
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The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
AMDH, AmDH4, amine dehydrogenase, D187_009359, DapB_1, NAD+-dependent amine dehydrogenase, Pmob_1166, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
AMDH
AmDH4
amine dehydrogenase
D187_009359
NAD+-dependent amine dehydrogenase
Pmob_1166
AMDH
-
-
ambiguous
-
amine dehydrogenase
-
-
ambiguous
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
a secondary-alkyl amine + H2O + NAD(P)+ = a ketone + NH3 + NAD(P)H + H+
-
-
-
-
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SYSTEMATIC NAME
IUBMB Comments
secondary-alkyl amine:NAD(P)+ oxidoreductase (deaminating)
The enzyme has been shown to react preferentially with short-chain ketones such as cyclohexanone, primary amine groups attached to secondary alkyl groups, or D- and L-amino acids. It also reduces aldehydes to primary amines. Cosubstrate preference depends on the substrate.
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(R)-1-phenethylamine + H2O + NAD+
acetophenone + NH3 + NADH + H+
-
-
-
-
r
(R,S)-2-amino-1-pentanol + NAD+ + H2O
2-oxo-pentan-1-ol + NH3 + NADH + H+
-
-
-
-
r
(R,S)-2-aminopentan-1-ol + H2O + NAD+
2-oxopentan-1-ol + NH3 + NADH + H+
-
-
-
-
r
(S)-1-phenethylamine + H2O + NAD+
acetophenone + NH3 + NADH + H+
-
-
-
-
r
(S)-1-phenethylamine + NAD+ + H2O
phenylacetaldehyde + NH3 + NADH + H+
-
-
-
-
r
(S)-2-amino-1-butanol + NAD+ + H2O
2-oxo-butan-1-ol + NH3 + NADH + H+
-
-
-
-
r
(S)-2-amino-3-methyl-1-butanol + NAD+ + H2O
2-oxo-3-methylbutan-1-ol + NH3 + NADH + H+
-
-
-
-
r
(S)-2-amino-3-methylbutan-1-ol + H2O + NAD+
3-methyl-2-oxobutan-1-ol + NH3 + NADH + H+
-
-
-
-
r
(S)-2-aminobutan-1-ol + H2O + NAD+
2-oxobutan-1-ol + NH3 + NADH + H+
-
-
-
-
r
(S)-2-aminoheptane + NAD+ + H2O
2-oxoheptane + NH3 + NADH + H+
-
-
-
-
r
(S)-isoleucinol + NAD+ + H2O
2-oxo-3-methylpentan-1-ol + NH3 + NADH + H+
-
-
-
-
r
(S)-leucinol + NAD+ + H2O
2-oxo-5-methylpentan-1-ol + NH3 + NADH + H+
-
-
-
-
r
(S)-methioninol + NAD+ + H2O
2-oxo-3-methylpentan-1-ol + NH3 + NADH + H+
-
-
-
-
r
1-hydroxy-4-methylpentan-2-one + NH3 + NADH + H+
2-amino-4-methylpentan-1-ol + H2O + NAD+
-
-
-
?
1-hydroxyhexan-2-one + NH3 + NADH + H+
(S)-2-aminohexan-1-ol + H2O + NAD+
-
-
-
?
2-amino-1-propanol + H2O + NAD+
1-hydroxyacetone + NH3 + NADH + H+
-
-
-
-
r
2-aminocyclohexanol + NAD+ + H2O
2-oxo-cyclohexanol + NH3 + NADH + H+
-
-
-
-
r
3-acetyl-1-propanol + NH3 + NADH + H+
3-aminobutan-1-ol + H2O + NAD+
-
-
-
-
r
3-buten-2-one + NH3 + NADH + H+
3-buten-2-amine + H2O + NAD+
-
-
-
?
3-hydroxy-2-butanone + NH3 + NADH + H+
3-amino-butan-2-ol + NAD+ + H2O
-
-
-
-
r
3-hydroxy-2-butanone + NH3 + NADH + H+
3-aminobutan-2-ol + H2O + NAD+
-
-
-
-
r
3-methylbutanal + NH3 + NADH + H+
3-methylbutan-1-amine + H2O + NAD+
-
214% of the activity with cyclohexanone
-
-
?
4-hydroxy-2-butanone + NH3 + NADH + H+
3-amino-butan-1-ol + NAD+ + H2O
-
-
-
-
r
4-hydroxy-2-butanone + NH3 + NADH + H+
3-aminobutan-1-ol + H2O + NAD+
-
-
-
-
r
4-hydroxyhexan-3-one + NH3 + NADH + H+
4-aminohexanan-3-ol + NAD+ + H2O
-
-
-
-
r
4-phenylbutan-2-one + NH3 + NADH + H+
4-phenylbutan-2-amine + NAD+ + H2O
-
-
-
-
r
5-hydroxyoctan-4-one + NH3 + NADH + H+
5-aminooctan-4-ol + NAD+ + H2O
-
-
-
-
r
5-hydroxypentan-2-one + NH3 + NADH + H+
5-aminopentan-1-ol + H2O + NAD+
-
-
-
-
r
acetophenone + NH3 + NADH + H+
(S)-alpha-methylbenzylamine + H2O + NAD+
-
-
-
-
?
acetophenone + NH3 + NADH + H+
1-phenylethan-1-amine + NAD+ + H2O
-
-
-
-
r
benzaldehyde + NH3 + NAD(P)H + H+
benzylamine + H2O + NAD(P)+
-
-
-
-
?
butan-2-one + NH3 + NADH + H+
2-butylamine + H2O + NAD+
-
5.5% of the activity with cyclohexanone
-
-
?
cyclohexanone + NH3 + NAD(P)H + H+
cyclohexylamine + H2O + NAD(P)+
-
-
-
-
?
cyclohexanone + NH3 + NADH + H+
cyclohexylamine + H2O + NAD+
-
-
-
-
?
D-aspartate + H2O + NAD+
2-oxobutanedioate + NH3 + NADH + H+
-
-
-
-
r
D-glutamate + H2O + NAD+
2-oxopentanedioate + NH3 + NADH + H+
-
-
-
-
r
D-glutamate + NAD+ + H2O
2-oxopentanedioic acid + NH3 + NADH + H+
-
-
-
-
r
D-serine + NAD+ + H2O
3-hydroxy-2-oxopropanoate + NH3 + NADH + H+
-
-
-
-
r
hydroxyacetone + NH3 + NADH + H+
1-aminopropanone + H2O + NAD+
-
-
-
-
r
hydroxyacetone + NH3 + NADH + H+
2-aminopropan-1-ol + NAD+ + H2O
-
-
-
-
r
isovaleraldehyde + NH3 + NAD(P)H + H+
3-methylbutan-1-amine + H2O + NAD(P)+
-
-
-
-
?
L-aspartate + H2O + NAD+
2-oxobutanedioate + NH3 + NADH + H+
-
-
-
-
r
L-aspartate + NAD+ + H2O
2-oxobutanedioic acid + NH3 + NADH + H+
-
-
-
-
r
L-glutamate + H2O + NAD+
2-oxopentanedioate + NH3 + NADH + H+
-
-
-
-
r
L-glutamate + NAD+ + H2O
2-oxopentanedioic acid + NH3 + NADH + H+
-
-
-
-
r
L-serine + NAD+ + H2O
2-oxopentanedioic acid + NH3 + NADH + H+
-
-
-
-
r
propionaldehyde + NH3 + NADH + H+
n-propylamine + NAD+ + H2O
-
-
-
-
r
(2R)-2-amino-4-oxopentanoate + NH3 + NADH + H+
(2R,4S)-2,4-diaminopentanoate + NAD+ + H2O
-
-
-
?
(2R)-2-amino-4-oxopentanoate + NH3 + NADH + H+
(2R,4S)-2,4-diaminopentanoate + NAD+ + H2O
-
-
-
?
(R)-1-phenethylamine + NAD+ + H2O
phenylacetaldehyde + NH3 + NADH + H+
-
-
-
-
r
(R)-1-phenethylamine + NAD+ + H2O
phenylacetaldehyde + NH3 + NADH + H+
Streptomyces virginiae IFO 12827
-
-
-
-
r
(R)-2-aminoheptane + NAD+ + H2O
2-oxoheptane + NH3 + NADH + H+
-
-
-
-
r
(R)-2-aminoheptane + NAD+ + H2O
2-oxoheptane + NH3 + NADH + H+
Streptomyces virginiae IFO 12827
-
-
-
-
r
(R)-2-butylamine + NAD+ + H2O
2-oxobutane + NH3 + NADH + H+
Streptomyces virginiae IFO 12827
-
-
-
-
r
1-cyclohexylethan-1-one + NH3 + NADH + H+
1-cyclohexylethyl-1-amine + NAD+ + H2O
-
-
-
?
1-cyclohexylethan-1-one + NH3 + NADH + H+
1-cyclohexylethyl-1-amine + NAD+ + H2O
-
-
-
?
1-cyclohexylethan-1-one + NH3 + NADH + H+
1-cyclohexylethyl-1-amine + NAD+ + H2O
-
-
-
?
1-cyclohexylethan-1-one + NH3 + NADH + H+
1-cyclohexylethyl-1-amine + NAD+ + H2O
-
-
-
?
1-hydroxybutan-2-one + NH3 + NAD(P)H + H+
(S)-2-aminobutan-1-ol + H2O + NAD(P)+
-
-
-
?
1-hydroxybutan-2-one + NH3 + NAD(P)H + H+
(S)-2-aminobutan-1-ol + H2O + NAD(P)+
-
-
-
?
1-hydroxybutan-2-one + NH3 + NAD(P)H + H+
(S)-2-aminobutan-1-ol + H2O + NAD(P)+
-
-
-
?
1-hydroxybutan-2-one + NH3 + NAD(P)H + H+
(S)-2-aminobutan-1-ol + H2O + NAD(P)+
-
-
-
?
1-hydroxybutan-2-one + NH3 + NAD(P)H + H+
(S)-2-aminobutan-1-ol + H2O + NAD(P)+
-
-
-
?
1-indanone + NH3 + NADH + H+
1-indanamine + NAD+ + H2O
-
-
-
?
1-indanone + NH3 + NADH + H+
1-indanamine + NAD+ + H2O
-
-
-
?
2-cyclohexen-1-one + NH3 + NADH + H+
2-cyclohexen-1-amine + H2O + NAD+
-
-
-
?
2-cyclohexen-1-one + NH3 + NADH + H+
2-cyclohexen-1-amine + H2O + NAD+
-
-
-
?
2-cyclohexen-1-one + NH3 + NADH + H+
2-cyclohexen-1-amine + H2O + NAD+
-
-
-
?
2-cyclohexen-1-one + NH3 + NADH + H+
2-cyclohexen-1-amine + H2O + NAD+
-
-
-
?
2-cyclohexen-1-one + NH3 + NADH + H+
2-cyclohexen-1-amine + NAD+ + H2O
-
-
-
?
2-cyclohexen-1-one + NH3 + NADH + H+
2-cyclohexen-1-amine + NAD+ + H2O
-
-
-
?
2-cyclohexen-1-one + NH3 + NADH + H+
2-cyclohexen-1-amine + NAD+ + H2O
-
-
-
?
2-cyclohexen-1-one + NH3 + NADH + H+
2-cyclohexen-1-amine + NAD+ + H2O
-
-
-
?
2-methylbutanal + NH3 + NADH + H+
2-methylbutan-1-amine + NAD+ + H2O
-
-
-
?
2-methylbutanal + NH3 + NADH + H+
2-methylbutan-1-amine + NAD+ + H2O
-
-
-
?
2-methylbutanal + NH3 + NADH + H+
2-methylbutan-1-amine + NAD+ + H2O
-
-
-
?
2-methylbutanal + NH3 + NADH + H+
2-methylbutan-1-amine + NAD+ + H2O
-
-
-
?
2-methylcyclohexanone + NH3 + NADH + H+
2-methylcyclohexylamine + H2O + NAD+
-
-
-
?
2-methylcyclohexanone + NH3 + NADH + H+
2-methylcyclohexylamine + H2O + NAD+
-
-
-
?
2-methylcyclohexanone + NH3 + NADH + H+
2-methylcyclohexylamine + H2O + NAD+
-
-
-
?
2-methylcyclohexanone + NH3 + NADH + H+
2-methylcyclohexylamine + H2O + NAD+
-
-
-
?
2-methylcyclohexanone + NH3 + NADH + H+
2-methylcyclohexylamine + NAD+ + H2O
-
-
-
?
2-methylcyclohexanone + NH3 + NADH + H+
2-methylcyclohexylamine + NAD+ + H2O
-
-
-
?
2-methylcyclohexanone + NH3 + NADH + H+
2-methylcyclohexylamine + NAD+ + H2O
-
-
-
?
2-methylcyclopentanone + NH3 + NADH + H+
2-methylcyclopentylamine + NAD+ + H2O
-
-
-
?
2-methylcyclopentanone + NH3 + NADH + H+
2-methylcyclopentylamine + NAD+ + H2O
-
-
-
?
2-methylcyclopentanone + NH3 + NADH + H+
2-methylcyclopentylamine + NAD+ + H2O
-
-
-
?
3,5-dimethylcyclohexanone + NH3 + NADH + H+
3,5-dimethylcyclohexylamine + NAD+ + H2O
-
-
-
?
3,5-dimethylcyclohexanone + NH3 + NADH + H+
3,5-dimethylcyclohexylamine + NAD+ + H2O
-
-
-
?
3,5-dimethylcyclohexanone + NH3 + NADH + H+
3,5-dimethylcyclohexylamine + NAD+ + H2O
-
-
-
?
3-hydroxybutan-2-one + NH3 + NADH + H+
3-aminobutan-2-ol + NAD+ + H2O
-
-
-
?
3-hydroxybutan-2-one + NH3 + NADH + H+
3-aminobutan-2-ol + NAD+ + H2O
-
-
-
?
3-hydroxybutan-2-one + NH3 + NADH + H+
3-aminobutan-2-ol + NAD+ + H2O
-
-
-
?
3-methylbutan-2-one + NH3 + NADH + H+
3-methylbutan-2-amine + H2O + NAD+
-
-
-
?
3-methylbutan-2-one + NH3 + NADH + H+
3-methylbutan-2-amine + H2O + NAD+
-
-
-
?
3-methylbutan-2-one + NH3 + NADH + H+
3-methylbutan-2-amine + H2O + NAD+
-
-
-
?
3-methylbutan-2-one + NH3 + NADH + H+
3-methylbutan-2-amine + H2O + NAD+
-
-
-
?
3-methylbutan-2-one + NH3 + NADH + H+
3-methylbutan-2-amine + NAD+ + H2O
-
-
-
?
3-methylbutan-2-one + NH3 + NADH + H+
3-methylbutan-2-amine + NAD+ + H2O
-
-
-
?
3-methylbutan-2-one + NH3 + NADH + H+
3-methylbutan-2-amine + NAD+ + H2O
-
-
-
?
3-methylcyclohexanone + NH3 + NADH + H+
3-methylcyclohexylamine + H2O + NAD+
-
-
-
?
3-methylcyclohexanone + NH3 + NADH + H+
3-methylcyclohexylamine + H2O + NAD+
-
-
-
?
3-methylcyclohexanone + NH3 + NADH + H+
3-methylcyclohexylamine + H2O + NAD+
-
-
-
?
3-methylcyclohexanone + NH3 + NADH + H+
3-methylcyclohexylamine + NAD+ + H2O
-
-
-
?
3-methylcyclohexanone + NH3 + NADH + H+
3-methylcyclohexylamine + NAD+ + H2O
-
-
-
?
3-methylcyclohexanone + NH3 + NADH + H+
3-methylcyclohexylamine + NAD+ + H2O
-
-
-
?
3-methylcyclopentanone + NH3 + NADH + H+
3-methylcyclopentylamine + NAD+ + H2O
-
-
-
?
3-methylcyclopentanone + NH3 + NADH + H+
3-methylcyclopentylamine + NAD+ + H2O
-
-
-
?
3-methylcyclopentanone + NH3 + NADH + H+
3-methylcyclopentylamine + NAD+ + H2O
-
-
-
?
4-hydroxybutan-2-one + NH3 + NADH + H+
3-aminobutan-1-ol + NAD+ + H2O
-
-
-
?
4-hydroxybutan-2-one + NH3 + NADH + H+
3-aminobutan-1-ol + NAD+ + H2O
-
-
-
?
4-hydroxybutan-2-one + NH3 + NADH + H+
3-aminobutan-1-ol + NAD+ + H2O
-
-
-
?
4-methylcyclohexanone + NH3 + NADH + H+
4-methylcyclohexylamine + H2O + NAD+
-
-
-
?
4-methylcyclohexanone + NH3 + NADH + H+
4-methylcyclohexylamine + H2O + NAD+
-
-
-
?
4-methylcyclohexanone + NH3 + NADH + H+
4-methylcyclohexylamine + H2O + NAD+
-
-
-
?
4-methylcyclohexanone + NH3 + NADH + H+
4-methylcyclohexylamine + NAD+ + H2O
-
-
-
?
4-methylcyclohexanone + NH3 + NADH + H+
4-methylcyclohexylamine + NAD+ + H2O
-
-
-
?
4-methylcyclohexanone + NH3 + NADH + H+
4-methylcyclohexylamine + NAD+ + H2O
-
-
-
?
4-oxopentanoate + NH3 + NADH + H+
(4S)-4-aminopentanoate + NAD+ + H2O
-
-
-
-
?
4-oxopentanoate + NH3 + NADH + H+
(4S)-4-aminopentanoate + NAD+ + H2O
-
-
-
-
?
4-oxopentanoate + NH3 + NADPH + H+
(4S)-4-aminopentanoate + H2O + NADP+
-
-
-
-
?
4-oxopentanoate + NH3 + NADPH + H+
(4S)-4-aminopentanoate + H2O + NADP+
-
-
-
-
?
5-oxohexanoate + NH3 + NADH + H+
(5S)-5-aminohexanoate + H2O + NAD+
-
-
-
-
?
5-oxohexanoate + NH3 + NADH + H+
(5S)-5-aminohexanoate + H2O + NAD+
-
-
-
-
?
5-oxohexanoate + NH3 + NADH + H+
(5S)-5-aminohexanoate + NAD+ + H2O
-
-
-
-
?
5-oxohexanoate + NH3 + NADH + H+
(5S)-5-aminohexanoate + NAD+ + H2O
-
-
-
-
?
benzaldehyde + NH3 + NADH + H+
benzylamine + H2O + NAD+
-
10.4% of the activity with cyclohexanone
-
-
?
benzaldehyde + NH3 + NADH + H+
benzylamine + NAD+ + H2O
-
-
-
?
benzaldehyde + NH3 + NADH + H+
benzylamine + NAD+ + H2O
-
-
-
?
but-3-en-2-one + NH3 + NADH + H+
but-3-en-2-amine + NAD+ + H2O
-
-
-
?
but-3-en-2-one + NH3 + NADH + H+
but-3-en-2-amine + NAD+ + H2O
-
-
-
?
but-3-en-2-one + NH3 + NADH + H+
but-3-en-2-amine + NAD+ + H2O
-
-
-
?
cyclohexanone + methylamine + NADH + H+
N-methylcyclohexylamine + NAD+ + H2O
-
-
-
?
cyclohexanone + methylamine + NADH + H+
N-methylcyclohexylamine + NAD+ + H2O
-
-
-
?
cyclohexanone + methylamine + NADH + H+
N-methylcyclohexylamine + NAD+ + H2O
-
-
-
?
cyclohexanone + methylamine + NADPH + H+
N-methylcyclohexanamine + H2O + NADP+
-
-
-
?
cyclohexanone + methylamine + NADPH + H+
N-methylcyclohexanamine + H2O + NADP+
-
-
-
?
cyclohexanone + methylamine + NADPH + H+
N-methylcyclohexanamine + H2O + NADP+
-
-
-
?
cyclohexanone + NH3 + NADH + H+
cyclohexylamine + NAD+ + H2O
-
-
-
?
cyclohexanone + NH3 + NADH + H+
cyclohexylamine + NAD+ + H2O
-
-
-
?
cyclohexanone + NH3 + NADH + H+
cyclohexylamine + NAD+ + H2O
-
-
-
?
cyclopentanone + NH3 + NADH + H+
cyclopentylamine + H2O + NAD+
-
-
-
?
cyclopentanone + NH3 + NADH + H+
cyclopentylamine + H2O + NAD+
-
-
-
?
cyclopentanone + NH3 + NADH + H+
cyclopentylamine + H2O + NAD+
-
3.4% of the activity with cyclohexanone
-
-
?
cyclopentanone + NH3 + NADH + H+
cyclopentylamine + H2O + NAD+
-
-
-
?
cyclopentanone + NH3 + NADH + H+
cyclopentylamine + H2O + NAD+
-
-
-
?
cyclopentanone + NH3 + NADPH + H+
cyclopentylamine + NADP+ + H2O
-
-
-
?
cyclopentanone + NH3 + NADPH + H+
cyclopentylamine + NADP+ + H2O
-
-
-
?
cyclopentanone + NH3 + NADPH + H+
cyclopentylamine + NADP+ + H2O
-
-
-
?
hexan-3-one + NH3 + NADH + H+
hexan-3-amine + NAD+ + H2O
-
-
-
?
hexan-3-one + NH3 + NADH + H+
hexan-3-amine + NAD+ + H2O
-
-
-
?
isobutanal + methylamine + NADH + H+
N,2-dimethylp