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Information on EC 1.3.1.77 - anthocyanidin reductase [(2R,3R)-flavan-3-ol-forming]

for references in articles please use BRENDA:EC1.3.1.77

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IUBMB Comments

The enzyme participates in the flavonoid biosynthesis pathway found in plants. It catalyses the double reduction of anthocyanidins, producing (2R,3R)-flavan-3-ol monomers required for the formation of proanthocyanidins. While the enzyme from the legume Medicago truncatula (MtANR) can use both NADPH and NADH as reductant, that from the crucifer Arabidopsis thaliana (AtANR) uses only NADPH. Also, while the substrate preference of MtANR is cyanidin>pelargonidin>delphinidin, the reverse preference is found with AtANR. cf. EC 1.3.1.112, anthocyanidin reductase [(2S)-flavan-3-ol-forming].

The expected taxonomic range for this enzyme is: Bacteria, Eukaryota

Synonyms
banyuls, csanr, vbanr, csanr2, rranr, mtanr, atanr, ptranr1, csanr1, bpanr, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a (2R,3R)-flavan-3-ol + 2 NAD(P)+ = an anthocyanidin with a 3-hydroxy group + 2 NAD(P)H + H+
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
2,3-cis-flavanols biosynthesis, proanthocyanidins biosynthesis from flavanols