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Information on EC 1.3.1.115 - 3-oxocholoyl-CoA 4-desaturase

for references in articles please use BRENDA:EC1.3.1.115

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IUBMB Comments

Contains flavin. The enzyme, characterized from the bacterium Clostridium scindens, participates in the bile acid 7α-dehydroxylation pathway. The enzyme catalyses the stereo-specific oxidation of its substrates and has no activity with the 7β anomers. cf. EC 1.3.1.116, 7β-hydroxy-3-oxochol-24-oyl-CoA 4-desaturase.

The expected taxonomic range for this enzyme is: [Clostridium] scindens

Synonyms
baicd, 3-oxo-delta4-cholenoic acid oxidoreductase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
7alpha,12alpha-dihydroxy-3-oxochol-24-oyl-CoA + NAD+ = 7alpha,12alpha-dihydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+
show the reaction diagram
(1)
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7alpha-hydroxy-3-oxochol-24-oyl-CoA + NAD+ = 7alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+
show the reaction diagram
(2)
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PATHWAY SOURCE
PATHWAYS
MetaCyc
bile acid 7alpha-dehydroxylation
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