Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Information on EC 1.3.1.114 - 3-dehydro-bile acid DELTA4,6-reductase

for references in articles please use BRENDA:EC1.3.1.114

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IUBMB Comments

Contains flavin. The enzyme, characterized from the bacterium Clostridium scindens, participates in the bile acid 7α-dehydroxylation pathway. The enzyme catalyses two subsequent reductions of the double bonds within the bile acid A/B rings, following 7α-dehydration.

The enzyme appears in viruses and cellular organisms

Synonyms
BaiN, CLOSCI_00523, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NAD+ = 12alpha-hydroxy-3-oxochol-4,6-dien-24-oyl-CoA + NADH + H+
show the reaction diagram
(4)
-
-
-
12alpha-hydroxy-3-oxocholan-24-oyl-CoA + NAD+ = 12alpha-hydroxy-3-oxochol-4-en-24-oyl-CoA + NADH + H+
show the reaction diagram
(3)
-
-
-
3-oxochol-4-en-24-oyl-CoA + NAD+ = 3-oxochol-4,6-dien-24-oyl-CoA + NADH + H+
show the reaction diagram
(2)
-
-
-
3-oxocholan-24-oyl-CoA + NAD+ = 3-oxochol-4-en-24-oyl-CoA + NADH + H+
show the reaction diagram
(1)
-
-
-
PATHWAY SOURCE
PATHWAYS
MetaCyc
bile acid 7alpha-dehydroxylation, bile acid 7beta-dehydroxylation
Highest Expressing Human Cell Lines
Cell Line Links Gene Links