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IUBMB Comments Also acts on several diphenols and phenylenediamines, but has low affinity for these substrates. Involved in the biosynthesis of mould metabolites related to the antibiotic griseofulvin.
Synonyms
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EC 1.10.3.7
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formerly
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Oxidase, sulochrin
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sulochrin oxidase
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2 sulochrin + O2 = 2 (+)-bisdechlorogeodin + 2 H2O
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MetaCyc
asterrate biosynthesis
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sulochrin:oxygen oxidoreductase (cyclizing, (+)-specific)
Also acts on several diphenols and phenylenediamines, but has low affinity for these substrates. Involved in the biosynthesis of mould metabolites related to the antibiotic griseofulvin.
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(+)-ascorbic acid + O2
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Substrates: -
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dihydrogeodin + O2
(+)-geodin + H2O
griseophenone A + O2
dehydrodemethylgriseofulvin + H2O
N,N,N',N'-tetramethyl-p-phenylenediamine + O2
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N,N-dimethyl-p-phenylenediamine + O2
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o-phenylenediamine + O2
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Substrates: -
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p-phenylenediamine + O2
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sulochrin + O2
(+)-bisdechlorogeodin + H2O
catechol + O2
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Substrates: -
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catechol + O2
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Substrates: -
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dihydrogeodin + O2
(+)-geodin + H2O
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Substrates: 195% of activity with sulochrin
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dihydrogeodin + O2
(+)-geodin + H2O
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Substrates: 195% of activity with sulochrin
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griseophenone A + O2
dehydrodemethylgriseofulvin + H2O
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Substrates: 7.8% of activity with sulochrin
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griseophenone A + O2
dehydrodemethylgriseofulvin + H2O
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Substrates: 7.8% of activity with sulochrin
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hydroquinone + O2
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Substrates: -
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hydroquinone + O2
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Substrates: -
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N,N,N',N'-tetramethyl-p-phenylenediamine + O2
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Substrates: -
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N,N,N',N'-tetramethyl-p-phenylenediamine + O2
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Substrates: -
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N,N-dimethyl-p-phenylenediamine + O2
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Substrates: -
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N,N-dimethyl-p-phenylenediamine + O2
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Substrates: -
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p-phenylenediamine + O2
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Substrates: -
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p-phenylenediamine + O2
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Substrates: -
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sulochrin + O2
(+)-bisdechlorogeodin + H2O
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Substrates: -
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sulochrin + O2
(+)-bisdechlorogeodin + H2O
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Substrates: stereospecific formation of (+)-isomer
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sulochrin + O2
(+)-bisdechlorogeodin + H2O
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Substrates: main function: synthesis of bisdechlorogeodin, involved in biosynthesis of mold metabolites related to the antibiotic griseofulvin
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sulochrin + O2
(+)-bisdechlorogeodin + H2O
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Substrates: -
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sulochrin + O2
(+)-bisdechlorogeodin + H2O
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Substrates: main function: synthesis of bisdechlorogeodin, involved in biosynthesis of mold metabolites related to the antibiotic griseofulvin
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copper
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copper
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enzyme contains 6 copper atoms
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Sodium diethyldithiocarbamate
additional information
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not inhibited by 2 mM neocuproin, 5 mM, potassium cyanide or 10 mM EDTA
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Sodium diethyldithiocarbamate
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0.1 mM, 66% inhibition, 1 mM, complete inhibition
Sodium diethyldithiocarbamate
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1 mM, 54% inhibition, activity is restored by addition of 0.2 mM Cu2+
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150
(+)-ascorbic acid
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1
N,N,N',N'-tetramethyl-p-phenylenediamine
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0.4
N,N-Dimethyl-p-phenylenediamine
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brenda
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brenda
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brenda
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brenda
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no extracellular activity
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no extracellular activity
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Highest Expressing Human Cell Lines
Filter by:
Cell Line Links
Gene Links
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110000
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2 * 110000, SDS-PAGE
27800
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1 * 85000 + 1 * 27800, possible structure: 2 noncovalently bound identical subunits, each of which consists of 3 smaller subunits, SDS-PAGE
85000
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1 * 85000 + 1 * 27800, possible structure: 2 noncovalently bound identical subunits, each of which consists of 3 smaller subunits, SDS-PAGE
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dimer
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2 * 110000, SDS-PAGE
dimer
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1 * 85000 + 1 * 27800, possible structure: 2 noncovalently bound identical subunits, each of which consists of 3 smaller subunits, SDS-PAGE
dimer
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1 * 85000 + 1 * 27800, possible structure: 2 noncovalently bound identical subunits, each of which consists of 3 smaller subunits, SDS-PAGE
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dimer
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2 * 110000, SDS-PAGE
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glycoprotein
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19.5% carbohydrate
glycoprotein
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19.5% carbohydrate
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10% glycerol stabilizes condiderably
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-20°C, pH 5.8, citrate-phosphate buffer, several months, no loss in activity
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ammonium sulfate, DEAE-cellulose, hydroxyapatite, Phenyl-Sepharose, Mono p, Mono Q, TSK G 3000
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ammonium sulfate, pH 3.3, isoelectric focusing, gel filtration
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Nordlv, H.; Gatenbeck, S.
Enzymatic synthesis of (+)- and (-)-bisdechlorogeodin with sulochrin oxidase from Penicillium frequentans and Oospora sulphurea-ochracea
Arch. Microbiol.
131
208-211
1982
Penicillium glabrum, Penicillium glabrum CMI 96659
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Huang, K.X.; Yoshida, Y.; Mikawa, K.; Fujii, I.; Ebizuka, Y.; Sankawa, U.
Purification and characterization of sulochrin oxidase from Penicillium frequentans
Biol. Pharm. Bull.
19
42-46
1996
Penicillium glabrum, Penicillium glabrum CMI 96659
brenda
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