Any feedback?
Please rate this page

BRENDA support

show all | hide all No of entries

Information on EC - acyl-CoA (8-3)-desaturase

for references in articles please use BRENDA:EC1.14.19.44
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
The enzyme introduces a cis double bond at carbon 5 of acyl-CoAs that contain a double bond at position 8. The enzymes from algae, mosses, mammals and the protozoan Leishmania major catalyse the desaturation of dihomo-gamma-linoleate [(8Z,11Z,14Z)-icosa-8,11,14-trienoate] and (8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoate to generate arachidonate and (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoate, respectively. The enzyme contains a cytochrome b5 domain that acts as the direct electron donor to the desaturase active site and does not require an external cytochrome. cf. EC, acyl-CoA 5-desaturase.
Specify your search results
Select one or more organisms in this record: ?
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
  • 6-desaturase
  • polyunsaturated
  • phospholipid
  • arachidonic
  • linoleic
  • pufas
  • eicosapentaenoic
  • 5-desaturation
  • omega
  • desaturases
  • docosahexaenoic
  • dihomo-gamma-linolenic
  • gamma-linolenic
  • eicosatrienoic
  • alpha-linolenic
  • eicosa-8,11,14-trienoic
  • coconut
  • linoleoyl-coa
  • linseed
  • fat-free
  • elongase
  • safflower
The enzyme appears in viruses and cellular organisms
delta 5-desaturase, more
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = arachidonoyl-CoA + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
(8Z,11Z,14Z,17Z)-icosa-8,11,14,17-tetraenoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoyl-CoA + 2 ferricytochrome b5 + 2 H2O
show the reaction diagram
Select items on the left to see more content.