Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 1.14.15.36 - sterol 14alpha-demethylase (ferredoxin)

for references in articles please use BRENDA:EC1.14.15.36
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
A cytochrome P-450 (heme-thiolate) protein found in several bacterial species. The enzyme, which is involved in sterol biosynthesis, catalyses a hydroxylation and a reduction of the 14alpha-methyl group, followed by a second hydroxylation, resulting in the elimination of formate and formation of a 14(15) double bond. The enzyme from Methylococcus capsulatus is fused to the ferredoxin by an alanine-rich linker. cf. EC 1.14.14.154, sterol 14alpha-demethylase.
Specify your search results
Select one or more organisms in this record: ?
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
The enzyme appears in viruses and cellular organisms
Reaction Schemes
hide(Overall reactions are displayed. Show all >>)
+
6
reduced ferredoxin [iron-sulfur] cluster
+
6
+
3
=
+
+
6
oxidized ferredoxin [iron-sulfur] cluster
+
4
Synonyms
CYP51, G419_21379, sterol demethylase 450, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a 14alpha-formylsteroid + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = a DELTA14-steroid + formate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
show the reaction diagram
(1c)
-
-
-
a 14alpha-hydroxymethylsteroid + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = a 14alpha-formylsteroid + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H2O
show the reaction diagram
(1b)
-
-
-
a 14alpha-methylsteroid + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = a 14alpha-hydroxymethylsteroid + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
show the reaction diagram
(1a)
-
-
-
a 14alpha-methylsteroid + 6 reduced ferredoxin [iron-sulfur] cluster + 6 H+ + 3 O2 = a DELTA14-steroid + formate + 6 oxidized ferredoxin [iron-sulfur] cluster + 4 H2O
show the reaction diagram
overall reaction
-
-
-
Select items on the left to see more content.