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IUBMB CommentsA cytochrome P-450 (heme-thiolate) protein involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus.
The enzyme appears in viruses and cellular organisms
Reaction Schemes
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2
reduced ferredoxin [iron-sulfur] cluster
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2
+
=
+
2
oxidized ferredoxin [iron-sulfur] cluster
+
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EC 1.14.99.49
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formerly
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NcsB3
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2-hydroxy-5-methyl-1-naphthoate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 = 2,7-dihydroxy-5-methyl-1-naphthoate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
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-
-
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2-hydroxy-5-methyl-1-naphthoate,reduced ferredoxin:oxygen oxidoreductase (7-hydroxylating)
A cytochrome P-450 (heme-thiolate) protein involved in the synthesis of neocarzinostatin in the bacterium Streptomyces carzinostaticus.
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2-hydroxy-5-methyl-1-naphthoate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2
2,7-dihydroxy-5-methyl-1-naphthoate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
2-hydroxy-5-methyl-1-naphthoate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2
2,7-dihydroxy-5-methyl-1-naphthoate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
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-
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?
2-hydroxy-5-methyl-1-naphthoate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2
2,7-dihydroxy-5-methyl-1-naphthoate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
the enzyme is involved in the biosynthesis of the enediyne antibiotic neocarzinostatin
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-
?
2-hydroxy-5-methyl-1-naphthoate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2
2,7-dihydroxy-5-methyl-1-naphthoate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
-
?
2-hydroxy-5-methyl-1-naphthoate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2
2,7-dihydroxy-5-methyl-1-naphthoate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
the enzyme is involved in the biosynthesis of the enediyne antibiotic neocarzinostatin
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
2-hydroxy-5-methyl-1-naphthoate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2
2,7-dihydroxy-5-methyl-1-naphthoate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
2-hydroxy-5-methyl-1-naphthoate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2
2,7-dihydroxy-5-methyl-1-naphthoate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
the enzyme is involved in the biosynthesis of the enediyne antibiotic neocarzinostatin
-
-
?
2-hydroxy-5-methyl-1-naphthoate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2
2,7-dihydroxy-5-methyl-1-naphthoate + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
the enzyme is involved in the biosynthesis of the enediyne antibiotic neocarzinostatin
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
cytochrome P-450
a heme-thiolate protein
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SwissProt
brenda
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SwissProt
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NCSB3_STRCZ
410
0
45493
Swiss-Prot
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A0A385ZZG3_9ACTN
489
0
54091
TrEMBL
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A0A7R8P1L6_9ACTN
415
0
44640
TrEMBL
-
A0A2P8AD85_9ACTN
409
0
44905
TrEMBL
-
A0A231GX15_9NOCA
405
0
44653
TrEMBL
-
A0A2I2KVT0_9ACTN
420
0
45696
TrEMBL
-
A0A387HIQ5_9ACTN
424
0
45831
TrEMBL
-
A0A231H7L7_9NOCA
417
0
45685
TrEMBL
-
A0A7K0C9F2_9ACTN
Streptomyces smaragdinus
406
0
43780
TrEMBL
-
A0A7K0DUC5_9NOCA
Nocardia aurantia
410
0
45002
TrEMBL
-
A0A2P7ZK47_9ACTN
408
0
44662
TrEMBL
-
A0A7K0CF60_9ACTN
Streptomyces smaragdinus
418
0
45775
TrEMBL
-
A0A7K0CEC2_9ACTN
Streptomyces smaragdinus
407
0
43891
TrEMBL
-
A0A231H1P9_9NOCA
410
0
44724
TrEMBL
-
A0A2S6X5R0_9ACTN
501
0
55344
TrEMBL
-
A0A7K0DEH8_9NOCA
Nocardia macrotermitis
434
0
48670
TrEMBL
-
A0A2P8A392_9ACTN
407
0
43861
TrEMBL
-
A0A231GUM4_9NOCA
409
0
44257
TrEMBL
-
A0A2S6X193_9ACTN
408
0
44564
TrEMBL
-
A0A7K0CVC6_9NOCA
Nocardia macrotermitis
408
0
45136
TrEMBL
-
A0A117NX75_9ACTN
465
0
50263
TrEMBL
-
A0A6I1Z635_9ACTN
421
0
44673
TrEMBL
-
A0A2P8A1T2_9ACTN
498
0
55189
TrEMBL
-
A0A7K0CED7_9ACTN
Streptomyces smaragdinus
413
0
45475
TrEMBL
-
A0A231GWA1_9NOCA
423
0
46016
TrEMBL
-
A0A7R8NYS3_9ACTN
409
0
44533
TrEMBL
-
A0A7R8P4F6_9ACTN
519
0
56500
TrEMBL
-
A0A231HBF4_9NOCA
427
0
46955
TrEMBL
-
A0A2S6X930_9ACTN
449
0
48651
TrEMBL
-
A0A7K0C1N7_9ACTN
413
0
44460
TrEMBL
-
A0A1K2FKM8_9ACTN
489
0
53540
TrEMBL
-
A0A7R8RY92_9ACTN
423
0
45855
TrEMBL
-
A0A7K0D6U8_9NOCA
Nocardia macrotermitis
412
0
44448
TrEMBL
-
A0A231H0I9_9NOCA
405
0
44366
TrEMBL
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A0A7K0C8G0_9ACTN
460
0
49490
TrEMBL
-
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heterologous expression of the gene together with ncsB and ncsB1 in Streptomyces lividans TK24
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Hang, V.T.T.; Oh, T.J.; Yamaguchi, T.; Sohng, J.K.
In vivo characterization of NcsB3 to establish the complete biosynthesis of the naphthoic acid moiety of the neocarzinostatin chromophore
FEMS Microbiol. Lett.
311
119-125
2010
Streptomyces carzinostaticus (Q84HB6), Streptomyces carzinostaticus, Streptomyces carzinostaticus ATCC 15944 (Q84HB6)
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