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(R,S)-citronellol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxycitronellol + [oxidized NADPH-hemoprotein reductase] + H2O
cis-nerol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxynerol + [oxidized NADPH-hemoprotein reductase] + H2O
farnesol + [reduced NADPH-hemoprotein reductase] + O2
12-hydroxyfarnesol + [oxidized NADPH-hemoprotein reductase] + H2O
geraniol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
geraniol + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
geranylgeraniol + [reduced NADPH-hemoprotein reductase] + O2
16-hydroxygeranylgeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
geranylgeraniol + [reduced NADPH-hemoprotein reductase] + O2
18-hydroxygeranylgeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
nerol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxynerol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
nerol + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxynerol + [oxidized NADPH-hemoprotein reductase] + H2O
additional information
?
-
(R,S)-citronellol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxycitronellol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
GC-MS product analysis
-
?
(R,S)-citronellol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxycitronellol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
GC-MS product analysis
-
?
cis-nerol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxynerol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
GC-MS product analysis
-
?
cis-nerol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxynerol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
GC-MS product analysis
-
?
farnesol + [reduced NADPH-hemoprotein reductase] + O2
12-hydroxyfarnesol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
farnesol + [reduced NADPH-hemoprotein reductase] + O2
12-hydroxyfarnesol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
GC-MS product analysis
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
GC-MS product analysis
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
development and validation of an HPLC detection method for quantification of geraniol and 10-hydroxygeraniol, with separation of geraniol and nerol, overview
-
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
mass spectrometrical product analysis
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
geranylgeraniol + [reduced NADPH-hemoprotein reductase] + O2
16-hydroxygeranylgeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
geranylgeraniol + [reduced NADPH-hemoprotein reductase] + O2
16-hydroxygeranylgeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
geranylgeraniol + [reduced NADPH-hemoprotein reductase] + O2
18-hydroxygeranylgeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
geranylgeraniol + [reduced NADPH-hemoprotein reductase] + O2
18-hydroxygeranylgeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
nerol + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxynerol + [oxidized NADPH-hemoprotein reductase] + H2O
-
cis-isomer of geraniol
-
-
?
nerol + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxynerol + [oxidized NADPH-hemoprotein reductase] + H2O
-
cis-isomer of geraniol
-
-
?
additional information
?
-
CrG10H also catalyzed 3'-hydroxylation of the flavanone naringenin to form eriodictyol, a reaction of the flavonoid 3'-hydroxylase. Analysis of the enzyme reactions of the recombinant enzyme with naringenin, apigenin, kaempferol, pcoumaric acid, and ferulic acid, mass spectrometric product analysis, overview
-
-
?
additional information
?
-
-
CrG10H also catalyzed 3'-hydroxylation of the flavanone naringenin to form eriodictyol, a reaction of the flavonoid 3'-hydroxylase. Analysis of the enzyme reactions of the recombinant enzyme with naringenin, apigenin, kaempferol, pcoumaric acid, and ferulic acid, mass spectrometric product analysis, overview
-
-
?
additional information
?
-
enzyme is a specialized multifunctional enzyme catalyzing two sequential oxidation steps leading to the formation of 8-oxogeraniol from geraniol. The first step, geraniol hydroxylation, is very efficient and fast enough to outcompete geraniol conjugation in plant tissues
-
-
?
additional information
?
-
-
enzyme is a specialized multifunctional enzyme catalyzing two sequential oxidation steps leading to the formation of 8-oxogeraniol from geraniol. The first step, geraniol hydroxylation, is very efficient and fast enough to outcompete geraniol conjugation in plant tissues
-
-
?
additional information
?
-
CYP76B10 is involved in production of swertiamarin
-
-
?
additional information
?
-
-
CYP76B10 is involved in production of swertiamarin
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(R,S)-citronellol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxycitronellol + [oxidized NADPH-hemoprotein reductase] + H2O
cis-nerol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxynerol + [oxidized NADPH-hemoprotein reductase] + H2O
geraniol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
geraniol + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
geranylgeraniol + [reduced NADPH-hemoprotein reductase] + O2
18-hydroxygeranylgeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
nerol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxynerol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
nerol + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxynerol + [oxidized NADPH-hemoprotein reductase] + H2O
additional information
?
-
(R,S)-citronellol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxycitronellol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
(R,S)-citronellol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxycitronellol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
cis-nerol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxynerol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
cis-nerol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxynerol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
(6E)-8-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
geraniol + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxygeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
-
?
geranylgeraniol + [reduced NADPH-hemoprotein reductase] + O2
18-hydroxygeranylgeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
geranylgeraniol + [reduced NADPH-hemoprotein reductase] + O2
18-hydroxygeranylgeraniol + [oxidized NADPH-hemoprotein reductase] + H2O
-
-
-
?
nerol + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxynerol + [oxidized NADPH-hemoprotein reductase] + H2O
-
cis-isomer of geraniol
-
-
?
nerol + [reduced NADPH-hemoprotein reductase] + O2
10-hydroxynerol + [oxidized NADPH-hemoprotein reductase] + H2O
-
cis-isomer of geraniol
-
-
?
additional information
?
-
CYP76B10 is involved in production of swertiamarin
-
-
?
additional information
?
-
-
CYP76B10 is involved in production of swertiamarin
-
-
?
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evolution
-
the enzyme belongs to the cytochrome-P450 monooxygenase family
evolution
the enzyme belongs to the cytochrome-P450 monooxygenase family
evolution
-
the enzyme is a cyt P450 monoterpene hydroxylase and belongs to the cytochrome-P450 monooxygenase family
evolution
-
the enzyme is a cyt P450 monoterpene hydroxylase and belongs to the cytochrome-P450 monooxygenase family
evolution
enzyme CsCPR I belongs to Class I of dicotyledonous CPRs
evolution
enzyme CYP76F45 belongs to the CYP76 family of dicotyledonous CPR class I
evolution
-
enzyme CYP76F45 belongs to the CYP76 family of dicotyledonous CPR class I
-
metabolism
-
G10H catalyses an early step of the biosynthesis of the monoterpene precursor of monoterpene indole alkaloids
metabolism
G10H catalyzes the first committed step of the biosynthetic pathway of strictosidine and other terpenoid indole alkaloids, overview
metabolism
G10H plays a role in the iridoid monoterpene and indole alkaloid biosynthesis
metabolism
-
the enzyme is involved in the monoterpene indole alkaloids
metabolism
-
the enzyme is involved in the monoterpene indole alkaloids, regulation of the enzyme activity involves two distinct calmodulin isoforms, CAM1 and CAM2, overview
metabolism
-
the enzyme is one of the key enzymes of the biosynthesis of monoterpene indole alkaloids that originate from the coupling of the indole and the iridoid pathways. Overview of metabolic pathways leading to the biosynthesis of monoterpene indole alkaloids and their metabolic regulation
metabolism
-
the enzyme is part of the terpenoid indole alkaloid pathway
metabolism
the enzyme plays an important role in the iridoid monoterpenoid and the indole alkaloid biosynthesis, overview
metabolism
the enzyme is catalyzing the first commited step to iridoid monoterpene biosynthesis and is involved in monoterpene indole alkaloid biosynthesis in specialized cells of the laticifer-idioblast system, overview
metabolism
-
the enzyme is involved in the 2-C-methyl-D-erythritol-4-phosphate/terpenoid metabolic pathway part of the iridoid pathway, overview. Induction of G10H is a requirement, but not the only, necessary to produce other terpenoid indole alkaloids than strictosidine
metabolism
-
the enzyme is involved in the biosynthesis of iridiod monoterpenoids
metabolism
-
the enzyme is involved in the biosynthesis of iridiod monoterpenoids
metabolism
the enzyme is involved in the biosynthesis of secologanin from geraniol, overview
metabolism
the enzyme is involved in biosynthesis of terpenoid indole alkaloids
metabolism
the enzyme is involved in terpenoid indole alkaloid (TIA) biosynthetic pathway
metabolism
the enzyme catalyzes the first committed step in the camptothecin biosynthetic pathway and a key regulation point of the campothecin biosynthetic pathway
metabolism
-
the enzyme is involved in the secoiridoid pathway and the biosynthesis of terpenoid indole alkaloid via strictosidine
physiological function
Vitis vinifera x Vitis vinifera
-
involved in terpenoid metabolism
physiological function
-
involved in terpenoid metabolism
physiological function
G10H hydroxylates geraniol and is involved in biosynthesis of swertiamarin via the iridoid pathway and of strictosidine via the indole pathway, overview, induced by methyljasmonate
physiological function
-
geraniol 10-hydroxylase is a cytochrome P450 monooxygenase involved in the biosynthesis of iridoid monoterpenoids and several classes of monoterpenoid alkaloids found in a diverse range of plant species. G10H plays a key regulatory role in terpenoid indole alkaloid biosynthesis
physiological function
-
the cytochrome P450 enzyme geraniol 10-hydroxylase plays an important role in the biosynthesis of pharmaceutically important alkaloids in Catharanthus roseus
physiological function
the enzyme is catalyzing the first commited step to iridoid monoterpene biosynthesis and is involved in monoterpene indole alkaloid biosynthesis in specialized cells of the laticifer-idioblast system, overview
physiological function
-
the enzyme is involved in the biosynthesis of iridiod monoterpenoids, which are important in plant defense systems against herbivores
physiological function
-
the enzyme is involved in the biosynthesis of iridiod monoterpenoids, which are important in plant defense systems against herbivores
physiological function
enzymes CYP97C27 and CPR I function as the enzyme geraniol-8-hydroxylase (G8H), which is likely to be involved in the biosynthesis of the indole alkaloid 19-E-vallesamine in Croton stellatopilosus
physiological function
overexpression of G10H alone or coexpression G10H with octadecanoid-derivative responsive Catharanthus AP2-domain gene ORCA3 in transgenic Catharanthus roseus plants. G10H transcripts show a significant increase under G10H and ORCA3 cooverexpression. ORCA3 and G10H overexpression significantly increase the accumulation of strictosidine, vindoline, catharanthine and ajmalicine but have limited effects on anhydrovinblastine and vinblastine levels
physiological function
the enzyme plays an important role in stimulating campothecin accumulation, capothecin has anti-tumor activity
physiological function
transient expression in Nicotiana benthamiana leaf leads to formation of 8-hydroxygeraniol and 8-oxogeraniol
physiological function
-
downregulation of CYP76B6 results in reduction of mRNA transcript levels as well as camptothecin content in comparison to control. Overexpression of CYP76B6 in leaf leads to significantly higher content of camptothecin
physiological function
-
enzymes CYP97C27 and CPR I function as the enzyme geraniol-8-hydroxylase (G8H), which is likely to be involved in the biosynthesis of the indole alkaloid 19-E-vallesamine in Croton stellatopilosus
-
additional information
-
geraniol 10-hydroxylase is a cytochrome P450 monooxygenase
additional information
-
geraniol 10-hydroxylase is a cytochrome P450 monooxygenase
additional information
geraniol 10-hydroxylase is a cytochrome P450 monooxygenase
additional information
-
geraniol 10-hydroxylase is a cytochrome P450 monooxygenase
additional information
-
geraniol 10-hydroxylase is a cytochrome P450 monooxygenase. It consists of a reductase and a monooxygenase. The cytochrome P450 reductase, EC 1.6.2.4, is a membrane-bound flavoprotein, which transfers electrons from NADPH to the cytochrome P450 monooxygenase, CPR requires the cofactors FMN, FAD and NADPH
additional information
-
the calmodulins CAM1 and CAM2 are required for monoterpene indole alkaloid biosynthesis in Catharanthus roseus cells by acting on regulation of expression of genes encoding enzymes that catalyse early steps of monoterpene indole alkaloid biosynthesis, such as 1-deoxy-D-xylulose 5-phosphate reductoisomerase and geraniol 10-hydroxylase, overview. CAM regulation by Ca2+, overview
additional information
-
the individual overexpression of the terpenoid genes 1-deoxy-D-xylulose synthase, DXS, and G10H resulted in mixed results in regards to the accumulation of terpenoid indole alkaloid metabolite pools
additional information
-
the transcription level of gene g10h is altered by treatment with Agrobacterium tumefaciens for induction of hariry root growth in second metabolite production, expression analysis, overview
additional information
-
molecular docking is used for accurate prediction of protein-ligand interaction geometries at molecular level, molecular interaction studies, overview. Geraniol interacts with G10H residues Ala303 and Thr307 from the central helix I
additional information
the enzyme contains specific oxygen- and heme-binding sites
additional information
the enzyme contains specific oxygen- and heme-binding sites
additional information
-
the enzyme contains specific oxygen- and heme-binding sites
additional information
the enzyme contains two FMN-, FAD-, and NADPH-binding sites and one P450-binding site
additional information
the enzyme contains two FMN-, FAD-, and NADPH-binding sites and one P450-binding site
additional information
-
the enzyme contains two FMN-, FAD-, and NADPH-binding sites and one P450-binding site
additional information
-
the enzyme contains specific oxygen- and heme-binding sites
-
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C76BA_SWEMU
495
1
55456
Swiss-Prot
Secretory Pathway (Reliability: 3)
C76B6_CATRO
493
0
55658
Swiss-Prot
Secretory Pathway (Reliability: 5)
A0A2P6R0X9_ROSCH
103
0
11804
TrEMBL
other Location (Reliability: 2)
A0A396HJD4_MEDTR
539
1
61027
TrEMBL
Secretory Pathway (Reliability: 1)
A0A7D3QN22_HYSOF
494
1
55536
TrEMBL
Secretory Pathway (Reliability: 2)
A0A2P6R0I6_ROSCH
499
1
56088
TrEMBL
Mitochondrion (Reliability: 5)
G7L1C3_MEDTR
503
0
56615
TrEMBL
Secretory Pathway (Reliability: 2)
A0A2P6R0M7_ROSCH
502
0
56854
TrEMBL
Secretory Pathway (Reliability: 5)
A0A396HJ99_MEDTR
475
1
53857
TrEMBL
Secretory Pathway (Reliability: 1)
A0A396HVC2_MEDTR
80
0
9609
TrEMBL
other Location (Reliability: 3)
A0A396JTM0_MEDTR
340
0
38297
TrEMBL
Secretory Pathway (Reliability: 5)
A0A2P6SEY0_ROSCH
76
0
8571
TrEMBL
Mitochondrion (Reliability: 2)
A0A396JRK2_MEDTR
234
0
26726
TrEMBL
other Location (Reliability: 3)
A0A396HWZ4_MEDTR
182
0
20919
TrEMBL
other Location (Reliability: 2)
A0A396H263_MEDTR
115
1
13187
TrEMBL
other Location (Reliability: 2)
G7L1D0_MEDTR
504
1
56667
TrEMBL
Secretory Pathway (Reliability: 3)
A0A2P6P7M4_ROSCH
157
0
17906
TrEMBL
other Location (Reliability: 3)
A0A2P6R0C2_ROSCH
80
0
9050
TrEMBL
Mitochondrion (Reliability: 3)
A0A2G9GCU5_9LAMI
494
0
55110
TrEMBL
Mitochondrion (Reliability: 5)
A0A396I806_MEDTR
501
0
56364
TrEMBL
Secretory Pathway (Reliability: 1)
A0A2P6PC62_ROSCH
88
0
9955
TrEMBL
other Location (Reliability: 2)
A0A2P6R0B7_ROSCH
55
0
6621
TrEMBL
other Location (Reliability: 3)
A0A2P6R0U9_ROSCH
519
0
58865
TrEMBL
Mitochondrion (Reliability: 4)
A0A2P6R0S7_ROSCH
128
0
14740
TrEMBL
Mitochondrion (Reliability: 3)
A0A2P6R0P1_ROSCH
109
0
12224
TrEMBL
Mitochondrion (Reliability: 2)
A0A2G9HLA0_9LAMI
498
1
56817
TrEMBL
Mitochondrion (Reliability: 5)
G7L1C7_MEDTR
503
1
56687
TrEMBL
Secretory Pathway (Reliability: 4)
A0A7S5T4Y0_DENOF
501
1
56792
TrEMBL
Mitochondrion (Reliability: 5)
A0A396JUW2_MEDTR
489
1
55640
TrEMBL
Secretory Pathway (Reliability: 5)
A0A072VK77_MEDTR
500
1
56607
TrEMBL
Secretory Pathway (Reliability: 1)
A0A2P6R0C5_ROSCH
503
0
56712
TrEMBL
Secretory Pathway (Reliability: 5)
A0A2P6R0I4_ROSCH
463
1
52149
TrEMBL
Secretory Pathway (Reliability: 2)
A0A396J999_MEDTR
486
1
54973
TrEMBL
Secretory Pathway (Reliability: 4)
A0A2P6R0K7_ROSCH
88
1
10006
TrEMBL
Secretory Pathway (Reliability: 3)
A0A396JZC6_MEDTR
489
0
55741
TrEMBL
Secretory Pathway (Reliability: 3)
A0A396HRG1_MEDTR
507
0
57629
TrEMBL
other Location (Reliability: 3)
A0A7D3UYJ8_NEPCA
492
1
55458
TrEMBL
Secretory Pathway (Reliability: 5)
A0A072VR50_MEDTR
499
0
56010
TrEMBL
Secretory Pathway (Reliability: 3)
A0A072VPS7_MEDTR
485
1
55163
TrEMBL
Secretory Pathway (Reliability: 2)
A0A2P6PC56_ROSCH
348
0
39960
TrEMBL
other Location (Reliability: 4)
A0A072VPG2_MEDTR
500
1
56077
TrEMBL
Secretory Pathway (Reliability: 3)
A0A2P6R0Y9_ROSCH
499
0
56065
TrEMBL
Mitochondrion (Reliability: 5)
A0A396JM78_MEDTR
48
0
5483
TrEMBL
Secretory Pathway (Reliability: 4)
G7L8J9_MEDTR
509
1
57341
TrEMBL
Secretory Pathway (Reliability: 2)
A0A396HZF1_MEDTR
218
0
24569
TrEMBL
other Location (Reliability: 3)
A0A396JSP8_MEDTR
489
1
55661
TrEMBL
Secretory Pathway (Reliability: 5)
A0A6M5CTG4_9ASPA
497
0
56408
TrEMBL
Mitochondrion (Reliability: 5)
A0A084G5A2_PSEDA
144
0
16098
TrEMBL
other Location (Reliability: 1)
A0A7D3QT71_NEPRA
492
1
55402
TrEMBL
Secretory Pathway (Reliability: 4)
A0A072VHN2_MEDTR
496
1
55929
TrEMBL
Secretory Pathway (Reliability: 2)
A0A6M3T0H4_9LAMI
334
0
37387
TrEMBL
other Location (Reliability: 4)
A0A2P6R0L5_ROSCH
85
1
9604
TrEMBL
Mitochondrion (Reliability: 5)
A0A396JM90_MEDTR
516
1
58437
TrEMBL
other Location (Reliability: 5)
G7L1C9_MEDTR
503
1
56692
TrEMBL
Secretory Pathway (Reliability: 4)
G7L8J6_MEDTR
509
1
57429
TrEMBL
Secretory Pathway (Reliability: 1)
A0A2P6R0L0_ROSCH
231
0
26365
TrEMBL
other Location (Reliability: 3)
A0A2P6QX13_ROSCH
501
0
56816
TrEMBL
Secretory Pathway (Reliability: 5)
A0A2P6QX98_ROSCH
163
0
18646
TrEMBL
other Location (Reliability: 4)
A0A2P6R0K1_ROSCH
381
0
42866
TrEMBL
other Location (Reliability: 3)
A0A2P6P7Q0_ROSCH
313
2
35671
TrEMBL
Secretory Pathway (Reliability: 5)
A0A396ISM9_MEDTR
123
1
14421
TrEMBL
other Location (Reliability: 2)
A0A072TSV1_MEDTR
530
2
59702
TrEMBL
Secretory Pathway (Reliability: 3)
A0A2P6PC22_ROSCH
182
2
20691
TrEMBL
other Location (Reliability: 3)
A0A2P6PCG6_ROSCH
502
1
57188
TrEMBL
Secretory Pathway (Reliability: 5)
A0A396JIF1_MEDTR
499
1
55972
TrEMBL
Secretory Pathway (Reliability: 4)
A0A2P6R0R3_ROSCH
502
0
57129
TrEMBL
Mitochondrion (Reliability: 5)
A0A2P6P9L9_ROSCH
500
1
56222
TrEMBL
Mitochondrion (Reliability: 5)
A0A2P6PDA4_ROSCH
511
1
57438
TrEMBL
Secretory Pathway (Reliability: 3)
A0A396J9M3_MEDTR
173
0
19655
TrEMBL
other Location (Reliability: 1)
A0A396JVM0_MEDTR
499
1
56467
TrEMBL
Mitochondrion (Reliability: 5)
G7L1C4_MEDTR
505
1
57085
TrEMBL
Secretory Pathway (Reliability: 3)
A0A2P6R0H6_ROSCH
153
1
16992
TrEMBL
Secretory Pathway (Reliability: 3)
A0A396J9A1_MEDTR
162
0
18234
TrEMBL
Secretory Pathway (Reliability: 5)
A0A0A7DLM4_9ROSI
507
0
56747
TrEMBL
-
A0A0A8KYK4_9ROSI
711
1
78744
TrEMBL
-
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cloning from a lambda-ZAPII library, recombinant expression in Saccharomyces cerevisiae strain YPH500 or in enzyme-deficient Catharathus roseus cell line MP183L, complementation
-
co-expression of G10H with the NADPH-cytochrome P450 reductase from Arabidopsis thaliana in Spodoptera frugiperda Sf9 cell microsomes using the baculovirus transfection method, quantitative expression analysis
co-overexpression of geraniol-10-hydroxylase and strictosidine synthase in Ophiorrhiza pumila
expression in Nothapodytes nimmoniana leaf
-
expression in Saccharomyces cerevisiae
expression in Spodoptera frugiperda SF9 cells, co-expression with NADPH:cytochrome P450 reductase NfCPR2 from Nothapodytes foetida and CPR2 from Arabidopsis thaliana
gene CrG10H, recombinant expression in transgenic Ophiorrhiza pumila hairy roots using Agrobacterium rhizogenes strain C58C1 for transfection
gene CsCPR I, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis and tree, recombinant expression of N-terminally His-tagged enzyme in Escherichia coli strain BL21(DE3). Only simultaneous incubation of the membrane-bound enzymes CsCYP76F45 and CsCPR I with the substrate geraniol and the coenzyme NADPH allows 8-hydroxygeraniol formation
gene CYP76B10, DNA and amino acid sequence determination and analysis, semi-quantitative RT-PCR expression analysis, sequence comparison and phylogenetic tree, expression in Pichia pastoris and in Escherichia coli
gene CYP76F45, DNA and amino acid sequence determination and analysis, sequence comparisons, phylogenetic analysis and tree, recombinant expression of N-terminally His-tagged enzyme in Escherichia coli strain BL21(DE3). Only simultaneous incubation of the membrane-bound enzymes CsCYP76F45 and CsCPR I with the substrate geraniol and the coenzyme NADPH allows 8-hydroxygeraniol formation
gene G10H, DNA and amino acid sequence determination and analysis, phylogenetic analysis and tree, quantitative RT-PCR enzyme expression analysis. Recombinant overexpression of the ginseng geraniol 10-hydroxylase P450 gene in Arabidopsis thaliana ecotype CS60000, from vector pCAMBIA1390 under control of promoter CaMV 35S, causes terpenoid indole alkaloid dihydrositsirikine production and also confers enhanced resistance to Pseudomonas syringae pv. tomato DC3000
-
gene g10h, quantitative real-time PCR expression analysis
-
overexpression in Catharanthus roseus hairy roots via Agrobacterium rhizogenes 15834 transfection system, co-expression with the 1-deoxy-D-xylulose synthase, DXS, from Arabidopsis thaliana
-
SmG10H, DNA and amno acid sequence determination and analysis, sequence comparisons and phylogenetic tree, semiquantitative RT-PCR expression analysis, recombinant expression in Escherichia coli strain BL21 and in Pichia pastoris
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Battilana, J.; Costantini, L.; Emanuelli, F.; Sevini, F.; Segala, C.; Moser, S.; Velasco, R.; Versini, G.; Stella Grando, M.
The 1-deoxy-D: -xylulose 5-phosphate synthase gene co-localizes with a major QTL affecting monoterpene content in grapevine
Theor. Appl. Genet.
118
653-669
2009
Vitis vinifera x Vitis vinifera, Vitis vinifera x Vitis riparia
brenda
Wang, J.; Liu, Y.; Cai, Y.; Zhang, F.; Xia, G.; Xiang, F.
Cloning and functional analysis of geraniol 10-hydroxylase, a cytochrome P450 from Swertia mussotii Franch
Biosci. Biotechnol. Biochem.
74
1583-1590
2010
Swertia mussotii (D1MI46), Swertia mussotii
brenda
Collu, G.; Unver, N.; Peltenburg-Looman, A.M.G.; van der Heijden, R.; Verpoorte, R.; Memelink, J.
Geraniol 10-hydroxylase, a cytochrome P450 enzyme involved in terpenoid indole alkaloid biosynthesis
FEBS Lett.
508
215-220
2001
Catharanthus roseus
brenda
Sung, P.-H.; Huang, F.-C.; Do, Y.-Y.; Huang, P.-L.
Functional expression of geraniol 10-hydroxylase reveals its dual function in the biosynthesis of terpenoid and phenylpropanoid
J. Agric. Food Chem.
59
4637-4643
2011
Catharanthus roseus (Q8VWZ7), Catharanthus roseus
brenda
Meijer, A.H.; De Waal, A.; Verpoorte, R.
Purification of the cytochrome P-450 enzyme geraniol 10-hydroxylase from cell cultures of Catharanthus roseus
J. Chromatogr. A
635
237-249
1993
Catharanthus roseus, Tabernaemontana divaricata, no activity in Tabernaemontana pandacaqui
-
brenda
Peebles, C.A.; Sander, G.W.; Hughes, E.H.; Peacock, R.; Shanks, J.V.; San, K.Y.
The expression of 1-deoxy-d-xylulose synthase and geraniol-10-hydroxylase or anthranilate synthase increases terpenoid indole alkaloid accumulation in Catharanthus roseus hairy roots
Metab. Eng.
13
234-240
2010
Catharanthus roseus
brenda
Collu, G.; Bink, H.H.J.; Moreno, P.R.H.; van der Heijden, R.; Verpoorte, R.
Determination of the activity of the cytochrome p450 enzyme geraniol 10-hydroxylase in plants by high-performance liquid chromatography
Phytochem. Anal.
10
314-318
1999
Catharanthus roseus
-
brenda
Oudin, A.; Courtois, M.; Rideau, M.; Clastre, M.
The iridoid pathway in Catharanthus roseus alkaloid biosynthesis
Phytochem. Rev.
6
259-276
2007
Catharanthus roseus
-
brenda
Poutrain, P.; Guirimand, G.; Mahroug, S.; Burlat, V.; Melin, C.; Ginis, O.; Oudin, A.; Giglioli-Guivarch, N.; Pichon, O.; Courdavault, V.
Molecular cloning and characterisation of two calmodulin isoforms of the Madagascar periwinkle Catharanthus roseus
Plant Biol.
13
36-41
2011
Catharanthus roseus
brenda
Wang, C.T.; Liu, H.; Gao, X.S.; Zhang, H.X.
Overexpression of G10H and ORCA3 in the hairy roots of Catharanthus roseus improves catharanthine production
Plant Cell Rep.
29
887-894
2010
Catharanthus roseus
brenda
Hallahan, D.; West, J.
Cytochrome P-450 in plant/insect interactions: geraniol 10-hydroxylase and the biosynthesis of iridoid monoterpenoids
Drug Metabol. Drug Interact.
12
369-382
1995
Catharanthus roseus, Nepeta racemosa
brenda
Burlat, V.; Oudin, A.; Courtois, M.; Rideau, M.; St-Pierre, B.
Co-expression of three MEP pathway genes and geraniol 10-hydroxylase in internal phloem parenchyma of Catharanthus roseus implicates multicellular translocation of intermediates during the biosynthesis of monoterpene indole alkaloids and isoprenoid-derive
Plant J.
38
131-141
2004
Catharanthus roseus (Q8VWZ7), Catharanthus roseus
brenda
Collu, G.; Garcia, A.; Van der Heijden, R.; Verpoorte, R.
Activity of the cytochrome P450 enzyme geraniol 10-hydroxylase and alkaloid production in plant cell cultures
Plant Sci.
162
165-172
2002
Catharanthus roseus
-
brenda
Huang, F.; Sung, P.; Do, Y.; Huang, P.
Differential expression and functional characterization of the NADPH cytochrome P450 reductase genes from Nothapodytes foetida
Plant Sci.
190
16-23
2012
Catharanthus roseus (Q8VWZ7)
brenda
Sintupachee, S.; Promden, W.; Ngamrojanavanich, N.; Sitthithaworn, W.; De-Eknamkul, W.
Functional expression of a putative geraniol 8-hydroxylase by reconstitution of bacterially expressed plant CYP76F45 and NADPH-cytochrome P450 reductase CPR I from Croton stellatopilosus Ohba
Phytochemistry
118
204-215
2015
Croton stellatopilosus (A0A0A7DLM4), Croton stellatopilosus (A0A0A8KYK4), Croton stellatopilosus, Croton stellatopilosus Ohba (A0A0A7DLM4), Croton stellatopilosus Ohba
brenda
Pandey, S.S.; Singh, S.; Babu, C.S.; Shanker, K.; Srivastava, N.K.; Shukla, A.K.; Kalra, A.
Fungal endophytes of Catharanthus roseus enhance vindoline content by modulating structural and regulatory genes related to terpenoid indole alkaloid biosynthesis
Sci. Rep.
6
26583
2016
Catharanthus roseus (Q8VWZ7), Catharanthus roseus
brenda
Liu, J.; Zhu, J.; Tang, L.; Wen, W.; Lv, S.; Yu, R.
Enhancement of vindoline and vinblastine production in suspension-cultured cells of Catharanthus roseus by artemisinic acid elicitation
World J. Microbiol. Biotechnol.
30
175-180
2014
Catharanthus roseus (Q8VWZ7), Catharanthus roseus
brenda
Madyastha, K.M.; Meehan, T.D.; Coscia, C.J.
Characterization of a cytochrome P-450 dependent monoterpene hydroxylase from the higher plant Vinca rosea
Biochemistry
15
1097-1102
1976
Catharanthus roseus
brenda
Suttipanta, N.; Pattanaik, S.; Gunjan, S.; Xie, C.H.; Littleton, J.; Yuan, L.
Promoter analysis of the Catharanthus roseus geraniol 10-hydroxylase gene involved in terpenoid indole alkaloid biosynthesis
Biochim. Biophys. Acta
1769
139-148
2007
Catharanthus roseus (Q8VWZ7), Catharanthus roseus
brenda
Hoefer, R.; Dong, L.; Andre, F.; Ginglinger, J.F.; Lugan, R.; Gavira, C.; Grec, S.; Lang, G.; Memelink, J.; Van der Krol, S.; Bouwmeester, H.; Werck-Reichhart, D.
Geraniol hydroxylase and hydroxygeraniol oxidase activities of the CYP76 family of cytochrome P450 enzymes and potential for engineering the early steps of the (seco)iridoid pathway
Metab. Eng.
20
221-232
2013
Catharanthus roseus (Q8VWZ7), Catharanthus roseus
brenda
Balusamy, S.; Rahimi, S.; Cho, Y.; Senthil, K.; Yang, D.
Overexpression of geraniol 10-hydroxylase from Panax ginseng conferred enhanced resistance to Pseudomonas syringae in Arabidopsis
Plant Growth Regul.
81
305-316
2017
Panax ginseng
-
brenda
Pan, Q.; Wang, Q.; Yuan, F.; Xing, S.; Zhao, J.; Choi, Y.H.; Verpoorte, R.; Tian, Y.; Wang, G.; Tang, K.
Overexpression of ORCA3 and G10H in Catharanthus roseus plants regulated alkaloid biosynthesis and metabolism revealed by NMR-metabolomics
PLoS ONE
7
e43038
2012
Catharanthus roseus (Q8VWZ7)
brenda
Cui, L.; Ni, X.; Ji, Q.; Teng, X.; Yang, Y.; Wu, C.; Zekria, D.; Zhang, D.; Kai, G.
Co-overexpression of geraniol-10-hydroxylase and strictosidine synthase improves anti-cancer drug camptothecin accumulation in Ophiorrhiza pumila
Sci. Rep.
5
8227
2015
Catharanthus roseus (Q8VWZ7), Catharanthus roseus
brenda
Soltani, N.; Nazarian-Firouzabadi, F.; Shafeinia, A.; Sadr, A.S.; Shirali, M.
The expression of terpenoid indole alkaloid (TIAs) pathway genes in Catharanthus roseus in response to salicylic acid treatment
Mol. Biol. Rep.
47
7009-7016
2020
Catharanthus roseus, Catharanthus roseus (Q8VWZ7)
brenda
Rather, G.; Sharma, A.; Pandith, S.; Kaul, V.; Nandi, U.; Misra, P.; Lattoo, S.
De novo transcriptome analyses reveals putative pathway genes involved in biosynthesis and regulation of camptothecin in Nothapodytes nimmoniana (Graham) Mabb
Plant Mol. Biol.
96
197-215
2018
Nothapodytes nimmoniana
brenda
Bai, C.; Wu, Y.; Cao, B.; Xu, J.; Li, G.
De novo transcriptome assembly based on RNA-seq and dynamic expression of key enzyme genes in loganin biosynthetic pathway of Cornus officinalis
Tree Genet. Genomes
14
57
2018
Cornus officinalis
-
brenda