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Information on EC 1.14.14.183 - taxoid 2alpha-hydroxylase

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EC Tree
IUBMB Comments
A cytochrome P-450 (heme-thiolate) protein from the yew tree Taxus cuspidata. Does not act on earlier intermediates in taxol biosynthesis.
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The expected taxonomic range for this enzyme is: Taxus cuspidata
Reaction Schemes
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[reduced NADPH—hemoprotein reductase]
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=
2alpha-hydroxytaxusin
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[oxidized NADPH—hemoprotein reductase]
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[reduced NADPH—hemoprotein reductase]
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=
2alpha,7beta-dihydroxytaxusin
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[oxidized NADPH—hemoprotein reductase]
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Synonyms
taxoid 2alpha-hydroxylase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
7beta-hydroxytaxusin + [reduced NADPHĀ—hemoprotein reductase] + O2 = 2alpha,7beta-dihydroxytaxusin + [oxidized NADPHĀ—hemoprotein reductase] + H2O
show the reaction diagram
(2)
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taxusin + [reduced NADPHĀ—hemoprotein reductase] + O2 = 2alpha-hydroxytaxusin + [oxidized NADPHĀ—hemoprotein reductase] + H2O
show the reaction diagram
(1)
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PATHWAY SOURCE
PATHWAYS
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