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IUBMB CommentsA cytochrome P-450 (heme-thiolate) protein. Involved in the biosynthetic pathway of the indole alkaloid verruculogen.
The expected taxonomic range for this enzyme is: Aspergillus subgen. Fumigati
Synonyms
EC 1.14.13.177,
ftmG,
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EC 1.14.13.177
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formerly
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ftmG
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fumitremorgin C + 2 [reduced NADPH-hemoprotein reductase] + 2 O2 = 12alpha,13alpha-dihydroxyfumitremorgin C + 2 [oxidized NADPH-hemoprotein reductase] + 2 H2O
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fumitremorgin C,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (12alpha,13alpha-dihydroxyfumitremorgin C-forming)
A cytochrome P-450 (heme-thiolate) protein. Involved in the biosynthetic pathway of the indole alkaloid verruculogen.
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fumitremorgin C + 2 [reduced NADPH-hemoprotein reductase] + 2 O2
12alpha,13alpha-dihydroxyfumitremorgin C + 2 [oxidized NADPH-hemoprotein reductase] + 2 H2O
fumitremorgin C + 2 [reduced NADPH-hemoprotein reductase] + 2 O2
12alpha,13alpha-dihydroxyfumitremorgin C + 2 [oxidized NADPH-hemoprotein reductase] + 2 H2O
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fumitremorgin C + 2 [reduced NADPH-hemoprotein reductase] + 2 O2
12alpha,13alpha-dihydroxyfumitremorgin C + 2 [oxidized NADPH-hemoprotein reductase] + 2 H2O
the enzyme is involved in the biosynthetic pathway of the indole alkaloid verruculogen
-
-
?
fumitremorgin C + 2 [reduced NADPH-hemoprotein reductase] + 2 O2
12alpha,13alpha-dihydroxyfumitremorgin C + 2 [oxidized NADPH-hemoprotein reductase] + 2 H2O
-
-
-
?
fumitremorgin C + 2 [reduced NADPH-hemoprotein reductase] + 2 O2
12alpha,13alpha-dihydroxyfumitremorgin C + 2 [oxidized NADPH-hemoprotein reductase] + 2 H2O
the enzyme is involved in the biosynthetic pathway of the indole alkaloid verruculogen
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
fumitremorgin C + 2 [reduced NADPH-hemoprotein reductase] + 2 O2
12alpha,13alpha-dihydroxyfumitremorgin C + 2 [oxidized NADPH-hemoprotein reductase] + 2 H2O
fumitremorgin C + 2 [reduced NADPH-hemoprotein reductase] + 2 O2
12alpha,13alpha-dihydroxyfumitremorgin C + 2 [oxidized NADPH-hemoprotein reductase] + 2 H2O
the enzyme is involved in the biosynthetic pathway of the indole alkaloid verruculogen
-
-
?
fumitremorgin C + 2 [reduced NADPH-hemoprotein reductase] + 2 O2
12alpha,13alpha-dihydroxyfumitremorgin C + 2 [oxidized NADPH-hemoprotein reductase] + 2 H2O
the enzyme is involved in the biosynthetic pathway of the indole alkaloid verruculogen
-
-
?
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heme
heme-thiolate protein (P-450)
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UniProt
brenda
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UniProt
brenda
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malfunction
the disruption of ftmG results in the loss of production of 12alpha,13alpha-dihydroxyfumitremorgin C and fumitremorgin B
malfunction
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the disruption of ftmG results in the loss of production of 12alpha,13alpha-dihydroxyfumitremorgin C and fumitremorgin B
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physiological function
the enzyme is involved in the biosynthetic pathway of the indole alkaloid verruculogen
physiological function
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the enzyme is involved in the biosynthetic pathway of the indole alkaloid verruculogen
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FTMG_ASPFM
504
1
56823
Swiss-Prot
Secretory Pathway (Reliability: 2)
FTMG_ASPFU
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
490
1
55052
Swiss-Prot
Secretory Pathway (Reliability: 2)
FTMG_NEOFI
Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)
504
1
57231
Swiss-Prot
Secretory Pathway (Reliability: 2)
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expressed in Saccharomyces cerevisiae
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Kato, N.; Suzuki, H.; Takagi, H.; Asami, Y.; Kakeya, H.; Uramoto, M.; Usui, T.; Takahashi, S.; Sugimoto, Y.; Osada, H.
Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus
ChemBioChem
10
920-928
2009
Aspergillus fumigatus (B9WZX6), Aspergillus fumigatus BM939 (B9WZX6)
brenda
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1.14.14.119 fumitremorgin C monooxygenase
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