Information on EC 1.14.13.15 - cholestanetriol 26-monooxygenase

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EC Tree 1 Oxidoreductases 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor 1.14.13.15 cholestanetriol 26-monooxygenase

IUBMB Comments

The enzyme requires ferredoxin and ferredoxin reductase. It catalyses the first three sterol side chain oxidations in bile acid biosynthesis via the neutral (classic) pathway. Can also act on cholesterol, cholest-5-en-3β,7α-diol, 7α-hydroxycholest-4-en-3-one, and 5β-cholestane-3α,7α-diol. The enzyme can also hydroxylate cholesterol at positions 24 and 25.

Synonyms
cholestanetriol 26-monooxygenase, more

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Release 2026.1 (March 2026)