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IUBMB Comments Requires Fe2+
Reaction Schemes
[2-(trimethylamino)ethyl]phosphonate
+
+
=
[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate
+
+
Synonyms tmpA ,
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gamma-butyrobetaine hydroxylase
misannotation
tmpA
-
-
-
-
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[2-(trimethylamino)ethyl]phosphonate + 2-oxoglutarate + O2 = [(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + succinate + CO2
-
-
-
-
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MetaCyc
(2-trimethylamino)ethylphosphonate degradation
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[2-(trimethylamino)ethyl]phosphonate,2-oxoglutarate:oxygen oxidoreductase (1R-hydroxylating)
Requires Fe2+ and ascorbate. The enzyme, found in bacteria, participates in a degradation pathway for [2-(trimethylamino)ethyl]phosphonate.
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2-aminoethylphosphonate + 2-oxoglutarate + O2
?
Substrates: -
?
3-aminopropylphosphonate + 2-oxoglutarate + O2
?
Substrates: -
?
phosphocholine + 2-oxoglutarate + O2
glycine betaine aldehyde + phosphate + succinate + CO2
Substrates: -
?
[2-(dimethylamino)ethyl]phosphonate + 2-oxoglutarate + O2
[(1R)-1-hydroxy-2-(dimethylamino)ethyl]phosphonate + 2-oxoglutarate + O2
Substrates: -
?
[2-(trimethylamino)ethyl]phosphonate + 2-oxoglutarate + O2
[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + succinate + CO2
Substrates: -
?
additional information
?
-
Substrates: no activity with gamma-butyrobetaine or analogue substrates
-
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[2-(trimethylamino)ethyl]phosphonate + 2-oxoglutarate + O2
[(1R)-1-hydroxy-2-(trimethylamino)ethyl]phosphonate + succinate + CO2
Substrates: -
?
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2-oxoglutarate
dependent on
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-
UniProt
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Highest Expressing Human Cell Lines
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Cell Line Links
Gene Links
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A0A4V8H042_9RHOB
377
0
41521
TrEMBL
-
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homodimer
2 * 41000, calculated from amino acid sequence
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in complex with Fe2+, [2-(trimethylamino)ethyl]phosphonate and 2-oxoglutarate, hanging drop vapor diffusion method, using 1.0-1.4 M Li2SO4 and 1.6-1.8 M (NH4)2SO4
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Ni-NTA column chromatography and Sephadex S-200 gel filtration
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expressed in Escherichia coli BL21(DE3) cells
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Rajakovich, L.; Pandelia, M.; Mitchell, A.; Chang, W.; Zhang, B.; Boal, A.; Krebs, C.; Bollinger, J.
A new microbial pathway for organophosphonate degradation catalyzed by two previously misannotated non-heme-iron oxygenases
Biochemistry
58
1627-1647
2019
Leisingera caerulea (A0A4V8H042)
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