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Information on EC 1.11.1.17 - glutathione amide-dependent peroxidase

for references in articles please use BRENDA:EC1.11.1.17

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IUBMB Comments

This enzyme, which has been characterized from the proteobacterium Marichromatium gracile, is a chimeric protein, containing a peroxiredoxin-like N-terminus and a glutaredoxin-like C terminus. The enzyme has peroxidase activity towards hydrogen peroxide and several small alkyl hydroperoxides, and is thought to represent an early adaptation for fighting oxidative stress . The glutathione amide disulfide produced by this enzyme can be restored to glutathione amide by EC 1.8.1.16 (glutathione amide reductase).

The enzyme appears in viruses and cellular organisms

Synonyms
glutathione amide-dependent peroxidase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 glutathione amide + H2O2 = glutathione amide disulfide + 2 H2O
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
glutathione amide metabolism
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