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The expected taxonomic range for this enzyme is: Streptomyces
Synonyms
FomC, more
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FomC
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2-hydroxyethylphosphonate + acceptor = phosphonoacetaldehyde + reduced acceptor
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-
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2-hydroxyethylphosphonate:acceptor oxidoreductase
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2-hydroxyethylphosphonate + NADP+
phosphonoacetaldehyde + NADPH + H+
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Substrates: -
Products: -
r
phosphonoacetaldehyde + reduced acceptor
2-hydroxyethylphosphonate + acceptor
Substrates: fomC is required for production of fosfomycin
Products: -
?
additional information
?
-
-
Substrates: no reaction is observed with hydroxymethylphosphonate and 3-hydroxypropylphosphonate
Products: -
?
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phosphonoacetaldehyde + reduced acceptor
2-hydroxyethylphosphonate + acceptor
Substrates: fomC is required for production of fosfomycin
Products: -
?
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NADPH
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FomC is an NADPH-dependent enzyme
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0.0098
NADPH
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in 50 mM HEPES, 200 mM NaCl, pH 7.5, temperature not specified in the publication
0.031
phosphonoacetaldehyde
-
in 50 mM HEPES, 200 mM NaCl, pH 7.5, temperature not specified in the publication
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1.3
phosphonoacetaldehyde
-
in 50 mM HEPES, 200 mM NaCl, pH 7.5, temperature not specified in the publication
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41
phosphonoacetaldehyde
-
in 50 mM HEPES, 200 mM NaCl, pH 7.5, temperature not specified in the publication
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7
-
phosphonoacetaldehyde reduction is more favorable under neutral conditions (optimal pH at 7.0)
9
-
2-hydroxyethylphosphonate oxidation is favored under basic conditions (optimal pH at 9.0)
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UniProt
brenda
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UniProt
brenda
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UniProt
brenda
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brenda
Highest Expressing Human Cell Lines
Cell Line Links
Gene Links
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malfunction
complementation of fomC disrupted mutants with 2-hydroxyethylphosphonate
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D2SNG2_STRFR
382
0
40186
TrEMBL
Secretory Pathway (Reliability: 1)
P96075_STRWE
262
0
27333
TrEMBL
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Talon immobilized metal affinity chromatography and Superdex 200 gel filtration
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cloning of the fosfomycin biosynthetic gene cluster
expressed in Escherichia coli BL21(DE3) cells as His6-tagged enzyme
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Woodyer, R.D.; Li, G.; Zhao, H.; van der Donk, W.A.
New insight into the mechanism of methyl transfer during the biosynthesis of fosfomycin
Chem. Commun. (Camb. )
4
359-361
2007
Streptomyces fradiae (D2SNG2)
brenda
Hidaka, T.; Goda, M.; Kuzuyama, T.; Takei, N.; Hidaka, M.; Seto, H.
Cloning and nucleotide sequence of fosfomycin biosynthetic genes of Streptomyces wedmorensis
Mol. Gen. Genet.
249
274-280
1995
Streptomyces wedmorensis (P96075), Streptomyces wedmorensis 144-91 (P96075)
brenda
Shao, Z.; Blodgett, J.A.V.; Circello, B.T.; Eliot, A.C.; Woodyer, R.; Li, G.; van der Donk, W.A.; Metcalf, W.W.; Zhao, H.
Biosynthesis of 2-hydroxyethylphosphonate, an unexpected intermediate common to multiple phosphonate biosynthetic pathways
J. Biol. Chem.
283
23161-23168
2008
Streptomyces wedmorensis
brenda
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