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Information on EC 1.1.5.2 - glucose 1-dehydrogenase (PQQ, quinone)
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1.1.5.2 glucose 1-dehydrogenase (PQQ, quinone)IUBMB Comments
Integral membrane protein containing PQQ as prosthetic group. It also contains bound ubiquinone and Mg2+ or Ca2+. Electron acceptor is membrane ubiquinone but usually assayed with phenazine methosulfate. Like in all other quinoprotein alcohol dehydrogenases the catalytic domain has an 8-bladed propeller structure. It occurs in a wide range of bacteria. Catalyses a direct oxidation of the pyranose form of D-glucose to the lactone and thence to D-gluconate in the periplasm. Oxidizes other monosaccharides including the pyranose forms of pentoses.
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Word Map
- 1.1.5.2
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quinoproteins
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electrode
- acinetobacter
- calcoaceticus
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gluconic
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bioelectrocatalytic
- gluconobacter
- oxydans
- biotechnology
- pqqh2
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fad-linked
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lactobionic
- diagnostics
- analysis
- biofuel production
- medicine
The expected taxonomic range for this enzyme is: Bacteria, Archaea, Eukaryota
Synonyms
quinoprotein glucose dehydrogenase, pqqgdh, m-gdh, pqq-gdh, membrane-bound glucose dehydrogenase, pyrroloquinoline quinone-dependent glucose dehydrogenase, soluble glucose dehydrogenase, pqq-dependent glucose dehydrogenase, gdh-b, pqqgdh-b, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
D-glucose:(pyrroloquinoline-quinone) 1-oxidoreductase
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dehydrogenase, glucose (pyrroloquinoline-quinone)
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EC 1.1.99.17
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formerly
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GCD
GDH
GDH-B
GDHm
GlcDH
glucose dehydrogenase
glucose dehydrogenase (PQQ dependent)
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glucose dehydrogenase (pyrroloquinoline-quinone)
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m-GDH
membrane-bound glucose dehydrogenase
mGDH
PQQ GDH
PQQ glucose dehydrogenase
PQQ-dependent GDH
PQQ-dependent glucose dehydrogenase
PQQ-dependent mGDH
PQQ-dependent soluble glucose dehydrogenase
PQQ-GDH
PQQ-glucose dehydrogenase
PqqC
PQQGDH
PQQGDH-B
pyrroloquinoline quinone dependent glucose dehydrogenase
pyrroloquinoline quinone glucose dehydrogenase
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pyrroloquinoline quinone-dependent glucose dehydrogenase
QGDH
quinone-dependent glucose dehydrogenase
quinoprotein aldose sugar dehydrogenase
quinoprotein D-glucose dehydrogenase
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quinoprotein glucose dehydrogenase
quinoprotein glucose DH
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s-GDH
sGDH
Tt_ASD
GDH
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PQQGDH
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pyrroloquinoline quinone-dependent glucose dehydrogenase
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quinoprotein glucose dehydrogenase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol
ping-pong mechanism
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D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol
active site structure
D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol
active site structure
D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol
hexa uni ping-pong mechanism
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D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol
active site structure contains a loop 6BC region which does not directly interact with the substrates
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D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol
active site structure from crystal structure, and detailed catalytic mechanism
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D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol
active site structure, putative catalytic mechanism and cycle involving Asp466 and Lys493
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D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol
catalytic mechanism, His144, Arg228, and Asn229 are involved
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D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol
ping pong reaction mechanism
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D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol
ping-pong mechanism
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D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
oxidation
redox reaction
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reduction
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oxidation
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
D-glucose:ubiquinone oxidoreductase
Integral membrane protein containing PQQ as prosthetic group. It also contains bound ubiquinone and Mg2+ or Ca2+. Electron acceptor is membrane ubiquinone but usually assayed with phenazine methosulfate. Like in all other quinoprotein alcohol dehydrogenases the catalytic domain has an 8-bladed propeller structure. It occurs in a wide range of bacteria. Catalyses a direct oxidation of the pyranose form of D-glucose to the lactone and thence to D-gluconate in the periplasm. Oxidizes other monosaccharides including the pyranose forms of pentoses.
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CAS REGISTRY NUMBER
COMMENTARY
81669-60-5
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-amino-D-glucose + pyrroloquinoline quinone
2-amino-D-glucono-1,5-lactone + pyrroloquinoline quinol
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?
2-deoxy-D-glucose + 2,6-dichlorophenolindolphenol
2-deoxy-D-glucono-1,5-lactone + ?
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?
2-deoxy-D-glucose + 2,6-dichlorophenolindophenol
2-deoxy-D-glucono-1,5-lactone + reduced 2,6-dichlorophenolindophenol
2-deoxy-D-glucose + oxidized N-methylphenazonium methyl sulfate
2-deoxy-D-glucono-1,5-lactone + reduced N-methylphenazonium methyl sulfate
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?
2-deoxy-D-glucose + phenazine methosulfate
2-deoxy-D-glucono-1,5-lactone + reduced phenazine methosulfate
2-deoxy-D-glucose + pyrroloquinoline quinone
2-deoxy-D-glucono-1,5-lactone + pyrroloquinoline quinol
3-deoxy-D-glucose + pyrroloquinoline quinone
3-deoxy-D-glucono-1,5-lactone + pyrroloquinoline quinol
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?
3-O-methyl-D-glucose + pyrroloquinoline quinone
3-O-methyl-D-glucono-1,5-lactone + pyrroloquinoline quinol
6-deoxy-D-glucose + pyrroloquinoline quinone
6-deoxy-D-glucono-1,5-lactone + pyrroloquinoline quinol
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?
alpha-D-lactose + phenazine methosulfate
alpha-D-lactono-1,5-lactone + reduced phenazine methosulfate
cellobiose + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
58% of the activity as compared to D-glucose
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?
cellobiose + pyrroloquinoline quinone
?
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70% of the activity with D-glucose
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?
D-allose + 2,6-dichlorophenolindophenol
D-allono-1,5-lactone + reduced 2,6-dichlorophenolindophenol
D-cellobiose + 2,6-dichloroindophenol
D-cellobiono-1,5-lactone + reduced 2,6-dichlorophenolindophenol
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?
D-cellobiose + phenazine methosulfate
D-cellobiono-1,5-lactone + reduced phenazine methosulfate
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?
D-fructose + 2,6-dichloroindophenol
? + reduced 2,6-dichlorophenolindophenol
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?
D-fucose + N-ethylphenazonium ethyl sulfate
6-deoxy-D-galactono-1,5-lactone + ?
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?
D-fucose + oxidized N-methylphenazonium methyl sulfate
6-deoxy-D-galactono-1,5-lactone + reduced N-methylphenazonium methyl sulfate
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?
D-fucose + pyrrolquinoline quinone
6-deoxy-D-galactono-1,5-lactone + pyrroloquinoline quinol
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?
D-galactose + 2,6-dichloroindophenol
D-galactono-1,5-lactone + reduced 2,6-dichlorophenolindophenol
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?
D-galactose + 2,6-dichlorophenolindophenol
D-galactono-1,5-lactone + reduced 2,6-dichlorophenolindophenol
D-galactose + oxidized N-methylphenazonium methyl sulfate
D-galactono-1,5-lactone + reduced N-methylphenazonium methyl sulfate
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?
D-galactose + phenazine methosulfate
D-galactono-1,5-lactone + reduced phenazine methosulfate
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?
D-glucosamino-1,5-lactone + reduced phenazine methosulfate
D-glucosamine + reduced phenazine methosulfate
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?
D-glucose + 2,3-dimethoxy-5-methyl-1,4-benzoquinone
D-glucono-1,5-lactone + ?
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?
D-glucose + 2,6-dichloroindophenol
D-glucono-1,5-lactone + reduced 2,6-dichloroindophenol
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?
D-glucose + 2,6-dichloroindophenol
D-glucono-1,5-lactone + reduced 2,6-dichlorophenolindophenol
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?
D-glucose + 2,6-dichlorophenolindophenol
D-glucono-1,5-lactone + reduced 2,6-dichlorophenolindophenol
D-glucose + 9,10-phenanthrenequinone
D-glucono-1,5-lactone + ?
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9,10-phenanthrenequinone shows low effectivity as redox mediator
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?
D-glucose + ?
D-glucono-1,5-lactone + ?
physiological electron acceptor in not known
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?
D-glucose + decylubiquinone
D-glucono-1,5-lactone + decylubiquinol
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?
D-glucose + N-ethylphenazonium ethyl sulfate
D-glucono-1,5-lactone + ?
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?
D-glucose + N-methylphenazonium methyl sulfate
D-glucono-1,5-lactone + ?
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D-glucose is the preferred substrate
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?
D-glucose + oxidized 2,6-dichlorophenolindophenol
D-glucono-1,5-lactone + reduced 2,6-dichlorophenolindophenol
D-glucose + oxidized N-methylphenazonium methyl sulfate
D-glucono-1,5-lactone + reduced N-methylphenazonium methyl sulfate
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?
D-glucose + ubiquinone Q1
D-glucono-1,5-lactone + ubiquinol Q1
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?
D-glucose + ubiquinone Q2
D-glucono-1,5-lactone + ubiquinol Q2
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?
D-glucose 6-phosphate + phenazine methosulfate
6-phospho-D-glucono-1,5-lactone + reduced phenazine methosulfate
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?
D-lactose + 2,6-dichlorophenolindophenol
D-lactono-1,5-lactone + reduced 2,6-dichlorophenolindophenol
D-maltose + 2,6-dichlorophenolindophenol
D-maltono-1,5-lactone + reduced 2,6-dichlorophenolindophenol
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71% activity compared to D-glucose
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?
D-mannose + 2,6-dichloroindophenol
D-mannono-1,5-lactone + reduced 2,6-dichlorophenolindophenol
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?
D-mannose + 2,6-dichlorophenolindophenol
D-mannono-1,5-lactone + reduced 2,6-dichlorophenolindophenol
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36% activity compared to D-glucose
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?
D-mannose + phenazine methosulfate
D-mannono-1,5-lactone + reduced phenazine methosulfate
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?
D-ribose + 2,6-dichloroindophenol
? + reduced 2,6-dichlorophenolindophenol
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?
D-ribose + phenazine methosulfate
D-ribono-1,4-lactone + reduced phenazine methosulfate
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?
D-ribose + pyrroloquinoline quinone
D-ribono-1,5-lactone + pyrroloquinoline quinol
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?
D-xylose + 2,6-dichloroindophenol
D-xylono-1,5-lactone + reduced 2,6-dichlorophenolindophenol
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?
D-xylose + 2,6-dichlorophenolindolphenol
D-xylono-1,5-lactone + ?
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?
D-xylose + 2,6-dichlorophenolindophenol
D-xylono-1,5-lactone + reduced 2,6-dichlorophenolindophenol
D-xylose + N-ethylphenazonium ethyl sulfate
D-xylono-1,5-lactone + ?
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?
D-xylose + N-methylphenazonium methyl sulfate
D-xylono-1,5-lactone + ?
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22% activity compared to D-glucose
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?
D-xylose + oxidized N-methylphenazonium methyl sulfate
D-xylono-1,5-lactone + reduced N-methylphenazonium methyl sulfate
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?
D-xylose + phenazine methosulfate
D-xylono-1,5-lactone + reduced phenazine methosulfate
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?
L-arabinose + 2,6-dichloroindophenol
? + reduced 2,6-dichlorophenolindophenol
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?
L-arabinose + 2,6-dichlorophenolindophenol
L-arabinono-1,5-lactone + reduced 2,6-dichlorophenolindophenol
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97% activity compared to D-glucose
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?
L-arabinose + N-ethylphenazonium ethyl sulfate
L-arabino-1,5-lactone + ?
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?
L-arabinose + oxidized N-methylphenazonium methyl sulfate
L-arabino-1,5-lactone + reduced N-methylphenazonium methyl sulfate
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?
L-arabinose + phenazine methosulfate
D-arabinono-1,5-lactone + reduced phenazine methosulfate
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?
lactose + 2,6-dichlorophenolindophenol
lactono-1,5-lactone + reduced 2,6-dichlorophenolindophenol
40% of the activity as compared to D-glucose
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?
maltose + 2,6-dichloroindophenol
maltono-1,5-lactone + reduced 2,6-dichlorophenolindophenol
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?
maltose + 2,6-dichlorophenolindophenol
maltono-1,5-lactone + reduced 2,6-dichlorophenolindophenol
91% of the activity as compared to D-glucose
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?
maltose + N-methylphenazonium methyl sulfate
maltono-1,5-lactone + ?
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17% activity compared to D-glucose
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?
maltose + phenazine methosulfate
D-maltono-1,5-lactone + reduced phenazine methosulfate
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?
maltotriose + phenazine methosulfate
D-maltotriono-1,5-lactone + reduced phenazine methosulfate
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?
sucrose + 2,6-dichlorophenolindophenol
? + reduced 2,6-dichlorophenolindophenol
30% of the activity as compared to D-glucose
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?
2-deoxy-D-glucose + 2,6-dichlorophenolindophenol
2-deoxy-D-glucono-1,5-lactone + reduced 2,6-dichlorophenolindophenol
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3% activity compared to D-glucose
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?
2-deoxy-D-glucose + 2,6-dichlorophenolindophenol
2-deoxy-D-glucono-1,5-lactone + reduced 2,6-dichlorophenolindophenol
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3% activity compared to D-glucose
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?
2-deoxy-D-glucose + phenazine methosulfate
2-deoxy-D-glucono-1,5-lactone + reduced phenazine methosulfate
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?
2-deoxy-D-glucose + phenazine methosulfate
2-deoxy-D-glucono-1,5-lactone + reduced phenazine methosulfate
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