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Information on EC 1.1.5.11 - 1-butanol dehydrogenase (quinone)
for references in articles please use BRENDA:EC1.1.5.11
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EC Tree 1 Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.5 With a quinone or similar compound as acceptor
1.1.5.11 1-butanol dehydrogenase (quinone)
IUBMB Comments
This periplasmic quinoprotein alcohol dehydrogenase, characterized from the bacterium Thauera butanivorans, is involved in butane degradation. It contains a tightly-bound pyrroloquinoline quinone (PQQ) cofactor. cf. EC 1.1.2.9, 1-butanol dehydrogenase (cytochrome c).
The enzyme appears in viruses and cellular organisms
showSynonyms
1-butanol dehydrogenase, AdhA, BDH, BOH, MEDH-PD Cyt c551i, NAD+-independent 1-butanol dehydrogenase, PQQ-ADH, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
1-butanol dehydrogenase
AdhA
BOH
PQQ-ADH
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
butan-1-ol + a quinone = butanal + a quinol
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
MetaCyc
butane degradation
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SYSTEMATIC NAME
IUBMB Comments
butan-1-ol:quinone oxidoreductase
This periplasmic quinoprotein alcohol dehydrogenase, characterized from the bacterium Thauera butanivorans, is involved in butane degradation. It contains a tightly-bound pyrroloquinoline quinone (PQQ) cofactor. cf. EC 1.1.2.9, 1-butanol dehydrogenase (cytochrome c).
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1-octanol + a quinone
octanal + a quinol
-
Substrates: 22% activity compared to butan-2-ol
Products: -
Products: -
?
1-pentanol + a quinone
pentanal + a quinol
-
Substrates: 34% activity compared to butan-2-ol
Products: -
Products: -
?
butyraldehyde + a quinol
?
-
Substrates: 25% activity compared to butan-2-ol
Products: -
Products: -
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octan-2-ol + a quinone
2-octanone + a quinol
-
Substrates: 15% activity compared to butan-2-ol
Products: -
Products: -
?
pentan-2-ol + a quinone
2-pentanone + a quinol
-
Substrates: 61% activity compared to butan-2-ol
Products: -
Products: -
?
propan-2-ol + a quinone
acetone + a quinol
-
Substrates: 0.7% activity compared to butan-2-ol
Products: -
Products: -
?
propionaldehyde + a quinol
?
-
Substrates: 33% activity compared to butan-2-ol
Products: -
Products: -
?
1-propanol + a quinone
propanal + a quinol
-
Substrates: 22% activity compared to butan-2-ol
Products: -
Products: -
?
1-propanol + a quinone
propanal + a quinol
-
Substrates: 22% activity compared to butan-2-ol
Products: -
Products: -
?
2-butanol + a quinone
2-butanone + a quinol
-
Substrates: -
Products: -
Products: -
?
2-butanol + a quinone
2-butanone + a quinol
-
Substrates: -
Products: -
Products: -
?
butan-1-ol + a quinone
butanal + a quinol
-
Substrates: 87% activity compared to butan-2-ol
Products: -
Products: -
?
butan-1-ol + a quinone
butanal + a quinol
-
Substrates: -
Products: -
Products: -
?
butan-1-ol + a quinone
butanal + a quinol
-
Substrates: 87% activity compared to butan-2-ol
Products: -
Products: -
?
butan-2-ol + a quinone
2-butanone + a quinol
-
Substrates: 100% activity
Products: -
Products: -
?
butan-2-ol + a quinone
2-butanone + a quinol
-
Substrates: 100% activity
Products: -
Products: -
?
butyraldehyde + a quinol
1-butanol + a quinone
-
Substrates: -
Products: -
Products: -
?
butyraldehyde + a quinol
1-butanol + a quinone
-
Substrates: -
Products: -
Products: -
?
ethanol + a quinone
acetaldehyde + a quinol
-
Substrates: 0.7% activity compared to butan-2-ol
Products: -
Products: -
?
ethanol + a quinone
acetaldehyde + a quinol
-
Substrates: 0.7% activity compared to butan-2-ol
Products: -
Products: -
?
methanol + a quinone
formaldehyde + a quinol
-
Substrates: 0.7% activity compared to butan-2-ol
Products: -
Products: -
?
methanol + a quinone
formaldehyde + a quinol
-
Substrates: 0.7% activity compared to butan-2-ol
Products: -
Products: -
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
butan-1-ol + a quinone
butanal + a quinol
-
Substrates: -
Products: -
Products: -
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
10 - 40
more than 60% activity between 10 and 40°C, no activity at 50°C
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pI VALUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
Highest Expressing Human Cell Lines
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
malfunction
-
insertional disruption of the enzyme gene adversely, but does not eliminate, butane utilization
malfunction
-
insertional disruption of the enzyme gene adversely, but does not eliminate, butane utilization
-
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). BOH_THABB
Thauera butanivorans (strain ATCC 43655 / DSM 2080 / JCM 20651 / CCUG 51053 / NBRC 103042 / IAM 12574 / Bu B1211)
623
0
67553
Swiss-Prot
-
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
DEAE Toyopearl column chromatography, CM Toyopearl column chromatography, and hydroxyapatite column chromatography
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
the enzyme's mRNAs is induced when the cell's 1-butanol oxidation activity is induced
the enzyme's mRNAs is induced when the cell's 1-butanol oxidation activity is induced
-
the enzyme's mRNAs is induced when the cell's 1-butanol oxidation activity is induced
-
-
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Vangnai, A.S.; Arp, D.J.; Sayavedra-Soto, L.A.
Two distinct alcohol dehydrogenases participate in butane metabolism by Pseudomonas butanovora
J. Bacteriol.
184
1916-1924
2002
Thauera butanivorans, Thauera butanivorans ATCC 43655
brenda
Treek, J.; Matsushita, K.
A unique enzyme of acetic acid bacteria, PQQ-dependent alcohol dehydrogenase, is also present in Frateuria aurantia
Appl. Microbiol. Biotechnol.
97
7369-7376
2013
Frateuria aurantia (S6D3Q2), Frateuria aurantia LMG 1558T (S6D3Q2)
brenda
Vangnai, A.; Sayavedra-Soto, L.; Arp, D.
Roles for the two 1-butanol dehydrogenases of Pseudomonas butanovora in butane and 1-butanol metabolism
J. Bacteriol.
184
4343-4350
2002
Thauera butanivorans, Thauera butanivorans ATCC 43655
brenda
EXTERNAL LINKS (specific for EC-Number 1.1.5.11)
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Release 2026.1 (March 2026)
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